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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Medula Jurnal Dunia Kesmas Journal of Language and Health Jurnal Farmasetis Sains Medisina JOURNAL OF Qualitative Health Research & Case Studies Reports Journal of Health Science and Medical Therapy JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Tri Umiana Soleha
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Overview of treatment success with short, long, and BPaL/M regimens in patients with drug resistant tuberculosis Nasution, Artika Ananda Putri; Soleha, Tri Umiana; Jausal, Anisa Nuraisa; Gozali, Achmad
JOURNAL OF Qualitative Health Research & Case Studies Reports Vol 6 No 1 (2026): January Edition 2026
Publisher : Published by: Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/quilt.v6i1.2220

Abstract

Background: Drug-resistant tuberculosis (DR-TB) remains a major challenge in global TB control efforts, particularly in middle-income countries such as Indonesia. Long-term regimens lasting 18–24 months have been associated with low treatment success rates due to their prolonged duration and high incidence of adverse drug reactions. More recent developments, namely the bedaquiline–pretomanid–linezolid regimen with or without moxifloxacin (BPaL/M), have demonstrated treatment success rates of up to 89–90% in international clinical trials. Purpose: To describe the treatment success of short-term, long-term, and BPaL/M regimens among patients with drug-resistant tuberculosis. Method: A retrospective descriptive study was conducted using medical record data of DR-TB patients who received long-term, short-term, or BPaL/M regimens during 2023–2024. Treatment outcome classification followed the WHO 2022 guidelines. The variables collected included patient characteristics, type of regimen, and treatment outcomes based on WHO standards: cured, treatment completed, treatment failed, lost to follow-up, and died. Results: Of the 148 DR-TB patients who met the inclusion criteria, 98 patients (66.2%) received long-term regimens, 17 patients (11.5%) received short-term regimens, and 33 patients (22.3%) were treated with the BPaL/M regimen. The treatment success rate (cured + treatment completed) for the short-term regimen was 76.5%, which was lower compared to the long-term regimen at 83.7%. The BPaL/M regimen demonstrated the highest treatment success rate at 87.9%. Conclusion: The treatment success rates for DR-TB patients at Dr. H. Abdul Moeloek Hospital indicate that the BPaL/M regimen provides the most favorable outcomes compared to long-term and short-term regimens. Keywords: BPaL/M Regimen; Drug-Resistant Tuberculosis; Long-Term Regimen; Short-Term Regimen; Treatment Success.    
Co-Authors Anggraeni Janar Wulan, Anggraeni Janar Anggraini, Dian Isti Ari Irawan Artanti, Mariesela Ayu S, Putu Ristyaning Bajuri, Annisa Nur Oktavia Betta Kurniawan, Betta Caesarridha, Dhaifany Karissa Cyntithia, L. Gita Damayanti, Ervina Dewayanti, Wahyu Dyah Wulan Sumekar Rengganis Wardani Ermin Rachmawati Ety Apriliana Fathunnisa, Ridha Riano Frauprades, Kaltihennah Oktavia Gliselda, Vika Kyneissia Gozali, Achmad Hanna Mutiara, Hanna Happy, Terza Aflika Helmi Ismunandar Indri Windarti Ismunandar, Helmi Ismunandar Jausal, Anisa Nuraisa Jessy Dewi Awali Juliana, Risna Junando, Mirza Kurniawaty, Evi Liana Sidharti, Liana Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Iqbal Muhammad Ricky Ramadhian Muhammad Yusran Nasution, Artika Ananda Putri Nikita, Marshanda Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Poty, Pitha Maykania Purba, Gemi Sabrina Putri, Abrila Tamara Putri, Yessa Rahmadini Rahel, Clara Arta Uli Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Sa'diyah, Isma Fadlilatus Sangging, Putu Ristyaning Ayu Septiani, Linda Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sinulingga, Anselmus Libreya Situmorang, Ezra Winandi Susianti, Susianti Sutyarso Sutyarso Syazili Mustofa Triyandi, Ramadhan Utami, Winda Trijayanthi Wibowo, Muhammad Rafi Wulan, Anggraini Janar Yunianto, Andi Eka Zahra, Aulia Jannatuz