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All Journal HAYATI Journal of Biosciences Jurnal Veteriner Pharmaciana: Jurnal Kefarmasian Biota Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Mandala Pharmacon Indonesia Dinamika Journal : Pengabdian Masyarakat Narra J INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Farmasi Indonesia
Firzan Nainu
Fakultas Farmasi, Universitas Hasanuddin
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Chemical fingerprinting and antioxidant properties of Glochidion philippicum Khairuddin, Khairuddin; Manggau, Marianti A.; Rante, Herlina; Hardiyanti, Widya; Latada, Nadila P.; Umar, Abdul H.; Nur, Syamsu; Wahyudin, Elly; Rahman, Latifah; Yulianty, Risfah; Nainu, Firzan
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1886

Abstract

Glochidion philippicum has been suggested to exhibit considerable pharmacological potential, yet its chemical composition and bioactivity remain inadequately explored. The aim of this study was to investigate the chemical fingerprint and antioxidant properties of G. philippicum leaf extracts using Fourier-transform infrared spectroscopy (FTIR) with chemometric analyses, and in vitro and in vivo evaluations. Four extraction methods (maceration, reflux, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE)) were optimized with water, 70% ethanol, ethyl acetate, and n-hexane as solvents. FTIR profiles were analyzed with principal component analysis (PCA), hierarchical cluster analysis, and orthogonal partial least squares discriminant analysis. An in vitro study assessing the free radical scavenging capacity was conducted using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) methods, while in vivo evaluations were conducted using Drosophila melanogaster to measure antioxidant enzyme activity and expression of endogenous antioxidant-related genes. FTIR profiles identified functional groups contributing to antioxidant activity. In vitro assays using ABTS and FRAP methods revealed that extracts obtained with 70% ethanol and water exhibited the highest antioxidant activity, attributed to key functional groups such as C=C (aromatic), O−H (acidic), N=O (nitro), and C−O (ester). In vivo studies showed that ethanol-based MAE extracts (MAEEO) significantly improved the survival of autoinflammatory PGRP-LBΔ mutant larvae exposed to heat-killed Escherichia coli. Real-time quantitative PCR analysis indicated this effect was dependent on endogenous antioxidant gene activation. The study highlights that G. philippicum leaf extracts as a natural source of bioactive compounds with exogenous antioxidant properties, offering potential for therapeutic applications.
Dual effects of Camellia sinensis and Andrographis paniculata on hyperglycemia and infection in Drosophila Nainu, Firzan; Sartini, Sartini; Subehan, Subehan; Sari, Dwi K.; Bahar, Muhammad A.; Mudjahid, Mukarram; Latada, Nadila P.; Asbah, Asbah; Hardiyanti, Widya; Pratama, Muhammad R.; Suhenro, Suhenro
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1972

Abstract

The coexistence of hyperglycemia and infectious diseases represents a critical global health challenge, particularly in resource-limited settings where it amplifies disease severity and complicates treatment approaches. Medicinal plants such as Camellia sinensis and Andrographis paniculata have gained recognition for their antioxidant, anti-inflammatory, and antimicrobial properties, making them promising candidates for addressing this double health burden. The aim of this study was to establish a preclinical model of hyperglycemia and infection (HI model) using Drosophila melanogaster and to investigate the therapeutic potential of C. sinensis and A. paniculata extracts in alleviating the burden associated with the HI condition. In this study, the HI model was established by simultaneously exposing D. melanogaster larvae to a high-concentration sucrose solution and Staphylococcus aureus for 24 hours. The larvae were then transferred to a high-sucrose diet supplemented with C. sinensis or A. paniculata extracts. Survival assays and molecular analyses were subsequently performed to evaluate the outcomes. Our findings revealed that the combination of hyperglycemia and infection significantly reduced survival rates in the Drosophila model. However, treatment with 1.25% C. sinensis and A. paniculata extracts notably improved survival, attributed to their antibacterial activity and regulation of key molecular pathways involved in immune responses, metabolic balance, and endogenous antioxidant defenses. These findings validate the utility of D. melanogaster as a model organism for investigating the double burden of HI. Furthermore, the study offers compelling evidence of the dual therapeutic potential of C. sinensis and A. paniculata in mitigating the detrimental effects of this condition. Overall, this research underscores the significant promise of plant-derived compounds in managing HI and paves the way for future studies to explore their underlying mechanisms and potential clinical applications.
Eksplorasi efek etanol terhadap survival dan status imunitas Drosophila melanogaster Rosa, Reski Amalia; Latada, Nadila Pratiwi; Asbah, Asbah; Mu'arif, Ahmad; Yulianty, Risfah; Nainu, Firzan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.803 KB) | DOI: 10.35617/jfionline.v13i2.85

Abstract

: High doses of ethanol in the body can elicit damage to organs including the brain, liver and kidneys. In addition, ethanol can trigger the formation of reactive oxygen species (ROS), where excess levels of ROS in the body can promote cell death through the apoptotic pathway. Apoptotic cells that are not phagocytosed will undergo necrosis. In the process of necrosis, cells release DAMPs, endogenous pro-inflammatory molecules and induce the core immune system in Drosophila that are homologues to humans, namely Toll, IMD (Immune Deficiency), and JAK-STAT (Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription). The aim of this research is to investigate how ethanol exposure influences gene expression in the Toll, Imd, and JAK-STAT pathways. The results showed that ethanol could affect the survival rate of male and female Drosophila melanogaster w1118. Exposure to ethanol at high concentrations (85%) caused a decrease in the expression of Drs, but not the expression of the Dpt. In addition, TotA expression, but not Upd3, was amplified significantly as the ethanol concentration increased. In conclusion, Drosophila experienced a decrease in the survival rate due to ethanol exposure which might be related to the stress response and the immune system which is mediated by certain pathways.
Review : Penggunaan Drosophila melanogaster Sebagai Organisme Model Dalam Penemuan Obat: Review : Application of Drosophila melanogaster as Model Organism in Drug Discovery Nainu, Firzan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.176 KB) | DOI: 10.22487/j24428744.2018.v4.i1.9969

Abstract

Uji pra-klinis kandidat obat baru menggunakan organisme model yang sesuai adalah salah satu fase yang wajib dilaksanakan dalam proses penemuan obat. Namun, seiring dengan meningkatnya perhatian masyarakat dunia terhadap etika penggunaan organisme model tradisional seperti mencit dan tikus, keberadaan organisme model alternatif pun sangat diperlukan. Untuk tujuan tersebut, lalat buah Drosophila melanogaster merupakan salah satu model yang patut diperhitungkan. Selain sejarah penggunaannya yang telah cukup lama, organisme model ini merupakan serangga di balik kesuksesan ilmuwan dalam mempelajari patogenesis penyakit mulai dari penyakit neurodegeneratif hingga sindrom metabolik terkait obesitas dan diabetes melitus. Oleh karena itu, tidaklah mengherankan jika delapan medali Nobel telah diberikan kepada para peneliti yang menggunakan Drosophila dalam eksperimen mereka. Pemetaan genom yang telah berhasil dilakukan menunjukkan bahwa Drosophila memiliki kemiripan genetik sekitar 75% dengan manusia. Ditunjang dengan ketersediaan berbagai model penyakit baik melalui manipulasi genetik (mutan/transgenik) maupun melalui induksi secara kimiawi, Drosophila merupakan organisme model yang sangat menjanjikan untuk digunakan dalam riset biomedik. Dengan tersedianya berbagai model penyakit dan informasi terkait Drosophila melanogaster yang mudah untuk diakses, penggunaan model penyakit berbasis lalat buah dalam proses penemuan obat merupakan salah satu terobosan yang layak untuk dipertimbangkan. Bukan tidak mungkin jika di kemudian hari model mungil ini akan menggantikan penggunaan hewan model tradisional dalam pengujian pra-klinik kandidat obat baru.
Fungi Endofit dari Tanaman Secang (Caesalpinia sappan L) Sebagai Penghasil Senyawa Antioksidan: Endophytic Fungi from Secang (Caesalpinia sappan L) as Producer of Antioxidant Compounds Amirullah, Amirullah; Sartini, Sartini; Nainu, Firzan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.294 KB) | DOI: 10.22487/j24428744.2019.v5.i1.12013

Abstract

Endophytic fungi are microbes that reside symbiotically in the plant tissues with undetected negative impacts to their host plants. These fungi are able to produce elements similar to those produced by their host plants. Secang (Caesalpinia sappan L.) has been known as one of the medicinal plants that contains compounds with antioxidant activity thus promote a hypothesis that its endophytic fungi may yield a similar antioxidant effect. In this study, the isolation of endophytic fungi from Secang as the producer of antioxidant compounds was carried out. At the initial stage, endophytic fungi were isolated from the leaves, the twigs, the stems, and the rootsof Secang using the agar plate method. Pure fungi isolates were then subjected to fermentation process using the PDBgrowth medium supplemented with yeast extractand wereconstantly shaken for 12 days at a speed of 200 rpm to produce secondary metabolites. Fermentatesobtained from all fungi isolates were then extracted using ethyl acetate and further tested for their antioxidant activities. In this study, of 19 isolates that were obtained from four parts of the Secang, five fungi isolates, coded as IFD1, IFD4, IFR5, IFA1, and IFA2 were found to yield antioxidant activities demonstrated by the presence of yellow spots on the chromatogram. elementary schools representatives “not good ranking”, the education did not influence their knowledge with a p value of 0.149. Analysis of the Wilcoxon test in all elementary schools showed a p value p ≤ 0,001, which meant that education had an influence on the knowledge of fifth grade students in elementary schools in Palu City.
Pemberdayaan unit Center of Excellence Fakultas Farmasi UNHAS melalui produksi produk inovatif minuman instan Ginger Creamy Plus Sartini, Sartini; Djide, Nana Juniarti Natsir; Nainu, Firzan; Amir, Muhammad Nur; Mangilep, Muhammad Agung Ady
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v6i2.592

Abstract

One of the key performance indicators (KPI/IKU) of the Ministry of Higher Education and Science and Technology is IKU 5: community recognition of lecturers' research outcomes. The PPUPIK-UNHAS community service program aimed to promote lecturers' innovative products for broader public recognition. In this community service initiative, we introduced an instant ginger-based beverage (Zingiber officinale), developed by modifying the traditional Sarabba drink with bee pollen. Ginger is well known for its health benefits, including antioxidant properties, improved digestion, pain and inflammation relief, enhanced immunity, and preventing nausea and vomiting. Including bee pollen—rich in amino acids, flavonoids, B vitamins, and minerals—further enhances the drink's functional health effects. The resulting product, Ginger Creamy Plus, was formulated as an instant drink, with each sachet containing 1.2 g of ginger and 0.3 g of bee pollen. This innovation has been registered with HAKI under the simple patent category and has received a P-IRT business permit. It is expected to be commercialized on an industrial scale in collaboration with UNHAS business units and registered with the Food and Drug Supervisory Agency.
Co-Authors Aamer Ikram Abdeen, Ziad Acharya, Yogesh Ahmad Mu'arif Ahmad Najib Ai Koyanagi Aksa, Rahmad Amanda Yufika Amir, Muhammad Nur Amirullah -, Amirullah Anak Agung Dewi Megawati, Anak Agung Dewi Anastasia Bondarenko Andi Maghfirah Nurul Fitri Andri Frediansyah Andri Frediansyah, Andri Arba, Muhammad Arsyik Ibrahim As'ad, Muhammad F. Asbah, Asbah Asri, Rangga M. As’ad, Muh. Fadhil Bahar, Muhammad A. Bapulo, Nurdewi N. Base, Nurul Hidayah Bob Wilffert Bohari Yusuf Bondarenko, Anastasia Chadran, Deepak Chaeratunnisa, Rizkya Chandran, Deepak Deepak Chandran Dewi Megawati Dewi Purwaningsih Dewi Yuliana Dewita Fatiah Dina E. Sallam Dini Ayu Ariastiwi B Djide, Nana Juniarti Natsir Elly Wahyudin Emil Salim Emran, Talha B. Endang Mutiawati Rahayuningsih* ENDANG MUTIAWATI, ENDANG Fahriani, Marhami Fajar, Jhonny K. Fathima, Raisha Fatmawati Fatmawati Fauzi Yusuf Fauzi Yusuf, Fauzi Filmaharani, Filmaharani Francesco Rosiello Gemini Alam Habibie Habibie HANIFAH YUSUF Hanifah Yusuf Harapan Harapan Harapan Harapan Harapan Harapan Hardiyanti, Widya Hassan , Wardah Herlina Rante Herlina Rante Herman Herman Hibban Ar Royan Husnah, Milda I Made W. Wardhana Ikram Ikram Ikram, Aamer Ilmawan, Muhammad Iqhrammullah, Muhammad Irfan Ullah Islamudin Ahmad Ismail Ismail J. Smith Torres-Roman James-Paul Kretchy Jhonny K. Fajar Jonny K. Fajar Katarzyna Kotfis Kazmi, Syeda K. Keam, Synat Khader, Yousef Khaerani, Mufliha Khairuddin - Khan Sharun Kidoura, Yuto Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kurnia F. Jamil Kurnia F. Jamil Laode Rijai Latada, Nadila P. Latada, Nadila Pratiwi Latief, Kamaluddin Latifah Rahman Lee Smith Lemu, Yohannes K. Lucia Ratna Winata Muslimin M. Natsir Djide M. Natsir Djide Maelani, Imelda Maliga, Helnida A. Malik Sallam Mamada, Sukamto Mamada, Sukamto S. Mangilep, Muhammad Agung Ady Marhami Fahriani Marianti A Manggau Marianti A.Manggau Marius Rademaker Masyeni, Sri Mellinia, Sania A. Memish, Ziad A. Milda Husnah Mirhansyah Ardana Mu'arif, Ahmad Mudatsir Mudatsir Mudjahid, Mukarram Mufidah Murdifin Muh. Akbar Bahar Muhammad Ahsan Muhammad Ilmawan Muhammad J. Tahir Muhammad Natsir Djide Mutiara, Suci Nakanishi, Yoshinobu Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Nur Rahma Rumata Ophinni, Youdiil Pratama, Muhammad R. Putri, Annisa A. Putri, Tenri ZAD. Rademaker, Marius Rangga Meidianto Asri Rezky Yanuarti Risfah Yulianty Rochmat Himawan Rosa, Reski A. Rosa, Reski Amalia Rosa, Sandro GV. Rosany tayeb Rosiello, Francesco Royan, Hibban Ar Rudi Arfiansyah Rudi Arfiansyah Rudi Arfiansyah Rudi Arfiansyah sakiya syahrir sudirman Salin Sirinam Sallam, Dina E. Sallam, Malik SALSABILA, ANNISA Samsul Anwar Sandro GV. Rosa Sandro Vento Sari, Dwi K. Sarifuddin Sarifuddin Sartini Sartini Sartini Sartini Selvi Jumiatul Astati Sharun, Khan Shiratsuchi, Akiko Sirinam, Salin Sitti Hadijah Sitti Nurhamidah Smith, Lee Subehan Subehan Subehan, Subehan Suhenro, Suhenro Sukamto Mamada Sukamto S. Mamada Syahraini, Aigia Syamsu Nur, Syamsu Syeda K. Kazmi Synat Keam Tahir, Muhammad J. Takayuki Kuraishi Talha B. Emran Toriba, Akira Torres-Roman, J. Smith Tri Puspita Roska Tri Puspita Roska Ullah , Irfan Umar, Abdul H. Usmar Usmar Usmar Usmar Vento, Sandro Wardah Hassan Yesi Astri Yogesh Acharya Yohannes K. Lemu Youdiil Ophinni Yousef Khader Yufika, Amanda Yulia Yusrini Djabir Ziad A. Memish Ziad Abdeen Zubair, Muhammad S.