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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Klinik Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Window of Health : Jurnal Kesehatan Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Care : Jurnal Ilmiah Ilmu Kesehatan Health Sciences and Pharmacy Journal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Medica Arteriana (Med-Art) Science Midwifery Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Avicenna : Journal of Health Research Asian Australasian Neuro and Health Science Journal (AANHS-J) Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Program Pengabdian Masyarakat Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Berita Kedokteran Masyarakat Indonesian Health Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Penelitian Keperawatan Journal of World Future Medicine, Health and Nursing
Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati
2Departemen Epidemiologi, Kesehatan Masyarakat Dan Kedokteran Keluarga, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta.
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Food poisoning outbreak caused dioscorea hispida dennst in Gading 10 Village, Gunung Kidul, Yogyakarta august 2020: a case report study Ayu Cahyaningtyas; Aryanto, Samsu; Hidayati, Titiek
BKM Public Health and Community Medicine PHS7 Accepted Abstracts
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: On August 12 2020, a food poisoning outbreak occurred in Gading 10 Village Gunung Kidul District. Health office of Gunung Kidul District were revealing three attendances who hospitalized in the hospital of Nur Rohmah after consuming gadung tubers (dioscorea hispida dennts.) and one of them passed away. Based on the information, we were doing an epidemiological investigation immediately to make sure of the existence of the outbreak. This study aimed to investigate the causative agents, source of food poisoning and mode of food poisoning transmission in Gading 10 Village. Method: This epidemiological investigation was using case report study design. Case defined as any residence who consumed gadung tubers in Gading 10 Village on August 12 2020. The data were collected using food poisoning questionnaire and medical record. Results: Based on the investigation results, three villagers who consumed gadung tubers were ill (100%) and one of them) was passed away (33,33%). The incubation period was around 5 minute until 4 hours. The predominate symptoms were vomiting, nausea, and headache. Gadung tubers (dioscorea hispida dennts.) was determined as the source of this food poisoning outbreak. Based on the incubation period and symptoms to the comparison diagnosis, dioscorine agent are suspected to be the cause of this food poisoning outbreak. Conclusion: The most likely source of contamination based on incubation period and symptoms was Dioscorine. Food poisoning outbreak was occurred in Gading 10 Village, Gunung Kidul District on August 12 2020. We recommend strengthening intervention community health education about safe processing gadung tubers for consumption.
Nanoemulsion Formulation of Kepok Banana Peel Extract and Yellow Watermelon Peel as a Kidney Stone Removal Diaz Habibah, Khalisha; Ogan Amirudin Lutfi, Dzaka; Thosimomia Tamimi, Nia; Kumala Syifa, Amira; Riska, Erlina; Hidayati, Titiek
Indonesian Health Journal Vol. 2 No. 4 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i4.270

Abstract

The kepok banana peel and yellow watermelon peel are still rarely appropriately used as medicine. The kepok banana peel and yellow watermelon peel contain flavonoids and potassium that function as kidney stone removers. This study aims to make a nanoemulsion formulation of kepok banana peel extract and yellow watermelon peel as a kidney stone remover. The preparation starts with extraction, testing the flavonoid content of the extract, testing the potassium content of the extract, making nanoemulsion using the homogenization method at a speed of 15,200 rpm, and analyzing the nanoemulsion formula that has been made. This study showed that the nanoemulsion extract contained flavonoids and potassium with a pH value of 7 and a viscosity value of 2.70 cP. The nanoemulsion of kepok banana peel and yellow watermelon peel extracts also has a size of 246.9 nm and a PDI of 0.618 with an oil-in-water (O/W) nanoemulsion type. The extracts of kepok banana peel and yellow watermelon peel in nanoemulsion preparation can be used as a medicine to remove kidney stones.
Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene Akrom, Akrom; Hidayati, Titiek; Sagiran, Sagiran; Indrayanti, Indrayanti
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp140-148

Abstract

Interferon-gamma (IFN-γ) is one of the central cytokines in the anti-carcinogenesis immune response. Black cumin seeds (BCS) have an active content of thymoquinone and unsaturated fatty acids with biological activity as immunomodulators. This study aimed to determine the effect of administration of BCS extract on IFN-γ secretion activity by DMBA-induced SD rat lymphocytes. In vivo experimental study on DMBA-induced SD rats, BCS extract was given with three doses for two weeks before being induced and five weeks during DMBA induction. IFN-γ levels in lymphocyte culture supernatants were determined by the ELISA method. The difference in IFN-γ levels between groups was analyzed by ANOVA test, the significance of 95%. The results showed that administration of BCS extract for 14 days did not affect cellular composition toward the edge of the test animal. BCS extract can increase IFN-γ secretion activity by DMBA-induced SD rat lymphocytes.Keywords: black cumin seed, IFN-γ; DMBA: immunomodulator, carcinogenesis.
GAMBARAN PENDIDIKAN SEXUAL PADA REMAJA DISABILITAS INTELEKTUAL: A LITERATURE REVIEW Kelrey, Fathimah; Hidayati, Titiek
Jurnal Penelitian Keperawatan Vol 5 No 2 (2019): Jurnal Penelitian Keperawatan
Publisher : STIKES RS Baptis Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32660/jpk.v5i2.408

Abstract

Pendidikan seksual adalah pemahaman tentang kesehatan seksual yaitu pengetahuan tentang kehamilan, infeksi seksual menular, disfungsi sexual, anatomi, kontrasepsi, menstruasi, masturbasi, negosiasi pengalaman seksual yang aman dan positif, hubungan, alat bantu seksual, perasaan seksual, pubertas, dan kenikmatan seksual(WHO, 2006). Tujuan mengkaji jurnal dan memberikaninformasi terkait pendidikan sex remaja disabilitas intelektual, peran orang tua, guru dan tenaga kesehatan. Metode Pencarian data menggunakan data base dari Ebsco, ProQues, Science Direct dan Pubmed, Pencarian data dengan kata kunci disability intelektual OR disabel AND sex educatioan OR sexual education. Hasil ditemukan pengetahuan dan perilaku remaja disabilitas intelektual tentang pendidikan sex masih terbatas/rendah dan belum optimalnya peran aktiv orang tua, guru dan tenaga kesehatan. Kesimpulan pengetahuan pendidikan sex, ketrampilan sosialisasi dan keterbatasan dalam mengungkapkan ekspresi dan perilaku sexual yang positif pada remaja dengan disabilitas intelektual perlu ditingkatkan dengan dukungan pelayanan yang maksimal dari orang tua, pihak sekolah (kurikulum) guru dan tenaga kesehatan.
Flavonoid synergy in antioxidant optimization: a study of Apium graveolens and Orthosipon stamineus Astuti, Febriana; Akrom; Setianto, Arif Budi; Hidayati, Titiek; Mustofa; Anwar, Muslih; Sun, Suny
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30599

Abstract

Oxidative stress, which arises by an imbalance among the formation of free radicals and the body's antioxidant defenses, is a pivotal factor in the pathogenesis of numerous degenerative abnormalities, comprising cardiovascular abnormality. Flavonoids, that are natural chemicals by antioxidant capabilities, have been identified as potential agents for protection against the adverse impacts of oxidative stress. The objective of this study was to ascertain the flavonoid substance of Apium graveolens and Orthosipon stamineus extracts and their antioxidant activity. The technique comprising qualitative and quantitative phytochemical tests to decide the flavonoid substance of the extracts. In addition, bioactive compounds were screened utilizing LC-HRMS, and antioxidant activity was evaluated utilizing the DPPH technique. The outcomes of this study drawn the presence of flavonoid compounds, alkaloids, tannins, and saponins in the Apium graveolens and Orthosipon stamineus extracts. The Orthosipon stamineus extract was found to contain steroid compounds. The screening of flavonoids compounds utilizing LC-HRMS has drawn the presence of the greatest diversity of flavonoid compounds in the Apium graveolens extract. The antioxidant activity assay employed quercetin as the standard, possessing an IC₅₀ value of 3.95 μg/mL. Apium graveolens extract exhibited an IC₅₀ value of 58.86±0.44μg/mL, Orthosiphon stamineus extract drawn an IC₅₀ value of 61.69±0.21 μg/mL, whereas the combined extract yielded an IC₅₀ value of 46.32±0.34 μg/mL. The outcomes indicate that the extract combination shows superior free radical scavenging ability compared to the individual extracts, suggesting its potential to enhance the antioxidant efficacy of bioactive compounds derived by herbal plants.
Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Peningkatan Risiko Stroke Non-Hemoragik Setelah Pemberian Ketorolac Pada Pasien Dengan Proktokolitis: Laporan Kasus Dzaka Ogan Amirudin Lutfi; Niken Palupi; Titiek Hidayati
Medica Arteriana (Med-Art) Vol 7, No 2 (2025): Desember 2025
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.7.2.2025.46-56

Abstract

Latar Belakang: Stroke non-hemoragik disebabkan oleh penyumbatan arteri yang mengurangi aliran darah dan oksigen ke otak, menyebabkan kematian jaringan saraf. Di Indonesia, prevalensi stroke meningkat dari 7% pada tahun 2013 menjadi 10,9% pada tahun 2018, dengan sekitar 2,1 juta penyintas. Faktor risiko utama meliputi hipertensi, diabetes, dislipidemia, obesitas, dan merokok. Obat anti-inflamasi nonsteroid seperti ketorolac diketahui dapat meningkatkan risiko kejadian kardiovaskular, termasuk stroke non-hemoragik, terutama pada pasien dengan penyakit inflamasi kronis.Kasus: Seorang pria berusia 57 tahun datang ke IGD RSUD Kota Yogyakarta dengan keluhan nyeri perut, sulit buang air besar dan buang angin sejak 3 bulan yang lalu. Kemudian pasien diberikan infus asering, injeksi ketorolac dan ranitidin. Tiga jam kemudian pasien tiba-tiba sulit diajak komunikasi, tampak linglung, sulit bicara dan sulit menggerakkan tubuh sisi kiri. MSCT Scan upper dan lower abdomen menunjukkan dolichocolon dengan proktokolitis, sedangkan CT-Scan kepala non kontras menunjukkan lesi hipodens regio oksipital kanan dengan kesan infark hiperakut. Diagnosis ditegakkan sebagai stroke non hemoragik dengan proktokolitis.Kesimpulan: Ketorolac dapat meningkatkan agregasi trombosit, vasokonstriksi, serta ketidakseimbangan prostasiklin tromboksan A2, sehingga memperbesar risiko trombosis serebral. Oleh karena itu, pemberian ketorolac harus dipertimbangkan secara hati-hati. Alternatif analgesik dengan risiko kardiovaskular dan gastrointestinal lebih rendah, serta pemantauan yang sangat dianjurkan untuk mencegah komplikasi serius.
Nutritional profile and immunomodulatory potential of a polyherbal honey formulation for stunted children Akrom Akrom; Titiek Hidayati; Arif Budi Setianto; Laela Hayu Nurani; Ikhwan Dahlan Rais; Nurkhasanah Nurkhasanah; Lukman Hardia; Prasasti Bintarum; Muslih Anwar
International Journal of Public Health Science (IJPHS) Vol 15, No 3: September 2026
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v15i3.23026

Abstract

Stunting remains a major public health challenge in Indonesia and has been linked to immune dysregulation, including increased pro-inflammatory TNF-α and reduced anti-inflammatory IL-4 activity. Nutrient-dense polyherbal supplementation may provide a complementary strategy to support nutritional status and immune function. This experimental study investigated the nutritional composition and immunomodulatory activity of polyherbal honey (PHH) formulated with curcuma xanthorrhiza, black cumin seeds, and honey. Vitamins, minerals, and bioactive constituents were characterized using laboratory assays. The immunomodulatory effects of PHH were subsequently evaluated in HTB-183 cells by measuring IL-4 and TNF-α expression after exposure to different formulation concentrations. The analysis confirmed the presence of vitamins A, C, and E; calcium and potassium; and several bioactive compounds in the PHH formulation. PHH exposure increased IL-4 expression and reduced TNF-α expression relative to untreated cells, although the magnitude of these responses varied across concentrations. These findings demonstrate that PHH contains nutritional and phytochemical constituents with potential immunomodulatory activity. Further preclinical and clinical investigations are required to determine its efficacy and safety as complementary nutritional support for children with stunting.
MIND THE GAP: LUNG CANCER KNOWLEDGE, PERCEIVED RISK, AND SYMPTOM LITERACY AMONG SUBURBAN RESIDENTS IN YOGYAKARTA, INDONESIA Khodijah Adha Kamila; Akrom Akrom; Titiek Hidayati
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 5 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i5.4043

Abstract

Lung cancer is a major contributor to mortality worldwide, yet late-stage diagnoses remain frequent due to inadequate public knowledge. This study aimed to assess lung cancer awareness, perceived risks, and symptom recognition among suburban residents in Yogyakarta, Indonesia, to provide data for public health initiatives. The research utilized a cross-sectional design, enrolling 100 individuals aged 18 to 80 from the Kasihan 1 Community Health Center area through consecutive sampling. Participants were given a validated questionnaire regarding their knowledge of lung cancer, its risk factors, and associated symptoms. Descriptive statistical analysis revealed that 63% had moderate knowledge, 22% exhibited good knowledge, and 15% showed poor knowledge. While 76% recognized lung cancer, 55% incorrectly considered it rare, and only 35% were informed about early screening opportunities. Participants demonstrated a strong awareness of active smoking (85%) and passive smoke exposure (82%), yet displayed limited knowledge of environmental carcinogens such as asbestos (35%) and genetic risks (49%). Most could identify key symptoms like shortness of breath (77%), chronic cough (76%), and chest pain (70%). The results highlight significant gaps in understanding non-tobacco-related risks and preventive measures, influenced by socioeconomic factors and local lifestyle habits. Overall, suburban residents show critical blind spots regarding non-behavioral risks for lung cancer, underscoring the need for enhanced primary care education and subsidized screening programs to promote early detection.
Co-Authors - nurkamila - nurkamila, - - Sagiran Ahmad Hamim Sadewa Akbar, Rizaluddin Akrom Akrom Akrom Akrom Akrom, Akrom Amal, Muhammad Ikhlasul Anwar, Muslih Ardhitapramesti A.H.P. Arif Budi Setianto Arif Santoso Arif Santoso Arya Adiningrat Aryanto, Samsu Ayu Cahyaningtyas azizah khoiriyati Briliian Wahyudi, Rizqy Cahya Ningrum, Windy Astuti Dewi Puspita Dhara Indah Kartika Jati, Dhara Indah Kartika Diaz Habibah, Khalisha Dzaka Ogan Amirudin Lutfi Eka Arikensiwi Eka Arikensiwi, Eka Emdat Suprayitno Emdat Suprayitno Endang Darmawan Erviana Erviana Erviana Erviana Fadil Abdillah Fahmi, Faradisa Yuanita Fahmy Abdul Haq Falasifah Ani Yuniarti, Falasifah Ani Fathimah Kelrey Febriana Astuti Fuadi, Akhsanul Ginandjar Zukhruf Saputri Ginanjar Zuhruf Saputri Gumson Joshua Tampubolon Halimatusa'diyah, Thoharoh Handa Meru Erio Rakihara Haris, Tauranaswa Farrelabhista Putra Hastin Munifah T.F.F.S. Iffa Karina Permatasari Iffa Karina Permatasari Ikhwan Dahlan Rais Indrayanti, Indrayanti Indrayanti, Indrayanti Indri Nurasa Indri Nurasa Irna Susiati Kailani, Dzaka Ogan Amirudin Lutfi Khodijah Adha Kamila Khoiriyati, Azizah Kumala Syifa, Amira Kusumo, Mahendro Prasetyo Laela Hayu Nurani Laela Hayu Nurani Laili Apriani Lilis Suryani Lukman Hardia Marsetyawan HNE Soesatyo Muslih Anwar Mustofa Mustofa Nanik Sulistyani Naylil Mawadda Rohma Neni Probosiwi Nevi Seftaviani Niken Palupi Nisa, Aida Novita Kurnisa Sari Nur Isnaini Nur Isnaini, Nur Nurcholid Umam Nurcholid Umam Kurniawan Nurisa Fikriyani L. Nurjanna Nurjanna Nurkhasanah Nurkhasanah Nurkhasanah Ogan Amirudin Lutfi, Dzaka Olyvia Wulan Kencana Panji Tutut Anggraeni Pradhana, Muhammad Ilham Satya Prasasti Bintarum Prasasti Bintarum Pratiwi, Adinda Aning Purwoko, Akhmad Edy Rachmayani, Tantri Rahmah Rahmah Ratna Indriawati Riska, Erlina Rizma Nurfadjrin Sagiran Sagiran Shabrina Arwi Laily Shiko Indrawan Siti Pandanwangi TW Sri Hesthi Sonyo Subroto, Bramastha Alfanda Sumaryani, Sri Sun, Suny Suprayitno, Emdat Tantri Rachmayani Theodola Baning Rahayujati Thoharoh Halimatusa'diyah Thoharoh Halimatusa’diyah Thosimomia Tamimi, Nia Tri Pitara Mahanggoro Tsai, Mei Ling Vivi Sofia Yuningtyaswari Yuningtyaswari Yuningtyaswari Yuningtyaswari Zuniarto, Ahmad Azrul