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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Global Medical and Health Communication MNJ (Malang Neurology Journal) Biomedical Journal of Indonesia Window of Health : Jurnal Kesehatan Collaborative Medical Journal (CMJ) Health and Medical Journal Human Care Journal Andalas obstetrics and gynecology journal Jurnal Ners Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Pharmaceutical and Sciences. Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Neurona Jurnal Sains Farmasi dan Kesehatan Jurnal Sains, Teknologi dan Kesehatan
Restu Susanti
Departemen Neurologi, Fakultas Kedokteran, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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HUBUNGAN STATUS MEROKOK TERHADAP KUALITAS TIDUR PADA REMAJA TINGKAT SLTA DI KECAMATAN BONJOL DAN LUBUK SIKAPING Abdi, Tri Jaya; Anggrainy, Fenty; Susanti, Restu
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.990

Abstract

Background: Smoking is the biggest health problem faced. This activity has at least had a negative impact  such as a decrease in sleep quality due the release of cathecholamines resulting in tachycardia and increase in blood preasure which increases alertness.Objective: This study aims to determine the characteristic, smoking status, and the relationship of smoking with the sleep quality of adolescent at the senior high school level. Methods: This type of research is a descriptive analytic study with a cross-sectional study design with convenience sampling technique. The population of this study was school-age students at the high school level in the districts of Bonjol and Lubuk Sikaping with a total sample of 96 people. Data obtained in the form of primary data from Pittsburgh Sleep Quality Index (PSQI) questionnaire Results: The highest group of school-aged adolescents were boys aged 17 and 18 years, with the most categories being smokers and poor sleep quality. Regarding the relationship between smoking status, there was a statistically significant relationship with sleep quality. This study also found that adolescents with smoking status were 5,402 times more likely than smokers (ex-smokers and non-smokers) to decrease sleep quality (p=0.001;OR=5.402) Conclusion: There is a significant relationship between smoking status and sleep quality.
ANALISIS KADAR AMILOID BETA PLASMA DENGAN GANGGUAN KOGNITIF PADA DIABETES MELITUS TIPE 2 Syafrita, Yuliarni; Amir, Darwin; Decroli, Eva; Susanti, Restu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.38

Abstract

   ANALYSIS OF PLASMA LEVELS OF BETA AMYLOID WITH COGNITIVE IMPAIRMENT IN TYPE 2 DIABETES MELLITUSABSTRACTIntroduction: Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease are two kind of neurodegenerative disease that related with age. Patients with DM show a tendency to develop Alzheimer’s disease, but there is no single marker for predicting a DM case will develop into Alzheimer’s disease. Amyloid cascade beta disturbance is one factor involved in the pathogenesis of DM disease as well as in Alzheimer’s disease, and still believed to be the main factor causing Alzheimer’s dementia.Aims: This research was aimed to determine the correlation between beta amyloid plasm level and demographic factors with the occurrence of cognitive dysfunction in type 2 diabetes mellitus patients.Methods: This was a cross-sectional design study on patients with DM in special DM clinic at M Djamil and Ibnu Sina hospital, Padang, between August—October 2016. Cognitive function was examined using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Beta amyloid level was measured by enzyme-linked immunosorbent assay (ELISA) technique. Beta amyloid diagnostic ability was analyzed by using receiver operating characteristics (ROC). The correlation between the variables were analyze by using Chi-square, and p value p<0.05 was considered to be significant. To determine the strongest variables which correlated to cognitive dysfunction, logistic regression analysis were performed.Result: 65 subjects included in this study, where cognititve dysfuntion were present in 35 patients (58.3%). There were significant correlation between disease duration and low levels of 42 beta amyloid in plasma (Aβ42) with the occur- rence of cognitive dysfunction. The multivariate analysis showed that the disease duration, followed by low levels of Aβ42 and education level were the variables correlated with cognitive dysfunction.Discussion: There were a correlation between low levels of 42 beta amyloid in plasma with the occurrence of cog- nitive dysfunction in type 2 diabetes mellitus patients.Keywords: Beta amyloid, cognitive impairment, demographic factors, type 2 DMABSTRAKPendahuluan: Penyakit diabetes melitus tipe 2 (DM) dan penyakit Alzheimer adalah dua penyakit neurodegeneratif yang sering berhubungan dengan usia. Pasien dengan DM menunjukkan kecenderungan untuk menderita penyakit Alzheimer, namun belum ada satupun penanda untuk memprediksi kasus DM yang akan berkembang menjadi penyakit Alzheimer. Gangguan kaskade amiloid beta merupakan faktor yang terlibat pada patogenesis penyakit DM maupun pada penyakit Alzheimer, dan sampai sekarang masih dipercaya sebagai faktor utama yang menyebabkan demensia Alzheimer.Tujuan: Mengetahui hubungan kadar amiloid beta plasma dan faktor demografi dengan gangguan fungsi kognitif pada penderita DM.Metode: Penelitian dengan desain potong lintang ini, terhadap pasien DM yang berobat di Poliklinik khusus diabetes RSUP Dr. M Djamil dan RS Islam Ibnu Sina, Padang, pada periode Agustus–Oktober 2016. Penilaian gangguan kognitif menggunakan Montreal Cognitive Assesment versi Indonesia (MoCA-Ina), dinyatakan terganggu jika nilai <26.Kadar amiloid beta diperiksa dengan metode enzyme-linked immunosorbent assay (ELISA) dan kemampuan diagnostik amiloid beta dianalisis dengan receiver operating characteristics (ROC). Hubungan antar variabel diuji dengan Chi- square, dikatakan bermakna bila nilai p≤0,05. Dilakukan analisis regresi logistik untuk menentukan variabel yang paling kuat hubungannya dengan gangguan fungsi kognitif.Hasil: Didapatkan 65 subjek dengan rerata usia 61,62+7,6 tahun dan sebanyak 53,8% mengalami gangguan fungsi kognitif. Didapatkan hubungan yang bermakna antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif. Pada analisis multivariat diketahui bahwa urutan kekuatan variabel yang berhubungan dengan terjadinya gangguan fungsi kognitif adalah lama sakit, rendahnya kadar Aβ42 plasma, dan tingkat pendidikan.Diskusi: Terdapat hubungan antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif pada penderita DM.Kata kunci: Amiloid beta, DM tipe 2, faktor demografi, gangguan kognitif
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Putri, Nabila Priscilla; Ali, Hirowati; Tofrizal, Tofrizal; Darwin, Eryati; Susanti, Restu; Hasmiwati, Hasmiwati
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Hubungan Aktivitas Fisik dengan Immediate Memory Lansia di Puskesmas Sikapak Salsabilah Firdausiah; Yuliarni Syafrita; Isnindiah Koerniati; Restu Susanti; Almurdi, Almurdi; Ida Rahmah Burhan
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2436

Abstract

Latar Belakang: Proses degeneratif akan terjadi seiring bertambahnya usia yang kemudian akan menyebabkan terjadinya penurunan pada fungsi immediate memory. Untuk menigkatkan fungsi memori seseorang maka perlu peningkatan aktivitas fisik dalam kehidupan sehari-hari. Objektif: Penelitian ini bertujuan mengetahui hubungan aktivitas fisik dengan immediate memory pada lansia. Metode: Penelitian ini merupakan penelitian analitik dengan metode cross sectional. Teknik pengambilan sampel dengan menggunakan metode consecutive sampling dengan jumlah sampel sebanyak 79 responden. Pengumpulan data responden didapat melalui pengisian kuesioner dan dianalisis menggunakan Fisher’s Exact Test. Hasil: Hasil penelitian ini menggambarkan bahwa kelompok usia terbanyak adalah usia 55-65 tahun (39,2%). Lebih dari setengah lansia merupakan perempuan (82,3%). Sebagian besar responden memiliki riwayat pendidikan rendah (89,9%) dan sebagian besar lansia tidak bekerja (74,7%). Mayoritas lansia melakukan tingkat aktivitas fisik sedang (64,6%). Kesimpulan: Tidak terdapat hubungan antara aktivitas fisik dengan immediate memory pada lansia di Puskesmas Sikapak Kecamatan Pariaman Utara Kota Pariaman (p> 0,05).
Serum Nerve Growth Factor as a Biomarker for Chemotherapy-Induced Peripheral Neuropathy: A Cross-Sectional Study Rifki Irsyad; Restu Susanti; Fanny Adhy Putri; Yuliarni Syafrita; Syarif Indra; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1292

Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment. Nerve growth factor (NGF) plays a crucial role in neuronal health and has been implicated in CIPN development. This study investigated the relationship between serum NGF levels and CIPN in cancer patients undergoing chemotherapy. Methods: A cross-sectional study was conducted on 60 cancer patients receiving chemotherapy at Dr. M. Djamil General Hospital Padang, Indonesia, from June to October 2024. Serum NGF levels were measured, and CIPN was assessed using the Toronto Clinical Scoring System (TCSS). The relationship between NGF and CIPN was analyzed using the Mann-Whitney test. Results: The median serum NGF level was significantly lower in patients with CIPN (n=43) compared to those without CIPN (n=17) (103.26 pg/ml vs. 148.91 pg/ml, p=0.029). No significant association was found between chemotherapy regimens and CIPN or NGF levels. Conclusion: Lower serum NGF levels are associated with CIPN in cancer patients undergoing chemotherapy. NGF may serve as a potential biomarker for CIPN, aiding in early detection and management. Further research is needed to explore the clinical utility of NGF as a predictive and monitoring tool for CIPN.
Neurovascular Inflammation and Oxidative Stress Markers in Chronic Migraine: Is Nitric Oxide the Key Link to Severity? Aulia Noza; Restu Susanti; Yuliarni Syafrita; Syarif Indra; Lydia Susanti; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1312

Abstract

Background: Nitric oxide (NO), a ubiquitous signaling molecule, has been implicated in migraine pathophysiology through mechanisms including vasodilation, neurogenic inflammation, and oxidative stress. However, its specific relationship with the clinical severity of chronic migraine required further elucidation. This study aimed to investigate the association between serum NO levels and the severity of chronic migraine in a cohort of female patients. Methods: An observational study employing a cross-sectional design was conducted between July 2024 and November 2024 at Neurology Clinics and Community Healthcare Centers in Padang City, Indonesia. Fifty-one female chronic migraineurs, diagnosed according to ICHD-3 criteria, were enrolled using consecutive sampling. Patients with specific comorbidities, pregnancy, breastfeeding, or Medication Overuse Headache (MOH) were excluded. Migraine severity during an ictal phase was assessed using the Migraine Severity Scale (MIGSEV). Venous blood samples were collected during migraine attacks (ictal phase), and serum NO levels were quantified using a colorimetric method. The association between NO levels and MIGSEV scores was analyzed using the Kruskal-Wallis test, followed by post-hoc Mann-Whitney U tests. Statistical significance was set at p < 0.05. Results: The study included 51 female chronic migraineurs with a median age of 33 years. Migraine severity distribution was: 10 (19.6%) mild, 26 (51.0%) moderate, and 15 (29.4%) severe. The overall median serum NO level was 74.8 nmol/ml (range: 32.20 - 169.15 nmol/ml). Median NO levels demonstrated a positive gradient with increasing migraine severity: mild group 47.31 nmol/ml (range: 34.85 - 67.15), moderate group 88.45 nmol/ml (range: 32.20 - 167.45), and severe group 96.71 nmol/ml (range: 65.45 - 169.15). The Kruskal-Wallis test revealed a statistically significant difference in NO levels across the severity groups (p < 0.01). Post-hoc analyses confirmed significant differences between the mild and moderate groups (p < 0.01) and between the mild and severe groups (p < 0.01). Conclusion: This study demonstrated a significant positive association between serum Nitric Oxide levels, measured during the ictal phase, and the severity of chronic migraine in female patients. Higher NO levels were correlated with greater migraine severity, suggesting NO may play a crucial role in the mechanisms underlying migraine intensity and potentially serve as a biomarker reflecting the clinical burden of chronic migraine.
Neuroinflammation and Sleep Dysfunction in Epilepsy: The Role of High Sensitivity C-Reactive Protein Akmal Irsyadi Iswan; Restu Susanti; Lydia Susanti; Syarif Indra; Fanny Adhy Putri; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1313

Abstract

Background: Emerging evidence suggests a bidirectional relationship between systemic inflammation and both epilepsy and sleep dysfunction. High-sensitivity C-reactive protein (Hs-CRP), a sensitive marker of low-grade systemic inflammation, is elevated in response to pro-inflammatory cytokines. However, the specific link between Hs-CRP levels and subjective sleep quality within the epilepsy population required further investigation. This study aimed to investigate the relationship between serum Hs-CRP levels and sleep quality in patients diagnosed with epilepsy. Methods: A cross-sectional study was conducted involving 40 patients diagnosed with epilepsy attending the neurology clinic at Dr. M. Djamil General Hospital, Padang, Indonesia, between January and February 2025. Patients aged over 17 years diagnosed by a neurologist were included. Serum Hs-CRP levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Sleep quality over the preceding month was assessed using the validated Indonesian version of the Pittsburgh Sleep Quality Index (PSQI). Mann-Whitney U test was employed to analyze the difference in median Hs-CRP levels between patients with good and poor sleep quality. Relationships between baseline characteristics and sleep quality were assessed using Chi-square/Fisher's exact tests for categorical variables and the Mann-Whitney U test for continuous variables. Results: Forty epilepsy patients (median age 25.5 years, range 17-50; 52.5% female) were enrolled. The median duration of epilepsy was 10 years (range 1-35). A majority of patients exhibited uncontrolled seizures (75%) and were receiving AED polytherapy (60%). Based on PSQI scores, 24 patients (60%) were classified as poor sleepers, while 16 (40%) were good sleepers. A significant difference was observed in median serum Hs-CRP levels between the two groups: patients with good sleep quality had significantly lower median Hs-CRP levels compared to those with poor sleep quality (1,271.50 ng/ml [range 58–5,837] vs. 2,771.50 ng/ml [range 509–27,187], p=0.027). Poor sleep quality was significantly associated with younger age (median 23 vs. 36 years, p=0.039) and AED polytherapy (75% vs. 25%, p=0.018). Conclusion: This study demonstrated a significant association between elevated serum Hs-CRP levels and poor subjective sleep quality in patients with epilepsy. Epilepsy patients experiencing poor sleep exhibited significantly higher levels of this inflammatory biomarker. These findings underscore the potential role of systemic inflammation in the complex interplay between epilepsy and sleep disturbances, suggesting Hs-CRP could serve as a potential biomarker linking these conditions.
Is Serum Vitamin D a Determinant of Carpal Tunnel Syndrome Severity? A Cross-Sectional Observational Study Rachmat Saleh Eka Putra; Syarif Indra; Lydia Susanti; Yuliarni Syafrita; Restu Susanti; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1317

Abstract

Background: Carpal tunnel syndrome (CTS) represents one of the most frequently encountered compressive neuropathies affecting the upper extremities. Emerging evidence suggests a potential link between vitamin D status and CTS incidence and severity, with vitamin D deficiency proposed as an independent risk factor influencing symptom severity. This study aimed to investigate the association between serum 25-hydroxyvitamin D levels and the electrophysiologically determined severity of CTS in a cohort of patients in Padang, Indonesia. Methods: This cross-sectional observational study was conducted over eight months, from July 2024 to February 2025, at the Neurological Polyclinic of Dr. M. Djamil General Hospital Padang. Patients diagnosed with CTS based on clinical presentation and confirmed by nerve conduction studies (NCS) were consecutively enrolled. Exclusion criteria were applied to ensure a homogenous study population. Serum 25-hydroxyvitamin D levels were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method. CTS severity was categorized as mild, moderate, or severe based on standardized NCS parameters. The association between serum 25-hydroxyvitamin D levels and CTS severity grades was analyzed using the Kruskal-Wallis test, with a p-value < 0.05 considered statistically significant. Results: A total of 45 subjects meeting the inclusion criteria were included in the final analysis. The median age of the participants was 36 years (range 20-71), with a predominance of female patients (n=37, 82.2%). The mean Body Mass Index (BMI) was 24.1 ± 4.66 kg/m². Based on NCS findings, CTS severity was classified as mild in 20 patients (44.4%), moderate in 16 patients (35.6%), and severe in 9 patients (20%). The overall median serum 25-hydroxyvitamin D level across all CTS patients was 27.80 ng/mL (range 10.4 - 278.4 ng/mL). When stratified by severity, the median vitamin D levels were 23.75 ng/mL for mild CTS, 27.95 ng/mL for moderate CTS, and 37.50 ng/mL for severe CTS. Despite an apparent trend of increasing median vitamin D levels with increasing CTS severity, the Kruskal-Wallis test revealed no statistically significant association between serum 25-hydroxyvitamin D levels and the severity of CTS (p = 0.094). Conclusion: Serum 25-hydroxyvitamin D levels were not found to be significantly associated with the severity of carpal tunnel syndrome as determined by nerve conduction studies. Further research with larger sample sizes and diverse populations is warranted to clarify the potential role of vitamin D in the pathophysiology and clinical presentation of CTS.
Chemotherapy-Induced Cognitive Impairment and Neuroaxonal Damage: Investigating the Role of Serum Neurofilament Light Chain Husni Minanda Fikri; Syafrita, Yuliarni; Lydia Susanti; Syarif Indra; Restu Susanti; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1319

Abstract

Background: Chemotherapy-induced cognitive impairment (CICI), colloquially termed "chemobrain," represents a significant challenge for cancer survivors, potentially affecting up to 85% of patients undergoing treatment. Diagnosis often relies on neuropsychological testing and imaging, which may lack sensitivity for early detection or reflect chronic changes. Neurofilament light chain (NfL), a neuronal structural protein released into biofluids upon neuroaxonal damage, emerges as a promising biomarker. This study investigated the relationship between serum NfL levels and the degree of cognitive impairment in patients receiving chemotherapy. Methods: An observational, cross-sectional study was conducted involving 50 cancer patients undergoing chemotherapy at Dr. M. Djamil General Hospital Padang between October and December 2024. Cognitive function was assessed using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina), and depression was screened using the Patient Health Questionnaire-9 (PHQ-9). Serum NfL levels were quantified using an Enzyme-Linked Immunosorbent Assay (ELISA) method. The Kruskal-Wallis test was employed to analyze the relationship between serum NfL levels and cognitive function status (normal, mild impairment, moderate-severe impairment). Results: Cognitive impairment (MoCA-Ina assessed) was identified in 41 (82%) of the 50 participants, with 30 (60%) exhibiting mild and 11 (22%) exhibiting moderate to severe impairment. The median serum NfL level across all subjects was 23.44 pg/ml (range: 13.81-68.71 pg/ml). A statistically significant relationship was observed between serum NfL levels and the presence and severity of cognitive impairment (p = 0.02). Median NfL levels progressively increased from the cognitively normal group (18.49 pg/ml) to the mild impairment group (23.5 pg/ml) and the moderate-severe impairment group (24.5 pg/ml). Post-hoc analysis revealed significant differences in NfL levels between the normal group and both the mild (p=0.03) and moderate-severe (p=0.01) impairment groups. Conclusion: This study demonstrated a significant positive association between serum NfL levels and the presence and severity of cognitive impairment in cancer patients undergoing chemotherapy. These findings support the potential utility of serum NfL as an accessible biomarker for detecting chemotherapy-associated neuroaxonal damage and concomitant cognitive decline.
Migraine And Pregnancy: What Should We Know Susanti, Restu; Muhammad, Syamel
Andalas Obstetrics And Gynecology Journal Vol. 4 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.251-260.2020

Abstract

Migraine is a common headache characterized by unilateral throbbing-like headache and pulsating in nature and sometimes associated with aura. Migraine is a disabling disorder that among adults is more prevalent among women than men. It is primary headache that is often found in pregnancy. Migraine is a common disorder in women of childbearing age, and usually requires pharmacological treatment. Migraine can be considered an important risk factor for hypertensive and vascular diseases during pregnancy. Migraine therapy in pregnancy is very challenging, it must taken into a consideration about the health of the mother and fetus.  Several effective antimigraine medications are reasonably safe for use by pregnant and breastfeeding women. Prophylactic theraphy should be given to patient with recurrent migraine attacks in pregnancy. Nonpharmacological strategies are always first-line treatment options for mild migraine, and should also be used complementarily whenever pharmacological treatment is required. Women with migraine should be offered periconceptional counselling to promote a safe and healthy pregnancy. Keywords: migraine; pregnancy; therapy
Co-Authors Abdi, Tri Jaya Abdillah, Tegar Abdul Razak Adzra Fadhila Iswan Afriani, Nita Afriwardi Afriwardi Afriyeni Sri Rahmi Akmal Irsyadi Iswan Almurdi Almurdi Anggrainy, Fenty Arina Widya Murni ATTIYA ISTARINI Aulia Noza Claudia Novi Wijaya Darwin Amir, Darwin Dea Rika Putri Purba Dedi Sutia Dhani Arief Prandana Dian Pertiwi Dian Pertiwi Alty Dicky Lesmana Eldi Sauma Eryati Darwin Eva Decroli Fadrian Herjunio Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Gunawan Septa Dinata Gunawan Septa Dinata Gusti Revilla Hanny Vidya Sari Hardianti, Sonia Harun Harnavi Hasmiwati Hendra Permana Hendra Permana Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husni Minanda Fikri Ida Rahmah Burhan Ilahi, Fitratul Indra, Syarif Isnindiah Koerniati Isnu Lucky Riandini Isnu Lucky Riandini, Isnu Lucky Istiqomah Kurniawan, Yoga Setia Lenny Arinda Lesti Marliana Lydia Susanti, Lydia Melda Yelmaiza Meuthia Yolanda Miftah Irramah Musrizal Adli Nabila Priscilla Putri Nada Utami Prahastiwi Nita Afriani Novia Riza Lestari Nur Indrawaty Lipoeto Priyanka Prima Putri Putra, Syandrea Prima Putri, Azhara Dhiya Yosse Putri, Fanny Adhy Putri, Nabila Priscilla Rachmat Saleh Eka Putra Reno Bestari Reno Bestari Reno Bestari Reno Bestari Ridho Ahmad Jabbar Rifki Irsyad Rika Susanti Rizki Muhammad Rananda Rudy Afriant Salsabilah Firdausiah Saptino Miro Selfi Renita Rusjdi Sonia Hardianti Sukri Rahman Sutia, Dedi Syamel Muhammad Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Tiara Mardalifa Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Umul Khair Yoga Setia Kurniawan Yulia Trisna Yuliarni Syafrita Yuliarni Syafrita Yulistini, Yulistini Yuniar Lestari Yusri, Elfira Zakiya Ifana Putri