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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE IDJP (Indonesian Journal of Pharmaceutics) Jurnal Kesehatan Bakti Tunas Husada IKRA-ITH Teknologi Jurnal Sains dan Teknologi Journal of Pharmacopolium Majalah Farmasetika Pharmacoscript Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Karya Kesehatan Siwalima Jurnal Pengabdian Masyarakat (Jupemas) Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Kesehatan Bakti Tunas Husada Jurnal Sains Farmasi dan Kesehatan Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Analit: Analytical And Environmental Chemistry Journal of Pharmascience
Garnadi Jafar, Garnadi
Fakultas Farmasi, Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Development of a natural nanostructured lipid carrier (NLC)-based delivery system as an antidiabetic and diabetic wound agent: A review Novianti, Tamia Rizqi; Kusriani, R. Herni; Jafar, Garnadi
Science Midwifery Vol 13 No 5 (2025): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2152

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion. Diabetes often causes serious complications such as diabetic wounds, which are characterized by the appearance of ulcers, infections, or tissue damage in the feet. Conventional therapeutic approaches often show less than optimal effectiveness due to limited drug penetration into damaged skin tissue. The use of natural ingredients with antidiabetic and wound healing activities has been widely studied, but their effectiveness is often hampered by low solubility, stability, and bioavailability. One innovative strategy to overcome these problems is the development of nanotechnology-based drug delivery systems, one of which is Nanostructured Lipid Carrier (NLC). NLC is a lipid delivery system that combines solid and liquid lipids to increase stability, drug loading capacity, and control the release of active compounds. Purpose: This article aims to review the development of formulations from natural ingredients that have potential as antidiabetic and diabetic wound healing activities. Methods: This study is a literature review of articles published in the last ten years (2015 – 2025) from the ScienceDirect, PubMed, and Google Scholar databases. Results: Based on several studies, it shows that various active compounds such as curcumin (Curcuma longa), bay leaves (Syzygium polyanthum), and other flavonoid compounds have been formulated in the NLC system with significant improvements in stability, bioavailability, and pharmacological effectiveness. Conclusion: The NLC-based drug delivery system from natural ingredients has proven potential in increasing the effectiveness of antidiabetic therapy and diabetic wound healing. Further research is needed to optimize formulation stability, long-term toxicity testing, and clinical validation to support its therapeutic application.
Preliminary study of blood pressure and arterial stiffness monitoring using the niva device (non-invasive vascular analyzer) Avianningsih, Reformia; Hasimun, Patonah; Jafar, Garnadi; Putriyanti, Al-fira; Zakaria, Hasballah
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2212

Abstract

Introduction: Measuring vascular parameters using the NIVA (Non-Invasive Vascular Analyzer) is an important step in assessing the health of blood vessels in the community, especially in groups at risk of hypertension. Objective: This study aims to describe the results of baseline blood pressure and vascular parameter examinations in respondents before further intervention. Methods: Respondents underwent an initial screening process including informed consent, anamnesis, and baseline blood pressure measurement. Results: The graph shows a balanced gender distribution and a dominance of the 31-40 and 41-50 age groups, which are age groups at high risk of experiencing increased arterial stiffness. The hand and foot blood pressure graphs show variations in systolic and diastolic values ​​​​in the mild to moderate hypertension range, indicating that the hemodynamic condition of the respondents is stable and safe for NIVA examination. NIVA measurements were performed by attaching a cuff to the upper arm and left ankle to obtain parameters such as baPWV, ABI, MAP, PP, and Vascular Age. Blood pressure variations in the baseline graph support accurate reading of vascular parameters, especially because there was no indication of peripheral stenosis based on the comparison of hand and foot blood pressure. The data recording and validation process was performed by comparing the measurement results to the baseline, which was consistent with the initial graph. Conclusion: The examination results indicate that the respondents' initial condition met the requirements for non-invasive vascular evaluation and provided a representative picture of blood vessel health status prior to clinical intervention.
Pendidikan Kesehatan Hipertensi Bagi Warga Cibiru Hilir Bandung Situmorang, Roganda; Jafar, Garnadi; Mulyati, Iceu; Karim, Fatmawati; Muthmainah, Siti Saidah
Karya Kesehatan Siwalima Vol 2, No 2 (2023): September
Publisher : Lembaga Penerbitan Fakultas Kesehatan, Universitas Kristen Indonesia Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54639/kks.v2i2.1088

Abstract

Sasaran mendasar pemeliharaan kesehatan masyarakat Indonesia untuk mencapai kesehatan nasional adalah keluarga. Informasi ditemukan bahwa dalam keluarga wilayah Desa Cibiru Hilir Bandung terdapat permasalahan masih banyak keluarga kurang mengetahui penyakit tidak menular (hipertensi). Tujuan kegiatan ini adalah mengimplementasikan upaya promosi dan preventif kesehatan berbasis kolaborasi antar profesi tentang pemberian pendidikan kesehatan hipertensi pada keluarga wilayah Desa Cibiru Hilir Bandung. Metode yang digunakan yaitu pemaparan materi, diskusi dan evaluasi kegiatan. Hasil dari pelaksanaan kegiatan ini terjadi peningkatan pengetahuan keluarga tentang hipertensi dari kurang baik menjadi baik. Perlunya sosialisasi secara berkala secara berkala dan melibatkan banyak masyarakat dan kader. Keluarga diharapkan mengaplikasikan dirumah dan disebar luaskan informasi terkait hipertensi.
FORMULASI NANOEMULGEL EKSTRAK KULIT MANGGIS (Garcinia Mangostana L.) Damayanti, Hilda; Wikarsa, Saleh; Jafar, Garnadi
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i3.53

Abstract

Antioxidant-containing cosmetic has antiaging therapy that can inhibit the free radical formation. Mangosteen peel extract has very strong antioxidant activity. To enhance the effect and comfortness of mangosteen peel extract use on the skin, it could be made into nanoemulgel. The article provides the information about method of preparation and evaluation of nanoemulsion-gel. The purpose of this study was to formulate a stable microemulgel of mangosteen peel extractusing halal materials declared halal according to Islamic Shari’a. the materials used don’t contain carrion, blood, pig and/ animals that don’t conform to Islamic Shari’a. Microemulgel mangosteen peel extract was made by varying plantacare® 1200 UP concentration as cosurfactant (5, 10, 15, 20 and 25%) in the microemulsion and it was incorporated into the gel base. Evaluations were included the antioxidant activity test and organoleptic, pH, viscosity, stability, particle size analysis and panelist test. The antioxidant activity determined by DPPH method showed that IC50 value of mangosteen peel extract was 5.54 ppm. The third microemulsion formula containing cosurfactant of 15% resulted in the best results in that the parameter of the product can be penetrated by ray laser was at particle size of 23.65 nm, was determined by tranmission Electron Microscopy (TEM). Microemulgel containing Viscolam® MAC 10 of seven percent gave the stable formula proofed by freeze thaw and sentrifuga test. The five microemulgel formulations were stable.
Nanophytosome delivery model based on a combination of bay leaf (syzygium polyanthum) and binahong (anredera cordifolia) extracts in gel formulation as a therapy for diabetic ulcers Saifurrohman, Arip; Jafar, Garnadi; Sutrisno, Entis
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2314

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia and associated with various complications, including diabetic foot ulcer (DFU), which may lead to infection, gangrene, amputation, and even death. Natural-based topical therapies have potential to support DFU healing; however, the limited solubility and permeability of active compounds, particularly polar phytochemicals, often reduce their therapeutic effectiveness. Nanophytosomes, a phospholipid–phytoconstituent complex system, are considered capable of enhancing the stability and penetration of herbal compounds. This study aimed to design and develop nanophytosomes containing a combination of bay leaf extract (Syzygium polyanthum) and binahong leaf extract (Anredera cordifolia), characterize the system, incorporate it into a gel formulation, and evaluate its wound-healing activity in a diabetic wound model. The study involved preparation of nanophytosomes from the combined extracts followed by characterization of particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and particle morphology. The nanophytosome system was then formulated into a gel and evaluated for physical quality parameters including pH, viscosity, spreadability, and stability. Wound-healing activity was assessed using a diabetic wound model in experimental animals by observing wound closure and histological parameters. The expected results include the formation of nanophytosomes with favorable physicochemical characteristics, a stable gel formulation, and improved diabetic wound healing compared with the control group. It is anticipated that the nanophytosome gel combining S. polyanthum and A. cordifolia extracts may serve as a promising innovative topical therapy for DFU.
Nanophytosome delivery system and in vivo test of combination of binahong leaf extract (Andredera cordifolia) and bay leaf (Syzygium polyanthum) as a diabetic wound healer Saifurrohman, Arip; Jafar, Garnadi; Sutrisno, Entris; Senjaya, Fathurahman Ari
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2326

Abstract

This study aimed to develop and characterize a nanophytosome system containing combined extracts of bay leaf (Syzygium polyanthum) and binahong leaf (Anredera cordifolia), and to evaluate its wound healing activity through in vivo study. The extracts were prepared by maceration using 96% ethanol and characterized through phytochemical screening and LC-MS/MS analysis. Nanophytosomes were formulated using phospholipid complexes with variations of surfactants, followed by homogenization and sonication. The formulations were evaluated for particle size, polydispersity index, zeta potential, and entrapment efficiency. The results showed that particle size ranged from 16.30 to 927.18 nm, with the smallest size observed in Tween 80-based formulation. The polydispersity index ranged from 0.20 to 0.86, indicating better homogeneity in Tween 80 systems. Zeta potential values ​​were in the range of −6 to −17 mV, suggesting moderate stability. Entrapment efficiency was high in all formulations (92.5–97.3%), with the highest value observed in Cremophor-based formulation. In vivo evaluation demonstrated that the nanophytosome significantly accelerated wound healing compared to control groups, as indicated by faster wound contraction and improved tissue regeneration. In conclusion, the nanophytosome system enhanced the physicochemical properties and delivery of bioactive compounds, showing potential as an effective therapeutic approach for wound healing.
219-13FR Sacha inchi oil-based nanoemulsion of bay leaf (syzygium polyanthum) and binahong leaf (anredera cordifolia) extracts and in vitro release using a dialysis membrane Hidayat, Dudy Agustian; Jafar, Garnadi; Rachmawati, Winasih; Aliza, Rieztya; Ratmoko, Sulthan Abdul Basith
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2327

Abstract

This study aimed to develop and characterize a nanoemulsion system containing combined extracts of bay leaf (Syzygium polyanthum) and binahong leaf (Anredera cordifolia) using sacha inchi oil, and to evaluate its in vitro release profile using a dialysis membrane method. The extracts were prepared by maceration using 96% ethanol and characterized through physicochemical and phytochemical analyses. Nanoemulsions were formulated using Cremophor RH40 and PEG 400, followed by homogenization and sonication. The formulations were evaluated for particle size, polydispersity index (PDI), zeta potential, and morphology. The results showed that the optimized formulation (NEC5) exhibited the smallest particle size (130.06 ± 56.66 nm), acceptable PDI (0.45 ± 0.12), and moderate zeta potential (−14.15 ± 4.88 mV), indicating good stability. Morphological analysis confirmed spherical and uniformly distributed droplets. In vitro release studies demonstrated an initial burst release followed by a more controlled release pattern, with the nanoemulsion showing more stable release compared to the extract. In conclusion, the nanoemulsion system successfully improved the physicochemical properties and controlled release behavior of the plant extracts, indicating its potential as an effective delivery system for plant-derived bioactive compounds.
Formulation and characterization of nanoparticles combination of binahong leaves and bay leaves as a thin oral herbal preparation for diabetes prevention Priana, Eka; Jafar, Garnadi; Kusriani, R. Herni; Meilani, Intan; Fitriani, Ranti
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2328

Abstract

Diabetes mellitus is a chronic metabolic disease with a steadily increasing prevalence globally. Binahong leaves (Anrederacordifolia) and bay leaves (Syzygiumpolyanthum) contains flavonoids, such as kaempferol, which have the potential as antidiabetics, but its use is limited by the low solubility, stability, and bioavailability of the active compounds. This study aims to formulate and characterize a nanoparticle herbal medicine combining the two leaves using PlantCrystal technology, and develop it into an oral thin herbal preparation. The simplicia was processed through sorting, washing, drying, grinding, and sieving, then characterized and screened for phytochemicals. The nanoparticle herbal medicine was evaluated based on particle size, polydispersity index, zeta potential, and particle morphology. The membrane lysis release test showed an increase in the release of active substances compared to the simplicia. Furthermore, the formulation was developed into an oral thin herbal and evaluated for its physical properties, including organoleptic, water content, pH, film thickness, fold resistance, weight uniformity, and disintegration time.
Formulation and characterization of nanostructured lipid carriers of curcumin and their development in topical gel preparations for drug delivery systems Jafar, Garnadi; Choerrunisa, Choerrunisa; Sukmawati, Ika Kurnia; Putriyanti, Al-fira
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2339

Abstract

Curcumin is a bioactive compound derived from Curcuma longa with anti-inflammatory and antioxidant activities; however, its topical application is limited due to poor solubility and stability. The development of nanoparticle-based delivery systems such as Nanostructured Lipid Carriers (NLC) can enhance drug stability and skin penetration. This study aimed to formulate curcumin-loaded NLC, evaluate its physicochemical characteristics, and develop a gel dosage form based on the optimized NLC formulation. The research methods included preliminary solubility testing of curcumin in various lipid and surfactant components, compatibility analysis using Differential Scanning Calorimetry (DSC), formulation of five NLC formulations using hot homogenization and probe sonication methods, and characterization including particle size, polydispersity index, zeta potential, entrapment efficiency, and morphology using Transmission Electron Microscopy (TEM). The selected NLC formulation was subsequently incorporated into a gel system and evaluated for pH, viscosity, and spreadability. The results demonstrated that the curcumin NLC exhibited nanoscale particle size with relatively uniform distribution, stable zeta potential values, and high entrapment efficiency. TEM analysis confirmed spherical particle morphology. The NLC-based gel formulation showed acceptable physicochemical properties, including skin-compatible pH, suitable viscosity, and optimal spreadability. In conclusion, curcumin was successfully formulated into an NLC system and further developed into a topical gel formulation with promising physicochemical characteristics as a lipid-based drug delivery system.
REVIEW ARTIKEL: POTENSI DAUN BINAHONG (Anredera cordifolia) SEBAGAI AGEN ANTIDIABETES Aliza, Rieztya; Kusriani, R Herni; Jafar, Garnadi
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1901

Abstract

Diabetes melitus merupakan penyakit metabolik kronis dengan prevalensi yang terus meningkat dan memerlukan strategi terapi yang efektif dan berkelanjutan. Keterbatasan terapi farmakologis seperti efek samping, biaya tinggi, dan kegagalan terapi jangka panjang mendorong pengembangan agen antidiabetes berbasis bahan alam. Daun binahong (Anredera cordifolia) secara empiris digunakan sebagai penurun kadar gula darah dan berpotensi sebagai agen antidiabetes. Artikel ini mereview aktivitas antidiabetes daun binahong berdasarkan 15 studi praklinis (2011–2025) yang mencakup penelitian in vivo, in vitro, dan molekuler. Hasil kajian menunjukkan bahwa ekstrak daun binahong mampu menurunkan kadar glukosa darah secara signifikan pada berbagai model hewan diabetes dalam rentang dosis tertentu, dengan efektivitas yang pada beberapa penelitian sebanding dengan obat antidiabetes oral standar. Selain efek hipoglikemik, daun binahong juga menunjukkan aktivitas pendukung berupa perbaikan kondisi metabolik, perlindungan terhadap komplikasi diabetes, serta perbaikan fungsi sel β pankreas. Temuan ini menunjukkan bahwa aktivitas antidiabetes daun binahong bersifat multifaktorial dan konsisten pada berbagai model uji. Review ini menegaskan bahwa daun binahong memiliki aktivitas antidiabetes multifaktorial yang konsisten pada berbagai model praklinis, dengan mekanisme melibatkan regulasi insulin, aktivasi GLUT4, penghambatan α-glukosidase, serta perlindungan sel β pankreas. Kebaruan kajian ini terletak pada sintesis terpadu antara efektivitas, mekanisme molekuler, dan pola dosis efektif. Namun, standarisasi ekstrak dan uji klinis masih diperlukan sebelum implementasi klinis.
Co-Authors Abdul Mulki Irpani Agung Laksono S, Moch Agus Sulaeman Agus Sulaeman Aligita, Widhya Aliyya Kurniasih Agustiani Aliza, Rieztya Amalia Putri, Amalia Anggraeni, Vina Juliana Ani Anggriani Arif Rubianto Ariqa Hidayatun Nisa Avianningsih, Reformia Bachrudin, Panji Buana Irviana Prita Choerrunisa, Choerrunisa Dadih Supriadi Damayanti, Hilda Deden I Dinata Deden Indra Dinata Deden Indra Dinata, Deden Indra Deny Puryani Devianti Sagita, Novaliana Dila Anggraeni Dinayanti, Westi Nur Dini Auliya Azmi Dwi C, Alya Elis Susilawati Elisabeth Weya Elsa Yunita Septiani Elvano, Deki Rifa Embas Saraswati, Dewa Ayu Emma Emawati, Emma ERISKA AGUSTIN Faisha Farras Kartanagara Fatmawati Fenti Fatmawati Karim Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Fitriani, Ranti Ghea Nadira Shinta Gustana, Erick Kurniawan Halizah, Arin Nur Hanaya, Cicia Rosa Hasimun, Patonah Helen Fitri Novianti Herni Kusriani, R. Hidayat, Dudy Agustian Iceu Mulyati Iin Siti Aminah, Iin Siti Ira Adiyati Jajang Japar Sodik Karim, Fatmawati Khiong, Tjia Khie Kusriani, R Herni Latifah, Zahra Alfa Lia Marliani Mahran A, Ghani Maisyah, Aini Marita Kaniawati Meilani, Intan Mindiarto, Ahmad Bagus Muhamad Reza Pahlevi Muthmainah, Siti Saidah Ningrum, Windi Pratama Novaliana Devianti Sagita Novianti, Tamia Rizqi Nurfadillah, Rizal Nurfaiza, Putri Nurul Rahmalia Olivia Eka Putri Pahlevi, Muhamad Reza Pasha, ED Yunisa Mega Patonah, Patonah Pebriawati, Silpi Pramudiahwardani, Ananda Rota Pratama, Reza Priana, Eka Putriyanti Al-fira Putriyanti, Al-fira R. Awaludin Nazal N Rachmat Mauludin Rachmawati, Winasih Rahmat Santoso Raisya Salsabila Ramadhoni, M Ayodia Ratmoko, Sulthan Abdul Basith Ratu Fania Aprilyanti Reza Pahlevi, Muhamad Ria Riantini Riantini, Ria Rismawanti, Rusi Roganda Situmorang Rosyana, Nasywa Rusi Rismawanti Sagita, Novaliana Devianti Saifurrohman, Arip Saleh Wikarsa, Saleh Salsabilla, Syifa Sasanti Tarini Darijanto, Sasanti Tarini Senjaya, Fathurahman Ari Septianti, Regina Dwi Shelvy E Suherman Siti Jamilah Siti Raeyuni Maulidia Belina Siti Saidah Muthmainah Situmorang, Roganda Sofian, Ryan Soni Muhsinin Sukmawati, ika kurnia Susilawati, Elis Sutiyah, Siti Sutrisno, Entis Sutrisno, Entris Syarfa, Ahmad Syerliana Syerliana Tambunan, Irisanna Wahyu Wijayanti Wijaya, Teguh Pradinata Winasih Rachmawati Yani Mulyani Yani Mulyani Yolanda Putri Aloenida Yuyun Yuyun Zakaria, Hasballah Zakiyah, Nadhira Zalfa Dary Pernadi Ziska, Rahma