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ANALISIS SISTEM PENATAAN DAN LASHING MUATAN DI KAPAL RO-RO SEBAGAI UPAYA DALAM MENINGKATKAN KESELAMATAN PELAYARAN Agustiawan, Galih Sakti Cahyo Samudro Armando; Kuncowati, Kuncowati; Supangat, Supangat
Zona Laut : Jurnal Inovasi Sains Dan Teknologi Kelautan Volume 7, Number 1, March 2026 Edition
Publisher : Departemen Teknik Kelautan Universitas Hasanuddin

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Abstract

Cargo arrangement and lashing systems on Ro-Ro vessels play an important role in maintaining ship stability and navigation safety. This study aims to evaluate the effectiveness of cargo arrangement and securing practices on a RoRo vessel and to identify the factors affecting their performance. The research employed a quantitative descriptive method through direct observation, literature review, and questionnaires distributed to 10 crew members of KM Mutiara Ferindo 5. The results show that 70% of the crew had not received formal training, 40% considered the lashing process not yet in accordance with standards, and 50% stated that full lashing was only carried out during bad weather conditions. The main problems identified include the absence of written standard operating procedures, worn lashing equipment, and inconsistent supervision. This study recommends the preparation of standard operating procedures and a Cargo Securing Manual, regular technical training, and periodic inspection and renewal of lashing equipment to improve navigation safety and reduce the risk of cargo shifting.
Alteration of Metformin Pharmacokinetic Profile in Rats Exposed to a Low Dose of Chlorpyrifos Insecticide Wisudanti, Desie Dwi; Abrori, Cholis; Sakinah, Elly Nuru; Komariah, Cicih; Supangat, Supangat
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.15-21

Abstract

Chlorpyrifos (CPF) is an organophosphate pesticide widely used by farmers to control pests and has a broad spectrum of action. Research has shown that organophosphate pesticides can affect efflux pumps, specifically P-glycoprotein (P-gp), which can alter drug absorption and metabolism, indicating the potential risk of changes in a drug's pharmacokinetic profile, which could affect the effectiveness of drugs such as Metformin. This study investigated the impact of low-dose CPF exposure on the pharmacokinetic profile of Metformin, a first-line treatment for type 2 diabetes mellitus (T2DM). This study used 16 rats to examine Metformin's pharmacokinetic profile and 12 for the creatinine clearance examination. The rats were divided into two groups: a control group given normal saline (+5% Tween 20) and a group given CPF 5 mg/kg BW/day, each administered for 7 days. Metformin was administered on day 8, and pharmacokinetic parameters were assessed using UV-HPLC by measuring metformin plasma levels at 0.5, 1, 2, 4, 6, 8, 12, and 24 hours. Serum creatinine levels were examined in 12 rats using the Jaffe method on day 8 after treatment. The pharmacokinetic analysis showed that there was a change in the metformin profile following CPF administration: an increase in the area under the curve (AUC) and peak concentration (Cmax), along with a decrease in time to peak concentration (Tmax), half-life (T½), clearance (Cl), and volume of distribution (Vd). Serum creatinine levels in the CPF-administered group increased significantly (p<0.05). Further research, including pharmacodynamic assessment and clinical trials, is recommended to guide therapeutic decisions in populations with pesticide exposure.
Co-Authors Abdul Ghofur Ade Rosad Agustiawan, Galih Sakti Cahyo Samudro Armando Ahmad Rosulana Ahmad Ulin Niam Akbar, M. Agung Al Munawir Aldri Frinaldi Alzitawi, Diaya Uddeen Deab Mahmoud Amir Tajrid Andika Saputra Angga Mardro Raharjo, Angga Mardro Anis Rahmawati Amna Annisa Annisa ansori ansori Arifa Mustika Aris Prasetyo Astri Ahmad, Wa Ode Athoillah, Nabil Azah Zumroh Baehaqi BJ Azmy As'ady Cholis Abrori, Cholis Cicih Komariah Dandi Dedy Mardiansyah Delastri , Lita Delastri, Ilta Desie Dwi Wisudanti Dwi Rohman Soleh, Dwi Rohman Dwisaraswati, Salma Aulia Dyah Pravitasari Dyah Pravitasari El Syam, Robingun Suyud Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Etty Nur Rahmawati Hairrudin Hairrudin HARJA, HARLINA Heri Triyanto, Heri Ida Srisurani Wiji Astuti Indey, Jennifer Florenzia Indey Ira Farazulika Jaelani, M Syahran Jamrizal, Jamrizal Januantoro, Ardy Jauhar Firdaus Jumanto Jumanto Justina Evy Tyaswati, Justina Evy Kasful Anwar Us, Kasful Anwar Khoiriyah, Ina Yatul Kristianningrum Dian Sofiana Kuncowati Kusumastuti, Inke Lailatul Fitriyah Laksmi Indreswari Listriyawati, Nyoman Marsudi, Sugeng Maulana Anwar Muhammad Rizki Afrizal Azhar Mukarromah, Laylatul Fitriyah Mukri, Anang Nelly Rustiati Ni Ketut Sujati Nor Kholidin NUR HASANAH Nurlita Dwi Oktavia Panji Kuncoro Hadi, Panji Kuncoro Pertiwi, Ratih Purnama Pralampita, Pulong Wijang Purnama Pertiwi, Ratih Raden Arfan Rifqiawan Raden Arfan Rifqiawan, Raden Arfan Rahmat, Indra Samudra Ratna Dewi, Tri Reny Ekawati Resti Septikasari Rismilda, Nela Aprilia Rochman, Mochamad Yovi Fatchur Rodin, Imam Rohmane, Syaiful Rukmanah Rukmanah Rumastika, Nindya Shinta Rustiati, Nelly Sahidin . Sakinah, Elly Nuru Samudra, Farel Rigel Sanad, Zakeya Saptia pratiwi, Mega septa surya wahyudi, septa surya Setiawan, Wahyu Danni Sheilla Rachmania, Sheilla Sholiq, M. Mudhafiq Siti Aisyah Sri Enggar Kencana Dewi Suhartono Suhartono Sukatin, Sukatin Sutaman, Sutaman Suwandi Suwandi Syaifullah, Firman Tri Ratna Dewi Ulum, M. Samsul Usman, Raihan Gymnastiar Usman Wibsono, Sony Widodo, Muhammad Rifqy Alvy Winarni, Dwi Putri Wiyono, S. Teguh yuliantoro, ahmad taufiq Zulkifli, Noor Fadzilah binti