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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Veteriner Microbiology Indonesia Indonesian Journal of Tropical and Infectious Disease UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Halal Science and Research Journal of Clinical Microbiology and Infectious Diseases Jurnal Widya Medika Folia Medica Indonesiana
Ni Made Mertaniasih
Departement Of Medical Microbiology, Faculty Of Medicine Universitas Airlangga, Dr. Soetomo General Hospital Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Prevalence And Pattern Sensitivity Multidrug Antibiotics Resistant Pseudomonas aeruginosa in the High Care Unit at Dr. Soetomo General Academic Hospital Period 2022-2023 Kusumawati, Ratna; Koendhori, Eko Budi; Mertaniasih, Ni Made; Ikhwani, Irfan Arif; Hidayat, Dimas Firman; Levani, Yelvi; Paramitha, Ayu Lidya
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.22152

Abstract

The prevalence of Multidrug antibiotic-resistant Pseudomonas aeruginosa (MDRPA) has been increasing during the decade And has become attention in hospital patients. This retrospective descriptive descriptive aimed to determine the prevalence of MDRPA and its sensitivity patterns. Data were taken from results of bacterial culture and antibiotic resistance tests from various clinical specimens from patients at Dr. Soetomo General Academic Hospital throughout 2022-2023. The resistance test was carried out using a Vitek 2 compact instrument. MDRPA is defined as Pseudomonas aeruginosa that is not sensitive to three or more of the following classes of antibiotics: meropenem or imipenem, ciprofloxacin, gentamicin or amikacin, ceftazidime or cefepime, and piperacillin/ tazobactam. The prevalence of MDRPA was 57.0%. MDRPA isolates were also the most common origin from the burn unit and HCU A (high care unit A), mostly from pus specimens and sputum. Pseudomonas aeruginosa sensitivity was best with piperacillin/tazobactam (55.5%), meropenem (54.8%), amikacin (47.5%), gentamicin (46.5%), cefepime (46.3%), ceftazidime (45.0%), ciprofloxacin (44.7%) and aztreonam (43.2%). The sensitivity of MDRPA to antibiotics is much lower than that of Pseudomonas aeruginosa. This study showed high number of MDRPA specifically in Surabaya and the pattern sensitivity of Pseudomonas aeruginosa can become guidelines in choosing antibiotics treatment for patients.
Prospects of red passion fruit seeds (Passiflora edulis Sims.) as a source of halal probiotics Nurrosyidah, Iif Hanifa; Mertaniasih, Ni Made; Isnaeni, Isnaeni
Journal of Halal Science and Research Vol. 4 No. 1 (2023): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v4i1.7004

Abstract

Indonesia is the most biodiversity country in the world, with a majority Muslim population, so halal issues are a priority. Natural resources are abundant, especially the tropical fruit that Allah SWT bestowed with a wide variety. Red Passion fruit (Passiflora edulis Sims.) is one of the tropical fruits widely consumed because of its delicious taste, rich in vitamins, minerals, and other active ingredients. The research reported that probiotics of Bacillus spp. Isolated from the red passion fruit seeds was proven to inhibit pathogenic microbes. Extended Strain Beta-Lactamase and Methicillin Resistant Staphylococcus aureus. The isolates also showed the ability to increase gamma interferon levels in the peripheral blood mononuclear cells in adult TB patients. Halal critical points for products containing probiotics can derive from raw material sources, especially those from animals. The Red passion fruit is classified as a safe, halal category. The process of isolating probiotics from red passion fruit seeds using fermentation technology in De man Rogose Sharp media, using simple materials, tools, and steps that are guaranteed to be halal. The compatibility of two probiotic isolates is the potential to be developed into a probiotic consortium for health supplement preparations and therapeutic complements.
Positivity of ExoU Gene of Type III Secretion System and Fluoroquinolone Resistance of Psedomonas aeruginosa from Sputum of Nosocomial Pneumonia Patients in Sanglah Hospital, Bali Saputra, I Wayan Agus Gede Manik; Mertaniasih, Ni Made; Fatmawati, Ni Nengah Dwi
Folia Medica Indonesiana Vol. 54, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Pseudomonas aeruginosa is one of the Gram-negative rods bacteria that frequently cause nosocomial pneumonia. One of the main virulent effector proteins on Type III secretion system (TTSS) of P. aeruginosa is Exoenzyme U ( ExoU). ExoU works as a phospholipase A2 activity and exhibits lung tissue injury effect in pneumonia. As an antibiotic that has activity against P. aeruginosa, fluoroquinolone resistance has increased as many as three fold since the last decade. Infections caused by P. aeruginosa that are fluoroquinolone resistant and positive for ExoU gene show worse clinical outcome. The aim of this study was to determine the positivity of ExoU gene TTSS and fluoroquinolone resistance of P. aeruginosa that isolated from sputum of nosocomial pneumonia patients in Sanglah Hospital, Bali. P. aeruginosa isolated from sputum of patient that diagnosed as nosocomial pneumonia, isolates had been identified phenotypically by Vitek2 Compact system (bioMérieux, Inc., Marcy-l'Etoile - France), and then continued by genotypic detection by PCR. The susceptibility testing of P. aeruginosa isolates to Ciprofloxacin were conducted by Vitek2 Compact, whereas ExoU genes were detected by PCR. Fifty-three P. aeruginosa isolates were identified in this study, in which 35 isolates (66.1%) had ExoU gene and 22 isolates (41.5%) were resistant to Ciprofloxacin. Based on nosocomial pneumonia type, the highest proportion of isolates genotipically ExoU+ and phenotypically Ciprofloxacin were on VAP group accounted for 57.1% and 54.5%, respectively. Chi-square analysis showed significant correlation between Ciprofloxacin resistance and ExoU gene (p=0.001). As a conclusion, the positivity of ExoU+ isolates were more likely found in Ciprofloxacin resistant group.
Antibiotic-Producing Streptomyces sp. Isolated from the Soil of a Mangrove Ecosystem Retnowati, Wiwin; Mertaniasih, Ni Made; Purwanta, Marijam; Wiqoyah, Nurul; , Atika; Maharani, Sekar; Mahdani, Wilda
Folia Medica Indonesiana Vol. 59, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. The unexplored soil of mangrove ecosystems in Surabaya, Indonesia, has the potential to be home to biodiversity, including Streptomyces sp. that can produce antibiotics. 2. Streptomyces sp. has antibacterial properties against Gram-positive and Gram-negative bacteria, and the duration of incubation plays a critical role in regulating the antibacterial activity. Abstract A mangrove ecosystem in Surabaya, Indonesia, has a high salinity, pH, potassium, phosphorus, and nitrate contents. This ecosystem comprises a mixture of sand, dust, mud, and clay, which has the potential to be a conducive environment for the isolation of Streptomyces. The importance of Streptomyces in biotechnology lies in its ability to produce bioactive secondary metabolites, which represent a valuable reservoir of antibiotics. This research aimed to assess the antibiotic activity exhibited by Streptomyces sp. isolated from the soil of a mangrove ecosystem in Wonorejo, Surabaya, Indonesia. The analysis focused on the potential of Streptomyces sp. to produce antibiotics that work against Gram-positive bacteria (i.e., Staphylococcus aureus ATCC 25923 and Bacillus subtilis) as well as Gram-negative bacteria (i.e., Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Salmonella Typhimurium). The antibacterial activity test was conducted using the modified agar diffusion method. Observations were performed to identify any clear zone formation around the Streptomyces sp. agar colonies with a diameter of 0.8 cm and a height of 3 mm. The clear zone diameter was measured every 24 hours during the 10-day incubation period to assess the diversity of antibacterial activity. The antibacterial profile of Streptomyces sp. exhibited varying levels of activity against different bacterial strains in the tests conducted. The inhibition zone diameters demonstrated the highest levels of activity in Bacillus subtilis (15.9 mm) on day 7, Staphylococcus aureus (27.6 mm) on day 2, Pseudomonas aeruginosa (24.3 mm) on day 7, Escherichia coli (29.2 mm) on day 5, and Salmonella Typhimurium (27.5 mm) on day 7. The results indicated that Streptomyces sp. had inhibitory effects against Gram-positive bacteria as well as Gram-negative bacteria. In conclusion, Streptomyces sp. is a source of biodiversity found in the soil of mangrove ecosystems and has the ability to produce antibiotics.
Co-Authors , Atika Abdul Rahman Bahmid Agnes Dwi Sis Perwitasari, Agnes Dwi Sis Aisah, Nurul Akirasena, Mayoori Alimsardjono, Lindawati Alvin Hartanto Kurniawan, Alvin Hartanto Ananda, I Gede Yogi Prema Andy Setiawan Asri Darmawati Atik Kurniawati Atika Ayu Lidya Paramita Ayu Lidya Paramitha Bagus Soebadi Budi Suprapti Budi Yanti Budi Yanti Catur Endra Arky, Catur Endra Deby Kusumaningrum Diah Savitri Ernawati Didik Didik Handijatmo, Didik Dimas Firman Hidayat Eko Budi Koendhori, Eko Budi Endraswari, Pepy Fedik Abdul Ratam Hanik Urifah, Hanik Hidayat, Dimas Firman I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Nyoman Wande I Wayan Agus Gede Manik Saputra I Wayan Sugiritama Idha Kusumawati Ikhwani, Irfan Arif Irfan Arif Ikhwani Irwanto Irwanto Isnaeni Isnaeni Isnaeni Isnin Anang Marhana Jayanti Putri, Jayanti Juita, Liza Puspa Senja Asmara Junus, Herisa Nataliana Kadariswantiningsih, Ika Kawilarang, Arthur Pohan Kusmiati, Tutik Kusmiati, Tutik Lestari, Aprilia Dwi Lyndia Effendy Maharani, Sekar Mahdani, Wilda Mangestuti Agil ManikRetno Wahyunitisari Maria Inge Lusida Marsha Maritsa, Olivia Mega Ferdina Suwito Mochamad Amin Mochammad Afif Ziaulhaq Muhammad Amin Muhammad Amin Mulyadi Mulyadi Ni Made Linawati Ni Nengah Dwi Fatmawati Ni Nyoman Sri Budayanti Nurrosyidah, Iif Hanifa Nurul Wiqoyah, Nurul Nuswantoro, Djohar Paramitha, Ayu Lidya Pepy Dwi Endraswari, Pepy Dwi Permatasari, Ariani Priyo Hadi Purwanta, Marijam Putranto, J.Nugroho Eko Raharjo, Dadik Rarome, Berlian Beatrix Ratna Kusumawati Ratna Kusumawati Rebekah Setiabudi, Rebekah Reiska Kumala Bakti Resti Yudhawati Retno Asih Setyoningrum Risa Etika, Risa S. Soedarsono Sakran, khawla Abdullah Salsabila, Sabila Sampurna, Mahendra Tri Arif Saputra, I Wayan Agus Gede Manik Sari, Trias Kusuma Sekar Maharani Setiawan, Firman Silvia Sutandhio Soedarsono Soedarsono SOETJIPTO . Soetjipto Soetjipto Sugeng Harijono, Sugeng Sulistyowati, Titiek Titiek Sulistyowati Titiek Sulistyowati Titiek sulistyowati VICTOR EKA NUGRAHAPUTRA Wayan Tunas Artama Widya, Alicia Margaretta Wilda Mahdani Wiwin Retnowati Yelvi Levani Yitijuatni Yudayanti, Elprania Credo