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Journal : JOURNAL LA MEDIHEALTICO

In Silico Study of Gamma-Mangostin Compound from Garcinia Mangostana L. Fruit Skin and Activity Test as an Alpha Amylase Inhibitor Kurniawan, Kurniawan; Marfu'ah, Nurul; Fazriah D., Gita
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.1889

Abstract

The aim of this study is to determine the interaction between the gamma-mangostin compound and the α-amylase enzyme using molecular docking modeling and in vitro. The results of molecular docking showed that all compounds could interact with the active site of the α-amylase enzyme. The gamma-mangostin compound has a fairly negative binding affinity. The binding affinity score of the compound was then compared with the control, namely the carbohydrate inhibitor acarbose. The results showed that the binding affinity quite close to the control, namely -9.1 kcal/mol, while the control was -16.4 kcal/mol, but the score was not negative enough. Interaction of the target protein with the alpha amylase compound to determine the amino acid residues on the active side of the protein. The results showed that there were hydrogen, alkyl and van der waals bonds on the active side of the protein that were the same as the control. In silico and in vitro, the gamma-mangostin compound has the potential to reduce blood sugar levels with an α-amylase inhibitor, in vitro with percentage of 43.33% approaching the positive control, namely acarbose, which is 56.25% at a concentration of 200 ppm and an IC50 value of 166.06 ppm.
Co-Authors Al Hasanah, Fauziyyah Alifya Nur Azizah Amal Fadholah Amala, Nur Amilia Yuni Damayanti Ananda, Mutiara Andi Sri Suriati Amal Andri Karin, Elsy Juni Anjani, Hanifa Dyanti Anugerah Suciati Astuti, Eti Aural Miftahul Hasanah Ava Zaujah Awaluddin, Rizki Ayu, Gustin Swastika Azzahra, Isma Chelsea Aulia Ramadhani Cisilliya Tandraini Damayanti, Widya Dewi Ratnasari Diah Ayu Mutmaina Dianti Desita Sari Diwana, Nida Khofiya Puspa Eva Nor Diana Lestari Fajri, Mathla’il Fardyatullail, Haila Farhana, Siti Awalisanah Hani Fauziatunnisa, Elok Fazriah D., Gita Fitrian, Ahyana Frida SA, Yuna Hafifah, Cut Ajma Fitira Hamzah Gita Sari Hartinah Yulianto, Siti Haryanto, Qurrah A'yuniyyah I Wayan Kasa Ichwanuddin Ichwanuddin Indah Tri Lestari Indahtul Mufidah Khodijah, Alisya Khomarul Kuniyati Kurniawan Kurniawan Kurniawan Kurniawan, Kurniawan Kusumasary, Dhiyah Ayu KW, Faradhita Lestari, Eva Nor Diana Lia, Melda Lija Oktya Artanti Lija Oktya Artanti Lutfi Shantia Luthfiya, Lulu' Luthfiya, Lulu’ Mafazatien Nailiyah Isna Mahirotun NS, Anggun Mahmudah, Amalia Nurul Mahmudah, Hilma Radhia Mathlail Fajri Maulia Isnaini MIFTAKHUL JANNAH Mira Dian Naufalina Mira Dian Naufalina Muhammad El Riza NA, Eldyamarta Nadia Iha Fatihah Nadia Mira Kusumaningtyas Nadia Saptarina Nadia Saptarina Nida Faradisa Fauziyah Nisrina, Salma Nur Hazlia, Syarifah Pertamana, Ropia Pibriyanti, Kartika Pratiwi, Arika Putri Putri, Kayla Radina Dwi Qurrah A'yuniyyah Haryanto Rabbaniyah, Muthi’ah Rahmat A Hi Wahid Rahmat A.H. Wahid Rauf, Ichsan Riyani, Retno Indra Riza Amalia Riza, Muhammad El Rizka Safira Rizki Awaluddin Rizki Awaluddin Rizky Dila Khairunnisa Rohmah Madya Ayu Fitriana Sagun Chandra Yowani Salma, Rahimia Nuzula Sari, Dianti Desita Sari, Nandita Aprilia Satwika Budi Sawitri Sawitri, Satwika Budi Sha’sha’ Luthfiana Shifa Syururin, Wakhidatus Sholihatin, Binti Siska Fatkhul Hidayati Siska, Awenda Siti Awalisanah Hani Farhana Sitti Hijraini Nur Solikah Ana Estikomah Sujiat Zubaidi Sulikhah, Novia Anggreani Surya Amal Susi Nurohmi Tri Harianto Wafa Aufia Wahid, Rahmat A Hi Wahid, Rahmat A Hi Widayanti, Erna Desi Widyaratna, Indriyanti Winati, Dian Eska Yulia Dwi Andarini Yuwono, Ratna Rahajeng Putri Zulianita Zulianita Zulvia Faridatul Munawaroh