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All Journal Buletin Udayana Mengabdi Jurnal Veteriner Indonesia Medicus Veterinus Jurnal Pengembangan Kota Jurnal Medik Veteriner Martabe : Jurnal Pengabdian Kepada Masyarakat Majalah Farmasetika Jurnal Gema Ngabdi Nusantara Science and Technology Proceedings Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Journal of Veterinary and Animal Sciences Jurnal Medika Veterinaria Buletin Veteriner Udayana Advances in Tropical Biodiversity and Environmental Sciences
I Made Merdana
Laboratorium Farmakologi Dan Farmasi Veteriner, Universitas Udayana
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Sebaceous Adenoma in a Geriatric Poodle Dog: A Case Report Winaya, Ida Bagus Oka; Adi, Anak Agung Ayu Mirah; Sudimartini, Luh Made; Merdana, I Made; Sudipa, Putu Henrywaesa; Pemayun, I Gusti Agung Gde Putra; Sewoyo, Palagan Senopati
Jurnal Medik Veteriner Vol. 7 No. 2 (2024): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss2.2024.413-419

Abstract

A 14-year-old black male Poodle was brought to the Animal Teaching Hospital, Udayana University by its owner with clinical signs of frequent licking of its left front paw. Upon examination, red bumps were observed on the left front leg, accompanied by small, round black spots scattered on the dorsal side of the body. Additionally, black nodules were present on the lower eyelids and hind limbs. Surgical intervention was undertaken to excise the tumor mass, with the animal under anesthesia induced by ketamine at 5 mg/kg BW intravenously. The reddish nodule was excised by performing an elliptical incision at the base of tumor. Postoperatively, the animal received an antibacterial injection comprising ceftriaxone and tazobactam at 25 mg/kg BW intramuscularly and antiseptic wound dressing for supportive care. Microscopic examination revealed neoplastic cells arranged into lobules of varying sizes and shapes within the tumor mass. These lobules consisted of differentiated sebocytes and basaloid cells. At the periphery of the neoplastic lobules, the basaloid cells displayed several layers and exhibited invasion with moderate anisocytosis. The mitotic index was no more than ten cells in one field of view. Based on these histopathological features, the tumor was confirmed to be a sebaceous adenoma. After a 10-month follow-up period, there were no signs of tumor recurrence observed.
Evaluasi Salep Simplisia Daun Kembang Sepatu yang Memiliki Potensi Terhadap Pertumbuhan Rambut Arinata, I Ketut Teguh; Sudira, I Wayan; Samsuri, Samsuri; Merdana, I Made; Dharmayudha, Anak Agung Gde Oka
Majalah Farmasetika Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i2.59421

Abstract

Berbagai studi mengenai potensi kembang sepatu sebagai tanaman obat yang memiliki pengaruh terhadap pertumbuhan rambut telah dilaporkan. Pada penelitian ini dibuat formulasi sediaan topikal yaitu salep dari simplisia daun kembang sepatu dengan bahan dasar hidrokarbon. Pengujian dilakukan untuk melihat kualitas fisik dari sediaan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi simplisia terhadap perolehan kualitas salep yang baik serta melihat potensi pembuatan salep menggunakan bahan dasar simplisia daun kembang sepatu. Simplisia daun kembang sepatu dicampur dengan bahan dasar salep hidrokarbon yaitu vaselin alba sehingga membentuk formulasi dengan konsentrasi simplisia yang bervariasi. Pengujian yang dilakukan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan cycling test. Hasil penelitian menunjukkan tidak ada perubahan secara organoleptik, tidak homogen, pH 6 yang sesuai dengan pH kulit, daya sebar di bawa standar menyebabkan konsistensi padat, tiga dari empat formulasi lolos standar daya lekat, dan hasil cycling test menunjukkan semua formulasi stabil pada proses penyimpanan. Berdasarkan hasil penelitian dapat disimpulkan konsentrasi simplisia daun kembang sepatu berpengaruh terhadap kualitas salep. Namun, sediaan salep tersebut belum memenuhi standar homogenitas dan daya sebar.
Pemberdayaan Masyarakat Untuk Pemanfaatan Bambu sebagai Perkuatan Lereng di Desa Guntur Macan Kecamatan Gunung Sari Lombok Barat Mahmud, Fathmah; Hariyadi, Hariyadi; Merdana, Merdana; Ngudiyono, Ngudiyono; Kencanawati, Ni Nyoman; Ali, Ahmad Muhammad
Jurnal Gema Ngabdi Vol. 7 No. 1 (2025): JURNAL GEMA NGABDI
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v7i1.550

Abstract

Guntur Macan Village is a hilly area located in the Gunung Sari sub-district, West Lombok Regency. The sandy hill soil, characterized by a significant slope, lacks cohesion, making the area prone to landslides, especially during heavy rainfall, flooding, or tectonic earthquakes. Landslides are further exacerbated by soil cracks filled with water, either from rain or other sources, which reduce the safety factor compared to soil without cracks. The closer the cracks are to the sliding surface, the more the safety factor decreases. In Guntur Macan Village and the surrounding areas of Gunung Sari sub-district, bamboo is widely planted. Bamboo, being cost-effective and environmentally friendly, can be utilized as a retaining structure to mitigate landslides. This Community Empowerment Program (PKM) commenced with a location survey conducted two weeks before implementation, followed by a two-day execution phase. On the first day, educational sessions were provided, covering topics such as bamboo cutting, preservation, and the construction of bamboo retaining walls. On the second day, bamboo retaining walls were built on residential land in Guntur Macan Village. Through this PKM activity, the residents of Guntur Macan are now capable of constructing bamboo retaining walls to prevent landslides.
PROGRAM DESA TANGGUH COVID-19 DI DESA PIKAT KABUPATEN KLUNGKUNG PROVINSI BALI Ani, Luh Seri; Arya Utami, Ni Wayan; Sri Darmayani, IGA; Merdana, I Made; Ari Mogi, I Komang
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 7 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i7.2364-2371

Abstract

The Covid-19 pandemic caused health problems in various countries including Indonesia. Various efforts have been made as a strategy to prevent the transmission of Covid-19 including the implementation of restriction on community activity to reduce mobility, implementing health protocols, namely wearing masks, social distancing, washing hands, tests, search, follow-up, and vaccinations.  The Covid-19 resilient village program was organized to raise public awareness about covid-19 infections and how to maintain physical and mental health. The Covid-19 resilient village program was implemented in Pikat Village, Klungkung Regency, Bali Province. The activity took place in July-August 2021. The target of the activity is the entire community in Pikat Village. The activity was carried out by a combination method online and offline in related the Covid-19 pandemic situation and the implementation of restrictions on activities for all communities including in Pikat Village. The Covid-19 resilient village program consists of 5 activities, namely Covid-19 contact trackers, mask waste processing education, mental health education, benefits education as an immunity-enhancing material, distribution of masks and handsanitizers for the community. This activity runs smoothly and provides benefits for the community so that it needs to be maintained the continuity of activities to educate the community in accordance with needs.
HISTOPATHOLOGICAL CHANGES IN THE LUNGS OF WHITE RATS POST ADMINISTRATION OF MIMOSINE FROM LEUCAENA LEAF SIMPLICIA Gheasella Fia Gunawan; I Ketut Berata; Hamong Suharsono; Ni Luh Eka Setiasih; I Made Merdana; I Wayan Sudira
Buletin Veteriner Udayana Bul. Vet. Udayana. August 2024 Vol. 16 No. 4
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2024.v16.i04.p43

Abstract

Lamtoro leaves (Leucaena leucochepala) are widely used as forage for cattle because they contain high protein, flavonoids, tannins and other useful nutrients. Apart from containing useful nutrients, it turns out that lamtoro leaves contain a toxic ingredient, namely mimosine, which can cause alopecia and reproductive disorders. This study aims to determine the histopathological changes in the lungs of white rats (Rattus norvegicus) after administration of mimosine from lamtoro leaf simplicia. The study used 20 rats divided into 4 treatment groups, namely P0 (negative control), P1 (positive control) which were given standard mimosine produced by Sigma 5 mg/head/day, P2 (treatment given mimosine from lamtoro leaf simplicia dose of 50 mg/day). head/day, and P3 (treatment given mimosine from lamtoro leaf simplicia dose of 150 mg/head/day. The treatment was given orally for 14 days. On the 15th day all experimental animals were sacrificed to have their lung tissue taken. Then preparations were made histopathology using the hematoxylin eosin (HE) staining method. Examination of histopathological changes including congestion, bleeding and inflammation was carried out using scoring to categorize mild, moderate and severe lesions. The results of the examination in the form of scoring data were analyzed using the Kruskall Wallis and Mann Whitney tests.The results showed that there were significant differences (P<0.05) in lesion congestion, bleeding and inflammation compared to controls. There was a significant difference (P<0.05) between treatments P2 (150mg/head/day) and P3 (50mg/head/day) based on inflammatory lesions, but not significant (P>0.05) on coagulation and bleeding lesions. The conclusion is that administration of mimosine from lamtoro leaf simplicia can cause histopathological lesions of congestion, bleeding and inflammation in the lungs of white rats. The difference in dose of mimosine from lamtoro leaf simplicia between 50mg/head/day and 150mg/head/day only differs in inflammatory lesions, but not in congestion and bleeding lesions. The suggestion is that this research can become a basic reference and that there be futher research regarding dose compared to control.
THE IMPACT OF ADMINISTRATION OF GUMITIR FLOWER SIMPLICIA OINTMENT ON COLLAGEN TISSUE DENSITY IN THE HEALING OF WHITE RAT BURNS I Gede Yoga Sukya Sumantara; I Wayan Gorda; Ida Ayu Pasti Apsari; I Made Merdana; Ida Bagus Oka Winaya
Buletin Veteriner Udayana Bul. Vet. Udayana. October 2024 Vol. 16 No. 5
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2024.v16.i05.p01

Abstract

Burns are a form of damage or loss of skin tissue caused by direct contact with heat sources such as fire, hot water, electricity and radiation. The wound healing process is not only limited to local regeneration processes, but is also greatly influenced by endogenous factors such as age, nutrition, immunology, use of drugs. One of the medicines made from nature is gumitir flowers. Gumitir flowers contain antioxidants which can help the healing process of burn wounds. This research was conducted with the aim of determining the effectiveness of administering gumitir flower simplicia ointment on collagen density in white rats that had suffered burns. In this study, 24 male Wistar rats were used and divided into 4 groups using RAL (completely randomized design). Then the mice were burned using a modified soldering iron, the wounds were made on the mice's backs at a temperature of 800C for 10 seconds. The results of the study showed that there was a difference in collagen density in the skin of white mice between white mice given gumitir flower simplicia ointment with a concentration of 0% (pure vaseline) with concentrations of 12.5%, 25% and 37.5%. The conclusion of this research is that gumitir flower simplicia ointment can help the healing process of burn wounds seen from its collagen density.
DETERMINATION OF NON-SPECIFIC AND SPECIFIC QUALITY PARAMETERS OF MARIGOLD SIMPLICIA AS A RAW MATERIAL FOR MEDICINAL PREPARATIONS Martina; Samsuri; I Made Merdana; I Wayan Sudira; Putu Devi Jayanti
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p31

Abstract

Marigold flower (Tagetes erecta L.) is a type of ornamental plant from the Asteraceae family that has significant potential for cultivation due to its numerous uses. Besides being an ornamental flower, a natural dye, and an attractant for pest predators, marigold contains carotenoids, which can act as antioxidants, relieve mild fever and sore throat, serve as a natural moisturizer, and function as a natural mosquito repellent. Given its various beneficial components and properties, marigold has the potential to be used as a raw material for pharmaceutical preparations. This study aims to determine whether marigold flower simplicia meets the requirements as a raw material for pharmaceutical preparations based on non-specific and specific parameters according to established standards. The non-specific parameters include moisture content and ash content tests, while the specific parameters include organoleptic tests, water-soluble extract content, ethanol-soluble extract content, and yield percentage. This research is an observational non-experimental study with a descriptive-qualitative analysis design. Data collection was carried out by conducting non-specific and specific tests to obtain results for each parameter. The obtained results were as follows: moisture content 4.95%, ash content 4.8%, water-soluble extract content 37.34%, ethanol-soluble extract content 28%, and yield 13.48%. Based on these results, it can be concluded that the marigold flower simplicia is suitable and meets the requirements to be used as raw material for medicinal preparations, in accordance with the previously established parameters, namely the Materia Medica Indonesia Volume VI of 1995, the Ministry of Health of the Republic of Indonesia in 2017, and the Regulation of the Head of the Indonesian Food and Drug Authority (BPOM) Number 32 of 2019 concerning the quality requirements for traditional medicines. Further quality standardization tests should be conducted, such as microbial contamination, total aflatoxin, heavy metal contamination, weight uniformity, and alcohol content determination in marigold flower simplicia to establish additional quality standards across different parameters.
THE EFFECT OF NATURAL GUARD SUPPLEMENT IN BROILER DRINKING WATER ON THE HEALTH AND SAFETY OF THE LIVER, SPLEEN, AND KIDNEYS Millaniladzim Baadilla; Ida Bagus Komang Ardana; I Ketut Eli Supartika; I Made Merdana Merdana; Luh Made Sudimartini
Buletin Veteriner Udayana Bul. Vet. Udayana. February 2025 Vol. 17 No. 1
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i01.p18

Abstract

The broiler industry in Indonesia has grown rapidly since the 1970s and has become a primary source of animal protein. However, the health of vital organs such as the liver, spleen, and kidneys plays a crucial role in broiler productivity. Natural Guard (NG) is a feed supplement claimed to benefit these organs, but research on its safety remains limited. This study aimed to evaluate the effect of NG supplementation through drinking water on the health of the liver, spleen, and kidneys in broilers. A completely randomized design (CRD) was used, with four treatment groups: control without NG (P0) and NG supplementation at 1 g/L (P1), 2 g/L (P2), and 4 g/L (P3). Histopathological analysis was performed using Hematoxylin-Eosin (HE) staining, and data were analyzed using the Kruskal-Wallis test. The results showed no necrotic lesions in any group, while congestion and inflammatory cell infiltration were observed at mild to moderate levels without significant differences (P>0.05). This indicates that NG supplementation up to 4 g/L does not cause harmful pathological changes in the liver, spleen, and kidneys of broilers. In conclusion, NG is safe to use as a feed supplement for broilers. Further research is needed to assess its long-term effects and impact on broiler productivity.
Phytochemical Test and Antioxidant Activity of Aqueous Extract of Marigold Flower I Made Merdana; Indira Laksmi Nandita; Pingkan Elia; Ida Ayu Pasti Apsari; I Wayan Gorda; Luh Made Sudimartini
Advances in Tropical Biodiversity and Environmental Sciences Vol. 8 No. 2 (2024): June 2024: Pages 58-118
Publisher : Institute for Research and Community Services Udayana University (LP2M Universitas Udayana)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ATBES.2024.v08.i02.p08

Abstract

Natural medicines are increasingly in demand for safety reasons and are believed to be able to cure certain diseases. Literacy reveals that the marigold flower (Tagetes erecta L.) has medicinal potential as an antioxidant, anti-bacterial, anti-inflammatory, and anti-carcinogen. This research aimed to identify marigold flower aqueous extract's phytochemical content and antioxidant activity. The method used in this exploratory research was the maceration of marigold flower simplicia using distilled water for 24 hours, followed by evaporation to obtain marigold flower aqueous extract. Then, phytochemical screening and antioxidant bioactivity tests were carried out using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The results of phytochemical screening showed that marigold flower water extract contained flavonoids, phenols, alkaloids, and tannins. Meanwhile, the antioxidant activity test obtained an IC50 value of 50.77 ppm. From these results, it can be concluded that the aqueous extract of marigold flowers has medicinal potential with vigorous antioxidant activity.
Co-Authors Adri Yana Rambu Anawenju Afrizal Choirul Umam Agustina, I Putu Sudana Ali, Ahmad Muhammad Alviana Rizqiyah Utami Anak Agung Ayu Mirah Adi Anak Agung Gde Arjana Anak Agung Gde Arjana Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Anastasia Bhala Ari Mogi, I Komang Arinata, I Ketut Teguh Ayu Prawitasari Citra Pratama Bina Ichsantya Darmawan, I Wayan Eka Dini Hilary Manullang Diyasa, I Gede Susrama Mas Domingas Pereira DWI SURYANTO Elsa Hidayati Elti Febilani Febrina Cicilia Br Ginting, Febrina Cicilia Firdaus, Ihsanul Franky Samuel Milenyano Chandra Fuady Muslih Gde Jasmara Muda Gea, Octo Berkat Gede Iwan Setiabudi Gede Yuda Darmadi Putra Genta Dhamara Adam Putranto Gheasella Fia Gunawan Gusti Agung Rama Wiratama Putra Hamong Suharsono Hariyadi, Hariyadi Hartati, Ruth Dwi Hendrawan, I Wayan Dika Wahyu I Dewa Made Nurja Sadhi I Gede Yoga Sukya Sumantara I Gusti Agung Gede Putra Pemayun I Gusti Ayu Sri Darmayani I Gusti Ketut Suarjana I Gusti Ngurah Sudisma I Gusti Putu Tovan Mahottama I GustiKetut Suarjana I Kadek Ariyuda Prasetya I Kadek Parnayasa I Ketut Berata I Ketut Berata I Ketut Eli Supartika I Ketut Suada I Ketut Suada I Komang Ari Mogi I Komang Ari Mogi I Made Damriyasa I Made Dira Swantara I Made Dodi Gunawan I Made Dwinata I Made Kardena I Made Oka Riawan I Made Robi I NYOMAN ADI SURATMA I Nyoman Sarsana I Nyoman Suartha I Nyoman Sulabda I Nyoman Sulabda I Putu Agus Hendra Wibawa I Putu Agus Santika Putra I Putu Dwi Komala Putra I Putu Mangku Mariasa I Wayan Gorda I Wayan Gorda I Wayan Sudira I Wayan Sudira I Wayan Sudira I Wayan Wirata Ida Ayu Pasti Apsari Ida Ayu Pasti Apsari Ida Bagus Komang Ardana Ida Bagus Komang Ardana Ida Bagus Made Oka Ida Bagus Oka Winaya Ika Hartini Hutasoit, Ika Hartini Indira Laksmi Nandita Iwan Harjono Utama Jihadulhaq, Jihadulhaq Kadek Febriana Marta Putra Kadek Teguh Wirasastra Ketut Budiasa Kusuma, Putu Winatha Luh Ani Luh Gde Sri Surya Heryani Luh Made Sudimartini Luh Made Sudimartini Luh Seri Ani Made Gede Adi Surya Saputra Mahardika, I Gusti Bagus Mahmud, Fathmah Martina Millaniladzim Baadilla Monica Lewinsky Ngudiyono Ngudiyono Ni Kadek Eka Widiadnyani Ni Luh Eka Setiasih Ni Luh Eka Setiasih Ni Luh Watiniasih Ni Nyoman Kencanawati Ni Wayan Arya Utami, Ni Wayan Arya Ningsih, Adriati NYOMAN DITA PAHANG PUTRA, NYOMAN Nyoman Sumiati Pingkan Elia Pradipta Hendra Setiawan, Pradipta Hendra Putera, I Gusti Ngurah Dwipayana Putra, I Dewa Agung Made Wihanjana Putra, I Made Arya Udyana Putra, Putu Adi Guna Purwaka Putri, Ayu Chitra Adhitya Putu Devi Jayanti Putu Devi Jayanti Putu Henrywaesa Sudipa Putu Suastika Rama Adi Putra, Rama Adi Sampurno, Ilham Ade Widya Samsuri Samsuri , Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Samsuri Saputra, I Dewa Ketut Ari Setyawati, Luh Gede Sewoyo, Palagan Senopati Sis wanto Siswanto, Riefqy Tepu Sri Darmayani, IGA ST Kholifah Nor Azizati Suci Nur Qurani Teja, Putu Tessa Hariys Septianda Theresia Ene Ujan, Katarina Kewa Yoga Eka Prasetyo Yoga Pratama Mambela Sarungallo