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Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial Putranto, Rudi; Setiati, Siti; Nasrun, Martina W.; Witjaksono, Fiastuti; Immanuel, Suzanna; Subekti, Imam; Harimurti, Kuntjoro; Siswanto, Agus; Shatri, Hamzah; Suwarto, Suhendro; Megantara, Marcelino A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1342

Abstract

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis and lower quality of life. Emerging evidence suggests that vitamin D deficiency contributes to the progression of T2DM and is closely associated with the development of depression. The aim of this study was to investigate the effects of cholecalciferol on depression in patients with T2DM, exploring its mechanisms by analyzing its impact on C-peptide, serotonin, and neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial was conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 to September 2022. Patients with T2DM and depressive symptoms were randomly assigned to two groups: received 4000 IU of cholecalciferol daily and received a placebo for 12 weeks. Depression was assessed using the Beck Depression Inventory-II (BDI-II) before and 12 weeks after the intervention. The levels of C-peptide, serotonin, and neurotrophin-3 were measured at the end of the fourth week of intervention using the enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons were made using independent Student t-tests and Mann-Whitney U tests. Paired Student t-tests or Wilcoxon tests were applied for within-group comparisons between pre- and post-intervention. A total of 70 T2DM patients with depression were included in this study, comprising 38 patients in the cholecalciferol group and 32 in the placebo group. C-peptide levels increased significantly in the cholecalciferol group compared to the placebo group (p=0.006). No significant differences were observed in serotonin and NT-3 levels between the cholecalciferol group compared to the placebo group. The cholecalciferol group had a significantly greater reduction in BDI-II scores compared to the placebo group (p<0.001). This trial highlights that taking cholecalciferol might help ease mild to moderate depression symptoms in patients with T2DM by enhancing c-peptide levels, though its effects on serotonin and neurotrophin-3 are still unclear.
Value Relevance of Fair Value of Financial Assets Among Indonesia Banking Companies Farhan Hariadi Pratama; Subekti, Imam
Reviu Akuntansi, Keuangan, dan Sistem Informasi Vol. 3 No. 2 (2024): Reviu Akuntansi, Keuangan, dan Sistem Informasi (REAKSI)
Publisher : Fakultas Ekonomi dan Bisnis Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/reaksi.2024.3.2.245

Abstract

This research aims to prove the value relevance of share price which are linked to Earning Per share and Book Value per share. Moderated by the fair value of financial assets. This research employs a quantitative approach. The population in this study are banking company listed on the Indonesia Stock Exchange (IDX). This research use banking companies as the sample, taking 68 observable data with a total sample size of 34 companies within 2 years of observation from 2021 to 2022 are collected from documentation of the annual reports.  This study used the method of multiple linear regression.  Within this research, it shows that earnings per share and book value per share have a positive and significant  effect on share prices. Then, the fair value of financial assets can strengthen the effect of earnings per share and book value per share on share prices.   Abstrak Penelitian ini bertujuan untuk membuktikan relevansi nilai terhadap harga saham yang diukut dengan Earning Per share dan Book Value per share serta dimoderasi oleh nilai wajar aset keuangan. Penelitian ini menggunakan pendekatan kuantitatif. Populasi pada penelitian ini adalah perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI). Penelitian ini menggunakan perusahaan perbankan sebagai sampel, mengambil 68 data yang dapat diobservasi dengan jumlah sampel 34 perusahaan dalam 2 tahun pengamatan dari 2021 sampai 2022 dikumpulkan dari dokumentasi berupa laporan tahunan. Penelitian ini menggunakan metode regresi linier berganda. Dalam penelitian ini, menunjukkan bahwa earning per share dan book value per share berpengaruh positif dan signifikan terhadap harga saham. Lalu, Nilai wajar aset keuangan dapat memperkuat pengaruh earning per share dan book value per share terhadap harga saham.
REFORMULASI KEBIJAKAN KRIMINAL DALAM PENANGGULANGAN KEJAHATAN BERBASIS TEKNOLOGI KECERDASAN BUATAN Subekti, Imam; Sukrisno, Heru; Wahyudi, Sugeng; Purwendah, Elly Kristiani
SETARA : Jurnal Ilmu Hukum Vol 5, No 2 (2024): SETARA : Jurnal Ilmu Hukum
Publisher : Universitas Bung Karno

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59017/setara.v5i2.559

Abstract

Reformulasi kebijakan kriminal dalam penanggulangan kejahatan berbasis kecerdasan buatan (AI) menjadi isu yang mendesak seiring dengan perkembangan teknologi yang pesat. Studi ini mengkaji tantangan hukum terkait kejahatan digital, penguatan regulasi, serta peran lembaga penegakan hukum dalam mengatasi masalah ini. Metode yang digunakan adalah studi literatur dengan pendekatan kualitatif. Hasilnya menunjukkan perlunya regulasi spesifik yang mengatur AI, pembentukan lembaga yang kompeten dalam teknologi, dan kerjasama internasional dalam penanggulangan kejahatan berbasis AI. Reformulasi kebijakan ini diharapkan dapat menciptakan sistem hukum yang lebih responsif terhadap ancaman digital.
LANDASAN FILOSOFIS PENDIDIKAN ISLAM DI INDONESIA Iswanto, Rudi; Fatmawati; Rahayu, Fitri; Subekti, Imam
Tashdiq: Jurnal Kajian Agama dan Dakwah Vol. 10 No. 1 (2024): Tashdiq: Jurnal Kajian Agama dan Dakwah
Publisher : Cahaya Ilmu Bangsa Institute

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Abstract

Landasan filosofis pendidikan Islam mencakup kajian mendalam terhadap prinsip-prinsip dasar yang mengintegrasikan ajaran wahyu, akal, dan nilai-nilai budaya lokal. Pendidikan Islam bertujuan menciptakan individu yang beriman, berilmu, dan berakhlak mulia, sesuai dengan tugas manusia sebagai hamba Allah dan khalifah di bumi. Penelitian ini menggunakan metode kajian teoritis dengan pendekatan kualitatif yang bertujuan untuk menganalisis dan membandingkan teori-teori terkait pendidikan Islam, khususnya dalam konteks filosofi pendidikan yang mengintegrasikan ajaran wahyu, akal, dan nilai-nilai budaya lokal. Metode ini mengutamakan eksplorasi mendalam dan interpretasi terhadap konsep-konsep atau teori yang relevan, tanpa melibatkan pengumpulan data kuantitatif. Hasil penelitian menyatakan bahwa di Indonesia, implementasi landasan ini diwujudkan melalui integrasi nilai-nilai Islam dan Pancasila dalam kurikulum berbasis agama dan kebangsaan. Kurikulum ini bertujuan membentuk generasi yang berilmu, beriman, dan berakhlak mulia sesuai dengan tujuan pendidikan nasional. Namun, tantangan globalisasi dan sekularisasi memerlukan penguatan budaya lokal dan pengembangan kurikulum yang adaptif terhadap perubahan zaman.
The Interplay of Organizational Culture and Governance in Enhancing Sustainability Performance Abdulrahim, Mohamed Omar; Sukoharsono, Eko Ganis; Setyarini, Any; Subekti, Imam
Economics and Business Solutions Journal Vol. 8 No. 2 (2024): Economics and Business Solutions Journal
Publisher : Universitas Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26623/ebsj.v8i2.8988

Abstract

It seems that Indonesia still lacks understanding about the disclosure of sustainability. Furthermore, it is believed that socioeconomic, cultural, governance and environmental challenges are crucial to the success of a business. The influence of corporate governance and organizational culture on sustainability performance, with strategic posture acting as a moderating variable, leads to intriguing issues that warrant further analysis. This study's population consists of all companies listed on the Indonesia Stock Exchange. Purposive sampling is used as a technique in this study. The company's website, which includes information from 2009 to 2018, was sourced from www.idx.co.id and other pertinent sources. Data collection was done, and Warp PLS algorithms were employed for the analysis method. After analyzing and debating the data, the following conclusion was reached: corporate governance and organizational culture greatly impact sustainable performance. When examining the impact of corporate governance and organizational culture on sustainability performance, strategic posture may act as a moderating factor
Pengaruh Edukasi Media Booklet Sindrom Geriatri Terhadap Dukungan Sosial Keluarga Lansia Di Wilayah Kelurahan Bareng Kota Malang Hafifa, Risma; Suprajitno; Marsaid; Subekti, Imam
Jurnal Keperawatan Muhammadiyah Vol 9 No 4 (2024): JURNAL KEPERAWATAN MUHAMMADIYAH
Publisher : UNIVERSITAS MUHAMMADIYAH SURABAYA

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Abstract

Objective: To identify the influence of media education booklet geriatric syndrome on the social support of elderly families in the area of Kelurahan Bareng Kota Malang. Methods: The research design uses quasi eksperimental methods with Pre Post Test Design with Two Groups. The sampling method used purposive samplings with 60 respondents divided into two groups. Results: The results showed that rhe average score of social family support before intervention was 44,73 (mid category), while the average score after the intervention was 65,47 (high category), and the results obtained were p value 0,000 (p value 0,000 < a 0,05), meaning that there is a effect of education with geriatric syndrome booklet for increase elderly’s family social support. Conclusion: Education with geriatric syndrome booklet can be used to increase elderly’s family social support.
The role of changes in metabolic syndrome status on health-related quality of life in Bogor City, West Java, Indonesia: A cross-sectional study Indriyati, Titi; Adisasmita, Asri C.; Nadjib, Mardiati; Subekti, Imam; Hatma, Ratna Djuwita; Kosen, Soewarta; Riyadina, Woro; Purnamasari, Telly
Belitung Nursing Journal Vol. 11 No. 2 (2025): March - April
Publisher : Belitung Raya Foundation, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33546/bnj.3543

Abstract

Background: Metabolic syndrome (MetS) is a cluster of chronic conditions, including central obesity, hypertension, impaired glucose metabolism, and dyslipidemia (low HDL, high LDL, and triglycerides). A diagnosis of MetS is made when three or more of these symptoms are present. If left unmanaged, MetS can lead to serious health complications such as cardiovascular disease and type 2 diabetes. Over time, individuals with MetS may experience a decline in their health-related quality of life (HRQoL), especially due to its chronic nature. Objective: This study aimed to evaluate the effects of changes in MetS status on HRQoL. Methods: This study employed a cross-sectional design. Secondary data from the cohort study of Non-Communicable Disease (NCD) risk factors, conducted by the Health Research and Development Agency of the Ministry of Health of the Republic of Indonesia in Bogor City, was used. Data from four follow-up periods (2011/2012 to 2017/2018) were analyzed. A total of 874 respondents were selected via total sampling based on inclusion and exclusion criteria. Data were collected in 2021, which included measures of knowledge, health check-ups, and HRQoL using the SF-36 questionnaire. Statistical analyses, including chi-square tests, t-tests, and multiple regression analyses, were conducted to examine the associations between MetS status and HRQoL. Results: Descriptive analysis revealed that 19% (171 participants) had worsened MetS status, while 80.4% (703 participants) showed improvement. Chi-Square analysis found that respondents with worsening MetS status were 1.6 times more likely to experience poor HRQoL in the physical dimension (95% CI = 1.1-2.3), but no significant effect was found for the mental dimension (PR = 1.1, 95% CI = 0.8-1.6). Multiple logistic regression analysis revealed that comorbidities interacted with worsening MetS status to significantly affect HRQoL in the physical dimension. The adjusted prevalence ratios (PR) were 27.5 (95% CI = 10.3-73.2) for those with comorbidities and 9.2 (95% CI = 5.7-15.0) for those without comorbidities, after controlling for age, mental health, BMI changes, routine health checks, and knowledge. Conclusion: Changes in MetS status towards worsening have a significant negative effect on HRQoL, particularly in the physical dimension. The presence of comorbidities in individuals with worsening MetS status greatly increases the risk of poor HRQoL. Healthcare professionals and nurses should consider the interaction between MetS and comorbidities in patient management. Nurses are encouraged to monitor HRQoL in patients with MetS, promote education on managing comorbidities, and collaborate across disciplines to enhance patient care and intervention programs aimed at improving HRQoL.
The Effect of Meditation on Blood Pressure in Middle Adult Hypertension Sufferers in the Pandanwangi Community Health Center Area, Malang City Subekti, Imam; Kartika, Nugrahani Candra; Suyanto, Edy
Journal of Rural Community Nursing Practice Vol. 2 No. 1 (2024): March
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jrcnp.v2i1.254

Abstract

Hypertension is the most common chronic disease suffered by people in Indonesia and is the main cause of death every year. Hypertension is called the silent killer because it is often experienced without complaints, and causes serious complications, especially in middle adulthood. Management of hypertension can be done with non-pharmacological therapy, one of which is meditation. This study aims to analyze the effect of meditation on reducing blood pressure in middle-aged hypertensive sufferers in the Pandanwangi Health Center working area, Malang City on April 2022. The research design was quasi experimental with a pre-test post-test design with control group. The total sample was 42 respondents divided into two groups (treatment and control). Statistical analysis uses the Mann Whitney test. The results showed that there was a decrease in the average systolic blood pressure from 148.33 mmHg to 139.28 mmHg and diastolic blood pressure from 89.04 mmHg to 83.57 mmHg in the treatment group after being given meditation for 3 sessions. The statistical test results show that the p-value for measuring post-treatment systolic blood pressure between the treatment group and the control group is 0.022 ≤ alpha 0.05, and the p-value for measuring post-treatment diastolic between the treatment group and the control group is 0.005 ≤ alpha 0.05. So, it can be concluded that there is an effect of meditation on reducing blood pressure in middle-aged hypertensive sufferers. It is hoped that in future research can be continued on the effect of meditation on blood pressure in other age groups (elderly age) by analyzing factors that can influence blood pressure, such as stress, physical activity and sleep patterns.
The Effect of Consuming Boiled Eggs on the Acceleration of Healing of Post Sectio Caesarea Wounds in the Working Area of the Pandanwangi Health Center, Malang City Subekti, Imam
Journal of Rural Community Nursing Practice Vol. 2 No. 2 (2024): September
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jrcnp.v2i2.399

Abstract

Caesarean Section (CS) is a surgical procedure to give birth to a baby by making an incision in the uterine wall. Healing of CS wounds requires high protein, but many mothers avoid protein-rich foods for fear of worsening the wound. One of the nutrients that is high in protein, economical, and easy to find is eggs, because one egg contains > 90% Ca and Fe, 9 essential amino acids, and 6 grams of quality protein proven to accelerate wound healing. The purpose of this study was to determine the effect of boiled eggs on accelerating wound healing Post Sectio Caesarea in the work area of the Pandanwangi Health Center, Malang City in 2024. This research method uses a Quasi Experiment design, the sampling method uses a purposive sampling technique with a sample size of 22 people divided into treatment groups and control groups. Data analysis used is univariate analysis and bivariate analysis with the Chi Square test. The results of the study obtained 11 Post Sectio Caesarea mothers who consumed boiled chicken eggs, 9 (81.8%) experienced faster healing compared to the control group (27.3%). Consumption of boiled chicken eggs showed a significant effect on the healing time of stitches in mothers after post-Cesarean section (p-value = 0.030). It is expected that health center officers can provide education to post-Cesarean mothers about the benefits of boiled eggs in accelerating the healing of Cesarean wounds.
The effect of corporate governance on earnings management moderated by political connection Rini Adriani Auliana; Bambang Subroto; Imam Subekti
Journal of Accounting and Investment Vol. 24 No. 3: September 2023
Publisher : Universitas Muhammadiyah Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jai.v24i3.17390

Abstract

Research aims: This research aims to prove the effect of independent commissioner performance and audit committee expertise on earnings management to avoid earnings decreases and political connections to strengthen independent commissioner performance and audit committee expertise to limit earnings management.Design/Methodology/Approach: The population was manufacturing firms listed on Indonesian Stock Exchange during 2017-2020. The sampling technique used purposive sampling with a sample of 102 firms for four years or 408 observations. Then, hypothesis testing employed multiple regression analysis and hierarchical regression analysis.Research findings: The results showcased that accrual earnings management and abnormal discretionary expenses were used by managers to avoid decreases in earnings. On the other hand, corporate governance, like audit committee expertise, could be used to limit earnings management. While the political connection could strengthen and weaken the effect of independent commissioner performances in limiting earning management, political connections could not strengthen audit committee expertise in limiting real and accrual earnings management.Theoretical contribution/Originality: This research contributes to the political connection and earning management literature and provides empirical evidence of agency theory, positive accounting theory, prospect theory, and resource dependence theory.Practitioner/Policy implication: This research contributes to investors in determining investment decisions.Research limitation/Implication: The limitation of this research is that independent variables only used two components of corporate governance, i.e., the independent commissioner performances and audit committee expertise, so the level of influence of the independent variables on the dependent was small.
Co-Authors . Rosidi Aabdulrahim, Mohamed Omar Abd. Rasyid Syamsuri Abdul Ghofar Abdulrahim, Mohamed Omar Achsin, M Aditya Pramudita Agus Siswanto Ahmad Syukri Aiman, Rahmat Ainurrizky, Faiz Alamsyah, Farhan Alshrife, Fouad Mohammed AM, Lutfirrahman Andriani, Rina Anna Retno Widayanti Any Setyarini, Any Aria Kekalih Arif, Taufan Ariyani, Imelda Aqhna Arum Prastiwi Asri C. Adisasmita Aulia Fuad Aulia Fuad Rahman Aulia, Nur Fitri aziwantoro, juni Bambang Hariadi Bambang Purnomosidhi Bambang Purnomosidhi Bambang Subroto Bambang Subroto Bambang Subroto Bani Alkausar Budi Sampurna Ciptaningtyas, Maria Diah Dahlia, Dina Dante S Harbuwono, Dante S Dante Saksono Harbuwono Denissa Nadya Tiffany Denny Suntoro DEWI DIAH FAKHRIYYAH Dewiruna, Intansari Dicky Andriyanto Dicky Andriyanto Dyah Puspasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edhi Martono Edy Suandi Hamid edy suyanto Eko Ganis Sukoharsono Ellis Afri Zumaila Elly Kristiani Purwendah Em Yunir, Em Endang Mardiati Enrico, Louis Erlina Suci Astuti, Erlina Suci Ernawati, Naya Erowati, Eti Mul Erwin Saraswati Esthika Dewiasty, Esthika Eva Fauzia Dian Pratiwi Eva Vajriyanti Faizal Angga Nugraha Fajar Lazuardi Sofwan Farhan Hariadi Pratama Fariz Hermawan Fathurahman, Meiduari Fatmawati Fatmawati Felicia Kurniawan, Felicia Fiastuti Witjaksono Fitri Purnamasari Fitri Rahayu Gracia Masita Gularso, Kurnadi Hafifa, Risma Hari Hendarto Hatma, Ratna Djuwita Hisky Ryan Kawulur Indah Putri Utami Indra Wijaya Kusuma Indriyati, Titi Inke Livia Inne Yuliawati, Inne Intan Lifinda Ayuning Putri Intansari Dewiruna Irawansyah, Melvin Iwan Triyuwono Kanti, Annisa Nabila Karnila, Dendang Kartika, Nugrahani Candra Kasful Anwar Kholilah Kholilah Kimiatissa'adah Kuntjoro Harimurti Kurniasari Novi Hardanti Kurniawidjaja, Meily Laurentius A Pramono, Laurentius A Laurentius Aswin Pramono Lias Hasibuan Lilik Purwanti Maharani, Karmelia Dwi Malawat, Fadli Fendi Malinda Kharista Mardiati, Endang Marsaid Megantara, Marcelino A. Meliana Octavia Meliana Octavia, Meliana Mohamad Fadhli Azhmi Mohamad Khoiru Rusydi Muhammad Arief Rasyid Muyassaroh, Isyrohil Nadia Damayanti Nadjib, Mardiati Nasrun, Martina W. Ni Luh Putri Setyastrini Ni Made Wisni Arie Pramuki Noval Adib Novita Ayu Chandra Dewi Novita Dewi NURUL HIDAYAH Nurul Pujiastuti ONIZ ULFA PERMATA Parida, Parida Pramita Sukma Wardani Pramuki, Ni Made Wisni Arie Prihartono, Nurhayati Adnan Prima Ramdani Ariesty Priyatna Bagus Susanto Ramadhani, Ranita Rampay, Arthur Samuel Ranita Ramadhani Rasyid, Muhammad Arief Rini Adriani Auliana Roekhudin, Roekhudin Roidah, Lidya Sara Ronasari Mahaji Putri Rudi Hamarno Rudi Iswanto, Rudi Rudi Putranto Sabarinah Prasetyo Safinatunnajah, Salma Setya Ardani, Devi Shalsadilla, Shavira Sirajudin Siti Setiati Soewarta Kosen Solikhah, Fitriana Kurniasari Sri Lestari SUADUON, JOGIE Sugeng Wahyudi, Sugeng Suhendro Suwarto, Suhendro Sukandar Sukrisno, Heru Sulastyawati Sulastyawati Sulistiyowati Gandariyah Afkari Suprajitno Susiaty SUTRISNO SUTRISNO SUTRISNO Sutrisno Sutrisno Suzanna Immanuel Syafi’i, Maulidya Sandi Syarif , Muhammad Teguh, Salman Al-Farizi Adi Telly Purnamasari Tjhin Wiguna Tyas, Maria Diah Ciptaning Unti Ludigdo Ustman Ustman Ustman Ustman Utari, Dewi Wahfiuddin, Muhammad Waskita Wijaya, Ananda Candra Widura Imam Mustopo, Widura Imam Widya, Yeney Wiyono, Joko Woro Riyadina Yayuk Totallia Yeney Widya Prihatiningtias Yessica Natalia Yuro Bimo Kusumo Yuyut Krisdiantoro Zaki Baridwan