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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Hemera Zoa Jurnal Sain Veteriner Buletin Peternakan Jurnal Veteriner BIOTROPIA - The Southeast Asian Journal of Tropical Biology Medical Journal of Indonesia Current Biochemistry Jurnal Ilmu Ternak Veteriner Warta IHP (Warta Industri Hasil Pertanian) Historika Jurnal Medik Veteriner ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Patologi Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat KIDDO: Jurnal pendidikan Islam Anak Usia Dini Indonesian Journal of Applied Research (IJAR) International Journal of Multidisciplinary: Applied Business and Education Research Journal of Education Research Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Journal of Research and Publication Innovation VALUTA Jurnal Administrasi Bisnis, Manajemen dan Ekonomi Policy Brief Pertanian, Kelautan, dan Biosains Tropika Health Gate Jurnal Agripet Civitas: Jurnal Pengabdian Masyarakat Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi Journal of Social Entrepreneurship and Creative Technology
Agus Setiyono
Departemen Klinik, Reproduksi Dan Patologi Fakultas Kedokteran Hewan, Institut Pertanian Bogor. Jl. Agatis Kampus IPB Dramaga 16680
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Journal : Current Biochemistry

 1 
Effectiveness of Gnetum gnemon Peel Extract as an Antihyperuricemic in White Rats Rattus norvegicus Akhmad Endang Zainal Hasan; Husnawati Husnawati; Chintia Ayu Puspita; Agus Setiyono
Current Biochemistry Vol. 7 No. 1 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.1.3

Abstract

Melinjo (gnetum gnemon) peel extract is believed to have potential as antihyperuricemic agent, however, in vivo assays have yet to be conducted to prove the antihyperuricemic activity. The objectives of this research were to analyze antihyperuricemic activity of melinjo peel extract in Sprague Dawley male white rat. A total of 24 rats were divided into 6 groups, which are a normal, positive, and negative group, 70% ethanolic extract of melinjo peel dose 450 mg/kg BW (ET I) and dose 900 mg/kg BW (ET II), and water extract of melinjo peel dose 93.35 mg/kg BW (EA). The results show that antihyperuricemic potency of 70% ethanolic extract of melinjo peel (ET1 and ET2) was more effective than allopurinol dose 90 mg/kg BW with a percentage decrease of 50% and 54%. Ethanol extract of melinjo peel was able to reduce uric acid levels to be in the range of normal values (<5 mg / dL). Bodyweight gain of rats given ethanol extract of melinjo peel dose 450 mg/kg BW had values that were close to the normal group. Melinjo peel extract contained flavonoid, tannins, saponin, and triterpenoid.
Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol Akhmad Endang Zainal Hasan; Agus Setiyono; Miko Afrian
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.4

Abstract

Negative effects on health will occur in excessive use of paracetamol. The main objective of this study was to determine the hepatoprotective activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats induced by paracetamol. The study was conducted on 36 Sprague Dawley rats with 6 rats in each group. Group 1 (normal control), group 2 (positive control, temulawak 42.86 mg/kg BW), group 3 (negative control), group 4 (infusion of Myrmeleon 10 mg/kg BW), group 5 (propolis extract 0.02 ml/kg BW), and group 6 (Hibiscus sabdariffa infusion 0.02 ml/kg BW). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were determined spectrophotometrically and microscopically for liver histopathology. The results showed that during three weeks of treatment with Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats, this treatment could decrease ALT and AST activity as the positive control. The ALT activity values ​​of the three materials were 69.26, 51.00, 51.00, 43.67, U/I with AST values ​​of 110.29, 97.33, 91.00, 91.33 U/I. Based on Duncan's test, there were significant differences between all treatments with negative and positive control groups. Likewise, with the histopathological scoring results, the negative control was found to be significantly different from all treatments. Therefore, treatment with propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. may have hepatoprotective benefit.
Co-Authors Aditya Dharmawan, Aditya Aditya Wahyu Nugraha Afifah, Amalia Aisjah Girinda Akhmad Endang Zainal Hasan Akterono D. Budiyati Allaily Allaily Alvin Jefry Amrozi Andre, Daniel Latief Andriyanto . Anggraini , Ninik Anita Esfandiari Annasit Annasit, Annasit Arif Yahya Arifianto, Dinar Ario Damar Astrie Kusuma Dewi, Astrie Kusuma Aulia Dina Kristina Bayu Sandi Chintia Ayu Puspita Cleopas Martin Rumende Darsono Darsono Desdiani Diah Nugrahani Pristihadi Dian Pratiwi DIMAS ANDRIANTO Djumali Mangunwidjaja Dwi Astuti E. Mulyati Effend Effend, E. Mulyati Eko Prasetyo Nugroho Eko Suryanto Ekowati Handharyani Elok Puspita Rini Elpita Tarigan Eny Nur Aisyah Evy Damayanthi Fachriyan Hasmi Pasaribu Feri Kusnandar Gani, Ainal Gatut Ashadi Hamid, Farid Alfalaki Handayu Untari Handayu Untari Handoko, Susilo Hanif Alamudin Manshur Hapsari Mahatmi Hardika Hardika, Hardika Harry Isbagio Hasim Hasim Hasim Hasim Hasim Hasim Hasim Hasim, . Hendry, Altaff Husnawati, . I Ketut Suada I Komang Gede Wiryawan I wayan Teguh Wibawan Idqan Fahmi Iftitah, Selfi Lailiyatul Ike Agustiani Imron Arifin Indriani, Erdila IPB, DGB Iris Rengganis Ismah Atika Salmah Japanis Permatasari, Retno Jusman, Sri Widia Azraki Kustiariyah Tarman Lala M Kolopaking Liesbetini Haditjaroko Lily Natalia Lisnawati Rachmadi M Agus Setiadi M. Aman Yaman M. Misbah, M. Ma'mun Sarma Maharani Maharani, Maharani Maningtyas, Rosydamayani Twinsari Maningtyas, Rosyidamyani Twinsari Masdiana C. Padaga Mega Safithri Miko Afrian Mochamad Alfinanda Santriagung Mohammad Irham Bagus Santoso Mohammad Sadikin Muhammad Daud Muhammad Ihsan Muhammad Ridla Muhammad Zuhdi Badruzzaman Muhammad Zulkifli Muharam Saepulloh Mutholaah Nahrowi Nahrowi Nahrowi Nathasia, Novena Neni Nuryani Nina Herlina Nugroho, Budi Sulistiyo Nurjati Chairani Siregar Nurliani Bermawie Nurliani Bermawie Nurliani Bermawie Nurrahman, Arif Nyoman Kertia Oktariza, Wawan Olive Wisepti Pratama Ono Suparno Permana, Nadine Hanifa Pramono Prastyo, Danang Pribadi, Yohanes Kusuma Purnamiharja, Tsulatsy Puspitasari Purwiyatno Hariyadi Putri C. Eyanoer Rachmat Nabib Rahman, Muhammad Luthfi Rahminiwati, Min Rayendra, Raendi Restu Librani Retno Damayanti Soejoedono Rianto Setiabudy Risa Tiuria Rudramurti, Win Satya Samsuridjal Djauzi Sandi, Bayu Sangko Sayuti Nasution Sangko Sayuti Nasution, Sangko Santi Noviasari Sekar Winahyu Ariadini Setiadi, Hirawan Shila Rahmafia Putri SILMI MARIYA Siti Zulaikhah Slamet Budijanto Sri Purwaningsih, Sri Sri Wahyuni Salam Sudradjat Sumiati Suradi Suria Darma Tarigan Syahruddin Said Syifa Khaerani Titi Candra Sunarti Tomas Iriyanto Tri Isyani Tungga Dewi Trioso Purnawarman Ulfah Juniarti Siregar Unang Patriana Upik Kesumawati Hadi Utami, Dian Maulia Utamimah, Sri Vetnizah Juniantito Wibowo, Suryo Anggoro Kusumo Widiyanto, Totok Winahyu Ariadini, Sekar Wiranda G Piliang Wiwin Winarsih Wiyono, W. WoroWiranti, Rahayu Yan, Teo Qin Yeni Kartika Sari, Yeni Kartika