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Siti Nurbaya
Mahasiswa S1 Prodi PGSD
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Journal : Journal of Tropical Biodiversity

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Potential of Flavonoid Compounds from Rhodomyrtus tomentosa as Anticholesterol: An In Silico Study Lumbantoruan, Lamtiur; Sinaga, Ernawati; Simanjuntak, Kristina; Nurbaya, Siti; Prasasty, Vivitri Dewi
Journal of Tropical Biodiversity Vol 4 No 3 (2024): August 2024
Publisher : Universitas Nasional Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59689/bio.v4i3.232

Abstract

Indonesia's biodiversity ranks second largest in the world. This vast potential, if managed well, can be utilized as raw materials for medicines. Currently, 96% of drug raw materials in Indonesia are still imported, making medicines expensive. Therefore, efforts are needed to achieve self-sufficiency in drug raw materials, including researching Indonesian plants with potential as hypercholesterolemia drugs to be used as native raw materials. This study aims to determine the potential of flavonoid compounds in Rhodomyrtus tomentosa fruit as an alternative hypercholesterolemia drug. Six flavonoids were identified: myricetin, quercetin, quercetin 7,4'-diglucoside, dihydromyricetin, kaempferol, and vitexin in R. tomentosa (Karamunting) fruit. The method used was an in silico study. In silico studies are used to screen compounds based on their mechanism of action against target proteins. In this study, myricetin, quercetin, dihydromyricetin, kaempferol, quercetin 7,4'-diglucoside, and vitexin were subjected to molecular docking using Autodock Vina software to determine the affinity and interaction of these six compounds with the HMG-CoA reductase enzyme, which acts as an intermediary in the mevalonate pathway for cholesterol metabolism. Simvastatin, a drug used for hypercholesterolemia treatment, was used as a comparison. The molecular docking results showed that the binding energy values for myricetin, quercetin, dihydromyricetin, kaempferol, quercetin 7,4'-diglucoside, and vitexin were -10.0, -9.4, -9.6, -9.2, -11.4, and -9.9 kcal/mol, respectively. These six flavonoid derivatives from Karamunting fruit have better inhibition scores compared to simvastatin, indicating that these flavonoid derivatives can inhibit cholesterol biosynthesis better than simvastatin and have potential as anticholesterol drugs.
Co-Authors . Zulfan Adiansyah Adiansyah, Adiansyah Ahmad Gazali, Ahmad Aini, Yulis Nurul Albert Rufinus Allevia Yumnanisha, Defin Anisa Anisa Aryo Tedjo Asnuddin, Asnuddin asyir, alfiah Asyir, Alfiah Khoiri Ayu Sulasari Azhar Alam Baharuddin Hamzah Bambang Suryanto Baroroh Lestari Br Brahmana, Nettietalia Chandra, Devina Chotimah, Octavia Christianta, David Dalimunthe, Agusmal De Lux Putra, Effendy Derlina . Dicky Yuswardi Wiratma Dwi Astuti, Leny Ellyn Eka Wahyu Eriwaty Silalahi, Yosy Cinthya Ernawati Sinaga Evelina, Tri Yulistyawati fahima, sinaida Faruqi, Muhammad Fauzi Ahmad Muda Fiernaningsih , Nilawati Fitrah, Harisa Fitri, Raissa Fitriani Fitriani Ginting, Pitalokasari br Gustiara, Gustiara Hasniati, Hasniati Hermawansyah Hermawansyah Hermiza Mardesci Heru Utomo, Heru Hutauruk, Dumartina Irianti Handayani, Supri Kholis Ridho, Kholis La Ode Sumarlin Laksono Trisnantoro Lestari, Wita Lumbantoruan, Lamtiur Manase, Pebrianti Manurung, Kesaktian Marpaung, Jon Kenedy Meyliana Wulandari Monica Suryani Muhammad Irfan MUHAMMAD TAUFIK Nasaruddin Nurfadillah, Ainaya Nurhalisa, Nurhalisa Nuriyanti Sirait Nurussakinah, Nurussakinah Palandi, Esther Hesline Pangaribuan, Novalina Perri, Perri Poernamawati, Diana Eka Pratiwi, Aulia Febriyanti Priltuis, Natanael Puji Sari Purba, Trionaldo Purwandari, Vivi Purwantini, Mei Rahmah, Fiska Rejekinta Munthe, Alfian rubino, rubino Ruslan Safwan, Ahmad Gazali Salsabila Shofia Rahma Samran, Samran Sapitri, Alfi Sembiring, Rinawati Setyawan Pujiono Sianipar, Artha Yuliana SIHOMBING, IWEL SUDARNO Silitonga, Maringan Simanjuntak, Kristina Simarmata, Yettrie Simatupang, Aprili Yanti Sitanggang, Berton Sitanggang, Eva Priasanti Sitanggang, Pontisari Siti Faridah Siti Maimunah Siti Nuryanti Sitompul, Desi Sitorus, Elly Sitorus, Elly Nurita Sitorus, Panal Situmorang, Winton F. Siva Fauziah, Siva Sofwan, Ahmad Gazali Sofyan . Sudjanarti, Dwi Suharyanisa Sukayasa Sumardi . Supartiningsih - - Supendi, Egih Suprianto Suprianto SURBAKTI, CHRISTICA ILSANNA Syahriani Syahriani, Syahriani SYAIFUL BAHRI Syed Azhar Syed Sulaiman, Syed Azhar Syed Tang, Muhammad Tarigan, Yenni Gustian Thaib, Cut Masyithah Tri Yulistyawati Evelina urai salam Veranita, Weri Vivitri Dewi Prasasty Wahyu, Ellyn Eka Wardani, Tri Istining Yamin, Ashabul Yanti Musyawarah Yosy Cinthya Eriwaty Silalahi Yusra, Yusra Zainuddin, Zainuddin Zuhairiah Nasution, Zuhairiah