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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Medula Jurnal Dunia Kesmas Journal of Language and Health Jurnal Farmasetis Sains Medisina JOURNAL OF Qualitative Health Research & Case Studies Reports Journal of Health Science and Medical Therapy JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Literasi Indonesia
Tri Umiana Soleha
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Overview of treatment success with short, long, and BPaL/M regimens in patients with drug resistant tuberculosis Nasution, Artika Ananda Putri; Soleha, Tri Umiana; Jausal, Anisa Nuraisa; Gozali, Achmad
JOURNAL OF Qualitative Health Research & Case Studies Reports Vol 6 No 1 (2026): January Edition 2026
Publisher : Published by: Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/quilt.v6i1.2220

Abstract

Background: Drug-resistant tuberculosis (DR-TB) remains a major challenge in global TB control efforts, particularly in middle-income countries such as Indonesia. Long-term regimens lasting 18–24 months have been associated with low treatment success rates due to their prolonged duration and high incidence of adverse drug reactions. More recent developments, namely the bedaquiline–pretomanid–linezolid regimen with or without moxifloxacin (BPaL/M), have demonstrated treatment success rates of up to 89–90% in international clinical trials. Purpose: To describe the treatment success of short-term, long-term, and BPaL/M regimens among patients with drug-resistant tuberculosis. Method: A retrospective descriptive study was conducted using medical record data of DR-TB patients who received long-term, short-term, or BPaL/M regimens during 2023–2024. Treatment outcome classification followed the WHO 2022 guidelines. The variables collected included patient characteristics, type of regimen, and treatment outcomes based on WHO standards: cured, treatment completed, treatment failed, lost to follow-up, and died. Results: Of the 148 DR-TB patients who met the inclusion criteria, 98 patients (66.2%) received long-term regimens, 17 patients (11.5%) received short-term regimens, and 33 patients (22.3%) were treated with the BPaL/M regimen. The treatment success rate (cured + treatment completed) for the short-term regimen was 76.5%, which was lower compared to the long-term regimen at 83.7%. The BPaL/M regimen demonstrated the highest treatment success rate at 87.9%. Conclusion: The treatment success rates for DR-TB patients at Dr. H. Abdul Moeloek Hospital indicate that the BPaL/M regimen provides the most favorable outcomes compared to long-term and short-term regimens. Keywords: BPaL/M Regimen; Drug-Resistant Tuberculosis; Long-Term Regimen; Short-Term Regimen; Treatment Success.    
Efektivitas Amoxicillin dan Piperacillin Terhadap Klebsiella pneumoniae pada Kasus Infeksi Saluran Pernapasan Akut di RSUD Dr. H. Abdul Moeloek Periode 2019 – 2023 Azalia, Nadhira; Soleha, Tri Umiana; Larasati, Ratri Mauluti; Utama, Winda Trijayanthi
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1846

Abstract

Acute respiratory tract infection (ARI) is one of the leading causes of morbidity that often requires antibiotic therapy, with Klebsiella pneumoniae being one of the most commonly found bacterial pathogens and known to have a high level of antibiotic resistance. Irrational use of antibiotics can accelerate the development of resistance, so the effectiveness of antibiotics needs to be evaluated periodically. Amoxicillin and piperacillin are commonly used antibiotics in the management of ARTI. This study aimed to evaluate the effectiveness of amoxicillin and piperacillin against Klebsiella pneumoniae in cases of ARTI at Dr. H. Abdul Moeloek General Hospital from 2019 to 2023. This study is an observational analytical study with a cross-sectional design using secondary data in the form of culture results and antibiotic sensitivity tests from patient medical records. The sampling technique used total sampling with a total of 106 Klebsiella pneumoniae isolates. Data analysis was performed using the Chi-Square test. The results showed that the resistance rate of Klebsiella pneumoniae to amoxicillin was 92.5% with a sensitivity of 7.5%. In contrast, piperacillin showed a higher sensitivity of 58.5% although resistance was still found at 41.5%. Statistical tests showed a significant relationship between the type of antibiotic and the level of bacterial sensitivity (p-value < 0.001). The conclusion of this study indicates that piperacillin is more effective than amoxicillin in the management of ARI caused by Klebsiella pneumoniae and can be considered in the selection of empirical antibiotic therapy.
Literature Review Article: Aktivitas Antioksidan Formulasi Sabun Cair Dari Berbagai Tanaman Andrifianie, Femmy; Anggraeni, Ranesya Eka; Afriyani, Afriyani; Soleha, Tri Umiana
⁠⁠Jurnal Literasi Indonesia Vol. 2 No. 8 (2025): Jurnal Literasi Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

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Abstract

Radikal bebas diketahui dapat menyebabkan kerusakan pada kulit, mempercepat penuaan, dan memicu berbagai gangguan kesehatan. Keberadaan antioksidan, terutama yang bersumber dari bahan alam seperti flavonoid, tanin, dan polifenol pada ekstrak tanaman, sangat penting untuk menetralkan radikal bebas dan melindungi kulit dari stres oksidatif. Tujuan pembuatan literatur review ini untuk memberikan informasi kepada pembaca mengenai tanaman apa saja yang berpotensi sebagai antioksidan dalam sediaan sabun cair. Metode yang dilakukan dalam penelitian literature review article ini yaitu menggunakan pencarian data base berupa Google Scholar dan PubMed pada 10 tahun terakhir. Berdasarkan hasil literature review didapatkan 10 jurnal dengan macam-macam tanaman antara lain ekstrak tomat (Solanum Lycopersicum L.), daun afrika (Gymnanthemum amygdalinum Del.), kulit buah naga (Hylocereus polyrhizuz), kopi robusta (Coffea canephora), daun teh hijau (Camellia sinensis L.), kombinasi daun kemangi (Ocimum sanctum L.) dan madu, daun jambu biji (Psidium guajava L.), umbi bit (Beta vulgaris L.), kulit wortel (Daucus carota L.) dan kulit salak (Salacca zalacca (Gaertn.). Dari semua jenis tanaman tersebut yang mempunyai aktivitas antioksidan sediaan sabun cair yang tergolong sangat kuat yaitu Daun Jambu Biji (Psidium guajava L.) dengan nilai IC50 yaitu 1,17 ppm.
Co-Authors Afriyani, Afriyani Andrifianie, Femmy Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Ranesya Eka Anggraini, Dian Isti Ari Irawan Artanti, Mariesela Ayu S, Putu Ristyaning Azalia, Nadhira Bajuri, Annisa Nur Oktavia Betta Kurniawan, Betta Caesarridha, Dhaifany Karissa Cyntithia, L. Gita Damayanti, Ervina Dewayanti, Wahyu Dyah Wulan Sumekar Rengganis Wardani Ermin Rachmawati Ety Apriliana Fathunnisa, Ridha Riano Frauprades, Kaltihennah Oktavia Gliselda, Vika Kyneissia Gozali, Achmad Hanna Mutiara, Hanna Happy, Terza Aflika Helmi Ismunandar Indri Windarti Ismunandar, Helmi Ismunandar Jausal, Anisa Nuraisa Jessy Dewi Awali Juliana, Risna Junando, Mirza Kurniawaty, Evi Larasati, Ratri Mauluti Liana Sidharti, Liana Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Iqbal Muhammad Ricky Ramadhian Muhammad Yusran Nasution, Artika Ananda Putri Nikita, Marshanda Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Poty, Pitha Maykania Purba, Gemi Sabrina Putri, Abrila Tamara Putri, Yessa Rahmadini Rahel, Clara Arta Uli Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Sa'diyah, Isma Fadlilatus Sangging, Putu Ristyaning Ayu Septiani, Linda Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sinulingga, Anselmus Libreya Situmorang, Ezra Winandi Susianti Susianti Sutyarso Sutyarso Syazili Mustofa Triyandi, Ramadhan Utami, Winda Trijayanthi Wibowo, Muhammad Rafi Winda Trijayanthi Utama, Winda Trijayanthi Wulan, Anggraini Janar Yunianto, Andi Eka Zahra, Aulia Jannatuz