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Journal : Paediatrica Indonesiana

Association between C-reactive protein levels and physical fitness in 7 to 9 year old children at poor elementary schools in Surakarta, Indonesia Lilisianawati Lilisianawati; Endang Dewi Lestari; Diana Mayasari Hadianto; Maria Galuh Kamenyangan Sari; Leilani Lestarina; Harsono Salimo
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.27 KB) | DOI: 10.14238/pi49.2.2009.75-81

Abstract

Background  Data  regarding inflammatory factors  in  children arenot  so  well developed  as  in adults. Higher levels  of  physical fitnessmay be helpful in modifying the low-grade inflammatory state  thatis  indexed  by  C-reactive protein (CRP) levels.Objective  To  evaluate the association  of  physical fitness with  CRPlevels in children  and  to identify the possible related factors.Methods  This  cross-sectional study was  conducted  at  poorelementary schools in Surakarta, Indonesia using a group  of  217underweight children aged from 7 to 9 years old. Physical fitnesswas assessed using a modified Harvard Step Test.  CRP  levels weremeasured using a high-sensitivity  assay.  The  association betweenphysical fitness and  CRP  level was assessed using linear regressionanalysis. Multivariate analyses were used to adjust covariates,and statistical analyses were performed using SPSS for Windowssoftware version 15.0.Results  Subjects were 48% female  and  52% male, and elevenchildren (5%) had a  CRP  level  >  5 mg/L. Mean fitness level  andCRP  level did not differ  by  age and gender. Fitness level was notinversely correlated with  CRP  (r=0.10,  P=0.14).  Physical fitnesswas significantly correlated with BMI  (r=0.14;  P=0.04),  physicalactivity  [0R=3.3  (95% CI  1.7  to 6.4)], and fat intake  [0R=0.5(95%  CI  0.2 to 0.9) ].Conclusion  These findings indicate  that  physical fitness  is  notinversely correlated to  CRP  levels in children. However, ourstudy reveased  an  association between high fat intake and lowphysical fitness as well  as  a significant association  betweenhigh physical activiry and physical fitness.
Effect of iron ... zinc fortified milk on iron status and functional outcomes in underweight children Endang Dewi Lestari; Saptawati Bardosono; Leilani Lestarina; Harsono Salimo
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.517 KB) | DOI: 10.14238/pi49.3.2009.139-148

Abstract

Background Iron and zinc are essential micronutrients duringschool-age period. Milk could be an alternative medium formineral fortification because it is consumed frequently bychildren.Objective To evaluate the effect of iron-zinc fortified milksupplementation on iron status and functional outcomes inunderweight children.Methods 44 2 underweight subjects aged 7-10 years attending 10primary schools in Jakarta and Solo were recruited in the study.Subjects who had chronic illnesses, severe anemia, thalassemiaor cow's milk allergy were excluded. Blood samples were analyzedto determine hemoglobin, serum ferritin and serum zinc. SerumCRP was measured in sub sampled subjects (n= 60). Subjectswere randomizedly allocated to receive iron-zinc fortified milk(n = 225) and standard milk (n = 217) for six months. The fortifiedmilk will provide additional6.3 mg iron and 1.5 mg zinc per day (2feeds). The main outcomes measured were iron status, cognitivefunction, growth, physical fitness and morbidity.Results Study groups were comparable at baseline. The fortifiedmilk group had better physical fitness score and exercise durationat baseline. Both milk supplementations reduced the prevalenceof anemia and iron deficiency. Fortified milk improved the speedprocessing score (P< 0.0001), height (P<0.0001) and sittingheight (P=O.Ol) significantly.Conclusion Supplementation of milk reduces the prevalence ofanemia and iron deficiency. Zinc-iron fortified milk gives positiveimpact on cognitive performance, growth, and physical fitness.
Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia Riza, Muhammad; Salimo, Harsono; Wasita, Brian; Idulhaq, Mujaddid; Saputra, Rhyan Darma; Widyaningsih, Vitri; Soestrisno, Soestrisno; Zahidah, Fairuz; Wayanshakty, Janur
Paediatrica Indonesiana Vol. 64 No. 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.10-6

Abstract

Background The advent of chemotherapy with multimodal treatment has improved the survival rate of osteosarcoma. However, the survival rate of patients with osteosarcoma in low- and middle-income countries (LMICs) remains lower than in high-income countries (HICs). Objective To assess prognostic factors associated with survival rate of pediatric patients with osteosarcoma in Moewardi Hospital, Surakarta. Methods This retrospective study was performed in pediatric osteosarcoma patients at Moewardi Hospital, Surakarta from 2018 to 2022. We described patients’ clinical presentations and assessed prognostic factors. Survival rate was calculated using Kaplan–Meier survival analysis. Prognostic factors were analyzed using univariate and multivariate Cox regression methods. Results Of the 82 patients included in the study, 40 (48.8%) were male and 42 (51.2%) were female. Most subjects (75.6%) were diagnosed with osteosarcoma at the age of >10 years, 45 patients (54.9%) had primary tumors in the femur, and 16 patients (19.5%) had limb salvage surgery. The mean event-free survival duration was 13.6 (95%CI 9.7 to 17.5) months. The mean duration of overall survival was 22.7 (95%CI 17.3 to 28.1) months, with a 44.1% survival probability. Type of surgery was a significant prognostic factor (P=0.018), with limb salvage having better survival probability (93.3%) than amputation (19.8%). Conclusion The overall survival rate of osteosarcoma patients at our center is still lower than in other regional centers. Limb salvage surgery was a significant prognostic factor for survival, while gender, location of primary tumor, histological subtype, and metastasis at the time of diagnosis were not.
Co-Authors -, Suradi Abd. Rasyid Syamsuri Adi Magna Patriadi Nuhriawangsa Alfianrisa, Anggityas Alinda Nur Ramadhani Anggraini, Yeni Anindya, Ivanda Glanny Annang Giri Moelyo Annang Giri Moelyo Argyo Demartoto, Argyo Aries - Krisbiyantoro Arini Tri Lestari Astuti, Fitriyani Dwi Azis Halid, A Annisa Ashliyatul Aziza Bachtiar, Harrys Bhisma Murti Brian Wasita Burhannudin Ichsan Catur Retno Lestari Desi Ekawati Dhewi Nurahmawati Diana Mayasari Hadianto Didik Tamtomo, Didik Dwi Hidayah Dwi Wijayanti Dyah Ratna Budiani Eko Dewi Ratna Utami Endang Dewi Lestari Endang Sutisna Sulaeman Eti Kuswandari Eti Poncorini Pamungkasari Fadhilah Tia Nur, Fadhilah Tia Farida, Jauharotul Fauziyah, Rahma Fitria Mushollini Galih Herlambang H.A.A. Soebijanto Hardilla, Dinda Septiani Hartanti, Ainurrizma Tri Idulhaq, Mujaddid Ika Yuli Ayuningrum Ilma, Nabilah Nurul Indita, Wiwen Indriasih, Merlita Indriasih, Merlita Indriyani, Eny Inggar Ratna Kusuma Irnawati, Prita Yuliana Iskandar, Nurdin Aji Ivanda Glanny Anindya Juhrotun Nisa, Juhrotun Khalifah, Intan Noor Kusumastuti, Nurry Ayuningtyas Kusumawardhani, Wahyu Leilani Lestarina Lestari, Nining Lilik Retna Kartika Sari Lilisianawati Lilisianawati Listiani, Funik Rahma Mei Maria Galuh Kamenyangan Sari Marlinawati, Iin Tri MS, Novi Paramitasari Muhammad Riza Muslimah, Putri Andini Nabilah Nurul Ilma Ningsih, Nur Isniani Nugraha, Sandi Nugroho, Irfan Dzakir Nur Hafidha Hikmayani Nurmayanti, Rika Palupi, Endang Poncorini, Eti Prasetyo, Medita Rahardjo, Setyo Sri Rahmah Rahmah Risya Cilmiaty, Risya Rita Adriani Benya Adriani Riza, Muhamad Rohaniyati, Retno Dwi Rokhayati, Rokhayati Rokhayati, Rokhayati Safriana, Latifah Sagita, Desita Ike Saptawati Bardosono Saputra, Rhyan Darma Sari, Lutfiana Puspita Setyorini, Wenny Sinta, Prabawati Soestrisno, Soestrisno Soetrisno Soetrisno Sri Lilijanti Widjaja Sri Martuti Sukoco, Amin Sumardiyono Sumardiyono Susanti, Isne Titah Pujangkara, Ajeng Ayu Tri Rejeki Andayani Trisnawati, Iga Uki Retno Budihastuti USMAN, FAHMIL Vitri Widyaningsih Wayanshakty, Janur yulia lanti retno dewi Yulia Lanti Retno Dewi Yulidar Hafidh Yusup Subagio Zahidah, Fairuz Zummatul Atika