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All Journal Bionatura Farmaka Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) IDJP (Indonesian Journal of Pharmaceutics) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Community Development Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Global Pharma Technology Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan

Taofik Rusdiana

Fakultas Farmasi - Universitas Padjadjaran

Author-ID : 2696149

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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POTENSI LIMBAH KULIT JERUK NIPIS (Citrus auronfolia) SEBAGAI INHIBITOR TIROSINASE Siti Hindun; Taofik Rusdiana; Marline Abdasah; Reti Hindritiani
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 2 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Hiperpigmentasi merupakan kelainan kulit wajah yang umum terjadi, terutama karena adanya peningkatan melanogenesis, dengan gambaran berupa warna kulit menjadi hitam atau coklat kehitaman. Kelainan ini terdapat pada beberapa macam penyakit kulit diantaranya melasma, melanoderma paska inflamasi, lentigo solaris dan freckles. Salah satu prinsip penanganan hiperpigmentasi yaitu menghambat sintesis melanin yang dapat dilakukan dengan menggunakan agen depigmentasi yang mekanisme kerjanya menghambat aktivitas enzim tirosinase. Penelitian ini bertujuan untuk menguji potensi kulit jeruk nipis sebagai inhibitor tirosinase. Kulit jeruk nipis diektraksi dengan etanol 96 %, identifikasi flavonoid, menghitung flavonoid total, kemudian diuji inhibisi tirosinase menggunakan instrumen microplate reader (ELISA). Hasil penelitian ekstrak kulit jeruk mengandung flavonid, dengan total flavonid totalnya 0,667 % b/b dan inhibition concentration (IC) 50 42,11 mg/mL, Kulit jeruk berpotensi sebagai inhibisi tirosinase.Kata kunci: Citrus auronfolia, Hiperpigmentasi, IC50, Tirosinase

Stability of Eleutherine americana (L.) Merr. Extract as Lipstick Colorants as the Change of Temperature, Time, Storage Condition and the Presence of Oxidator Dewi Mayasari; Taofik Rusdiana; Yulien Ratu Kania; Marline Abdassah
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Bawang Tiwai (Eleutherine americana (L.) Merr bulbus. is a typical plant from Kutai tribes which commonly used as an anti-bacterial and food coloring. The stability test is performed to determine the stability of the extract. Stability test was conducted in two solvents are distilled water and ethanol include the effects of temperature (25°C, 50°C, 80°C), pH (3, 5, 7), an oxidant for 6 hours, conditions of storage at room temperature and the temperature of the refrigerator for 24 hours and storage for 2 weeks. The absorbance of extract in ethanol and aquadest was decreasing due to the change of temperature, time, the presence of oxidator but due to pH changes, the absorbance of extract was increasing. Meanwhile, on the storage condition, showed the highest absorbance on dark, and room temperature storage compared to other condition.Key words: Eleutherine americana (L.) Merr bulbus, stability, color pigment

Validation of UV-Vis spectrophotometry methode for analysis of apigenin in celery extract (Apium graveolens L.) Asep Nurrahman Yulianto; Taofik Rusdiana; Muchtaridi Muchtaridi; Anas Subarnas
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Apigenin is one of the flavonoid compounds contained in celery (Apium graveolens L.) and has been used for the treatment of various diseases. This study aims were to ensure the validity and accuracy of analytical method for apigenin assay in celery extract using UV-Vis spectrophotometry. The flavonoids test of celery extract give a positive result which produces a yellow color that can be drawn by amyl alcohol. The result of TLC test using a mobile phase of chloroform and methanol (9.5 : 0.5) produced Rf value of 0.75. Validation of analytical methods were sensitivity, linearity, limit of detection as well as limit of quantification, accuracy, and precision. Validation of analytical methods showed that sensitivity results as represented by molar extinction (Îµ) was 77004.35 M-1cm-1. Linearity from calibration curve at concentration of 2, 4, 6, 8, and 10 mgL-1 resulted an equation of y = 0.074x â€“ 0.0011 with coefficient correlation (r) of 0.9996. The limit of detection and limit of quantification were 2.99 mgL-1 and 9.92 mgL-1 respectively with recovery percentage of 97.59% and the coefficient variation values were 1.53%; 2.43% and 1.68%. The average contents of apigenin in the celery extract were of 3.74 Â± 0.09%.Â

PENGARUH KOMPLEKSASI INKLUSI ATORVASTATIN DENGAN Î²-SIKLODEKSTRIN TERHADAP FORMULASI DAN EVALUASI FAST DISINTEGRATING TABLETS (FDT) ATORVASTATIN Dilal Adlin Fadil; Taofik Rusdiana; Muchtaridi Muchtaridi
Media Farmasi: Jurnal Ilmu Farmasi Vol 13, No 2: September 2016
Publisher : Universitas Ahmad Dahlan

Atorvastatin merupakan salah satu zat aktif penurun kolesterol darah golongan statin atau inhibitor HMG-CoA reductase. Atorvastatin memiliki karaktersitik biofarmasetik kelarutan dalam air yang buruk tetapi Â permeabilitas dalam membran usus yang tinggi (BCS kelas II), sehingga untuk memperbaiki bioavailabilitasnya dapat diupayakan dengan cara memperbaiki tingkat kelarutannya dalam air. Penelitian ini bertujuan untuk mengetahui pengaruh kompleksasi inklusi atorvastatin dengan Î²-siklodekstrin terhadap kelarutan dan disolusinya serta terhadap proses formulasi sediaan Fast Disintegrating Tablets (FDT). Kompleks inklusi dibuat dengan cara kneading method dengan perbandingan molar atorvastatin dengan Î²-siklodkestrin; 1:1, 1:2, dan 1:3. Studi ketetapan kesetimbangan kompleks didapat 502,087 M-1. Hasil uji disolusi dalam medium buffer fosfat pH 6,8 menunjukkan peningkatan laju disolusi atorvastatin dalam kompleks inklusi atorvastatin-Î²-siklodkestrin (KIAS) masing-masing sekitar 5,76% (1:1); 8,89% (1:2); dan 7,73% (1:3). Hasil karakterisasi KIAS dengan metode X-ray difraction (X-RD), spektroskopi inframerah, dan differential scaning calorimetry (DSC) menunjukkan adanya pembentukan kompleks inklusi. Formulasi FDT dibuat dengan menggunakan metode kempa langsung terhadap 6 formula (3 formula menggunakan KIAS dan 3 formula tanpa KIAS), superdisintegrat yang digunakan adalah Kyron T 314 dengan variasi penggunaannya masing-masing sebanyak 2, 4, dan 6% dan variasi kekerasan tablet sebesar 4 dan 6 N. Hasil evaluasi FDT menunjukan bahwa FDT dengan KIAS lebih baik dibandingkan dengan FDT tanpa KIAS. Hasil uji disolusi FDT dalam medium buffer fosfat pH 6,8 diketahui terjadi peningkatan laju disolusi atorvastatin dalam FDT KIAS. Dengan demikian, dapat disimpulkan bahwa kompleksasi inklusi atorvastatin dengan Î²-siklodkestrin dapat meningkatkan laju disolusi atorvastatin secara signifikan.

Efek Antikalkuli Ekstrak Etanol Herba Seledri (Apium graveolens L.) terhadap Tikus yang Diinduksi Hidroksiprolin Taofik Rusdiana; Lutfi Sulaiman; Eli Halimah; Ami Tjitraresmi; Sri Adi Sumiwi; Yanni D. Mardhiani; Anas Subarnas
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2052

The investigation efforts of an alternative treatment of the kidney stone disease by utilizing Indonesian native plants have still continued both for treatment and prevention. This study aims to strengthen the scientific evidence of the activity of celery as an anticalculi by in vivo assessment using hydroxyprolineinduced rat method. The white male wistar rats used in this study were intraperitoneally induced by hydroxyproline in order to form kidney stones, the celery extract preparations were then given at a dose of 50, 100, and 200 mg/kg of body weight orally for 5 days and observed following parameters: concentration of filtrate urinary calcium, concentration of urinary sediment calcium, as well as kidney to body weight ratio. The results showed that the concentration of filtrate urinary calcium in the test group at a dose of 200 mg/ kg body weight was significantly higher than those of negative control group, whereas the other test groups were not significantly different with the negative control group. The similar result was also shown on the parameter of calcium concentration in the urine sediment, while the ratio of kidney to body weight showed significant differences between all test groups and the negative control group. It can be concluded that the ethanol extract of the herb celery has an anticalculi activity in rats at a dose of 200 mg/kg of body weight.

Formulation and Physical Stability Testing of Chitosan Gel from Vaname Shrimp Shell (Litopenaeus Vannamei) with Carbopol 940 Gelling Agent Norisca Aliza Putriana; Taofik Rusdiana; M. Abdul Aziz Prakoso
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Wound is defined as a disorder of normal anatomy and skin’s function that occurs as a result of tissue injury or patalogic process resulting in epithelium discontinuity, with or without lossing underlying connective tissue. The use of chitosan in medicine, especially in surgery, gives many advantages in terms of wound healing that stimulates hemostasis of cell. Chitosan gel is one of the alternative wound treatments that still needs improvement, especially in terms of the effectiveness of the formulation. In this study, the physical stability of chitosan gel formulations was tested in various concentration of carbopol 940 as a gelling agent i.e, 0,5%, 1% and 1,5%. The parameters observed during the physical stability testing of this gel research were pH, viscosity, spreadability, homogeneity, organoleptic and sineresis gel. The result of the physical stability testing of chitosan gel stored for 56 days showed that formula 1 has the best result according to all parameters. Formula 1 has pH 5,8-6,2 at 25oC and 40oC, the best organoleptic stability, viscosity shift 9% at 25oC and 13,8% at 40oC, spreadability shift 10,9% at 25oC and 14,4% at 40oC. The best chitosan gel formulation for physical stability testing is chitosan gel with carbopol 940 concentration of 0.5%Keywords: Wound, Chitosan gel, Physical Stability

Microcrystalline Cellulose Isolated from Rami (Boehmeria nivea L. Gaud) used as a Disintegrant in Dimenhydrinate Tablets Nagina Gulab Belali; Anis Y. Chaerunisaa; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.30857

Microcrystalline cellulose was isolated from rami (Boehmeria Nivea L. Gaud), and applied as disintegrant in tablets of dimenhydrinate, made by direct compression and wet granulation. The aim of this study is to produce dimenhydrinate tablets with Microcrystalline Cellulose Rami (MCC Rami) isolated from Rami (Boehmeria Nivea L. Gaud), as a disintegrant and assess the effect of MCC Rami and Granulation technique on physical properties of drug such as, disintegration time, drug release and dissolution. Formulations of dimenhydrinate 100mg tablets were prepared with a combination of mannitol and lactose as a filler and MCC Rami as disintegrant in a concentration of 10-20%. The formulas were directly compressed or were compressed into tablets after wet granulation. The mechanical properties, drug release, physical properties and effects of process parameters, methods of applying disintegrant in tablet formulas were examined. A significant difference in disintegration time of tablets that were produced by direct compression and wet granulation was seen, that can be attributed to the porous structure of granules that enhanced fast disintegration, which had eventually improved dissolution and drug release. F1 and F2 with MCC Rami and physical mixture of MCC Rami with crosspovidone as a disintegrant that were directly compressed disintegrated in 79 and 72 seconds respectively thats not a significant difference, however when MCC was applied in an intragranular way its disintegration time is 67 seconds. The results showed that the method of disintegrant application and press of tableting has a significant effect on drug release and dissolution.Keywords : Microcrystalline Cellulose, wet granulation, disintegrant, Boehmeria Nivea L. Gaud.

Isolation and Characterization of Microcrystalline Cellulose Derived from Plants as Excipient in Tablet : A Review Nagina Gulab Belali; Anis Yohana Chaerunisaa; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 1, Issue 2, May - August 2019
Publisher : Universitas Padjadjaran (Unpad)

Microcrystalline cellulose (MCC) is a versatile and frequently used material in different industries such as pharmaceuticals production, medical, cosmetics, and food industry. Its qualities of being inert, economic, compatibility, compatibility, non-toxicity, biodegradability, good mechanical properties, high surface area, variety and availability of different grades and biocompatibility has made it very popular. Many research has been done on MCC to isolate it from different plant sources that are economical and eco-friendly. MCC is extracted from α cellulose that is abundant in nature as most of MCC is produced from wood. However, new eco-friendly sources with changes in methods of isolation have been applied for the production of MCC. In this review MCC isolated from different plant-based resources, extraction process parameters, the origin of raw material and its influence on critical material attributes of MCC has been outlined and discussed thoroughly. Since these critical material attributes have a significant effect on tablet making process parameters (compressibility, compatibility and etc) and its post-compression characters.Keywords: Microcrystalline cellulose, isolation, characterization, raw material, tablet

Interaction of Warfarin with Herbs Based on Pharmacokinetic and Pharmacodynamic Parameters Amelia Soyata; Aliya Nur Hasanah; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27289

Warfarin is an oral anticoagulant that has been widely used and has strong efficacy, but the use of warfarin is still a concern because of its narrow therapeutic index which cause interactions when co-administration with drugs, herbs or food. This interaction can affect the pharmacokinetics and pharmacodynamics of warfarin and the most fatal effect from warfarin interactions is bleeding. In this review article data on warfarin-herbs interactions were collected based on pharmacokinetic parameters (AUC0-∞, Cmax, T1/2, Cl/F, and V/F), while pharmacodynamic parameters (International normalized ratio (INR), platelet aggregation, AUC INR and Protombine Time). As a result some herbs had significant interactions with warfarin. Herbs that affect warfarin pharmacokinetic were Danshen gegen, echinacea, St. John's wort and caffeine and herbs that affect pharmacodynamic were policosanol, Ginkgo biloba, cranberry, St. John's wort, ginseng, pomegranate, Psidium guajava and curcumin, so co-administration warfarin with herbs need to be considered.Keywords: Warfarin, Interactions, Herbs, Pharmacokinetics, Pharmacodynamics

Preparation and Characterization of Glucosamine Nanoparticle by Ionic Gelation Method Using Chitosan and Alginate Yuli Agung Prasetyo; Taofik Rusdiana; Marline Abdassah
Indonesian Journal of Pharmaceutics Vol 1, Issue 1, Jan - April 2019
Publisher : Universitas Padjadjaran (Unpad)

Osteoarthritis is a chronic degenerative disease of the joints that usually treated by NSAID drugs in the long term leading to cardiovascular and gastrointestinal disorders. Glucosamine is a precursor in the formation of progression of joint which have not a significantly side effect. The problem in glucosamine administration occured when it is administered through the oral route resulting in first pass metabolism, while when it is administered via intavena route resulting in insulin resistance. Those problems can be solved by developing glucosamine into nanoglucosamine in order to increase the enzymatic stability which will protect the active ingredient from diminishing by the first pass effect hence the dose can be reduced, consequenlty it will reduce the insulin resistance, and increase the permeation. In this study, the nanoparticles of glucosamine with chitosan polymer and crosslinker alginate was prepared by the ionic gelation method with the principle of continued cross forming polyelectrolyte complexes. This study started from preformulation such as solubility and identify study by FTIR, then the formulations of chitosan: glucosamine: alginate = 5:1:1 (volume ratio) with the variation of concentration in the FI (chitosan: glucosamine: alginate = 0.08 %: 0.1%: 0.08%) and FII (chitosan: glucosamine: alginate = 0.1%: 0.1%: 0.08%). Results of nanoparticle characterization by particle size analyzer in the FI showed the better formula indicating a foggy coloid, no precipitation, the pH was 2.90±0.05, and the percent transmittance was 99.35%. The distribution of particle size, polydispersity index, and zeta potential for the formula I were 76.0 ± 21.8 nm; 0.300; and -0.30 mV, respectively. It could be concluded that the nanoparticle system of glucosamine can be better prepared from the 0.08% of chitosan, 0.1% of glucosamine and 0.08% of alginate.Keywords: alginate, chitosan, ionic gelation method, glucosamine nanoparticle

Co-Authors Abdasah, Marline Aep W Irwan Aep W Irwan, Aep W Afra, Dinda Nur Ajeng Diantini, Ajeng Alfaqeeh, Mohammed Aliya Nur Hasanah Amelia Soyata Ami Tjitraresmi, Ami Amira Nur Hasanah ANANG SUBGHAN Anas Subarnas Anas Subarnas Anis Khorunisa Anis Khorunisa, Anis Anis Y. Chaerunisaa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Anis Yohana Chaerunnisa Arna Ningsih1, Endah ARVENDA REZKY PRATAMA Asep Nurrahman Yulianto Azizul Hakim Camellia Panatarani CINDY MELINDA SOFYANI Dani Sujana Dessy Ikasari Desy Nawangsari Desy Nawangsari Dewi Mayasari Dewi Mayasari Dewi, Febrina Aulia Dika P. Destiani Dilal Adlin Fadil Dolih Gozali Dwi Retno Sari Eka Riza Maula Eli Halimah, Eli Elis Lisnawati Elizabeth, Maria Ella Fazila Fadil, Dilal Adlin Fadil, Dilal Adlin FAJAR SETIAWAN Febrina Aulia Dewi Firman Gustaman Firmansya, Ardianes Fitrileni - Fitrileni -, Fitrileni Fitrileni Fitrileni Gaharani, Prodio Efa Gracia Anastasya GUSTIN HIDAYATI Hindun, Siti I Made Joni Ina Widia Insyirah, Ariani Iyan Sofyan, Iyan Iyan Sopyan Jajan Solahudin Jajan Solahudin, Jajan Keri Lestari Khairinisa, Miski A. Lana Labibah Lanny Indah Permatasari, Lanny Indah Linda Apriyanti LINDA APRIYANTI, LINDA Lusi Nurdianti, Lusi Lutfi Sulaiman M. Abdul Aziz Prakoso Mardhiani, Yanni Dhiani Mardhiani, Yanni Dhiani Maria Elizabeth Marline Abdasah Marline Abdassah Marline Abdassah Marline Abdassah Marline Abdassah Marline Abdassah, Marline Mentari Luthfika Dewi Mohamad Aprianto Paneo Mohammad R. Akbar Muchtaridi Muchtaridi Muhammad Habil Abrar Alhamdra Muhammad Lukman Nur Hakim Multiani S Latif Mutakin Mutakin Nagina Gulab Belali Nagina Gulab Belali Nasrul Wathoni NOPI RANTIKA Norisca A. Putriana Norisca A. Putriana Norisca A. Putriana Norisca Aliza Putriana Norisca Aliza Putriana Patihul Husni Patihul Husni PATIHUL HUSNI Pratama, Rizky Farhan Putri, Norisca A. Putri, Norisca A. Rambia, Ikhsan Ratu Kania, Yulien RENATA VANIA Reti Hindritiani Revika - Rachmaniar RIFA NURFAUZIAH Rizki Akbar Rizki Akbar, Rizki SABNABILA KHOERUN NISA Selifiana, Nita Shinta Lestari Shofiyyah Sayyidah Silvia, Nurfianti Siti Hindun Sri A Sumiwi Sri A Sumiwi, Sri A Sri Adi Sumiwi Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Stiani, Sofi Nurmay Suseno Amin Suseno Amin, Suseno Suwandi, Deden Winda Tina Rostinawati Wirna Grace Tua Sihombing Yedi Herdiana, Yedi Yoga Windhu Wardhana Yuli Agung Prasetyo Yulianto, Asep Nurrahman Yulien Ratu Kania YUNIKE KARUNIA PUTRI Yuti Mutiawati Yuti Mutiawati Yuti Mutiawati, Yuti

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