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All Journal Buletin Veteriner Udayana Buletin Udayana Mengabdi Jurnal Veteriner Indonesia Medicus Veterinus Jurnal Pengembangan Kota Jurnal Medik Veteriner Martabe : Jurnal Pengabdian Kepada Masyarakat Majalah Farmasetika Jurnal Gema Ngabdi Advances in Tropical Biodiversity and Environmental Sciences Nusantara Science and Technology Proceedings Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Journal of Veterinary and Animal Sciences Jurnal Medika Veterinaria

I Made Merdana

Laboratorium Farmakologi Dan Farmasi Veteriner, Universitas Udayana

Author-ID : 2926118

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Pertambahan Bobot Badan Anak Babi Persilangan Jantan Periode Nurserry setelah Pemberian Enzim Pencernaan dan Tepung Kunyit I Made Merdana; I Wayan Sudira; Gede Yuda Darmadi Putra
Buletin Veteriner Udayana Vol. 11 No. 2 Agustus 2019
Publisher : The Faculty of Veterinary Medicine, Udayana University

This study aims to determine the effect of the addition of feed enzymes containing xylanase, amylase and protease with turmeric flour (Curcuma domestica) to increase the body weight of male crossbreed nursing piglets. Using a completely randomized design, thrty-two male crossbreed piglets aged four weeks weighing 7-9 kg were divided into four groups (P0, P1, P2 and P3) with eight replications. The enzymes and turmeric flour are given through feed for five weeks. Group P0 as a control given feed without treatment. Group P1 was given enzyme dose 0.1% of feed. Group P2 was given turmeric flour dose 1% of feed. Group P3 was given a combination of enzymes and turmeric flour with a dose 0.1% and 1% of feed. Data on absolute growth of piglets was obtained from the difference in weighing the initial with the final body weight. The mean of body weight gain as follows P0 = 14.81 ± 1.11; P1 = 15.99 ± 1.79; P2 = 16.94 ± 0.84 and P3 = 17.68 ± 1.62 kg. Statistical analysis showed that the addition of enzymes and turmeric flour through feed had a significant effect on the weight of the nursing piglets. The best results on the combination treatment of feed enzymes and turmeric flour with a dose of 0.1% and 1% of feed.

Perubahan Histopatologi Ginjal Tikus Putih yang diberikan Ekstrak Sarang Semut diinduksi Parasetamol Dosis Toksik Wayan Sudira; Made Merdana; Ida Bagus Oka Winaya; I Kadek Parnayasa
Buletin Veteriner Udayana Vol. 11 No. 2 Agustus 2019
Publisher : The Faculty of Veterinary Medicine, Udayana University

The aims of this study were to prove that the administration of toxic doses of paracetamol affects the histopathology of the kidneys and to know the effect of ant nests on the protective effect on kidney rats given paracetamol toxic dose. This study used 24 white male rats consisting of four treatments, ie control group P0 without treatment, treatment group P1 given paracetamol dose 250 mg/kg BW, treatment group P2 given paracetamol dose 250 mg/kgBW plus ant nest dose 250 mg/kgBW, treatment P3 given ant nest 250 mg/kgBW for seven days after it was given extract of ants and paracetamol dose 250 mg/kgBW. Paracetamol and ant nest extract are administered orally for ten days. After that, necropsies and kidney organs were taken aseptically for the preparation of histopathological preparations with hematoxylin and Eosin staining. The variables examined were congestion, bleeding, necrosis and inflammation. From the examination obtained results of kidney damage in the form of congestion, bleeding, necrosis and inflammation. The Kruskall-Wallis test showed a significant difference in mean congestion, bleeding, necrosis, and inflammation of the tested group. From this study, it can be concluded that paracetamol dose 250 mg/kg BW can cause kidney damage. Ant nest dose 250 mg/kg BW able to repair damage to the kidney tissue

Perubahan Histopatologi Hati Tikus Putih yang diberikan Ekstrak Etanol Sarang Semut dan Gentamisin Gde Jasmara Muda; Anak Agung Gde Arjana; I Ketut Berata; I Made Merdana
Buletin Veteriner Udayana Vol. 12 No. 1 Pebruari 2020
Publisher : The Faculty of Veterinary Medicine, Udayana University

This study aims to evaluate that the administration of ant nest reduces the side effects of toxic doses of gentamicin seen from the histopathological changes in hepar of white rats (Rattus norvegicus). This study used 24 male white rats, divided into four treatment groups, namely negative controls (P0) there were only given food and drink, positive controls (P1) administered gentamicin at a dose of 100mg/kgBB intraperitoneally for 10 days. The group (P2) was given gentamicin 100mg/kgBB intraperitoneally and ant nest extract with a dose of 250mg/kgBB orally for 10 days. The group (P3) was given 250mg/kgBB of ant nest extract for 7 days, after which ant nest extract was given at a dose of 250mg/kgBB and gentamicin with a dose of 100mg/kgBB intraperitoneally for 10 days.White rat hepar was taken and processed for making histopathological preparations, with hematoxylin eosin (HE) staining. The results showed that there was a significant difference between negative control and positive control groups. The mean score of improvement in hepar damage of white rats was significantly different between treatment P1, P2 and P3. The P2 and P3 groups that showed the most change near the mean score of the negative control group. Giving ant nest extracts to white rats for 17 days at a dose of 250mg/kgBB can improve the side effects of the administration of gentamicin 100mg/kgBB in the hepar of white rats.

Pengaruh Pemberian Propolis Terhadap Gambaran Histopatologi Ginjal Tikus Putih yang Diberikan Parasetamol Dosis Tinggi Elti Febilani; I Ketut Berata; Samsuri Samsuri; I Made Merdana; Luh Made Sudimartini
Buletin Veteriner Udayana Vol. 9 No. 1 Pebruari 2017
Publisher : The Faculty of Veterinary Medicine, Udayana University

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The purpose of this study is to determine the effect of propolis on kidney histopathological representation of white rats were given the toxic dose paracetamol. 25 male rats males were used in this study who were divided into 5 groups, control group (P0) without treatment, group 1 (P1) that was given paracetamol doses 250mg/kg, group 2 (P2), group 3 (P3), and group 4 (P4), given paracetamol dose of 250mg / kg and propolis added 0.25 ml (P2), 0.50 ml (P3), and 0.75 ml (P4). Paracetamol and propolis were given orally by mixing it into the water provided ad libitum for 10 days. Then performed a necropsy and kidney were taken aseptically for making of histopathology preparations with hematoxylin eosin (HE) staining. The examined variables were fatty degeneration and necrosis in the proximal tubules of the kidney. Results indicate that fatty degeneration and necrosis were showed in treatment P1, while the entire treatment P2, P3, and P4 show the repair from the damage caused by the paracetamol. Treatment P4 gives the best results in reducing the effects of the paracetamol. Kruskal-Wallis showed a significant difference from fatty degeneration and necrosis of the tested group. From this study it can be concluded that the propolis with dose 0.75 ml giving better protection than 0.25 ml and 0.50 ml dose.

Efektivitas Vitamin E dan Deksametason pada Otak Tikus Putih Afrizal Choirul Umam; I Ketut Berata; Samsuri Samsuri; I Wayan Sudira; Luh Made Sudimartini; I Made Merdana
Buletin Veteriner Udayana Vol. 10 No. 1 Pebruari 2018
Publisher : The Faculty of Veterinary Medicine, Udayana University

Provision of dexamethasone for the long term and large doses may cause disturbances in the brain. To prevent disruption to the brain, it needs antioxidant such as vitamin E. The aims of this study is to prove the administration of dexamethasone cause interference on white rat brain and determine the effects of vitamin E supplementation in preventing the side effects of dexamethasone in the brains of rats. This study used 25 male rats were divided into 5 groups, namely negative control was only given food and drink, positive control is given dexamethasone at a dose of 0.13 mg/kg bw, P1 given dexamethasone 0.13 mg/kg of body weight and vitamin E at a dose of 100 mg/kg bw, P2 given dexamethasone 0.13 mg/kg bw and vitamin E at a dose of 150 mg/kg bw, P3 given dexamethasone 0.13 mg/kg bw and vitamin E at a dose of 200 mg/kgbw. Treatment was given for 14 days, then the experimental animals necropsied. Brain tissue was taken and processed for making histopathology preparations using hematoxylin-eosin staining. Variables examined include perivascular edema lesions and congestion. The result found a significant difference between negative and positive control. The mean score improvement of brain damage was not significantly different between the treatment P1, P2, and P3. P1 treatment groups showed mean score approached the negative control. The conclusions of this research was the dexamethasone caused histopathological changes to rat brains. Supplementation of vitamin E up to doses of 200 mg /kg of body weight have not been able to reduce the side effects of dexamethasone on the brain.

Pengaruh Suplementasi Vitamin E terhadap Efek Samping Deksametason pada Paru-Paru Tikus Putih Jantan Bina Ichsantya; I Ketut Berata; Samsuri Samsuri; I Made Merdana
Buletin Veteriner Udayana Vol. 9 No. 2 Agustus 2017
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.203 KB)

Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi vitamin E sebagai antioksidan dalam mengurangi efek samping deksametason pada paru-paru. Penelitian ini menggunakan 25 ekor tikus putih jantan yang dibagi dalam lima kelompok perlakuan, yaitu: kelompok kontrol negatif yang diberi pakan dan minum saja, kelompok kontrol positif yang diberi deksametason secara subkutan dengan dosis 0,13 mg/kg bb, kelompok P1 yang diberi deksametason secara subkutan dengan dosis 0,13 mg/kg bb dan vitamin E per oral dengan dosis 100 mg/kg bb, kelompok P2 yang diberi deksametason secara subkutan dengan dosis 0,13 mg/kg bb dan vitamin E per oral dengan dosis 150 mg/kg bb dan kelompok P3 yang diberi deksametason secara subkutan dengan dosis 0,13 mg/kg bb dan vitamin E per oral dengan dosis 200 mg/kg. Setelah diberikan perlakuan selama 14 hari, kemudian dilakukan nekropsi,. Organ paru-paru diambil untuk diproses menjadi sediaan histopatologi dengan metode pewarnaan Hematoxylin-Eosin (HE). Variabel yang diperiksa meliputi edema, perdarahan dan peradangan. Hasil penelitian menunjukkan terdapat perubahan histopatologis pada jaringan paru yang berbeda nyata antara kelompok kontrol positif dan kelompok kontrol negatif, sedangkan perubahan kearah perbaikan pada jaringan paru tidak berbeda nyata pada seluruh kelompok P1, P2 dan P3. Simpulan dari penelitian ini adalah: pemberian deksametason dosis 0,13 mg/kg bb menyebabkan perubahan histopatologis pada jaringan paru tikus putih meliputi edema, perdarahan dan peradangan. Suplementasi vitamin E hingga dosis 200 mg/kg bb belum memberikan perbaikan yang signifikan pada jaringan paru tikus putih yang diberi deksametason.

Gambaran Histopatologi Hepar Mencit Yang Diberikan Ekstrak Etanol Sarang Semut Yoga Eka Prasetyo; I Made Merdana; I Made Kardena; I Wayan Sudira
Buletin Veteriner Udayana Vol. 11 No. 1 Pebruari 2019
Publisher : The Faculty of Veterinary Medicine, Udayana University

Anthill plants attracted many people as an alternative medicine because proven efficacious for treating tumor diseases, cancer, tuberculosis, stroke, coronary heart disease, diabetes mellitus, nosedleeds, ulcer, hemorrhoids, facilitate breastfeeding, increase stamina and sexual arousal. This study aimed to determine the effect of ethanol extract of the anthill plant to the mice liver histopathology. This study is an experimental laboratory. Twenty fourth male mice 10-12 weeks of age with a body weight of 25-35 grams were divided into 4 groups, each group consisting of 6 mice were given treatment that Control Group, Group I (doses 100mg/kg BW), Group II (doses 200mg/kg BW) and Group III (doses 300mg/kg BW) for 21 days. Hepatic histopathological changes were observed and assessed by histological damage in the form of infiltration of inflammatory cells, lipid degeneration and necrosis. Data were analyzed using statistical test of Kruskal-Wallis followed with Mann-Whitney Test (p<0.05). Kruskal-Wallis test result showed ethanol extract anthill very significant (p<0.01) effect on the incident of lipid degeneration, necrosis and infiltration of inflammatory cell of liver cells. Based on these result it can be concluded that the ethanol extract of anthill can cause histological changes in the liver of mice.

UJI DAYA HAMBAT EKSTRAK DAUN KEDONDONG (LANNEA GRANDIS ENGL) TERHADAP PERTUMBUHAN BAKTERI ERWINIA CAROTOVORA I Wayan Sudira; I Made Merdana; I Putu Agus Hendra Wibawa
Buletin Veteriner Udayana Vol. 3 No. 1 Pebruari 2011
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (38.839 KB)

Research with the title of the inhibition test kedondong leaf extract (Lannea grandisENGL)on the growth of bacteria Erwinia carotovora, causes soft rot of Aloe vera have beenconducted in vitro on media PPGA and testing of antibacterial activity of leaf extractkedondong on aloe vera leaf pieces. This study aims to determine the bactericidal activityof leaf extract and concentration kedondong minimal constraints on the growth ofbacteria Erwinea carotovora. Bacteria E. Carotovora isolated from the Aloe Vera plant softrot disease.Sections of leaves among the sick and the healthy cut to the size of ± 3 cm andcleaned with water and then soaked with 70% alcohol for 2 minutes inserted into laminar flow. Leaves clean kedondong have weighed as much as 100 grams chopped, then addedwith 1000 ml of methanol solvent. Immersion extract was filtered with filter paper watmanNo. 2.The filtrate obtained was evaporated by vacuum rotary evaporator to separate thesolvent (methanol) and the extract, made up to concentration. Bacteria isolated on mediapropagated PPGA tilted as stock for testing bacterial pathogens isolated colony of yellowwhitecolor with the aroma of sulfur-like smell of gas.Based on research results, it can beconcluded that the leaf extract could inhibit bacterial growth kedondongE carotovora withdoses at least 4% concentration in media PPGA and pieces of aloe vera leaves, whereas atconcentrations of 1, 2 and 3% have not been able to provide inhibition.

HISTOPATOLOGI HEPAR TIKUS PUTIH (Rattus novergicus) SETELAH PEMBERIAN EKSTRAK SARANG SEMUT (Myrmecodia pendans)YANG DIINDUKSI PARACETAMOL DOSIS TOKSIK I Made Merdana; I Made Kardena; Ketut Budiasa; I Made Dodi Gunawan
Buletin Veteriner Udayana Vol. 11 No. 1 Pebruari 2019
Publisher : The Faculty of Veterinary Medicine, Udayana University

This study aim was to determine the influence ant nest plant extract (Myrmecodia pendans) on histopathological changeof white rat liver (Rattus novergicus) due to induced with paracetamol toxic dose. This study used 24 male white rats, divided into four groups, negative control group (P0) given placebo, positive control group (P1) given paracetamol dose 250 mg / kg bw for 10 days, P2 given ant nest extract 250 mg / kg bw and paracetamol dose 250 mg / kg bw for 10 days, P3 given ants nest extract 250 mg / kg bw for seven days, then continued by giving paracetamol and ants nest extract with dose 250 mg / kg bw for ten days. After the treatment done, all the rats were dinecropsed. Liver organs were taken and processed for making histopathology preparations. Parameters examined included hemorrhage, congestion, degeneration and necrosis. The data obtained were analyzed statistically by using Kruskal Wallis test followed by Mann Whitney test. Mann Whitney test results for all categories of histopathologic changes in hemorrhagic, congestion, degeneration, and necrosis between negative control group (P0) and positive control group (P1) were significantly different (P <0.05), between negative control (P0) with P2 and P3 there was no significant difference (P> 0,05). Afterward, between the positive control (P1) and P2 with P3 there was a significant difference (P <0.05). I can be concludedthat the administration of paracetamol dose 250 mg/kg bw for 10 days affects the histopathologic changes of white rat liver. The administration of ant nest plant extracts can reduce the side effects of toxic doses of paracetamol.

Struktur Histopatologi Paru-Paru Tikus Putih yang di Berikan Ekstrak Sarang Semut dan Diinduksi Parasetamol dengan Dosis Toksik I Made Merdana; I Gusti Putu Tovan Mahottama; I Ketut Berata; Luh Made Sudimartini
Buletin Veteriner Udayana Vol. 14 No. 2 April 2022
Publisher : The Faculty of Veterinary Medicine, Udayana University

Myrmecodia pendan is an epiphytic plant that attaches to large trees. Myrmecodia pendans plant contains chemical compounds such as flavonoids and tannins that are known can cure various diseases. The study aimed to determine the effect of giving myrmecodia pendans extract to the histopathological lung in white rats due to the administration of toxic doses of paracetamol. This study used 24 male white rats and divided into 4 treatment groups. The histopatological changes observed were bleeding, inflammation, congestion and necrosis. The results obtained were the administration of toxic doses of paracetamol orally causes bleeding, inflammation, congestion and necrosis in the lungs of white rats. Giving extract of myrmecodia pendans can improve lung tissue due to the administration of toxic doses of paracetamol which experience bleeding, inflammation, congestion and necrosis in the white rats.

Co-Authors Adri Yana Rambu Anawenju Afrizal Choirul Umam Agustina, I Putu Sudana Ali, Ahmad Muhammad Alviana Rizqiyah Utami Anak Agung Ayu Mirah Adi Anak Agung Gde Arjana Anak Agung Gde Arjana Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Anastasia Bhala Ari Mogi, I Komang Arinata, I Ketut Teguh Ayu Prawitasari Citra Pratama Bina Ichsantya Darmawan, I Wayan Eka Dini Hilary Manullang Diyasa, I Gede Susrama Mas Domingas Pereira DWI SURYANTO Elsa Hidayati Elti Febilani Febrina Cicilia Br Ginting, Febrina Cicilia Firdaus, Ihsanul Franky Samuel Milenyano Chandra Fuady Muslih Gde Jasmara Muda Gea, Octo Berkat Gede Iwan Setiabudi Gede Yuda Darmadi Putra Genta Dhamara Adam Putranto Gusti Agung Rama Wiratama Putra Hariyadi, Hariyadi Hartati, Ruth Dwi Hendrawan, I Wayan Dika Wahyu I Dewa Made Nurja Sadhi I Gusti Agung Gede Putra Pemayun I Gusti Ayu Sri Darmayani I Gusti Ketut Suarjana I Gusti Ngurah Sudisma I Gusti Putu Tovan Mahottama I GustiKetut Suarjana I Kadek Ariyuda Prasetya I Kadek Parnayasa I Ketut Berata I Ketut Berata I Ketut Suada I Ketut Suada I Komang Ari Mogi I Komang Ari Mogi I Made Damriyasa I Made Dira Swantara I Made Dodi Gunawan I Made Dwinata I Made Kardena I Made Oka Riawan I Made Robi I NYOMAN ADI SURATMA I Nyoman Sarsana I Nyoman Suartha I Nyoman Sulabda I Nyoman Sulabda I Putu Agus Hendra Wibawa I Putu Agus Santika Putra I Putu Dwi Komala Putra I Putu Mangku Mariasa I Wayan Sudira I Wayan Wirata Ida Ayu Pasti Apsari Ida Bagus Komang Ardana Ida Bagus Made Oka Ida Bagus Oka Winaya Ika Hartini Hutasoit, Ika Hartini Iwan Harjono Utama Jihadulhaq, Jihadulhaq Kadek Febriana Marta Putra Kadek Teguh Wirasastra Ketut Budiasa Kusuma, Putu Winatha Luh Ani Luh Gde Sri Surya Heryani Luh Made Sudimartini Luh Seri Ani Made Gede Adi Surya Saputra Mahardika, I Gusti Bagus Mahmud, Fathmah Monica Lewinsky Ngudiyono Ngudiyono Ni Kadek Eka Widiadnyani Ni Luh Eka Setiasih Ni Luh Watiniasih Ni Nyoman Kencanawati Ni Wayan Arya Utami, Ni Wayan Arya Ningsih, Adriati NYOMAN DITA PAHANG PUTRA, NYOMAN Nyoman Sumiati Pradipta Hendra Setiawan, Pradipta Hendra Putera, I Gusti Ngurah Dwipayana Putra, I Dewa Agung Made Wihanjana Putra, I Made Arya Udyana Putra, Putu Adi Guna Purwaka Putri, Ayu Chitra Adhitya Putu Devi Jayanti Putu Henrywaesa Sudipa Putu Suastika Rama Adi Putra, Rama Adi Sampurno, Ilham Ade Widya Samsuri , Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Saputra, I Dewa Ketut Ari Setyawati, Luh Gede Sewoyo, Palagan Senopati Sis wanto Siswanto, Riefqy Tepu Sri Darmayani, IGA ST Kholifah Nor Azizati Suci Nur Qurani Teja, Putu Tessa Hariys Septianda Theresia Ene Ujan, Katarina Kewa Yoga Eka Prasetyo Yoga Pratama Mambela Sarungallo

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