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All Journal E-Jurnal Medika Udayana e-GIGI ODONTO Dental Journal Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat Journal of Indonesian Dental Association Jurnal Kreativitas PKM E-Prodenta Journal of Dentistry Jurnal Material Kedokteran Gigi Jurnal Kedokteran Gigi Terpadu JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Odonto dental journal
Deviyanti Pratiwi
Department Of Dental Materials, Faculty Of Dentistry, Universitas Trisakti, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Potensi brown anchovy dalam remineralisasi gigi: tinjauan terhadap kekerasan dan mikroporositas email Shafira Prana, Indira; Ratnasari, Dina; Elline; Elsa Prahasti, Anastasia; Ariwibowo, Taufiq; Pratiwi, Deviyanti
Jurnal Kedokteran Gigi Terpadu Vol. 7 No. 1 (2025): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v7i1.23790

Abstract

The process of dental demineralization can lead to the dissolution of minerals in hydroxyapatite crystals, increasing interprismatic spaces and decreasing enamel hardness. This demineralization can be inhibited through remineralization, supported by natural ingredients such as brown anchovy, which have potential as remineralizing agents. The remineralization process can be observed through changes in enamel microhardness and microporosity. Objectives: This article aims to provide information about the potential of brown anchovy and its effects on enamel microhardness and microporosity. Conclusion: There is potential of brown anchovy and its benefit in teeth remineralization.
Cytotoxicity of β-tricalcium phosphate chitosan gelatin composite scaffold as a bone substitute: in vitro study Putri, Tansza Setiana; Eddy, Eddy; Pratiwi, Deviyanti; Kurniawan, Florencia Livia; Swe, Thet Thet
Padjadjaran Journal of Dentistry Vol 38, No 1 (2026): March 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no1.63795

Abstract

Introduction: Beta-tricalcium phosphate (βTCP) has higher solubility than hydroxyapatite (HA), allowing it to be more easily resorbed and replaced by newly formed bone. This higher solubility enables the release of calcium and phosphate ions that play important roles in bone remodeling and osteoblast activity; however, excessive ion release may lead to cytotoxic effects. Limestone, mainly composed of calcium carbonate (CaCO₃), can serve as a calcium source for the fabrication of βTCP. βTCP scaffolds can be combined with organic components such as chitosan and gelatin to form composite scaffolds for bone tissue engineering. Therefore, this study aimed to analyze the cytotoxicity of a β-tricalcium phosphate–chitosan–gelatin composite scaffold as a bone substitute. Methods: Type of research was experimental laboratory. Freeze-drying method was used to produce a composite scaffold which was divided into two groups: chitosan-gelatin scaffold as control group and βTCP-chitosan-gelatin scaffold (each group consisted of three samples) To evaluate cytotoxicity, composite scaffolds were tested on osteoblast cells and the MTT assay was measured and assessed based on time evaluation at 24 hours and 72 hours. Cytotoxicity was determined based on the percentage of viable cells obtained from the MTT assay. Results: Viable cells percentage on the chitosan-gelatin scaffold was 70.32% at 24 h and increased to 99.52% at 72 h. While on the chitosan-gelatin-βTCP scaffold there were 85.11% viable cells at 24 h and increased to 89.54% at 72 h. Statistical analysis using one-way ANOVA showed no significant difference among all groups (p>0.05). However, Fisher’s LSD test indicated a significant difference in cell viability between 24 hours and 72 hours within the chitosan gelatin group. Conclusion: The βTCP-chitosan-gelatin composite scaffold demonstrated no cytotoxic effect on osteoblast cells, indicating its biocompatibility and potential suitability as a bone substitute material.
Co-Authors Abdul Gani Soulisa Abdul Gani Soulisa Abdul Gani Soulissa Achmad E. Z. Hasan Ade Prijanti Dwisaptarini Advita Azalia Akhmad Endang Zainal Hasan Andrian Nova Fitri Andy Wirahadikusumah Anisa, Syafira Annisa Kesumaningrum Annisa Putri Ariyani Arianne Dwimega Ariesanti, Yessy Ariyani, Annisa Putri Armelia Sari Bernard Ongki Iskandar Binartha, Cipthadi Tri Oka Carolina Damayanti Marpaung Caroline Caroline Citra Puspandari Handayaningrum Cokro, Ingrid Aurelia Genacia Dewi Liliany Margaretta, Dewi Liliany Dewi Priandini Dewi Priandini, Dewi Dhyani Widhianingsih Dody Prayitno Eddy Eddy Eddy Eddy, Eddy Elline Elline, Elline Elsa Prahasti, Anastasia Erawati, Jeti Esa Bella Ferry Sandra Fibryanto, Eko Florencia Livia Kurniawan Gabriel Rainheart Genesis Genesis, Gabriel Rainheart Harryanto Wijaya Harryanto Wijaya Helen Cyntya Andany Ingrid Aurelia Genacia Cokro Intan Farizka Iskandar, Mochammad Marshalldanard A. Izah, Nurul Janti Sudiono Jeddy Jeddy Kesumaningrum, Annisa Komariah Komariah Komariah Komariah Komariah Komariah Komariah Komariah Komariah Liliany Margaretta, Dewi Meidianti, Dwi Harini Endah Melaniwati Mikha Sundjojo Najla Nadiah Natanael, Christian Niko Falatehan Nuroh Arifah Octarina Prawira, William Putri Rejeki Ratnasari, Dina Ria Puspitawati Richentya Feiby Salim Richentya Feiby Salim Riko Nofrizal Rosalina Tjandrawinata Rosita Stefani Salim, Richentya Feiby Santosa, Didi Nugroho Sari, Armelia Saristi, Salsabila Shafa Sastra Kusuma Widjaya Shafira Prana, Indira Shariff, Khairul Anuar Soulisa, Abdul Gani Sri Ratna Laksmiastuti Sutrisno, Juanita Andriani Swe, Thet Thet Syifa Annisa Tanaya, Namyera Tansza Setiana Putri Taufiq Ariwibowo Teguh, Sharren Thomas Aurelius Dharma Tiffany Hartono Tri Erri Astoeti Trijani Suwandi Trisfilha, Pretty Wijaya, Livia Wita Anggraini Yenny Pragustine Yoana Winardi