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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Klinik Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Window of Health : Jurnal Kesehatan Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Care : Jurnal Ilmiah Ilmu Kesehatan Health Sciences and Pharmacy Journal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Science Midwifery Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Avicenna : Journal of Health Research Asian Australasian Neuro and Health Science Journal (AANHS-J) Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Program Pengabdian Masyarakat Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Berita Kedokteran Masyarakat Indonesian Health Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Journal of Public Health and Pharmacy Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Penelitian Keperawatan
Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati
2Departemen Epidemiologi, Kesehatan Masyarakat Dan Kedokteran Keluarga, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta.
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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An evaluation of integrated antenatal care program in Bantul District on 2019 - 2020 Ayu Cahyaningtyas; Aryanto, Samsu; Hidayati, Titiek
BKM Public Health and Community Medicine PHS7 Accepted Abstracts
Publisher : Universitas Gadjah Mada

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Abstract

Objective: Maternal mortality has become the second cause of women mortality in reproductive ages after HIV/AIDS (WHO, 2019). Bantul District is one of the districts in Yogyakarta which has the highest maternal mortality rate with 20 cases reported in 2020. Based on the result audit of maternal perinatal in Bantul District, it was found that most of the maternal mortality caused by the lack of early detection by health workers and community, caused the referral management leads. This evaluation purpose to identify the implementation and success of an integrated antenatal care program in Bantul District. Method: This evaluation program was using descriptive study design. The evaluation program was conducted in 17 community health centers and health office Bantul District in December 2020 – February 2021. The respondents were 35 people which consisted of the head of community health centers, coordinating midwife and Bantul District health officer. The data were collected using questionnaires. Result: In 17 community health centers, four of them (23,53%) have integrated antenatal care 100%. Eight of community health centers (47,01 %) stated that lack of cooperation by related health workers and lack of time in integrated antenatal care services. Four of the community health centers (23,53 %) stated that the quantity of health workers were limited especially with a large workload. One of the community health centers stated that ambulance drivers are not ready 24 hours (still on call) at the time of antenatal care services. Conclusion: The most of community health centers were felt constrained by the lack of cooperation by related health workers and lack of time in integrated antenatal care services. Improving the quality of integrated antenatal care and strengthening cooperation with related health workers can improve the integrated antenatal care services and prevent maternal mortality in Bantul District.
Food poisoning outbreak caused dioscorea hispida dennst in Gading 10 Village, Gunung Kidul, Yogyakarta august 2020: a case report study Ayu Cahyaningtyas; Aryanto, Samsu; Hidayati, Titiek
BKM Public Health and Community Medicine PHS7 Accepted Abstracts
Publisher : Universitas Gadjah Mada

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Objective: On August 12 2020, a food poisoning outbreak occurred in Gading 10 Village Gunung Kidul District. Health office of Gunung Kidul District were revealing three attendances who hospitalized in the hospital of Nur Rohmah after consuming gadung tubers (dioscorea hispida dennts.) and one of them passed away. Based on the information, we were doing an epidemiological investigation immediately to make sure of the existence of the outbreak. This study aimed to investigate the causative agents, source of food poisoning and mode of food poisoning transmission in Gading 10 Village. Method: This epidemiological investigation was using case report study design. Case defined as any residence who consumed gadung tubers in Gading 10 Village on August 12 2020. The data were collected using food poisoning questionnaire and medical record. Results: Based on the investigation results, three villagers who consumed gadung tubers were ill (100%) and one of them) was passed away (33,33%). The incubation period was around 5 minute until 4 hours. The predominate symptoms were vomiting, nausea, and headache. Gadung tubers (dioscorea hispida dennts.) was determined as the source of this food poisoning outbreak. Based on the incubation period and symptoms to the comparison diagnosis, dioscorine agent are suspected to be the cause of this food poisoning outbreak. Conclusion: The most likely source of contamination based on incubation period and symptoms was Dioscorine. Food poisoning outbreak was occurred in Gading 10 Village, Gunung Kidul District on August 12 2020. We recommend strengthening intervention community health education about safe processing gadung tubers for consumption.
Nanoemulsion Formulation of Kepok Banana Peel Extract and Yellow Watermelon Peel as a Kidney Stone Removal Diaz Habibah, Khalisha; Ogan Amirudin Lutfi, Dzaka; Thosimomia Tamimi, Nia; Kumala Syifa, Amira; Riska, Erlina; Hidayati, Titiek
Indonesian Health Journal Vol. 2 No. 4 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i4.270

Abstract

The kepok banana peel and yellow watermelon peel are still rarely appropriately used as medicine. The kepok banana peel and yellow watermelon peel contain flavonoids and potassium that function as kidney stone removers. This study aims to make a nanoemulsion formulation of kepok banana peel extract and yellow watermelon peel as a kidney stone remover. The preparation starts with extraction, testing the flavonoid content of the extract, testing the potassium content of the extract, making nanoemulsion using the homogenization method at a speed of 15,200 rpm, and analyzing the nanoemulsion formula that has been made. This study showed that the nanoemulsion extract contained flavonoids and potassium with a pH value of 7 and a viscosity value of 2.70 cP. The nanoemulsion of kepok banana peel and yellow watermelon peel extracts also has a size of 246.9 nm and a PDI of 0.618 with an oil-in-water (O/W) nanoemulsion type. The extracts of kepok banana peel and yellow watermelon peel in nanoemulsion preparation can be used as a medicine to remove kidney stones.
Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene Akrom, Akrom; Hidayati, Titiek; Sagiran, Sagiran; Indrayanti, Indrayanti
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp140-148

Abstract

Interferon-gamma (IFN-γ) is one of the central cytokines in the anti-carcinogenesis immune response. Black cumin seeds (BCS) have an active content of thymoquinone and unsaturated fatty acids with biological activity as immunomodulators. This study aimed to determine the effect of administration of BCS extract on IFN-γ secretion activity by DMBA-induced SD rat lymphocytes. In vivo experimental study on DMBA-induced SD rats, BCS extract was given with three doses for two weeks before being induced and five weeks during DMBA induction. IFN-γ levels in lymphocyte culture supernatants were determined by the ELISA method. The difference in IFN-γ levels between groups was analyzed by ANOVA test, the significance of 95%. The results showed that administration of BCS extract for 14 days did not affect cellular composition toward the edge of the test animal. BCS extract can increase IFN-γ secretion activity by DMBA-induced SD rat lymphocytes.Keywords: black cumin seed, IFN-γ; DMBA: immunomodulator, carcinogenesis.
GAMBARAN PENDIDIKAN SEXUAL PADA REMAJA DISABILITAS INTELEKTUAL: A LITERATURE REVIEW Kelrey, Fathimah; Hidayati, Titiek
Jurnal Penelitian Keperawatan Vol 5 No 2 (2019): Jurnal Penelitian Keperawatan
Publisher : STIKES RS Baptis Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32660/jpk.v5i2.408

Abstract

Pendidikan seksual adalah pemahaman tentang kesehatan seksual yaitu pengetahuan tentang kehamilan, infeksi seksual menular, disfungsi sexual, anatomi, kontrasepsi, menstruasi, masturbasi, negosiasi pengalaman seksual yang aman dan positif, hubungan, alat bantu seksual, perasaan seksual, pubertas, dan kenikmatan seksual(WHO, 2006). Tujuan mengkaji jurnal dan memberikaninformasi terkait pendidikan sex remaja disabilitas intelektual, peran orang tua, guru dan tenaga kesehatan. Metode Pencarian data menggunakan data base dari Ebsco, ProQues, Science Direct dan Pubmed, Pencarian data dengan kata kunci disability intelektual OR disabel AND sex educatioan OR sexual education. Hasil ditemukan pengetahuan dan perilaku remaja disabilitas intelektual tentang pendidikan sex masih terbatas/rendah dan belum optimalnya peran aktiv orang tua, guru dan tenaga kesehatan. Kesimpulan pengetahuan pendidikan sex, ketrampilan sosialisasi dan keterbatasan dalam mengungkapkan ekspresi dan perilaku sexual yang positif pada remaja dengan disabilitas intelektual perlu ditingkatkan dengan dukungan pelayanan yang maksimal dari orang tua, pihak sekolah (kurikulum) guru dan tenaga kesehatan.
Flavonoid synergy in antioxidant optimization: a study of Apium graveolens and Orthosipon stamineus Astuti, Febriana; Akrom; Setianto, Arif Budi; Hidayati, Titiek; Mustofa; Anwar, Muslih; Sun, Suny
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30599

Abstract

Oxidative stress, which arises by an imbalance among the formation of free radicals and the body's antioxidant defenses, is a pivotal factor in the pathogenesis of numerous degenerative abnormalities, comprising cardiovascular abnormality. Flavonoids, that are natural chemicals by antioxidant capabilities, have been identified as potential agents for protection against the adverse impacts of oxidative stress. The objective of this study was to ascertain the flavonoid substance of Apium graveolens and Orthosipon stamineus extracts and their antioxidant activity. The technique comprising qualitative and quantitative phytochemical tests to decide the flavonoid substance of the extracts. In addition, bioactive compounds were screened utilizing LC-HRMS, and antioxidant activity was evaluated utilizing the DPPH technique. The outcomes of this study drawn the presence of flavonoid compounds, alkaloids, tannins, and saponins in the Apium graveolens and Orthosipon stamineus extracts. The Orthosipon stamineus extract was found to contain steroid compounds. The screening of flavonoids compounds utilizing LC-HRMS has drawn the presence of the greatest diversity of flavonoid compounds in the Apium graveolens extract. The antioxidant activity assay employed quercetin as the standard, possessing an IC₅₀ value of 3.95 μg/mL. Apium graveolens extract exhibited an IC₅₀ value of 58.86±0.44μg/mL, Orthosiphon stamineus extract drawn an IC₅₀ value of 61.69±0.21 μg/mL, whereas the combined extract yielded an IC₅₀ value of 46.32±0.34 μg/mL. The outcomes indicate that the extract combination shows superior free radical scavenging ability compared to the individual extracts, suggesting its potential to enhance the antioxidant efficacy of bioactive compounds derived by herbal plants.
Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Co-Authors - nurkamila - nurkamila, - - Sagiran Ahmad Hamim Sadewa Akbar, Rizaluddin Akrom Akrom Akrom Akrom Akrom, Akrom Amal, Muhammad Ikhlasul Anwar, Muslih Ardhitapramesti A.H.P. Arif Budi Setianto Arif Santoso Arif Santoso Arya Adiningrat Aryanto, Samsu Ayu Cahyaningtyas azizah khoiriyati Briliian Wahyudi, Rizqy Cahya Ningrum, Windy Astuti Dewi Puspita Dhara Indah Kartika Jati, Dhara Indah Kartika Diaz Habibah, Khalisha Eka Arikensiwi Eka Arikensiwi, Eka Emdat Suprayitno Emdat Suprayitno Endang Darmawan Erviana Erviana Erviana Erviana Fadil Abdillah Fahmy Abdul Haq Falasifah Ani Yuniarti, Falasifah Ani Faradisa Yuanita Fahmi Fathimah Kelrey Febriana Astuti Fuadi, Akhsanul Ginandjar Zukhruf Saputri Ginanjar Zuhruf Saputri Gumson Joshua Tampubolon Halimatusa'diyah, Thoharoh Handa Meru Erio Rakihara Haris, Tauranaswa Farrelabhista Putra Hastin Munifah T.F.F.S. Iffa Karina Permatasari Iffa Karina Permatasari Indrayanti, Indrayanti Indrayanti, Indrayanti Indri Nurasa Indri Nurasa Irna Susiati Kailani, Dzaka Ogan Amirudin Lutfi Khoiriyati, Azizah Kumala Syifa, Amira Kusumo, Mahendro Prasetyo Laela Hayu Nurani Laela Hayu Nurani Laili Apriani Lilis Suryani Lukman Hardia Marsetyawan HNE Soesatyo Mustofa Mustofa Nanik Sulistyani Naylil Mawadda Rohma Neni Probosiwi Nevi Seftaviani Nisa, Aida Novita Kurnisa Sari Nur Isnaini Nur Isnaini, Nur Nurcholid Umam Nurcholid Umam Kurniawan Nurisa Fikriyani L. Nurjanna Nurjanna Nurkhasanah Ogan Amirudin Lutfi, Dzaka Olyvia Wulan Kencana Panji Tutut Anggraeni Pradhana, Muhammad Ilham Satya Prasasti Bintarum Pratiwi, Adinda Aning Purwoko, Akhmad Edy Rachmayani, Tantri Rahmah Rahmah Ratna Indriawati Riska, Erlina Rizma Nurfadjrin Sagiran Sagiran Shabrina Arwi Laily Shiko Indrawan Siti Pandanwangi TW Sri Hesthi Sonyo Subroto, Bramastha Alfanda Sumaryani, Sri Sun, Suny Suprayitno, Emdat Tantri Rachmayani Theodola Baning Rahayujati Thoharoh Halimatusa'diyah Thoharoh Halimatusa’diyah Thosimomia Tamimi, Nia Tri Pitara Mahanggoro Tsai, Mei Ling Vivi Sofia Yuningtyaswari Yuningtyaswari Yuningtyaswari Yuningtyaswari Zuniarto, Ahmad Azrul