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Journal : Sinteza

Validasi Metode dan Penetapan Kadar Sirup Kering Cefadroxil dengan Metode FTIR-ATR Rahmasari, Khusna Santika; Alfarizi, Muhammad Bahtiar
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.19812

Abstract

Cefadroxil is a broad-spectrum bactericidal antibiotic belonging to the first group of cephalosporins produced by the fungus Cephalosporium acremonium. This study aims to validate the method and determine the concentration of cefadroxil dry syrup using FTIR-ATR. The method used is FTIR-ATR with aquabides as a solvent. Parameter Validation of the analysis method carried out includes linearity, accuracy, precision, Limit of Detection (LOD) and Limit of Quantification (LOQ). The results of the linearity test show a value of r = 0.999 which indicates linear. The accuracy obtained is 97 - 105.5%. Precision with an Relative Standard Deviation (RSD) value of 0.54%, LOD of 469.72 µg/mL and LOQ of 1423.6 µg/mL. The results of determining the levels of cefadroxil dry syrup with three samples, namely sample A 100.2%; sample B 100.5%; sample C 100.1%. Based on the research results, it can be concluded that the FTIR-ATR method is valid and the sample concentration complies with the provisions of the Indonesian Pharmacopoeia Edition VI, namely the concentration of cefadroxil in dry syrup preparations is not less than 90% and not more than 120%.
Co-Authors A'yun, Qurrata Achmad Ridlo Achmad Vandian Nur, Achmad Vandian Adelia Fitriani Ainin, Shabrina Ainun Muthoharoh, Ainun Alfarizi, Muhammad Bahtiar ALIYAH, HIMATUL Allam, Faiq Aminuyati apt. Eko Mugiyanto, Eko Arum Dwi Nanda, Arum Atifah, Husnia Ayu Dyah Purwati Ayu Setyowati Azzahra, Nafisa Aufa Bagus Pambudi, Dwi Balqis, Fadia Indah Bayu Ishartono Bayu Ishartono citra_dinda Wardany Dwi Bagus Pambudi Eka Anydia Putri Eko Mugiyanto Eko Mugiyanto, Eko Elsa Septiana Khoirunnisa Fachry Abda El Rahman Fadhilah, Isna Fadillah, Rahma Ayu Firman Faradisi Fitriani, Adelia Fortuna, Putri Asabella Fuadiya, Laila Azka Giani Khairunnisa, Cantika Haqiqi, Izzatul Huda, Muhammad Syahrian Ida Astuti Ida Astuti Indriyani, Puspa Irma Suryani Irsyad, Khabibullah Isyti'aroh Izzahra, Astrid Ika Kamilah, Rasya Rizqi Khoirunnisa, Aishwarya Khoirunnisa, Elsa Septiana Kholisatuz Zahro Mafruroh, Mafruroh Maharani, Vanesa Maharisti, Retno Aulia Maulvi, M. Arsyi Muhammad Bahtiar Alfarizi Muhammad Syahrian Huda Nadia Salsabila Ulfa Naila Izza Sabila Ningrum, Wulan Agustin Nirmala, Mutiara Suci Nunung Mufida Nunung Mufida Nur, Achamd Vandian Nurul Janah, Fatimah Oktaviani, Riska Kurnia Pambudi, Dwi Bagus Pambudi, Dwi Bagus Prastika, Sisca Windy Putri, Eka Anidya Putriautami, Fernanda Meyra Rahmatullah, ST. Rasya Rizqi Kamilah Retno Aulia Maharisti Rina Widhyani Rini Kristiyanti S Slamet S Slamet, S Sabilla, Elsa Safitri, Arista Salsabila, Salma Fi Slamet Slamet . Slamet Slamet Slamet, Slamet Sugiharto, Sugiharto Supriyanto, Lukman Ulfa, Nadia Salsabila Ulhaq, M Daffa’ Dhiya’ Urmatul Waznah Utami, Budi Vandian Nur,, Achmad Vanesa Maharani Vira Septiya W Wirasti Wirasti Wirasti Wirasti Wirasti, W Wirasti, Wirasti Wulan Agustin Ningrum Wulandari, Hilda Fitria Yuvinda Devi Erviani Yuvinda Zahratulhakimah, Putri Balqis