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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE IDJP (Indonesian Journal of Pharmaceutics) Jurnal Kesehatan Bakti Tunas Husada IKRA-ITH Teknologi Jurnal Sains dan Teknologi Journal of Pharmacopolium Majalah Farmasetika Pharmacoscript Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Karya Kesehatan Siwalima Jurnal Pengabdian Masyarakat (Jupemas) Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Kesehatan Bakti Tunas Husada Jurnal Sains Farmasi dan Kesehatan Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Analit: Analytical And Environmental Chemistry Journal of Pharmascience
Garnadi Jafar, Garnadi
Fakultas Farmasi, Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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COMPARISON OF ANALYSIS METHODS FOR CURCUMIN DETERMINATION: A LITERATURE REVIEW Jajang Japar Sodik; Deden Indra Dinata; R. Herni Kusriani; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.850

Abstract

Curcuminoids such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the major bioactive components found in Curcuma species, including turmeric (Curcuma longa L.). Curcumin is a polyphenol that is used as an antioxidant. Various analytical methods have been developed for the detection of curcumin, each with its advantages and limitations. Selection of an appropriate analytical method is crucial for obtaining accurate results. Although critical reviews on the chemical, biological, and pharmacological properties of curcumin are widely available, reviews specifically focusing on the different analytical methods for curcumin are limited. This review article aims to provide an overview of several analytical methods for the determination of curcumin. This is expected to encourage readers to choose a suitable analytical method for their specific needs. The articles used in this review were sourced from international English-language publications obtained from Science Direct, PubMed, and Google Scholar. The search was performed using keywords such as "Instrumental analysis of curcumin" and "Analytical techniques for curcumin analysis." The results reveal that spectrophotometric methods are simple techniques used to estimate curcumin content; however, their utility is limited to cases where the concentration of each curcuminoid is not a critical quality parameter. Accurate quantification and detection of trace amounts of curcuminoids and metabolites require the use of chromatographic separation methods combined with mass spectrometry detection (LC-MS/MS) because of their high accuracy, reproducibility, and sensitivity with low limits of detection (LOD) and lower limits of quantification (LLOQ). Keywords: Analytical methods, Curcumin, Determination
ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT Abdul Mulki Irpani; Deden Indra Dinata; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1062

Abstract

The uncontrolled growth of abnormal cells in one area of the body can spread to other tissues and create more cancer cells, a disease known as cancer. Malignant cancer cells have the potential to become fatal. After cardiovascular disease, cancer is the second most common cause of mortality. Numerous cancer types exist, including stomach, liver, colorectal, lung, breast, and cervical cancers. More than 70% of cancer-related deaths occur in low- and middle-income nations, and the number of cancer-related deaths is predicted to rise steadily, hitting 11.5 million by 2030. Some of the resources utilized to look up information on curcumin's application as an anticancer agent are PubMed, Science Direct, and Google Scholar. Most of the articles that were used were published between 2013 and 2023, or within the last ten years. These journals were found using the following keywords: "Curcumin," "Cancer," "Curcumin as an Anticancer," and "Utilization of Curcumin as an Anticancer Agent." Scholars from many nations have conducted comparable investigations on the application of curcumin as an anticancer agent. Furthermore, it has been established that curcumin directly inhibits cancer cells when used as an anticancer drug. This suggests that curcumin does have anticancer properties. Keywords: Curcumin, Cancer, Curcumin as an Anticancer agent
REVIEW: REVIEW ARTICLE LIPID-BASED NANOTECHNOLOGY Garnadi Jafar; R. Awaludin Nazal N; Entris Sutrisno
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1084

Abstract

Nanotechnology is defined as engineering the creation of materials, functions, and devices on the nanometer scale. Nanoscience is increasingly developing and becoming a part of various fields, such as electronics, materials, and biology. Lipid nanoparticles are a major application in nanotechnology. In formulas II and III, smaller results were obtained compared with the other formulas. Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and each test met the range. From the explanation above, it can be concluded that lipid-based nanotechnology has great potential in various fields such as medicine, cosmetics, and agriculture. Its use can provide great benefits such as increasing the effectiveness of drug administration, increasing the absorption of nutrients in food, and developing cosmetic products. which one is safer and more effective. To compare several types of nanoparticle methods, such as Liposomes, Neosomes, Etosomes, SLN, and NLC for selection of the lipid base, namely NLC. It is important to ensure that the use and development of this technology are safe and beneficial for humans and the environment. Keywords : Nanotechnology, Nanoparticles, Lipid-Based Nanoparticles
REVIEW: THE POTENTIAL OF HERBAL PLANTS AS ANTI-ALOPECIA MEDICINES Arif Rubianto; Garnadi Jafar; Deden Indra Dinata; Jajang Japar Sodik
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1204

Abstract

Hair loss, or alopecia, is a common dermatological condition that affects up to 2% of the world's population. It is often caused by genetic factors, such as male or female pattern baldness, but can also be attributed to various environmental factors, an imbalanced diet, or chronic illnesses. While hair loss is not life-threatening, it can lead to significant anxiety, depression, and other psychological issues, ultimately affecting one's quality of life. Various treatments for baldness, including synthetic drugs like minoxidil and finasteride, or herbal remedies, have been approved by the Food and Drug Administration. Although synthetic drugs are effective, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating baldness because many chronic disorders can lead to alopecia. Therefore, this review focuses on identifying efficient alternative treatment agents with limited side effects. Specifically, it considers medicinal plants as potential healing agents for treating baldness. To gather relevant information for this study, several databases were searched, including Scopus, PubMed, and Google Scholar. Comprehensive searches were conducted using various search terms, such as "baldness," "alopecia," "natural remedies for baldness," "herbal treatment for baldness," and others, to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential for reducing baldness, thanks to their anti-inflammatory and antioxidant properties. According to existing literature, extracts of medicinal plants and formulations derived from plants, such as Eclipta alba (L.) Hassk, Arctium lappa L., Centella asiatica L., Morinda citrifolia, Acorus calamus var. angustatus, Alpinia zerumbet, ...
PENDEKATAN SISTEM PENGHANTARAN NANOPARTIKEL BERBASIS LIPID SEBAGAI OBAT ANTIJERAWAT : REVIEW: Putriyanti Al-fira; Jafar Garnadi; Mulyani Yani
Pharmacoscript Vol. 7 No. 2 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i2.1761

Abstract

Jerawat adalah gangguan kulit yang terjadi ketika folikel rambut tersumbat oleh minyak dan sel kulit mati. Bakteri gram positif propionibacterium acnes adalah akar dari jerawat. Propionibacterium acne tumbuh karena akumulasi sebum, yang menyebabkan jerawat. Untuk mengatasi jerawat, berbagai bahan aktif dan metode pengobatan telah dikembangkan. Penghantaran melalui nanoteknologi adalah metode terbaru yang digunakan. Ini dipilih karena kemampuan nanoteknologi untuk meningkatkan stabilitas bahan aktif, meningkatkan penetrasi bahan aktif ke dalam kulit, dan memungkinkan zat aktif dibawa ke area yang ditargetkan. Metode yang digunakan yaitu Artikel ilmiah dikumpulkan dari sumber nasional dan internasional 10 tahun terakhir (2014-2024). Hasil yang ditunjukkan bahwa metode nanopartikel menunjukkan potensi besar sebagai bahan aktif anti jerawat karena ukurannya yang kecil memungkinkan penetrasi kulit lebih baik, pelepasan bahan aktif secara terkendali, dan perlindungan dari degradasi lingkungan. Keberhasilannya terbukti dalam berbagai studi dan uji klinis, dengan penurunan signifikan jerawat dan peningkatan kondisi kulit. Pengembangan terbaru, seperti nanopartikel lipid, nanopartikel polimer, dan nanopartikel metal. Diskusi dalam review artikel ini melakukan pendalaman terhadap pengembangan obat dan sitem penghantaran obat baru, meliputi proses sintesis, karakterisasi, mekanisme kerja, dan hasil uji klinis yang relevan. Penggunaan nanopartikel lipid telah menunjukkan potensi besar sebagai penghantar obat yang efektif,  nanopartikel polimer menawarkan kontrol pelepasan obat yang lebih baik dan nanopartikel logam menawarkan sifat antimikroba intrinsik. dan Kesimpulannya review artikel ini akan mengulas secara menyeluruh berbagai penelitian mengenai penghantaran zat aktif terbarukan melalui nanoteknologi untuk terapi jerawat.
Penentuan Aktivitas Antioksidan dari Tiga Jenis Simplisia Jahe (Gajah, Emprit, Merah) untuk Pengobatan Tradisional Chinese Medicine (TCM) Maisyah, Aini; Jafar, Garnadi; Khiong, Tjia Khie
Majalah Farmasetika Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i3.54494

Abstract

Jahe merupakan tanaman yang banyak dibudidayakan di Indonesia. Rimpang jahe diketahui mempunyai banyak khasiatnya terhadap kesehatan. Jahe sering dijumpai dalam racikan  pengobatan Traditional Chinese Medicine (TCM). Hal ini ada kaitannya dengan kandungan antioksidan pada jahe. Tujuan Penelitian ini bertujuan untuk menentukan aktivitas antioksidan pada simplisia tiga jenis simplisia jahe (gajah, emprit, merah). Metode Tiga jahe diberikan perlakuan yaitu sortasi basah dan kering, pembuatan simplisia, karakterisasi simplisia, uji aktivitas antioksidan menggunakan metode 2,2-Diphenyl-1-picrylhydrazyl (DPPH). Hasil rendemen simplisia tiga jahe (gajah 19,00%, emprit 15,26%,  merah 12,61%), pengujian  kadar air simplisia dari tiga jahe (gajah 7,315 %, emprit 7,439%,  merah 8,576 %) selanjutnya pada penentuan uji aktivitas antioksidan jahe gajah 77,03%, jahe emprit 61,91%, jahe merah 67,94%. aktivitas Aktivitas antioksidan dari ketiga jahe  dengan metode DPPH  menunjukkan nilai inhibitory concentration (IC50 ) mempunyai kategori kuat yaitu ada diantara 50-100 µg/ml.
OPTIMASI SISTEM PENGHANTARAN OBAT ANTIDIABETES ORAL MELALUI POMPA OSMOTIK UNTUK PENINGKATAN BIOAVAILABILITAS DAN EFEKTIVITAS TERAPI Elvano, Deki Rifa; Jafar, Garnadi
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 24, No 2 (2024)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v24i2.1402

Abstract

Peningkatan prevalensi Diabetes Melitus Tipe 2 di Indonesia memerlukan pengobatan yang efektif untuk mengontrol kadar glukosa darah. Obat antidiabetes oral semakin disukai karena kemudahan penggunaannya, meskipun sering kali menyebabkan fluktuasi kadar glukosa darah. Review artikel ini bertujuan untuk mengeksplorasi sistem pompa osmotik sebagai metode penghantaran obat yang dapat memberikan pelepasan obat yang lebih stabil, meningkatkan bioavailabilitas obat, dan efektivitas terapi. PubMed, Science Direct dan Google scholar adalah beberapa sumber artikel yang digunakan dalam pencarian informasi mengenai sistem penghantaran obat baru untuk antidiabetes oral. Artikel-artikel yang digunakan mayoritas adalah artikel terbaru yang ditulis dalam kurun waktu 10 tahun terakhir yaitu dari tahun 2014-2024. Kata kunci yang digunakan dalam pencarian jurnal-jurnal tersebut adalah "drug design diabetes" “new drug delivery diabetes” “drug delivery system for oral antidiabetes” “osmotic pump capsule”. Melalui pencarian yang komprehensif, 10 artikel yang memenuhi kriteria inklusi dipilih untuk dianalisis. Artikel-artikel ini memberikan wawasan yang berharga mengenai perkembangan terbaru dalam bidang ini, termasuk desain formulasi, evaluasi kinerja, dan potensi klinis. Formulasi yang dioptimalkan menunjukkan laju pelepasan obat yang konstan dan kinerja yang lebih baik dibandingkan dengan formulasi yang ada di pasaran, serta meningkatkan bioavailabilitas obat antidiabetes. Pendekatan ini diharapkan dapat memberikan solusi inovatif dalam pengobatan DMT2, dengan potensi untuk meningkatkan efektivitas terapi dan mengurangi frekuensi dosis.
REVIEW ARTICLE: NANOHERBAL AS A NATURAL SOLUTION FOR BACTERIAL DIARRHEA PROBLEMS Embas Saraswati, Dewa Ayu; Jafar, Garnadi; Sulaeman, Agus; Mulyani, Yani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1248

Abstract

Diarrhea is a global health problem that is often caused by bacterial infections, including Escherichia coli and Staphylococcus aureus. The use of conventional antibiotics in treating diarrhea often faces challenges, such as drug resistance and adverse side effects. As an alternative, current research interest is focused on the use of nanoparticles from herbal ingredients as potential antibacterial agents in the treatment of diarrhea. This review article aims to present the latest developments in the use of herbal nanoparticles as an anti-bacterial therapy for diarrhea. The literature search method was carried out via PubMed, Science Direct, and Google Scholar using relevant keywords. Selected articles must meet inclusion criteria, such as originality, language, period, and availability of full text. After the selection process, articles that meet the criteria will be reviewed to identify findings related to the use of herbal nanoparticles in treating diarrhea. Data analysis was conducted to compare the findings of each article and draw appropriate conclusions. Therefore, this review article aims to provide a comprehensive understanding of the potential use of nanoparticles from herbal ingredients as an effective and safe solution to treat diarrhea problems, while also highlighting interesting research possibilities to be carried out in the future. effectiveness and bioavailability in the treatment of diarrhea. By increasing absorption and penetration into bacterial cells, this therapy can serve as an effective and sustainable antibacterial agent ...
Review: Karakterisasi Modifikasi Bahan Aktif Farmasi Menjadi Kokristal Menggunakan Instrument Ftir, Sem, Xrd, Dan Dsc Muhamad Reza Pahlevi; Ratu Fania Aprilyanti; Ariqa Hidayatun Nisa; Aliyya Kurniasih Agustiani; Nurul Rahmalia; Garnadi Jafar; Novaliana Devianti Sagita
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2124

Abstract

Kokristalisasi merupakan salah satu teknik yang berkembang dalam modifikasi bahan aktif farmasi untuk meningkatkan karakteristik fisikokimia dari bahan aktif, khususnya yang memiliki kelarutan rendah. Penelitian ini bertujuan untuk mengevaluasi pengaruh metode karakterisasi, yaitu Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffractometry (XRD), dan Differential Scanning Calorimetry (DSC), terhadap kualitas kokristal bahan aktif farmasi dari tahun 2015 hingga 2024. Metode penelusuran pustaka dilakukan melalui Google Scholar. Hasil tinjauan literatur menunjukkan bahwa setiap teknik karakterisasi memiliki peran spesifik dalam memahami perubahan struktur dan sifat fisikokimia kokristal, seperti peningkatan kelarutan, stabilitas termal, dan morfologi permukaan. Berdasarkan hasil analisis pustaka, metode FTIR, SEM, XRD, dan DSC memberikan kontribusi penting dalam optimasi kualitas kokristal, yang berpotensi meningkatkan bioavailabilitas dan efektivitas bahan aktif farmasi.
Formula development and characterization of nanostructured lipid carriers (NLC) vitamin E acetate with solid lipids compritol and precirol Salsabilla, Syifa; Jafar, Garnadi; Fatmawati, Fenti
Science Midwifery Vol 12 No 5 (2024): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i5.1752

Abstract

Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but its nature is very lipophilic (log p±12.2) and has the potential to degrade. To overcome the problems of permeability and stability, vitamin E acetate needs to be developed in Nanostructured Lipid Carrier (NLC), which is a nano delivery system based on solid lipids and liquid lipids stabilized by surfactants as a colloidal system. The formulation of vitamin E acetate into NLC was carried out using the heat homogenization method, then sonicated using a probe sonicator. The materials used were 2% vitamin E acetate, 2-6% Compritol® and Precirol® solid lipids, 1% Myritol®, and 1-3% Chremophore and Plantacare® surfactants. The NLC results were then characterized by measuring particle size, zeta potential, polydispersity index, entrapment efficiency, and morphology. The characterization results showed that NLC vitamin E acetate had a particle size of 280-375 nm, a zeta potential of -23 mV to -28 mV, a polydispersity index <0.5, an entrapment efficiency of 92-97%, and a spherical morphology. The results showed that Nanostructured Lipid Carrier vitamin E acetate gave good results.
Co-Authors Abdul Mulki Irpani Agung Laksono S, Moch Agus Sulaeman Agus Sulaeman Aligita, Widhya Aliyya Kurniasih Agustiani Aliza, Rieztya Amalia Putri, Amalia Anggraeni, Vina Juliana Ani Anggriani Arif Rubianto Ariqa Hidayatun Nisa Avianningsih, Reformia Bachrudin, Panji Buana Irviana Prita Choerrunisa, Choerrunisa Dadih Supriadi Damayanti, Hilda Deden I Dinata Deden Indra Dinata Deden Indra Dinata, Deden Indra Deny Puryani Devianti Sagita, Novaliana Dila Anggraeni Dinayanti, Westi Nur Dini Auliya Azmi Dwi C, Alya Elis Susilawati Elisabeth Weya Elsa Yunita Septiani Elvano, Deki Rifa Embas Saraswati, Dewa Ayu Emma Emawati, Emma ERISKA AGUSTIN Faisha Farras Kartanagara Fatmawati Fenti Fatmawati Karim Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Fitriani, Ranti Ghea Nadira Shinta Gustana, Erick Kurniawan Halizah, Arin Nur Hanaya, Cicia Rosa Hasimun, Patonah Helen Fitri Novianti Herni Kusriani, R. Hidayat, Dudy Agustian Iceu Mulyati Iin Siti Aminah, Iin Siti Ira Adiyati Jajang Japar Sodik Karim, Fatmawati Khiong, Tjia Khie Kusriani, R Herni Latifah, Zahra Alfa Lia Marliani Mahran A, Ghani Maisyah, Aini Marita Kaniawati Meilani, Intan Mindiarto, Ahmad Bagus Muhamad Reza Pahlevi Muthmainah, Siti Saidah Ningrum, Windi Pratama Novaliana Devianti Sagita Novianti, Tamia Rizqi Nurfadillah, Rizal Nurfaiza, Putri Nurul Rahmalia Olivia Eka Putri Pahlevi, Muhamad Reza Pasha, ED Yunisa Mega Patonah, Patonah Pebriawati, Silpi Pramudiahwardani, Ananda Rota Pratama, Reza Priana, Eka Putriyanti Al-fira Putriyanti, Al-fira R. Awaludin Nazal N Rachmat Mauludin Rachmawati, Winasih Rahmat Santoso Raisya Salsabila Ramadhoni, M Ayodia Ratmoko, Sulthan Abdul Basith Ratu Fania Aprilyanti Reza Pahlevi, Muhamad Ria Riantini Riantini, Ria Rismawanti, Rusi Roganda Situmorang Rosyana, Nasywa Rusi Rismawanti Sagita, Novaliana Devianti Saifurrohman, Arip Saleh Wikarsa, Saleh Salsabilla, Syifa Sasanti Tarini Darijanto, Sasanti Tarini Senjaya, Fathurahman Ari Septianti, Regina Dwi Shelvy E Suherman Siti Jamilah Siti Raeyuni Maulidia Belina Siti Saidah Muthmainah Situmorang, Roganda Sofian, Ryan Soni Muhsinin Sukmawati, ika kurnia Susilawati, Elis Sutiyah, Siti Sutrisno, Entis Sutrisno, Entris Syarfa, Ahmad Syerliana Syerliana Tambunan, Irisanna Wahyu Wijayanti Wijaya, Teguh Pradinata Winasih Rachmawati Yani Mulyani Yani Mulyani Yolanda Putri Aloenida Yuyun Yuyun Zakaria, Hasballah Zakiyah, Nadhira Zalfa Dary Pernadi Ziska, Rahma