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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Akuakultur Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Buletin Peternakan JURNAL KIMIA SAINS DAN APLIKASI Jurnal Teknosains Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Biodidaktika : Jurnal Biologi dan Pembelajarannya Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Aquaculture Journal Jurnal Riset Akuakultur Jurnal Medik Veteriner ARSHI Veterinary Letters Berkala Penelitian Hayati Jurnal Kedokteran Hewan Jurnal Medika Veterinaria
Agustin Indrawati
Bagian Mikrobiologi Medik, Departemen Ilmu Penyakit Hewan Dan Kesmavet, Fakultas Kedokteran Hewan Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Social Sciences Veterinary Other

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Deteksi Gen Resistensi Aeromonas hydrophila yang Diisolasi dari Budidaya Ikan Lele Di Jambi titis wulandari; Tri Wiyoko; Tri Wera Agrita; Nabila Swarna Puspa Hermana; Agustin Indrawati
Jurnal Penelitian Pendidikan IPA Vol 10 No 2 (2024): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i2.6868

Abstract

Aeromonas hydrophila is one of the causative agents for Motile Aeromonas Septicemia (MAS) in catfish. MAS treatment is generally carried out by administering antibiotics. This study aimed to determine the antibiotic resistance profile of A. hydrophila and detect the presence of resistance genes. The samples are archived A. hydrophila isolates isolated from catfish ponds in the district of Muara Jambi, Bungo, Jambi Province, and Merangin total of 18 isolates. Testing the antibiotic resistance profile was carried out using the disk diffusion method against tetracycline, oxytetracycline, ampicillin, amoxicillin, ciprofloxacin, enrofloxacin, and streptomycin. The detected resistance genes were ampC, qnrA, qnrB, and qnrS. The results showed A. hydrophila isolates were resistant to tetracycline (100%), oxytetracycline (94.42%), ampicillin (77.70%), and amoxicillin (77.72%) and still sensitive to ciprofloxacin (83.32%), enrofloxacin (100 %), and streptomycin (100%). The ampC gene was found in 8 out of 14 isolates resistant to beta-lactam antibiotics (57.14%). The qnrA and qnrS genes were found in 3 out of 4 isolates resistant to quinolone antibiotics (75%), while qnrB was found in 1 isolate (25%). A. hydrophila isolated from catfish ponds in Jambi develops resistance to antibiotics and resistance genes found in isolates resistant to antibiotics.
Computational screening of boswellic acid for its antibacterial activity against acne-causing bacteria via molecular docking Dedi Damhuri; Ietje Wientarsih; Rini Madyastuti Purwono; Agustin Indrawati; Asri Rizky; Jessica Anggun Safitri; Ahmad Syarifuddin
Jurnal Teknosains Vol 15, No 1 (2025): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.106278

Abstract

Acne vulgaris (AV) is a common inflammatory-skin disorder associated with bacterial infections, particularly Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The rising resistance to conventional antibiotics has prompted the exploration of natural compounds such as boswellic acid, which is known for its antibacterial potential. This study aimed to evaluate the antibacterial activity of boswellic acid using an in-silico approach through molecular docking against several essential bacterial target proteins implicated in acne pathogenesis. The boswellic acid ligand was obtained from the PubChem database, while the three-dimensional structures of the target proteins were retrieved from the RCSB Protein Data Bank. Blind docking was performed using AutoDock Tools version 1.5.7 and AutoDock Vina, followed by interaction analysis using Discovery Studio Visualizer and Visual Molecular Dynamics (VMD). Nine bacterial proteins involved in vital cellular processes such as metabolism, protein synthesis, biofilm formation, and DNA replication were selected, including transcriptional regulator TcaR, penicillin-binding proteins (PBPs), tyrosyl-tRNA synthetase (TyrRS), 3-ketoacyl-ACP synthase III (KAS III), CRISPR-associated protein, DNA gyrase, transcriptional regulator MarR, methylmalonyl-CoA epimerase, and accumulation-associated protein (Aap). The docking results demonstrated that all target proteins exhibited negative binding energy values (< 0), indicating thermodynamically stable and spontaneous interactions. Among these, TcaR displayed the highest binding affinity with a binding energy of −10.2 kcal/mol and formed nine conventional hydrogen bonds, reflecting a particular and stable interaction. Key interacting residues included Gln: B61, HisA:42, AsnA:20, AsnB:17, and Arg1:110. In contrast, the Aap protein formed only one covalent bond, indicating the weakest interaction. These findings suggest that boswellic acid effectively inhibits key bacterial proteins, particularly those involved in transcriptional regulation and biofilm development. Therefore, boswellic acid holds significant potential as a safe and effective topical antibacterial agent for further growth in biomedical engineering-based formulations.
Co-Authors . Darniati Aditya Primawidyawan Afifah Nurhasanah Afiff , Usamah Agus Sjahrurachman ahmad syarifuddin Ambar Retnowati Ambar Retnowati ANGELA MARIANA LUSIASTUTI Angela Mariana Lusiastuti ANGELA MARIANA LUSIASTUTI Apris Beniawan Ardiana Ardiana Arum, Diah Sekar Asri Rizky Bayu Febram Prasetyo Betty Ernawati Damhuri, Dedi Damiana Rita Ekastuti Darniati D, Darniati Denny Widaya Lukman Destri Prameswari, Alvira Diah Sekar Arum Dwi Endrawati Edi Purwanto Elmanaviean Eni Kusumaningtyas Erdina Pangestika Erin Kurnianingtyas Fachriyan H Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fadlilah, Ulfi Nurul Fera Ibrabim Guntari Titik Mulyani Hadri Latif Hamdika Yenri Handayani Halik Handina Rakhmawati HELGA SEEGER Hendarko, Sriani Herwin Pisestiyani I Wayan T. Wibawan I wayan Teguh Wibawan Idwan Sudirman Ietje Wientarsih Ita Krissanti Jefri Naldi Jeni Maharani Jessica Anggun Safitri Julia Rosmaya Riasari Kuntum Khoirani Kurnia Tiara Aulia Lee Xia Meen Leila Nur Aziah Leila Nur Azizah Lila Gardenia Madyastuti, Rini Maharani, Jeni Mangaraja Pidoli Tampubolon Mardiastuti Mardiastuti MICHAEL ZSCHÖCK Mira Mawardi Mirnawati Bachrun Sudarwanto Mirnawati Sudarwanto Muh Ramadhan Nabila Swarna Puspa Hermana Nabila Swarna Puspa Hermana Nabila Swarna Puspa Hermana Nafiqoh, Nunak Naldi, Jefri Nauval Firdana, Chorrysa Navasuriya Radha Krisnan Nazmi Zahir B. Mohd Zaini Ni Luh Putu Ika Mayasari Ni Luh Putu Ika Mayasari Nining Arini Novita, Hessy Nurhasanah, Afifah Nurul Fadillah Nurul fadillah, Nurul Oktaviani, Dian Okti Nadia Poetri Penataseputro, Tanjung Pratitis S Wibowo Pratitis S Wibowo Rahmat Hidayat Rahmat Hidayat Ramadhaniah, Vetty Reinilda Alwina Retno D. Soejoedono Retno Damajanti Retno Damayanti Soejoedono Rifky Danial Rifky Rizkiantino Risqika Aqla Velayati Romsyah Maryam Rukmi, M.G. Isworo Ryan Septa Kurnia Safika S, Safika Sapto Andriyono Sartika Juwita Seruni Agistiana Setiadi Setiadi Siti Fatimah Siti Gusti Ningrum, Siti Gusti Siti Nur Jannah Sucitya Purnama Suhartila Suhartila Suherman . Surachmi Setiyaningsih Susan M Noor Susan M Noor Susanti, Wiwik Susanto Nugroho Syahidah, Dewi Teguh Budipitojo Titiek Sunartatie Titis Wulandari Tri Wiyoko Trioso Purnawarman Triwardhani Cahyaningsih Ulfi Nurul Fadlilah Uni Purwaningsih Uni Purwaningsih Upik Kesumawati Hadi Usama Affif Usamah Afif Uus Saepuloh Velayati, Risqika Aqla Wattiheluw, Muhammad Subhan Yan Evan Yenri, Hamdika Yuda Heru Fibrianto