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Eka Safitri
STMIK AMIKOM Yogyakarta
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Journal : Journal Of Carbazon

 1 
Montmorillonite-Chitosan as a Biocomposite Encapsulation for Ibuprofen in Drug Release Afifi, Muhammad Ridho; Irwandi, Dodi; Safitri, Eka; Syafei, Dedri; Ngapa, Yulius Dala
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42149

Abstract

Ibuprofen is a type of anti-inflammatory drug. However, its use faces challenges in the medical field due to its rapid degradation, low bioavailability, limited solubility, and high permeability. One approach to address these issues is the encapsulation of ibuprofen by coating it with Montmorillonite (MMT) and Chitosan (CS) to control the released dosages of Ibuprofen. MMT and CS were used to coat ibuprofen using four methods. These methods were compared through dispersing MMT in water, mixing with chitosan, and combining ibuprofen under different conditions. Subsequently, tests were conducted on ibuprofen coated with MMT-CS, including morphology, efficiency, and release profile. The most effective method for controlling ibuprofen release was shown in the third method, where MMT-CS was first modified, and then ibuprofen was added to the modified MMT-CS. This method showed the highest encapsulation efficiency of 61.51%, the best release profile with 21.59% ibuprofen release within 90 minutes, and the most uniform encapsulation morphology. These studies indicated that the MMT-CS biocomposite effectively improves ibuprofen release efficiency, potentially enhancing therapeutic outcomes while reducing side effects of ibuprofen.
Co-Authors Abdul Karim Achmad Yanu Aliffianto Afifi, Muhammad Ridho Agung Hartoyo Ahmad Mujahid, Ahmad Ahmad, Nursaidah Akastangga, Muhammad Dedad Bisa Raguna Al Af Ghoni, Achmad Solakhuddin Al Khasy, Moh. Ali Qorror ALDIANSYAH, TEUKU Alexander Hamonangan Simamora Alghiffary, Muhammad Amalia, Rika Sri Andika, Iswandi Anita Anita Annas Alkhowarizmi Aprinal Adila Asril Arfa Azkiyah, Desintya Arifin , Atwal Arifin, Ahmad Kamal Arsyad, Muhammad Rizal Aviv Pasa, Muhammad Awalia, Hu’shilla Azis, Nurul Ni'ma Azmi, Abdullah Binawati Ginting Bistari Budi Sustriawan Budiman, Muh. Arief Chandra, Novrina Cloudya, Afifah Dani Rizana Dayanti, Meri Dedi Junaedi, Dedi Dedri Syafei Dodi Irwandi, Dodi Edi Suharto Evi Novita Evi Widowati EVY FITRIA, EVY Fahruddin Ali Sabri Fazriani, Eva Tatia Fega, Nabila Fera Sriyunianti Fitri Dara Fitria Budi Utami Fitriyana Fitriyana, Fitriyana Fonna, Syafrizal Ginting, Rahmadani Ftri Hadi, Mukhammad Nur Hanum, Dania Febyola Harisa, Muh. Hermaliana, Mia I Kadek Suartama Ilham Maulana Isti Handayani Jannah, Firaihanil Julinawati, Julinawati Khulduniah, Khulduniah Laksono, Muharram Budi Lelifajri Lelifajri Luthfi, Rantika M. Zulkarnain Maesaroh, Nur Maharani, Alviah Camilla Masum, Ahmad Md Sani, Nor Diyana Mohamed Salem Alawadi, Elsayed Mu'arif, Mohammad Wildan Muhammad Idrus Muhammad Ihsan Muhammad Isa Muhsin Riyadi MUNASIB MUNASIB, MUNASIB Mustanir Mustanir Mustaufik N. Nazaruddin Nasrullah Idris NAZARUDDIN, SALSABILLA LATANSA Nina Herlina Nur Aini Nur Huda Nurhaida Nurhaida Nurhayati Nurhayati Priyono, Habib Putri, Najwa Auliya Qodri Rahil Helmi Rahmadi Rahmadi Ramadani, Nurista Riski Rikki Vitria Rinaldi Idroes Riski, Novia Riza Chamadi, Muhammad Riza Multazam Luthfy Rosalina, Ranti Resmi Rumpoko Wicaksono Sa'dudin, Ihsan Sa’dudin, Ihsan Sagir Alva Sa’dudin, Ihsan Sinaga, Sunita Siregar, Nasrun Salim Siti Aminah SITI KHOLIFAH Siti Mujanah Siti Nurhayati Sitti Saleha, Sitti Sontani, Uep Tatang Suci Maulina Suedah, Suedah Suhud, Khairi Sukoma, Sukoma Supriatno Suriani, Seri Suwardinata, Amiliya Syatta, Indy Mafiiqo Taher, Rusdee Ulfah Ulfah Umamah, Umamah Wahyuni, Eni Wirawan Fadly Yuliah, Elah Yulius Saprianus Dala Ngapa Zuliaha, Isnaini