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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Medula Pharmascience Jurnal Dunia Kesmas Journal of Language and Health Jurnal Farmasetis Sains Medisina JOURNAL OF Qualitative Health Research & Case Studies Reports Journal of Health Science and Medical Therapy JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Tri Umiana Soleha
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Overview of treatment success with short, long, and BPaL/M regimens in patients with drug resistant tuberculosis Nasution, Artika Ananda Putri; Soleha, Tri Umiana; Jausal, Anisa Nuraisa; Gozali, Achmad
JOURNAL OF Qualitative Health Research & Case Studies Reports Vol 6 No 1 (2026): January Edition 2026
Publisher : Published by: Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/quilt.v6i1.2220

Abstract

Background: Drug-resistant tuberculosis (DR-TB) remains a major challenge in global TB control efforts, particularly in middle-income countries such as Indonesia. Long-term regimens lasting 18–24 months have been associated with low treatment success rates due to their prolonged duration and high incidence of adverse drug reactions. More recent developments, namely the bedaquiline–pretomanid–linezolid regimen with or without moxifloxacin (BPaL/M), have demonstrated treatment success rates of up to 89–90% in international clinical trials. Purpose: To describe the treatment success of short-term, long-term, and BPaL/M regimens among patients with drug-resistant tuberculosis. Method: A retrospective descriptive study was conducted using medical record data of DR-TB patients who received long-term, short-term, or BPaL/M regimens during 2023–2024. Treatment outcome classification followed the WHO 2022 guidelines. The variables collected included patient characteristics, type of regimen, and treatment outcomes based on WHO standards: cured, treatment completed, treatment failed, lost to follow-up, and died. Results: Of the 148 DR-TB patients who met the inclusion criteria, 98 patients (66.2%) received long-term regimens, 17 patients (11.5%) received short-term regimens, and 33 patients (22.3%) were treated with the BPaL/M regimen. The treatment success rate (cured + treatment completed) for the short-term regimen was 76.5%, which was lower compared to the long-term regimen at 83.7%. The BPaL/M regimen demonstrated the highest treatment success rate at 87.9%. Conclusion: The treatment success rates for DR-TB patients at Dr. H. Abdul Moeloek Hospital indicate that the BPaL/M regimen provides the most favorable outcomes compared to long-term and short-term regimens. Keywords: BPaL/M Regimen; Drug-Resistant Tuberculosis; Long-Term Regimen; Short-Term Regimen; Treatment Success.    
Perbandingan Uji Daya Hambat Ekstrak Biji Kopi Robusta (Coffea canephora) dan Ekstrak Buah Lada Hitam (Piper nigrum) terhadap Jamur Malassezia furfur in vitro Baradatu, Mirza Sultan; Soleha, Tri Umiana; Lusina, Septia Eva; Apriliana, Ety
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 3 (2026): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.3 (2026) : Article i
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i3.1089

Abstract

Pendahuluan: Infeksi Malassezia furfur yang umum di Indonesia memerlukan alternatif pengobatan alami karena efek samping dan kasus resistensi pengobatan antijamur. Penelitian ini bertujuan membandingkan potensi antijamur ekstrak etanol 96% biji kopi robusta (Coffea canephora) dan lada hitam (Piper nigrum) yang merupakan komoditas lokal Provinsi Lampung dalam menghambat pertumbuhan Malassezia furfur secara in vitro. Metode: Studi eksperimental Post-test Only Control Group Design ini menguji ekstrak hasil maserasi etanol 96% menggunakan metode difusi sumuran pada media SDA. Perlakuan meliputi lima konsentrasi (100%, 50%, 25%, 12,5%, 6,25%), kontrol positif (Terbinafine), dan kontrol negatif (Akuades). Diameter zona hambat yang terbentuk diukur dan dianalisis secara statistik. Hasil: Ekstrak kopi robusta konsentrasi 100%; 50%; 25%; 12,5%; 6,25% menghasilkan zona hambat berturut-turut 13,39 mm; 11,25 mm; 5,72 mm; 1,99 mm dan 0 mm. Sedangkan ekstrak lada hitam menghasilkan 7,75 mm; 6,94 mm; 1,60 mm; dan 0 mm pada konsentrasi 12,5% dan 6,25%. Kontrol positif (Terbinafine) sebesar 23,32 mm dan kontrol negatif 0 mm. Pembahasan: Ekstrak kopi robusta lebih unggul karena kandungan asam klorogenat dan kafeinnya mampu melisiskan sel jamur Malassezia furfur dan berdifusi baik. Berbeda dengan lada hitam, senyawa piperin yang bersifat lipofilik memiliki keterbatasan difusi pada media uji, sehingga zona hambatnya terbatas. Simpulan: Ekstrak etanol 96% biji kopi robusta memiliki daya hambat yang lebih besar dan signifikan dibandingkan ekstrak buah lada hitam dalam menghambat pertumbuhan jamur Malassezia furfur.
Profil Pasien Tuberkulosis Resistan Obat (TB RO) dengan Penyakit Paru Obstruktif Kronis (PPOK) di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Nabila, Afia Farah; Soleha, Tri Umiana; Morfi, Chicy Widya
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 3 (2026): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.3 (2026) : Article i
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i3.1094

Abstract

Background: Drug-resistant tuberculosis (DR-TB) is an increasingly complex health issue, especially when accompanied by chronic obstructive pulmonary disease (COPD) comorbidity, which can exacerbate lung conditions, affect therapeutic response, and reduce treatment success. This study aims to describe the characteristics of DR-TB patients with COPD comorbidity at RSUD Dr. H. Abdul Moeloek from 2022 to 2024. Method: This study utilized a retrospective descriptive design. Data used were secondary data from patient medical records. Univariate analysis was performed to describe subject characteristics. Results: Among 46 patients, the majority were male (78.3%) aged 41–60 years (50%). RR-TB classification (76.1%) and long-term regimens (78.3%) dominated the findings. Therapeutic outcomes recorded 54.3% cured, 30.4% treatment completed, 8.7% failed, and 6.5% deceased. Discussion: DR-TB patients with COPD are more frequently observed in middle-aged males due to smoking exposure and occupational factors. The majority were classified as RR-TB, consistent with gradual resistance patterns. Long-term regimens were preferred as they are considered safer for lung function. Although COPD aggravates the condition, therapy remains likely to succeed with appropriate drug selection and patient adherence. Conclusion: DR-TB patients with COPD comorbidity are generally middle-aged males with a relatively good proportion of treatment success. Appropriate regimen selection and strict monitoring are required to optimize treatment outcomes.
Efektivitas Amoxicillin dan Piperacillin Terhadap Klebsiella pneumoniae pada Kasus Infeksi Saluran Pernapasan Akut di RSUD Dr. H. Abdul Moeloek Periode 2019 – 2023 Azalia, Nadhira; Soleha, Tri Umiana; Larasati, Ratri Mauluti; Utama, Winda Trijayanthi
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1846

Abstract

Acute respiratory tract infection (ARI) is one of the leading causes of morbidity that often requires antibiotic therapy, with Klebsiella pneumoniae being one of the most commonly found bacterial pathogens and known to have a high level of antibiotic resistance. Irrational use of antibiotics can accelerate the development of resistance, so the effectiveness of antibiotics needs to be evaluated periodically. Amoxicillin and piperacillin are commonly used antibiotics in the management of ARTI. This study aimed to evaluate the effectiveness of amoxicillin and piperacillin against Klebsiella pneumoniae in cases of ARTI at Dr. H. Abdul Moeloek General Hospital from 2019 to 2023. This study is an observational analytical study with a cross-sectional design using secondary data in the form of culture results and antibiotic sensitivity tests from patient medical records. The sampling technique used total sampling with a total of 106 Klebsiella pneumoniae isolates. Data analysis was performed using the Chi-Square test. The results showed that the resistance rate of Klebsiella pneumoniae to amoxicillin was 92.5% with a sensitivity of 7.5%. In contrast, piperacillin showed a higher sensitivity of 58.5% although resistance was still found at 41.5%. Statistical tests showed a significant relationship between the type of antibiotic and the level of bacterial sensitivity (p-value < 0.001). The conclusion of this study indicates that piperacillin is more effective than amoxicillin in the management of ARI caused by Klebsiella pneumoniae and can be considered in the selection of empirical antibiotic therapy.
Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Lycopersicon esculentum mill. as a Drug Candidate for Alopecia Treatment Oktoba, Zulpakor; Patala, Recky; Sayoeti, Muhammad Fitra Wardhana; Sangging, Putu Ristyaning Ayu; Soleha, Tri Umiana
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24836

Abstract

Alopecia is a disorder of the hair follicles that causes hair loss, either in limited areas or throughout the entire body. This study aims to evaluate the potential and molecular interactions of compounds found in the Rampai plant (Lycopersicon esculentum Mill.). The Rampai plant is known to contain various secondary metabolites such as alkaloids, flavonoids, arbutin, amygdalin, and pectin, which have the potential to be developed as antialopecia drug candidates through an in-silico approach to androgen receptors (PDB ID: 4K7A) and ADME-Tox profile predictions. The in-silico approach was conducted using the molecular docking method to predict the interaction between the active compounds from the Rampai plant and the androgen receptor using Autodock Tools 1.5.7 and Vina software, while the ADME-Tox analysis was conducted through the pkCSM platform. The molecular docking results showed that the reference ligand (Minoxidil) had an affinity energy of −7.353 kcal/mol, while the test compound with the best affinity was isorhamnetin with a value of −8.398 kcal/mol, which was lower (more stable) than Minoxidil. In addition, the ADME-Tox prediction results for isorhamnetin show favorable pharmacokinetic characteristics, especially in terms of skin permeability, absorption and distribution. Thus, isorhamnetin has the potential as an androgen receptor antagonist and a role in the development of therapies for alopecia.
Co-Authors Anggraeni Janar Wulan, Anggraeni Janar Anggraini, Dian Isti Ari Irawan Artanti, Mariesela Ayu S, Putu Ristyaning Azalia, Nadhira Bajuri, Annisa Nur Oktavia Baradatu, Mirza Sultan Betta Kurniawan, Betta Caesarridha, Dhaifany Karissa Cyntithia, L. Gita Damayanti, Ervina Dewayanti, Wahyu Dyah Wulan Sumekar Rengganis Wardani Ermin Rachmawati Ety Apriliana Fathunnisa, Ridha Riano Frauprades, Kaltihennah Oktavia Gliselda, Vika Kyneissia Gozali, Achmad Hanna Mutiara, Hanna Happy, Terza Aflika Helmi Ismunandar Indri Windarti Ismunandar, Helmi Ismunandar Jausal, Anisa Nuraisa Jessy Dewi Awali Juliana, Risna Junando, Mirza Kurniawaty, Evi Larasati, Ratri Mauluti Liana Sidharti, Liana Lusina, Septia Eva Mallarangeng, Andi Nafisah Tendri Adjeng Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Ricky Ramadhian Muhammad Yusran Nabila, Afia Farah Nasution, Artika Ananda Putri Nikita, Marshanda Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Poty, Pitha Maykania Purba, Gemi Sabrina Putri, Abrila Tamara Putri, Yessa Rahmadini Rahel, Clara Arta Uli Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Recky Patala Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Sa'diyah, Isma Fadlilatus Sangging, Putu Ristyaning Ayu Septiani, Linda Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sinulingga, Anselmus Libreya Situmorang, Ezra Winandi Susianti, Susianti Sutyarso Sutyarso Syazili Mustofa Triyandi, Ramadhan Utami, Winda Trijayanthi Wibowo, Muhammad Rafi Winda Trijayanthi Utama, Winda Trijayanthi Wulan, Anggraini Janar Yunianto, Andi Eka Zahra, Aulia Jannatuz