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Gambaran Fungsi Kognitif pada Pasien Keganasan Payudara yang Menjalani Kemoterapi di RSUP Dr. M. Djamil Padang Zakiya Ifana Putri; Restu Susanti; Selfi Renita Rusjdi
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 3 (2021): September 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i3.477

Abstract

Latar Belakang: Kemoterapi pada pasien keganasan payudara dapat menyebabkan gangguan kognitif. Sebuah studi menjelaskan bahwa terdapat 65% pasien dengan keganasan payudara mengalami gangguan kognitif akut dan 60% dari mereka mengalami penurunan kognitif terlambat Objektif: Mengetahui gambaran fungsi kognitif pada penderita keganasan payudara yang menjalani kemoterapi di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini adalah penelitian deskriptif dengan desain cross-sectional. Pengambilan sampel dilakukan dengan teknik simple random sampling sebanyak 44 orang. Penelitian ini berlangsung dari Maret 2020-Januari 2021. Hasil: Sebanyak 75% subjek penelitian mengalami gangguan kognitif. Gangguan kognitif paling banyak ditemukan pada kelompok usia pertengahan dan pada tingkat pendidikan rendah, yaitu 100%. Gangguan kognitif mulai ditemukan pada kemoterapi kedua, paling banyak ditemukan pada kemoterapi ketiga dan keempat (18,2 %). Gangguan kognitif terjadi pada semua obat kemoterapi dan paling banyak ditemukan pada penggunaan obat kombinasi CAF. Kesimpulan: Gangguan kognitif terbanyak ditemukan pada usia pertengahan dengan tingkat pendidikan yang rendah, pada subjek yang menjalani kemoterapi yang ketiga dan keempat, serta pada pemberian terapi kombinasi 5-Flourouracil-Doxorubicin-Cyclophosphamide
Relationship of Parathyroid Hormone Levels with Uremic Neuropathy in Chronic Kidney Disease Patients Rizki Muhammad Rananda; Yuliarni Syafrita; Restu Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.697

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Background: Parathyroid hormone is known as one of the main uremic toxicants, which, if the amount increases in plasma, will affect motor conduction in patients with chronic kidney disease. This study aims to determine the relationship between Parathyroid hormone levels with uremic neuropathy in patients with chronic kidney disease. Methods: This study was an analytic observational study with a cross-sectional approach, where as many as 42 subjects participated in this study. Data analysis was performed using SPSS using univariate and bivariate, with p<0.05. Results: There was a difference in the average thyroid hormone levels in neuropathy and without neuropathy, but statistically, it was not different p>0.05. Conclusion: There is no relationship between parathyroid hormone and uremic neuropathy in patients with chronic kidney disease.
The Relationship between Dickkopf-Related Protein-1 (DKK-1) Plasma Levels and Impaired Cognitive Function in HIV Patients Yulia Trisna; Yuliarni Syafrita; Restu Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.780

Abstract

Background: Dickkopf-related protein – 1 (DKK-1) is an antagonist protein to the Wingless (Wnt)-β catenin signal. Dysregulation of Wnt-β catenin signaling by DKK-1 causes disruption of neuronal synapses, which can result in impaired cognitive function. Impaired cognitive function in people with HIV or HIV-associated neurocognitive disorder (HAND) is a spectrum of cognitive disorders related to HIV neuroinvasion and neuroinflammation, which significantly results in impaired cognitive function and daily activity. This study aimed to assess the relationship between plasma DKK-1 levels and impaired cognitive function in HIV patients. Methods: This study used a cross-sectional design, consisting of 84 HIV sufferers who went to the voluntary counseling and testing (VCT) polyclinic at Dr. M. Djamil General Hospital, Padang, Indonesia, in the period December 2022 - March 2023, who met the inclusion and exclusion criteria. Cognitive function was assessed using the Montreal Cognitive Assessment Indonesian version (MoCa-Ina), and daily activity function using the instrumental activity of daily living (IADL) examination. Plasma DKK-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: The mean plasma DKK-1 level of HIV sufferers was 358.4 (+ 157.6) pg/mL. ANI type disorder was found in 78.6%, MND in 21.4%, and no HAD type. There was a significant relationship between plasma DKK-1 levels and impaired cognitive function in HIV patients (OR = 2.82, CI95% = 1.128-7.043, p = 0.025), but there was no significant difference in plasma DKK-1 levels between types of cognitive impairment ANI and MND (p = 0.858). Conclusion: Plasma DKK-1 levels are significantly associated with impaired cognitive function in HIV patients.
Profil Pasien Glaukoma Juvenil di Poliklinik Mata RS Dr. M. Djamil Padang Tahun 2017-2020 Hanny Vidya Sari; Fitratul Ilahi; Restu Susanti
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.606

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Latar Belakang: Glaukoma juveinil adalah bagian dari glaukoma primer sudut terbuka atau primary open angle glaucoma (POAG) dengan karakteristik penurunan secara autosomal dominan dan terjadi pada usia muda, sekitar 4 hingga 35 tahun. Glaukoma juveinil berkaitan dengan peningkatan tekanan intraokular (TIO) akibat struktur trabecular meshwork yang abnormal sehingga menyebabkan gangguan aliran aqueous humor. Peningkatan tekanan intraokular dapat mengakibatkan kerusakan permanen pada saraf optik yang menyebabkan perubahan ukuran cup disk ratio (CDR) sehingga dapat berujung pada kebutaan. Objektif: Untuk mengetahui profil pasien glaukoma juveinil di Poliklinik Mata RS Dr. M. Djamil Padang Tahun 2017-2020 Metode: Jenis penelitian ini adalah deskriptif. Populasi penelitian ini adalah seluruh pasien yang terdiagnosis glaukoma juveinil oleh klinisi di Polikinik Mata RS Dr. M. Djamil Padang dengan jumlah sampel sebanyak 42 orang dengan total 84 mata pasien dari tanggal 1 Januari 2017 – 31 Desember 2020. Hasil: Hasil penelitian didapatkan pasien glaukoma juvenil sebagian besar laki-laki sebanyak 52,4% dengan kelompok umur terbanyak ≤20 tahun sebanyak 50%. Faktor resiko terbanyak ditemukan adalah dengan ada riwayat keluarga 64,3%, miopia 33.3%, dan TIO ≤21 mmHg 77,4%. 47,6% sampel memiliki visus normal. Stadium terbanyak adalah stadium sedang sebesar 79,8%. Tatalaksana terbanyak yaitu dengan monoterapi 76,2%. Kesimpulan: Karakteristik pasien glaukoma juveinil paling banyak yaitu laki-laki dan berada pada kelompok usia ≤20 tahun. Faktor resiko yang terbanyak adalah pada yang memilki riwayat keluarga dan miopia. Pasien terbanyak dengan visus normal dengan stadium sedang. Tatatalaksana yang paling banyak dilakukan adalah dengan monoterapi.
Gambaran Faktor Risiko Penderita Stroke dengan COVID-19 di RSUP Dr. M. Djamil Padang Musrizal Adli; Restu Susanti; Gusti Revilla; Afriwardi Afriwardi; Dedi Sutia; Eldi Sauma
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.1054

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Latar Belakang : Stroke merupakan penyakit dengan angka kematian tertinggi kedua di dunia. Pada massa pandemi COVID-19 berbagai temuan neurologis termasuk stroke ditemukan pada penderita COVID-19. Terjadinya stroke pada pasien COVID-19 dipicu keadaan hiperinflamasi dan hiperkoagulasi yang umum terjadi pada pasien COVID-19. Objektif : Mengetahui gambaran faktor risiko penderita stroke dengan COVID-19 di RSUP Dr. M. Djamil Padang periode Maret 2020-Desember 2021. Metode : Penelitian ini menggunakan metode cross sectional menggunakan data rekam medis pasien yang terdiagnosis stroke dengan COVID-19. Pengambilan sampel dengan metode total sampling. Analisis data secara univarian untuk mencari distribusi frekuensi dan bivariat menggunakan uji fisher exact untuk mengetahui hubungan faktor risiko dengan penyakit storke pada pasien COVID-19. Hasil : Hasil penelitian didapatkan 381 pasien stroke. Pasien stroke dengan COVID- 19 sebanyak 36 orang (9,4%). Stroke iskemik dengan COVID-19 sebanyak 26 orang (72,22%) dan stroke hemoragik dengan COVID-19 sebanyak 10 orang (27,78%). Kelompok usia terbanyak ≥65 tahun (47,2%) dan lebih banyak berjenis kelamin laki-laki (55,5%). Urutan faktor risiko mulai dari yang terbanyak yaitu hiperkoagulsi, hipertensi, diabetes melitus, dislipidemia, obesitas, dan riwayat penyakit jantung. Penelitian ini menunjukkan adanya hubungan antara hipertensi dengan terjadinya stroke dengan COVID-19. Kesimpulan : Frekuensi pasien stroke dengan COVID-19 sebesar (9,4%). Pasien umumnya mengalami gangguan koagulasi, ditandai dengan peningkatan nilai D-dimer. Pada penelitian ini terdapat hubungan antara faktor risiko hipertensi dengan kejadian stroke pada pasien COVID-19. Kata kunci: Faktor risiko, Stroke, Iskemik, Hemoragik, COVID-19 Background : Stroke is the sceond leading highest mortality rate in the world. During the COVID-19 pandemic, various neurological findings including stroke in patient with COVID-19 disease. Stroke in COVID-19 patients is triggered by hiperinflammation and hypercoagulability which are common in COVID-19 patients. Objective : To describe the risk factors of stroke on COVID-19 Patients hospitalized in DR. M. Djamil Padang during Maret 2020-Desember 2021 period. Methods : This study used a cross-sectional method using medical record data of patients diagnosed with stroke in COVID-19 patients. The sample was taken using the total sampling method. The data analysis was conducted Univariate to find the frequency distribution and bivariate using the Fisher's exact test to determine the relationship between risk factors and stroke in COVID-19 patients. Results : The result of study were 381 patients strokes. There are 36 patients strokes with COVID-19. Patient ischemic stroke with COVID-19 were 26 (72,22%) and hemorrhagic stroke with COVID-19 were 10 (27,78%). The most age group is ≥65 years old (47,2%) and the gender are more male (55,5%). The sequence of risk factors starting from the most is hypercoagulation, hypertension, diabetes mellitus, dyslipedimia, obesity, and history of heart disease. This study showed relationship between hypertension and the occurence of stroke in COVID-19 patients. Conclusion : The frequency of stroke in COVID-19 patient is 9,4%. Patient generally had coagulation disorders which are showed by increased D-dimer values. This study also showed the relationship between hypertension and the occurence of stroke in COVID-19 patients while other risk factors have no relationship. Keyword: Risk Factors, Stroke, Ischemic, Hemorrhagic, COVID-19
Hubungan Kualitas Tidur dengan Tekanan Darah pada Lansia di Kecamatan Kuranji Kota Padang Dea Rika Putri Purba; Restu Susanti; Rika Susanti; Hendra Permana; Arina Widya Murni; Eldi Sauma
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.1077

Abstract

Latar Belakang: Peningkatan angka harapan hidup yang terjadi menyebabkan peningkatan penyakit degeneratif pada lansia, salah satunya hipertensi. Proses penuaan pada lansia menyebabkan lansia mengalami beberapa perubahan fisiologi salah satunya fisiologi tidur, struktur, durasi, kedalaman, dan kontinuitas tidur akan pada lansia. Kualitas tidur buruk dapat menyebabkan meningkatnya tekanan darah melalui aktivasi sistem saraf simpatis. Objektif: Mengetahui hubungan kualitas tidur dengan tekanan darah pada lansia di kecamatan Kuranji Kota Padang. Metode: Jenis penelitian ini merupakan penelitian analitik dengan desain studi cross-sectional. Sampling from the population using consecutive sampling techniques in the elderly recorded in Kuranji District, Padang City and conducting interviews with PSQI questionnaires and blood pressure measurements directly on the samples. Hasil: Terdapat sebanyak 67 responden (69,1%) memiliki kualitas tidur buruk dan 30 responden (36,1%) memiliki kualitas tidur baik. Sebanyak 62 responden (63,9%) mengalami hipertensi. Hasil analisis data dengan SPSS menggunakan uji Chi-square diperoleh nilai p = 0,000 < 0.05 ( α = 0,05 ). Kesimpulan: Terdapat hubungan antara kualitas tidur dan tekanan darah pada lansia di Kecamatan Kuranji Kota Padang sehingga H1 ditolak.
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Nabila Priscilla Putri; Hirowati Ali; Tofrizal Tofrizal; Eryati Darwin; Restu Susanti; Hasmiwati Hasmiwati
Jurnal Kesehatan Andalas Vol 12, No 2 (2023): Online July 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

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The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Harun, Harnavi
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10964

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Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p<0.05. The average age of the subjects was 51.4±11.4 years, with 53% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/ml, range: 11–1,709 ng/ml) compared to the control group (6.028±1.829 ng/ml), with a significant difference (p<0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/ml (range: 29–1,709 ng/mL) in the impaired executive function group and 71.22 ng/ml (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.
GAMBARAN HISTOPATOLOGI SEL SARAF TIKUS WISTAR (RATTUS NORVEGICUS) LIKE MODEL ALZHEIMER PADA DAERAH KORTEKS SEREBRI AKIBAT INDUKSI ALUMINIUM KLORIDA Abdillah, Tegar; Afriani, Nita; Susanti, Restu
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.975

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Objective: To determine the histopathological features of the nerve cells of Wistar rats (Rattus norvegicus) like the Alzheimer's model in the cerebral cortex due to aluminum chloride induction. Method: This study uses a quantitative descriptive method. This research was conducted at the Laboratory of Anatomical Pathology, Faculty of Medicine, Andalas University. The study was conducted from January to December 2022. The sample consisted of 14 preparations with 7 preparations in each group. Calculation of nerve cells with the Image J application and calculated the percentage of damaged nerve cells. Results: Nerve cells underwent apoptosis and necrosis in rats given aluminum chloride. The mean percentage of nerve cell damage in the control group and the aluminum chloride group was 4.82% and 15.88%. Conclusion: The histopathological picture of the brain neurons of wistar rats in the cerebral cortex induced by aluminum chloride shows the appearance of neurons undergoing apoptosis and necrosis. The percentage of nerve cell damage was higher in aluminum chloride-induced mice than in mice that were not aluminum chloride-induced..
PROFIL PASIEN COVID-19 DI RUMAH SAKIT UNIVERSITAS ANDALAS Putri, Azhara Dhiya Yosse; Lestari, Yuniar; Susanti, Restu; Afriant, Rudy; Putra, Syandrea Prima; Yusri, Elfira
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.986

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   Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS- CoV-2 virus. The outcomes of COVID-19 patients were found to be influenced by the presence of comorbidities of the patient. Furthermore, this will affect the healing process in the patient itself. The most common comorbidity in COVID-19 patients is hypertension followed by diabetes mellitus. Hypertension is mentioned as the predominant factor of COVID-19 infection. Objective: This study aims to determine the profile of COVID-19 patients with hypertension. Methods: The type of this research is observational descriptive which was conducted in October 2021 – November 2022 at the Medical Record Installation of Rumah Sakit Universitas Andalas. This study was conducted using a total sampling technique with a total sample of 161 patient. Results: The results showed that the frequency of female was more than male (60.9:39.1). The frequency of >50 years old is almost the same as 50 years old (50.9:49.1). There are more patients without comorbid hypertension than patients with comorbid hypertension (64.6:35.4). Conclusions: There are more COVID-19 patients treated at Andalas University Hospital aged 50 years with female sex and more patients without hypertension comorbid.  
Co-Authors Abdi, Tri Jaya Abdillah, Tegar Abdul Razak Adzra Fadhila Iswan Afriani, Nita Afriwardi Afriwardi Afriyeni Sri Rahmi Akmal Irsyadi Iswan Almurdi Almurdi Anggrainy, Fenty Arina Widya Murni ATTIYA ISTARINI Aulia Noza Claudia Novi Wijaya Darwin Amir, Darwin Dea Rika Putri Purba Dedi Sutia Dhani Arief Prandana Dian Pertiwi Dian Pertiwi Alty Dicky Lesmana Eldi Sauma Eryati Darwin Eva Decroli Fadrian Herjunio Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Gunawan Septa Dinata Gunawan Septa Dinata Gusti Revilla Hanny Vidya Sari Hardianti, Sonia Harun Harnavi Hasmiwati Hendra Permana Hendra Permana Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husni Minanda Fikri Ida Rahmah Burhan Ilahi, Fitratul Indra, Syarif Isnindiah Koerniati Isnu Lucky Riandini Isnu Lucky Riandini, Isnu Lucky Istiqomah Kurniawan, Yoga Setia Lenny Arinda Lesti Marliana Lydia Susanti, Lydia Melda Yelmaiza Meuthia Yolanda Miftah Irramah Musrizal Adli Nabila Priscilla Putri Nada Utami Prahastiwi Nita Afriani Novia Riza Lestari Nur Indrawaty Lipoeto Priyanka Prima Putri Putra, Syandrea Prima Putri, Azhara Dhiya Yosse Putri, Fanny Adhy Putri, Nabila Priscilla Rachmat Saleh Eka Putra Reno Bestari Reno Bestari Reno Bestari Reno Bestari Ridho Ahmad Jabbar Rifki Irsyad Rika Susanti Rizki Muhammad Rananda Rudy Afriant Salsabilah Firdausiah Saptino Miro Selfi Renita Rusjdi Sonia Hardianti Sukri Rahman Sutia, Dedi Syamel Muhammad Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Tiara Mardalifa Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Umul Khair Yoga Setia Kurniawan Yulia Trisna Yuliarni Syafrita Yuliarni Syafrita Yulistini, Yulistini Yuniar Lestari Yusri, Elfira Zakiya Ifana Putri