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Jasril Jasril
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Journal : JURNAL KIMIA SAINS DAN APLIKASI

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Microwave-assisted synthesis of 1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one and its activities as an antioxidant, sunscreen, and antibacterial Ihsan Ikhtiarudin; Nesa Agistia; Neni Frimayanti; Tria Harlianti; Jasril Jasril
Jurnal Kimia Sains dan Aplikasi Vol 23, No 2 (2020): Volume 23 Issue 2 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.264 KB) | DOI: 10.14710/jksa.23.2.51-60

Abstract

Chalcone analogs have been reported to have a variety of exciting biological activities, such as anticancer, anti-inflammatory, antioxidant, photoprotective, antibacterial, and antidiabetic activities. Therefore, analogs of these compounds have been widely synthesized as intermediate compounds or target molecules in the discovery of bioactive compounds to be applied in the pharmaceutical field. The purpose of this study is to synthesize chalcone analog compounds (E)-1-(4-hydroxyphenyl)-3-(4-methoxyphenyl) prop-2-en-1-on with the microwave irradiation method and explore some of the biological activities of these compounds, including testing the antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, in vitro sunscreen activity by microplate method, and antibacterial activity by disk diffusion method. DPPH test results indicate that the compound has weak antioxidant activity, with an IC50 value of 300.43 µg/mL. However, the compound showed excellent potential as a UV B and UV A filter at a concentration of 150 µg/mL with a value of %Te of 0.73±0.10% (sunblock), %Tp of 0.07±0.00% (sunblock), SPF value of 21.10±1.46 (ultra-protection) and potentially better than benzophenone-3 as a standard sunscreen. Then, disk diffusion testing showed that the compound had weak antibacterial activity against Staphylococcus aureus and did not show antibacterial activity against Escherichia coli bacteria at test concentrations of 30, 60, and 120 µg/disk.
Co-Authors - Aisyah - Nurlaili -, Sulismayati A, Muhammad Rizki Abdul Aziz Adel Zamri Adel Zamri Afrita, Indra agistia, nesa Ahmad Fauzan Ainil Mardiyah Aisyah Aisyah Aisyah, - Akbar, Unggul Al Fiqri, M. Faiz Alfarabi.B, Alif Ananda, Muthia Ananda, Sherly Anggita, Anggi Fisi Anori, Sartika Aprilia, Tasya Asmawati Asmawati Ayasrah, Firas Tayseer Baehaqi Bintal Amin Christine Jose Christine Jose Dampang, Hasria Darian Alfatos Delsi K Delsi K Delsina Faiza Denai Wahyuni Denai Wahyuni Desviana, Laila Dewi, Erna Puspita Elin Haerani Elka Yuslinda Elvia Budianita Elviyenti, Elviyenti Fadhilah Syafria Fadhli, Irfan Faladhin, Johan Fatila, Mutia Fauzi, Faradiba Kamilia Fawrin, Heralda Febi Yanto Fernando, Rivan Fiffah, Chainul Firmathoina, Aisyah Fitra Perdana Fitri Insani Fitria Novitasari Frischa Meivilona Yendi Guspriadi, Yan Gusti, Siska Kurnia Haiyul Fadhli Hamersat, Danu Hardiansyah, Muhammad Vio Haresman, Haresman Hariansyah, Jul Hasmalina Nasution Hendra, Rudi Hilwan Yuda Teruna Hurria, Hurria Ihsan Ikhtiarudin Iis Afrianty Ika Parma Dewi Ikhtiaruddin, Ihsan Illahi, Ridho Indah Wulandari Insani (Scopus ID: 57190404820), Fitri Işık, Kenan Isnaniar Iswantir M Jufrizal Syahri Laila Desviana Lazulva Lazulva, Lazulva Lestari Handayani Lisa Utami Mar'arif, Muhammad Mulky Marzalius, Lira Rahma Masykur Hz Masykur HZ Muhammad Affandes Muhammad Irsyad Muhdarina Muhdarina Muhdarina Muliani, Sarifah Muslim Syaifullah, Mhd Nazir, Alwis Nazruddin Safaat H Negara, Benny Sukma Neni Frimayanti Nofirda, Fitri Ayu Novianty, Riryn Nuraini Ramadhani Nurhayati Nurlaili Nurlaili Nurlaili, - Nurwijayanti Oktavia, Lola Pranata, Joni Prasetya Prasetya, Prasetya Putra, Ade Herdian Putra, Rido Putri, Atika Putri, Rahmayani Indah Rahayu, Anggi Putri Rahma Dona Rahmadini Syafri Rahmiwati Hilma Ramadhani, Eka Ramadhani, Siti Ramadhanti, Aulia Rizki Retno Hidayati Rudi Hendra Sardi, Hajra Sari, Meidita Kemala Sari, Nila Puspita Silvera Devy Siregar, Alfi Salimah Siregar, Sri Hilma Siregar, srihilma Soeci Izzati Adlya Sofyan Husein Siregar Sulismayati - Surya Agustian Suwanto Sanjaya Sya'ban, Andrian Nur Thamrin Tri Windarti Tri Windarti Tria Harlianti Triana, Yeni Umar Hamdan, Umar Veithzal Rivai Zainal Wan, Xue Wenni, Osriza Wulan Sari, Wulan Yasthophi, Arif Yeni, Wila Mutiara Yuana Nurulita Yuca, Verlanda Yuharmen - Yum Eryanti Yuni Fatisa Zadrian Ardi Zahra, Fadhila Az Zahri, Firman Zikra, Nadila `Nasution, Hasmalina