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All Journal Jurnal Natur Indonesia Jurnal Perikanan dan Kelautan Jurnal Sains Dasar Jurnal Ilmu Perairan (Aquatic Science) JURNAL PETERNAKAN Jurnal Riset Kimia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biology, Medicine, & Natural Product Chemistry Medical Laboratory Technology Journal ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia JOPS (Journal Of Pharmacy and Science) JURNAL PHOTON JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Jurnal Dunia Farmasi Asian Journal of Aquatic Sciences Acta Chimica Asiana Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Journal of Artificial Intelligence and Digital Business Jurnal Katalisator Jurnal Farmasi Indonesia Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Perikanan dan Kelautan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Musyirna Rahmah Nst
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Analysis of Infusion and Ethanol Extract of Tamarindus indica L, Scurrula Sp, Mimosa pudica D of Fresh and Dry as Amylase Enzyme Inhibitor Devi. Sy, Silvera; Nst, Musyirna Rahmah; Jannah, Ninuk Rodhiatul
Jurnal Natur Indonesia Vol 17, No 2 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.136 KB) | DOI: 10.31258/jnat.17.2.25-31

Abstract

α-amilase is one of digestive enzyme that hydrolize starch to maltose by α-glukosidase and degradation to form a glucose and continue with blood adsorption through villi of small intestine. Consomption of acarbose drug is one of ways for diabetic treatment to inhibit the activity of α-amilase. Tamarind leaves (Tamarindus indica L) herbal benalu api (Scurrula Sp) and herbal putri malu (Mimosa pudica D) regularly used as medical plant with activity of antidiabetic medicine. The aims of this studies was to analyze the potency of three medical plant with form of infusa and ethanol extract from fresh or dried plant to inhibit activity of α-amilase and akarbose used as positive control. Inhibition potency of sample against activity of α-amilase were determine base on maltose produced by of starch hydrolysis α-amilase to reduction dinitrosalicylic acid become 3-amino-5-nitrosalicylic acid and the absorbance were measured with spektrofotometer at 530 nm. Resulted of percentage inhibition against activity of α-amilase were herbal infusa from dried benalu api 85.58 ± 2,93%, infusa of fresh putri malu 87.40 ± 1,81%, and the dried 98,85 ± 0,66%. These results did not significancy different with inhibition of akarbose 93.89 + 0,02%. Infusa herbal of dried benalu api, fresh and dried putri malu were potential cover for acarbose to used as alternative medicine.
Molecular Docking and Molecular Dynamic Simulation of 1,5-Benzothiazepine Chalcone Derivative Compounds as Potential Inhibitors for Zika Virus Helicase Frimayanti, Neni; Nasution, Musyirna Rahmah; Etavianti, Elsa
Jurnal Riset Kimia Vol 12, No 1 (2021): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i1.365

Abstract

Zika virus caused of the emerging infections characterized by fever, Guillain-Barré syndrome (GBS) for adults. In the current work, we aimed to study the binding orientation of 1,5-benzothiazepine compounds as new potential agent against Zika virus inhibitor through molecular docking and molecular dynamic simulation. Since, 1-5-Benzothiazepines are particular interest for drug discovery and they also has some biological activities. However, their antiviral activities and in silico studies of the binding to their biological targets have not been extensively investigated. Molecular docking study of 1,5-benzothiazepine chalcone derivatives compounds with protein target 5GJB (PDB ID) and this protein was taken from the crystallographic structure. In this study, twelve 1,5-benzothiazepine chalcone derivative compounds were docked to the protein with the grid box along x, y and z radius of 26.85, 28.17 and 24.43 Å, respectively. Suramin was used as positive control. Thus, it can be used as a reference for design new inhibitors for Zika virus helicase. Based on the docking results, it is observed that compounds MA3 and MA8 are estimated to have activity as inhibitors for Zika virus helicase with binding free energy values of -4.6490 and -4.9291 kcal/mol, respectively. MA3 and MA8 were also stable during the MD simulations with the hydrogen bonding are still maintained before and after MD simulation. Furthermore, both of these compounds can be used an early stage for drug design and drug delivery process.
KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook) Rahayu Utami Utami; Ginta Rio Maranti; Mustika Furi; Melzi Octaviani; Septi Muharni; Fina Aryani; Husnawati; Wira Noviana Suhery; Musyirna Rahmah Nst; Haiyul Fadhli; Emma Susanti; Emrizal
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1418

Abstract

Simpur air is one of plant that has been using as traditional medicine for treating several diseases. Some studies on its chemical constituents and biological activities of this species have been published. However, chemical constituents and antioxidant activity of this plant which is Riau origin has not been reported before. This study aims to determine the total of phenolic and flavonoid content as well as its antioxidant activity of methanol extracts of roots, leaves and flowers of simpur air. Determination of total of phenolic and flavonoid content was performed by spectrophotometric method using Folin Ciocalteu and AlCl3 as reagents, respectively. Whereas, its antioxidant activity was evaluated using DPPH method. The results showed that methanol extracts of its roots afforded the highest total of phenolic and flavonoid content and also its antioxidant activity. The total of phenolic content of methanol extracts of its roots of 428.131 GAE/mg extract; its total of flavonoid content of 766.164 QE/mg extract; as for its antioxidant activity gave IC50 value of 3.852 µg/ml.
Penentuan Aktivitas Tabir Surya Ekstrak Etanol Daun Marpuyan (Rhodamnia cinerea Jack.) secara In Vitro Musyirna Rahmah Nasution; Annisa Riski Permata Sari; Intan Putri Utami; Tria Halianti
Jurnal Dunia Farmasi Vol 4, No 2 (2020): Edisi April
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v4i2.4599

Abstract

Pendahuluan: Marpuyan (Rhodamnia cinerea Jack.) merupakan salah satu tumbuhan obat tradisional yang mengandung senyawa flavonoid dan fenolik. Senyawa tersebut diketahui memiliki berbagai aktivitas biologis. Tujuan: untuk mengetahui potensi aktivitas tabir surya ekstrak etanol daun marpuyan secara in vitro dengan metode spektrofotometri. Metode:Pengujian aktivitas tabir surya dilakukan dengan menentukan nilai Sun Protection Factor (SPF), nilai persentase Transmisi eritema (%Te) dan persentasi Transmisi pigmentasi (%Tp) menggunakan alat Microplate Reader. Hasil: Berdasarkan hasil pengujian menunjukkan bahwa ekstrak etanol daun marpuyan memiliki aktivitas tabir surya pada konsentrasi 1000 ppm dengan kategori %Te 0,422 (Sunblock), %Tp 10,566 (Sunbock) dan SPF 20,765 (Proteksi ultra). Kesimpulan: Ekstrak etanol daun marpuyan berpotensi sebagai bahan aktif antioksidan dan tabir surya.
AKTIVITAS ANTIOKSIDAN SEDUHAN DAUN KOPI KAWA KERING (Coffea arabica L) DENGAN METODE DPPH Musyirna Rahmah Nasution; Martina Br Manullang
Jurnal Insan Farmasi Indonesia Vol 3 No 1 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i1.467

Abstract

Kawa Coffee is a traditional beverage made from coffee leaves which is a typical drink in Tanah Datar in West Sumatra. The dried kawa coffee leaves are brewed with hot water to produce a brownish color.Kawa coffee leaves (Coffea robusta L) containsecondary metabolites such as flavonoids. Flavonoids have been known to have antioxidant activity. Research has been conducted to determine antioxidant activity from steeping kawa coffee leaves using the DPPH method by spectrophotometry. The test concentrations used were 5%, 2.5%, 1.25%, 0.625%, 0.313%, 0.156%. The results showed that steeping dried kawa coffee leaves at a concentration of 5% had given DPPH radical inhibition of 87.036%. The IC50 obtained is 0.591%. Steeping kawa coffee leaves is a health drink that has strong antioxidant activity.
PEMERIKSAAN RESIDU ANTIBIOTIK PADA HATI KERBAU DAN IKAN NILA DENGAN METODA DIFUSI AGAR Musyirna Rahmah NST; Rahayu Utami; Nur Rahmadani Fitri
Jurnal Peternakan Vol 7, No 1 (2010): Februari 2010
Publisher : State Islamic University of Sultan Syarif Kasim Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24014/jupet.v7i1.466

Abstract

This study was aimed to identify antibiotic residue on buffalo liver (Bubalus bubalis) dan nila fish (Oreochromis niioticus). Detection of antibiotic residu was used antibacterial assay by diffusion methode. The result indicated that some of samP/i:.s at concentration 25% contained antibiotic residue with inhibited growth rate Escherichia coli 12,3 nun.
Molecular Docking and Molecular Dynamic Simulation of 1,5-Benzothiazepine Chalcone Derivative Compounds as Potential Inhibitors for Zika Virus Helicase Neni Frimayanti; Musyirna Rahmah Nasution; Elsa Etavianti
Jurnal Riset Kimia Vol. 12 No. 1 (2021): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i1.365

Abstract

Zika virus caused of the emerging infections characterized by fever, Guillain-Barré syndrome (GBS) for adults. In the current work, we aimed to study the binding orientation of 1,5-benzothiazepine compounds as new potential agent against Zika virus inhibitor through molecular docking and molecular dynamic simulation. Since, 1-5-Benzothiazepines are particular interest for drug discovery and they also has some biological activities. However, their antiviral activities and in silico studies of the binding to their biological targets have not been extensively investigated. Molecular docking study of 1,5-benzothiazepine chalcone derivatives compounds with protein target 5GJB (PDB ID) and this protein was taken from the crystallographic structure. In this study, twelve 1,5-benzothiazepine chalcone derivative compounds were docked to the protein with the grid box along x, y and z radius of 26.85, 28.17 and 24.43 Å, respectively. Suramin was used as positive control. Thus, it can be used as a reference for design new inhibitors for Zika virus helicase. Based on the docking results, it is observed that compounds MA3 and MA8 are estimated to have activity as inhibitors for Zika virus helicase with binding free energy values of -4.6490 and -4.9291 kcal/mol, respectively. MA3 and MA8 were also stable during the MD simulations with the hydrogen bonding are still maintained before and after MD simulation. Furthermore, both of these compounds can be used an early stage for drug design and drug delivery process.
Isolasi Dan Identifikasi Mikroba Penghasil Antibiotika Dari Sampel Lumpur Sungai Kampar Riau Musyirna Rahmah Nst; Akmal Djamaan; Gustina '
Ilmu Perairan (Aquatic Science) Vol 8, No 2 (2010)
Publisher : Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jipas.8.2.p.1-11

Abstract

Isolation of microbes that produce antibiotic found in the sludge of Kamparriver has been carrie out using crowded plate method. The sludge were inoculated inPDA and NA, and incubated for 24 hours. Microbes showing clear zone wereobserved, this indicated the microbes produce antibiotics. The microbes wereisolated and identified. The result showed there were three species Bacillus sp ofwhich potencial to produce antibiotic compund.Key words: microbe, isolation,antibiotic
UJI POTENSI TABIR SURYA EKSTRAK ETANOL DAUN TENGGEK BURUNG (Euodia redlevi) SECARA IN VITRO musyirna rahmah nasution; Afrida Yeti; Bella Ardhiyati
JURNAL FARMASI DAN MAKANAN Vol 4 No 2 (2021): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i2.1764

Abstract

Daun tenggek burung (Euodia redlevi) secara tradisional digunakan untuk mengobati tekanan darah tinggi, melancarkan peredaran darah, mencegah penuaan dini, mengobati diabetes mellitus serta memberikan efek kebugaran.Daun tenggek burung merupakan salah satu tumbuhan obat yang mengandung diketahui mengandung senyawa fenolik yang berpotensi sebagai tabir surya.Tujuan dari penelitian ini untuk mengetahui aktivitas tabir surya pada ekstrak etanol daun tenggek burung dengan metode spektrofotometri.Pengujian aktivitas tabir surya dilakukan dengan menentukan nilai persentase Transmisi eritema (%Te), Transmisi pigmentasi (%Tp), dan Sun Protection Factor (SPF) menggunakan microplate reader. Berdasarkan hasil pengujian ekstrak etanol daun tenggek burung (Euodia redlevi) menunjukan aktivitas tabir surya yang baik pada konsentrasi 250 ppm dengan nilai %Te sebesar 0,4252% (Sunblock), nilai %Tp sebesar 0,3150% (Sunblock) dan nilai Sun Protection Factor (SPF) 21,624 (proteksi ultra).
AKTIVITAS INHIBISI α-GLUKOSIDASE INFUSA KAYU MANIS (Cinnamomum verum J.Presl), KUNYIT (Curcuma domestica Val) DAN KOMBINASINYA Wulan Desmar Utari; Musyirna Rahmah Nasution
JURNAL FARMASI DAN MAKANAN Vol 5 No 1 (2021): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i1.2145

Abstract

Pengobatan diabetes melitus khususnya tipe 2 biasanya diatasi menggunakan obat akarbose yang akan menginhibisi aktivitas enzim α-glukosidase, enzim α-glukosidase dalam proses pencernaan akan menghidrolisis amilum menjadi glukosa. Penelitian ini bertujuan untuk melihat potensi aktivitas inhibisi enzim α-glukosidase secara in vitro infusa tunggal dari kedua tanaman kayu manis (Cinnamomum verum J.Presl) dan Kunyit (Curcuma domestica Val) dan melihat apakah ada aktivitas sinergis terhadap kombinasi dari kedua infusa. % inhibisi infusa terhadap aktivitas glukosidase ditentukan menggunakan substrat p-nitrofenil-α-D-glukopiranosida (p-NPG). Absorbansi hasil reaksi diukur menggunakan microplate reader pada panjang gelombang 410 nm. Hasil Penelitian menunjukkan bahwa pada formula kombinasi infusa kayu manis dan kunyit memiliki efek sinergis dalam menginhibisi enzim α-glukosidase, akan tetapi tidak lebih baik dibanding dengan formula I infusa tunggal kayu manis yaitu % inhibisi sebesar 97,21 %, serta analisis one way ANOVA terhadap aktivitas enzim α-glukosidase dari semua formula memiliki perberbedan yang sangat nyata (p<0,05).
Co-Authors -, Hasmalina Abdi Wira Septama Abdifi, Reza Afnita, Fakhiratunnisa Afrida Yeti Afrizal Tanjung Agfa Febriyananda Agustini, Tiara Tri Akmal Djamaan Amnan, Wekis Raya Anggraini, Annisa Fitri Anita Lukman Annisa Riski Permata Sari Antasya, Vaylia Aqilla, Alya Armon Fernando Armon Fernando Arundita, Silvy Aulya, Nurliza Ayuni, Putri Azhari, Weriska Restu Bella Ardhiyati BENNI ISKANDAR Cahyani, Ardhia Regita Dasni Syafril Dasni Syafril Deni Anggraini Diwa, Resi Oktamara Dwi Andreyas Elsa Etavianti Emrizal Enda Mora Etavianti, Elsa Febrian, Dyan Fina Aryani, Fina Firman Nugroho Fitri, Ramadini Fitri, Valentina Furi, Mustika Ginta Rio Maranti Gressy Novita Gustina &#039; Haiyul Fadhli Hanifa, Elvi Hasmalina - Hasmalina Nasution Husnawati Ihsan Ikhtiarudin Intan Putri Utami Irwan Irwan Jannah, Ninuk Rodhiatul Ladiona, Maria Yella Lamun Bathara Manik, Dhea Putri Bertuah Br Maria Yella Ladiona Martina Br Manullang Masnun, Lidiatil Meiriza Djohari, Meiriza Melati, Putri Melzi Octaviani Milianty, Jesy Muthmainnah, Nurillah Nabilah, Clara Nabilla, Vivi Gita Nanang Nasution, Tio Afandi Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nur Rahmadani Fitri Nurhapipah, Nurhapipah Pardede, Depa Gloria Kristin Peng, Wei-Ching Peng-Wei, Ching Putri Lestari, Putri Putri Putri, Putri Rabiatul Adawiyah Rahayu Utami Rahayu Utami Utami Rahma Dona Rahman, Sumiati Rajeb Fadillah ramadhan, alfitrah Ramadhani, Elsha Fadhika Dwi Ratna Sari Dewi Reza Abdifi Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Ronapadua Sahara Ruska, Shinta Liana S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Sahara, Ronapadua Sakinah, Norma Septi Muharni Silvera Devi Simanjuntak, Asnika Putri Sri Hardianti Sudarsi, Yulisma Suhelmi - Suhelmi - Sumiati Rahman Syahbandi, Ilham Syahril Nedi Syamira Tri Budhi Murdiati Tri Budhi Murdiati Tria Halianti Triani, Leni Winda Sri Wahyuni Wira Noviana, Wira Noviana Wulan Desmar Utari Yuharmen - Yulisma Sudarsi Yunelva, Rinda