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Jafriati
Fakultas Kesehatan Masyarakat Universitas Halu Oleo
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pogostemon cablin from North Konawe Targets MCF-7 Cells and Inflammatory Responses Through Protein Denaturation and Membrane Stabilization Fristiohady, Adryan; Jafriati, Jafriati; Anwar, Irvan; Asasutjarit, Rathapon; Purnama, La Ode Muhammad Julian; Haruna, Lidya Agriningsih; Yodha, Agung Wibawa Mahatva; Hariana, Hariana; Bafadal, Mentarry
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.10168

Abstract

Pogostemon cablin (Patchouli), a medicinal plant traditionally used in Indonesia, is gaining scientific attention for its potential pharmacological activities. This study aimed to investigate the anti-inflammatory and anticancer effects of P. cablin ethanolic leaf extract specifically sourced from North Konawe, Southeast Sulawesi. To evaluate its anti-inflammatory activity, two in vitro models were used: the protein denaturation inhibition assay, simulating inflammatory protein response, and the human red blood cell (HRBC) membrane stabilization assay, which mimics lysosomal membrane stability in inflamed tissues. The extract showed significant, dose-dependent inhibition of protein denaturation, with an IC50 value of 62.98 µg/mL. In the HRBC assay, the extract demonstrated membrane stabilization activity with a maximum inhibition of 64.24% at the highest tested concentration (100 µg/mL). The cytotoxic potential was assessed using the MTT assay on MCF-7 hormone-responsive breast cancer cells. The extract exhibited potent anti-proliferative activity, with an IC50 value of 91.56 ± 1.31 µg/mL, indicating its effectiveness in inhibiting breast cancer cell growth. These findings highlight P. cablin from North Konawe as a promising natural source of anti-inflammatory and anticancer agents, with the potential to contribute to the development of plant-based therapeutics. However, this study is limited to in vitro analyses; further investigations are needed to isolate active compounds and confirm efficacy through in vivo and mechanistic studies.
Co-Authors AA Sudharmawan, AA Adius Kusnan Adius Kusnan Al Edy Dawu Ali Imran Amiruddin Amiruddin Anisa Ninuk Melania Anoamo, Wa Ode Rahmadani Anwar, Irvan Ardiansyah, Ririn Teguh Arianti, Dina Arnisyah Amir Asasutjarit, Rathapon Asmawati Asmawati Asnia Zainuddin Asnia Zainuddin Asnia Zainuddin Asnia Zainudin Asriati Asriati, Asriati Aulia Ghibrani Haidir Azim, La Ode Liaumin Bafadal, Mentarry Cece Suryani Ismail Devi Takin Dewi Liesnoor Setyowati Dewi Vidayani Dewi, Sri Tungga Dhiya Ramadhani Dian Safitri Efendy, Devi Savitri EVI FEBRIANI Febriana Muchtar Febriana Muchtar Fera Rahayu Ningsi Fifi Nirmala FINDARI RAHMAN Firnanda, Nova Fristiohady, Adryan Hariana, Hariana Hariati Lestari Harjunia, Ria Harleli Harleli Hartoyo, Agnes Mersatika Haruna, Lidya Agriningsih Hasriani, Siti Herman, Sriyana Hermanto T. Joewono Ibrahim, Karma Ilham Ibnu Ahmadi Ilmayanti Rukmana Irma Irma Irma Yunawati Irma Yunawati Ismawati Ismawati jufri, Nurnashriana Jumakil Jumakil Junaid Junaid Junaid Junaid, Junaid Jusniar Rusli Afa Karimuna, Siti Rabbani Karimuna, Siti Rabbani Kartini Kartini kusnan, adius L. Lisnawaty La Ode Ahmad Saktiansyah La Ode Arsad Sani Lajumadil Akhmad Tiu Latifa Salim lisnawaty lisnawaty Lisnawaty Lisnawaty Lisnawaty Lisnawaty, Lisnawaty Lisnawaty, L. Listy Handayani Lymbran Tina Maulidyah, Nurfadila Mubarak Muchtar, Febriana Muhammad Bazal Muharram Musdalifah, Siti Muthmainnah Muthmainnah Muthmainnah S Saad, Wiwik Nani Yuniar Nova Lianti Nurfajriyanti Hamka Nurfifi, Sahida Nurmaladewi Nurmaladewi Nurmaladewi, Nurmaladewi Paridah Paridah Paridah Paridah Pebrianti Pebrianti Puput Monica Rifty Purnama, La Ode Muhammad Julian Rahman Rahman Ramadhan Tosepu Ramadhan Tosepu Resti Nur Pratiwi Rina Asriani Rizka Amaliya Nur Sulastri Roswati Roswati Ruslan Majid Ruslan Majid, Ruslan Ruwiah Ruwiah Salifa, Siti Saptaputra, Syawal Kamiluddin Sari, Monde Setiawan, Eris Siti Fatmawati Siti Nurfadilah H Siti Nurwahida Siti Rabbani Karimuna Siti Rabbani Karimuna Sitti Fadila Sitti Farida Sri Tungga Dewi Suhadi Suhadi Suhadi Suhadi Suprianty, Hesty Susanty, Sri Susi Asrianti Syawal Kamiluddin Saptaputa Syawal Kamiluddin Saptaputra Wa Ode Salma Wally, Puput Wd.Najwa Sandrina Shihab Wuna Saputri Mulia Sari Yasnani Yasnani, Yasnani Yodha, Agung Wibawa Mahatva Yunawati, Irma Yusuf Sabilu, Yusuf Zainuddin, Asnia