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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Of Nursing Practice Jurnal Surya Masyarakat Jurnal Kesehatan Islam : Islamic Health Journal Medical Technology and Public Health Journal Medical and Health Science Journal Community Development Journal Biomolecular and Health Science Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang REMIK : Riset dan E-Jurnal Manajemen Informatika Komputer Community Development Journal: Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat Indonesia Berdaya Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat International Islamic Medical Journal Jurnal Kesehatan Tambusai Prominentia Medical Journal Journal for Quality in Public Health Maslahat
Salim, Hotimah Masdan
Universitas Nahdlatul Ulama Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Prominentia Medical Journal

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Efektivitas Penggunaan Hidrogel Kratom Terhadap Kadar Gula Darah Pada Ulkus Diabetikum Rihhadatulays, Khuzaimah Nur Juhanifah; Pramesti, Rosandhy Alifyah; Hanafi, Eka Satria Akbar Ferdinan; Jazuli, Muhammad Aqil Siroj; Salim, Hotimah Masdan; Amani, Fariska Zata; Aisyah, Aisyah
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.6076

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. One of the most common complications is diabetic ulcers, which are often associated with vascular impairment, infection, and poor glucose stability. The search for alternative therapies continues to develop, including the use of Mitragyna speciosa (kratom) leaves, which contain mitragynine and flavonoids that have been shown to inhibit α-glucosidase and enhance antioxidant activity. This study aimed to evaluate the effect of kratom hydrogel on blood glucose levels in an animal model of diabetic ulcers. Using a posttest-only control group design, mice (Mus musculus) were induced with streptozotocin to establish a type 2 diabetes model. The animals were divided into three groups: positive control, 5% kratom hydrogel, and 15% kratom hydrogel. Blood glucose levels were measured weekly over a two-week period. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison test. The results showed differences in blood glucose levels among all treatment groups. The 15% kratom hydrogel group demonstrated a significant reduction in blood glucose, approaching near-normal levels compared with the positive control (p < 0.05). Statistical analysis indicated a more dominant effect compared to the variation of treatment types. These findings suggest a synergistic mechanism through α-glucosidase inhibition and enhanced antioxidant activity. Therefore, kratom hydrogel has potential as a complementary therapy for glycemic control in patients with type 2 diabetes mellitus complicated by diabetic ulcers.
Analisis Efek Mitragynine Terhadap Metabolisme Glukosa melalui Uji Toleransi Glukosa (OGTT) dan Uji Toleransi Insulin (ITT) pada Model Tikus Diabetes Awwalia, Evi Sylvia; Faradis, RA. Hani; Wulandari, Devyana Dyah; Salim, Hotimah Masdan
Prominentia Medical Journal Vol 7 No 1 (2026): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v7i1.6054

Abstract

Mitragynine is the major alkaloid found in Mitragyna speciosa (kratom) and has been reported to possess various biological activities, including potential effects on glucose metabolism. However, scientific evidence regarding its role in glucose tolerance and insulin sensitivity remains limited. This study aimed to evaluate the effects of methanolic extract of Mitragyna speciosa containing mitragynine on glucose metabolism through the Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) in experimental animals. Experimental animals were divided into groups consisting of a control and treatment groups receiving methanolic extract of M. speciosa at doses of 15 mg/kg BW and 30 mg/kg BW. Parameters observed included blood glucose levels at different time points following glucose administration (OGTT) and the response to exogenous insulin administration (ITT). Administration of mitragynine extract significantly reduced blood glucose levels compared with the control group in the OGTT, particularly at the 30 mg/kg BW dose. Furthermore, the ITT demonstrated improved insulin sensitivity, with a more rapid decline in blood glucose levels in the treatment groups. These effects showed a dose-dependent pattern, with the higher dose producing more pronounced improvements. Methanolic extract of Mitragyna speciosa containing mitragynine has the potential to enhance glucose metabolism by improving glucose tolerance and increasing insulin sensitivity. These findings suggest that mitragynine could be explored as a potential adjuvant agent in managing glucose metabolism disorders; however, further investigations are needed to elucidate its molecular mechanisms and long-term safety.
Co-Authors A., Ratna Ariesta Dwi Abdul Muhith Achmad Hilman Fahmy Aditya Bhayusakti Adyan Donastin Afiyah, R. Khairiyatul Aisyah Aisyah Aji, Audi Ikhfina Tanra Akas Yekti Pulih Asih Alam, Ilham Putera Alam, Ilham Putra Alfina Andasari Algristian, Hafid Andi Roesbiantoro Andreas Putro Ragil Santoso, Andreas Putro Ragil Anggara Kidung Pranata Anggraini, Yasi Ardianti, Ami Arif Rahman Hakim Atika Maulida Inastiti Awwalia, Evi Sylvia Awwaliya, Evi Awwaliyah, Evi Sylvia Awwaliyah, Evy Silvia Bagas Setiawan Ihsan Zaini Bagas Setiawan Ihsan Zaini Bariyah, Khadijah Khairul Bermawi, Bastiana Bintarti, Tri Wahyuni Bintarti, Tri Wahyuni Charissa Balqis Choiriya, Dian Dakwatul Choirotussanijah Choirotussanijah Choirotussanijjah Danny Irawan David Sajid Muhammad Dayu Satriya Wibawa Deny Febriwijaya Romadhani Desi Irawati, Adinda Devyana Dyah Wulandari Dwi Arman Prasetya Dwimantoro EBISINTEI, PRECIOUS Edza Aria Wikurendra Endah Budi Permana Putri Erfina Miftakhul Zannah Ersalina Nidianti Evi Octavia Djamaludin Fadilah Nisa Purwanti Fahrizal Amin Nurfaizi Faraadies, Rangga Azhaar Faradis, RA. Hani Farah Dina Amalia Farhatu Aini Fariska Zata Amani Fatmawati, Ulik Ferdinan Hanafi, Eka Satria Akbar Fifi Khoirul Fitriyah Garfansa, Marchel Putra Hanafi, Eka Satria Akbar Ferdinan Handayani Handayani Handayani, Nanik HAQUE, ZAMIRAH MABARROH EL Hudzaifah Hamidy Ika Mardiyanti Ika Maysaroh Lesparwati Ilham Putera Alam Ilham Putra Alam Ima Kurniastuti Ismail Ibrahim Ismail, Zainul Hadi Wildan ISWAHYUDI ISWAHYUDI Iswahyudi Iswahyudi Izki Masyaqqoni Pujiana Jamhuri, Nur Syazwani Jazuli, Muhammad Aqil Siroj Jessica Puspa Kencana Jinan, Puspita Rahmatul Karina Dwiyanti Kencana, Jessica Puspa Lea Maera Shanty Lintan Farizqi Kurnia Lysa Veterini Machmudah, Machmudah Maria Ulfa Marinda Dwi Puspitarini Marotur Rohima Marselli Widya Lestari Michio Shimabukuro Miftakhul Dwi Ersanti Muhammad Aqil Siroj Jazuli Muhammad, Akbar Reza Muhammad, David Sajid Muhammada, Davida Sajid Mukhtar Adi Nugroho Muliani, Nurlina Mulyadi Mulyadi Mutmainnah Nadia Nisaussholihah Nadzirah Sylvia Nahdatien, Ima Nanda Fadhilah Witris Salamy Nanik Handayani Nisaussholihah, Nadia Novera Herdiani, Novera Nur Azizah AS Nurul Munawaroh Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Puspitasari, Mia Puspitasari, Renny Novi Putra, Reza Hery Mahendra R.A. Hani Faradis Raniyah Diva Rosalbah Ratna Ariesta Dwi Andriani Reza Mahendra Rezky Dwinda Pratiwi Rihhadatulays, Khuzaimah Nur Juhanifah Rofik, Ainul rofiq, ainul Romadhani, Deny Febriwijaya Rosda Rodhiyana Salfa Salsabilah Zain Savitri, Ardyarini Dyah Siti Nur Hasina Siti Robi’atus Sholiha Sohaimi, Ainur Elliana Sonny Edbert Syafiuddin, Achmad Tri Deviasari Wulan Tri Wahyu Bintarti Ubaidillah Zuhdi Widya Dio Kharisma Wiratama, Rahardyan Dika Yanti, Alfiyah Indah Yasi Anggraini Yenni Arista Cipta Ekalaturrahmah Yuani Setiwati Zannah, Erfina Miftakhul