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Journal : The Indonesian Biomedical Journal

Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Muhammad Ryan Radix Rahardhian; Fahriza Ardiansyah; Yasmiwar Susilawati; Gofarana Wilar; Sri Adi Sumiwi; Jutti Levita; Muchtaridi Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Adhinagoro, Bagus Aeni, Wida Nur Ahmadi, Nurish Farisha Ahsanul Haq, Fahmi Ajeng Diantini, Ajeng Al Faruq, Muhammad Ariq Alifa Dhia Shalima Aliya Nur Hasanah Alya Novia Hanifa Ami Tjiraresmi Anas Subarnas Anas Subarnas Andini, Nasywa Putri Andri Kusmayadi Andri Nugraha Nugraha Sutomo Angga Geganaputra Anggi, Joseph Fide Anggraeni, Diyani Sovia Annisa Rafashafly Anton Apriyantono Aprilio, Kevin Arief Cahyanto Arif Budiman Arif Budiman Asep Kuswandi Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Athaya, Salsabila Atusholihah, Annisa Ayu Nursiti Fatimah Aziz, Calista Sasikirana Finola Bagus Adhinagoro Banowati, Nadya Dwi Basuki Hidayat C. Suhandi Cecep Suhandi Chindiana Khutami Christine Christine Christy, Alicia Cindy Aprillianie Wijaya CINDY APRILLIANIE WIJAYA Cleopatra D. Semesta Desra Widdy Syafra Destia, Melsa Devani Olivia Winardi Dewi Permatasari Dewi, Humaira Praswatika Diah Lia Aulifa Diantini, A. - Dilal Adlin Fadil Dini Rochdiani Dipadharma, Ratu Hanifa Fayza Djamaluddin, Muhammad Ilham Dolih Gozali E. Laelasari E. Novianti Eli Halimah, Eli Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Elvian, Elvian F. Ardiansyah Fadhilah, Ersa Fadil, Dilal Adlin Fadil, Dilal Adlin Fahriza Ardiansyah Faizal Hermanto Fakhirah, Maitsa Alya Fatharan, Rahma Haniyyah FATHIA NABILA AULANI Fatiya, Nadia Ulil Fernanda, Frisca Florencia, Carla Ganendra Akbar Hadiyanto Gazzali, Amirah Mohd Gia A. Faradiba Gin Gin Ginanjar, Gin Gin Gofarana Wilar Gramita, Widya Siva Hadiwijaya, Nathannael Adrya Hafidh Beta Arif Putra Hanifahzin Khatami Hartono, Sugianto Ayudha Hasna Chaerunisa Herlina Herlina I Made Joni I. R. Hartanti Ichsani, Luthfia Nur Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Ikram, NKK Imam Adi Wicaksono Iyan Sopyan Jessica Tristi Jessyca Sirait Jhoni, I Made Johnessa Cung Jutti Levita Karyadi Karyadi Karyn Elizabeth Keiichi Motoyama Kevin Reinard Lie Kezia Stella Carmencinta Salvi Khairul Ikram, Emmy Hainida Khairul Ikram, Nur Kusaira Kusnadi, Ivanna Fauziyah L. Pangestu Lestyawan, Samuel Levita, J. - Liawardi, Petra Pahlawanda Chrisanto Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Mardisanutol, Harsoning Tyas Mardisanutomo, Harsoning Tyas Marhaendra, Laurentius Ivan Ageng Martalena Ramli MEGANTARA, SANDRA Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhammad Ryan Radix Rahardhian Muhammad Syahid Abdillah Muhammad Yusuf Muhammad Yusuf Muhammad, Rosmaliza Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad NAELI FARHATY Nahariyah, St. Rohmani Nalia El-Huda Ismail Napitupulu, Gloria Nasrul Wathoni Nazwa N. Mikdar Neli Neli Nia Yuniarsih Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurhanifah Puspitadewi Nurjanah, Yuni Nursuhud Nursuhud Nursuhud Nurulaini, Siti Nunung NUZAHA BAQIYATUS SHOLIHAH AZIMAH Oktariani, Anisa Pebriani, Fathia Pratomo, Muhammad Fadhil Prayoga, Randy Rassi Ramdani, Aura Radiatia Sesiani Refitha N. Putri Renggana, Hesti Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Riska Prasetiawati, Riska Riyaldi, Muhammad Raihan Ronny Lesmana Rusdin, Agus S. Hidayat Salsa Sagitasa Salsabila, Salma Salsabila, Shela Savira Silma Aulia Setyawati, Luthfi Utami Setyowati, Lulu Alya Shafa Nurul Fadilah Shela Salsabila Siagian, Virginia Heaven Mariboto Silvia, Nurfianti Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein Stepanus Massora Sugianto, Nada Sekar Martani Suhandi, Cecep Suhendi, Cece Suryanto, Rajwa Dwifauza Susy Tjahjani Susyati Susyati Suwandi, Deden Winda Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Tina Rostinawati Udin. L.Z - Ujang Hidayat Tanuwiria W. Oktavelia Wa Ode Ida Fitriah Warid Ali Qosim Wirantono, Sebastian Nathanoel Wiwit Nurhidayah Yasmiwar Susilawati Yudi Rosandi Yulianto, Asep Nurrahman Yunita Al-Azzahra Yustiandini, Benedicta Andrea Zahra, Citra Aulia Zelika Mega Ramadhania