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All Journal VALENSI Biotika: Jurnal Ilmiah Biologi Alchemy : Journal of Chemistry EduChemia: Jurnal Kimia dan Pendidikan JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Science and Technology Indonesia Jurnal Kimia Terapan Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia FITOFARMAKA: Jurnal Ilmiah Farmasi Indonesian Journal of Halal Research Pharmacoscript Jurnal Abdimas Kartika Wijayakusuma Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Akademika Kimia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Pada Masyarakat Jurnal Akademika Kimia KOPEMAS Jurnal Pengabdian Ilmu Kesehatan
Tarso Rudiana, Tarso
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Journal : alchemy journal of chemistry

 1 
Karakterisasi Fraksi Aktif Antioksidan dari Biji Gandaria (Bouea macrophylla) Maidah Nopiana; Erica Mutiara Putri; Annastaya Novariyan; Iip Pahrudin; Candra Junaedi; Tarso Rudiana
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.17711

Abstract

Gandaria (Bouea macrophylla) plants contain antioxidant compounds that can reduce free radicals. Free radicals are one of the causes of various degenerative diseases. The purpose of this study was to determine the fraction that had the highest antioxidant activity, and to determine the secondary metabolites contained in the most active fraction of B. macrophylla seeds based on LCMS/MS analysis. Maceration of B. macrophylla seeds with ethanol solvent. Ethanol maserate was concentrated and fractionated by liquid-liquid extraction method using n-hexane, ethyl acetate and ethanol as solvents. Antioxidant activity was measured by the free radical scavenger method with 1,1-diphenyl-2-picrylhidrazil as a source of radicals and characterization of the secondary metabolites contained in the most active fraction using a Liquid Chromatography-Mass Spectrometer. B. macrophylla seed ethanol extract has a % yield of 31.75%. The ethyl acetate fraction of B. macrophylla seeds has the highest mass compared to other fractions and has strong antioxidant activity with an IC50 value of 2.95 ppm. The ethyl acetate fraction of B. macrophylla seeds contains tannins, phenolic, flavonoid dan alkaloid compounds. Based on the results of the identification of secondary metabolites by LC-MS/MS, the ethyl acetate fractions of B. macrophylla seeds contained phenylalalnine compounds.
Sediaan Gel dari Kombinasi Ekstrak Buah Gandaria (Bouea macrophylla Griff.) dan Ekstrak Belimbing Wuluh (Averhoa bilimbi L) dan Bioaktivitasnya Jayantie, Dhyneu Dwi; Khaerunnisa, Arini; Renaldy, Renaldy; Suryani, Nani; Rudiana, Tarso
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.23451

Abstract

Melanin is the main pigment thfunctions to protect the skin from exposure to ultraviolet light, excessive melanin synthesis can cause skin hyperpigmentation. A. bilimbi and B. macrophylla fruits have bioactive compounds such as phenolics, flavonoids that function as antioxidants and tyrosinase inhibitors. This study aims to formulate a gel preparation of a combination of fruit extracts of A. bilimbi and B. macrophylla, test antioxidant activity using the DPPH method, and test tyrosinase inhibition enzymes. Three formulas were made, namely F0 (Basis), FI (50x extract), and FII (100x extract). Physical evaluation includes organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, viscosity and irritation. Test of antioxidant activity and tyrosinase enzyme inhibition. Then the data were analyzed descriptively and statistically. The results of the evaluation of homogeneous preparations, dispersion, pH, viscosity, mandatory, meet the standards. Adhesion below standard, irritation test (mild irritation). The results of IC50 antioxidants were F0 (2,352 ppm), FI (1,448 ppm), FII (419,74 ppm) and gel brand x (77,429 ppm). The results of the tyrosinase inhibition test were the highest concentration of 10% F0 (7.828%), a concentration of 10% FI (18.245%), a concentration of 10% FII (25.814) kojic acid gel (brand x) as a comparison with a concentration of 10% (51.211%). The higher the concentration used, the greater the inhibition of the tyrosinase enzyme produced
Isolasi dan Identifikasi Metabolit Sekunder dari Kulit BatangBintangur (CALOPHYLLUM BICOLOR) Sukandar, Dede -; Abbas, Jamillah; Habibah, Nurfitriany; Rudiana, Tarso; Rohman, Saeful
ALCHEMY:Journal of Chemistry Vol 12, No 2 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i2.26634

Abstract

Isolation and identification of secondary metabolite compounds from stem bark of Bintangur (Calophyllum bicolor) have been reported. Isolation was carried out using the maceration method with 70% ethanol solvent and fractionation of the ethanol extract by column chromatography using n-hexane solvent. The n-hexane fraction resulting from column chromatography was subjected to gravity chromatography with the mobile phase n-hexane: ethyl acetate (8:2) producing isolate 1. The results of purification of isolate 1 using fast column chromatography with the mobile phase dichloromethane: methanol (1:1) and a UV light detector at ƛ 254 nm, compound 1 was obtained. Meanwhile, identification of compound 1 was carried out through UV-Vis spectroscopy, FTIR and LCMS analysis. The identification results of compound 1 using UV-Vis spectroscopy showed the presence of an aliphatic ring double bond chromophore (λmax 233.5; 295 nm). FTIR results indicated the presence of vibrations of the OH group (3417 cm-1), CH alkanes (2933; 2864; 1456; 545 cm-1), and C=C alkenes (1618 cm-1). Analysis results using LCMS showed a molecular ion peak at [M]+ m/z = 386.96 at a retention time of 11.6 minutes, indicating a molecular weight of 386 and a molecular formula (C27H46O) that corresponds to a terpenoid compound. Keywords: isolation, identification, terpenoid, bintangur (Calophyllum bicolor) AbstrakIsolasi dan identifikasi senyawa metabolit sekunder dari kulit batang bintangur   (Calophyllum   bicolor)   telah   dilaporkan.  Isolasi dilakukan dengan metode maserasi dengan pelarut etanol 70% dan fraksinasi ekstrak etanol dengan kromatografi kolom menggunakan pelarut n-heksana. Fraksi n-heksana hasil kromatografi kolom dikromatografi grafitasi dengan fase gerak n- heksana : etil asetat (8:2) menghasilkan isolat 1. Hasil pemurnian isolat 1 menggunakan kromatografi kolom cepat dengan fase gerak diklorometana : metanol (1:1) dan  detektor sinar UV pada ƛ 254 nm diperoleh senyawa    1. Sedangkan identifikasi  senyawa 1 dilakukan melalui analisis spektroskopi UV-Vis, FTIR, dan LCMS. Hasil identifikasi senyawa 1 menggunakan spektroskopi UV-Vis  menunjukkan adanya kromofor ikatan rangkap cincin alifatik (λmaks 233,5 nm; 295 nm). Hasil FTIR mengindikasikan adanya vibrasi gugus OH (3417     cm-1), CH alkana (2933; 2864; 1456; 545 cm-1), dan C=C alkena (1618 cm-1). Hasil Analisa menggunskan LCMS menujukkan puncak ion molekul pada [M]+ m/z = 386,96 pada waktu retensi 11,6 menit, menunjukkan berat molekul 386 dan rumus molekul (C27H46O) yang sesuai dengan senyawa terpenoid. Kata kunci: isolasi, elusidasi, terpenoid, bintangur (Calophyllum bicolor)
Co-Authors Abbas, Jamillah Adawiah Adawiah Adawiah Adawiah Adnan, Aditya Agung Sugiarto Agus Setiawan Ahmad Fathoni Ahmad Fathoni Ahmad, Syadzwina Nurdzakiyyah Alfindah Rusanti Amilia, Nurul Andree Saylendra Andree Saylendra, Andree Ani Susilawati Annastaya Novariyan Anriani, Nurul Arini Khaerunnisa Arini Khaerunnisa Arini Khaerunnisa Ashari, Tiara Hadi Asih Widi Wisudawati Candra Junaedi Cory Novi Dede Sukandar Dhyneu Dwi Jayanti Dhyneu Dwi Jayantie Dimas Danang Indriatmoko Dimas Danang Indriatmoko Dimas Danang Indriatmoko Ditta Ahmad Herviana Djamil, Ratna Dwi Marwati Juli Siswanti Eka Yulli Kartika Eneng Elda Ernawati Erica Mutiara Putri Erwin Erwin Erwin Erwin Euis Julaeha Fachrudin Perdana Farhan Riza Afandi Firdaus, Rizki Amsyarul Fitriah Hatiningsih Fitriyani Fitriyani fitriyanti fitriyanti Frida Elasjulia Gina Siti Nurhayati Habibah, Nurfitriany Haddiana Hadi Susilo Haerul Anwar Hasanah Hasanah Herviana, Ditta Ahmad Ibnu Umarudin Umedi Iip Pahrudin Indriatmoko, Dimas Danang Irwan Irwan Irwanto Irwanto Jarinah, Jarinah Jayantie, Dhyneu Dwi Ken Virginia Komalasari Komalasari Komarudin, Nanang Kuncoroyekti, Prasetyo Alfaridzi Lilik Sulastri Maidah Nopiana Mila Kurniah Muda, Nurhali Mulyaningsih, Asih Mulyaningsih, Asih Nani Suryani Nani Suryani Nani Suryani Neneng Rohimah Nur Azizah, Yulyani Nur Thooyibah Nuramalia, Sifa Nurgraha, Auliyah Aisyah Nurhakiki, M. Nurul Anriani Partomuan Simanjuntak Partomuan Simanjuntak Pratiwi Nur Kinasih Putri, Widiya Ratna Djamil Renaldy, Renaldy Saeful Rohman Salma, Aninda Sandra Hermanto Sartika, Nenden Suciyati Siti Nurbayti Siti Nurbayti Siti Nurbayti Siti Solehah Slamet Wiyono Sri Yadial Chalid Suhroji Adha Sulistriyani, Sulistriyani Swastika Oktavia Syadzwina Nurdzakiyyah Ahmad Tati Herlina Tsalats Wahyul Husna Tuti Rostianti Maulani Ucu Wandi Somantri Widiya Putri Wiyono, Slamet Zein, Muhammad Ihda Hamlu Liwaissunati Zhorif, Sherina Arestia