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Journal : Journal of Dentistry Indonesia

Detection of Epstein-Barr Virus in Saliva and Gen LMP1 among HIVInfected Patients Munthe, Eliza Kristina M; Wisaksana, Rudi; Amalia, Riezki; Sufiawati, Irna
Journal of Dentistry Indonesia Vol. 26, No. 2
Publisher : UI Scholars Hub

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Abstract

Epstein-Barr virus (EBV) is also called human herpes virus 4 (HHV-4), has detected 95% of the population and shows an asymptomatic state. EBV is etiological agent of oral hairy leukoplakia (OHL) in HIV patients. Latent membrane protein 1 (LMP1), an integral EBV protein can modulate growth, differentiation, induce the expression of several cells, activation of antigens, and adhesion molecules. The LMP1 gene has been associated with OHL. Objectives: to determine the prevalence of EBV in saliva and the LMP1 gene in HIV/AIDS patients with EBV positive. Methods: A cross-sectional was conducted on HIV/AIDS patients. The presence of EBV in saliva was done by mciroarray PCR. LMP1 is examined by using nested PCR. Results: The research subjects involved 30 HIV/AIDS patients consisting 70% men and 30% women, with 50 % age group of 31-40 years old and 40% had CD4 counts <200 cells/mm3 (40%). EBV in saliva was found in 26 out of 30 (87%) HIV patients and LMP1 was detected in 17 patients (65.38%). Conclusion: The high prevalence of EBV in saliva and the LMP1 gene may increase the risk of OHL. Early screening for EBV infection in patients with HIV/AIDS is important to reduce the risk of EBV-associated diseases.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Noerkhaerin Putra Adi Ahmad Yusuf Adji Kusumadjati Aga Satria Nurrachman Agnes Rengga Rendati Alamsyah Piliang Alongsyah Zulkarnaen Ramadhan Amalia, Riezki An Nisaa Mardhatillah Ananda Sagita Andiesta, Niekla Survia Arny E. Muryah Arny E. Muryah, Arny E. Asri Arum Sari Budi Setiabudiawan Dani R. Firman Dani R. Firman Dendi Sandiono Dewi - Dewi Kania Intan Permatasari Dewi Marhaeni Diah Herawati Dewi Oktafia Traktama Dewi Puspasari Dewi Puspasari Dewi Zakiawati Dewi Zakiawati Dewi Zakiawati Dida Akhmad Gurnida Dida Akhmad Gurnida Dudi Aripin Eliza Kristina M. Munthe Eriska Riyanti Etis Duhita Rahayuningtyas Farhani Azizah Farina Pramanik Hapid, M. Hasan Harry Galuh Nugraha Hartati Purbo Darmadji, Hartati Purbo Harum Sasanti, Harum Husnul Mahfaza Ibnu Suryatmojo Ignatius Setiawan Indah Suasani Wahyuni Indra Gunawan Isabellina Dwades Tampubolon Larasati Dyah Utami Lusi Epsilawati Maulani, Intan Merry Annisa Mieke Hemiawati Satari Munthe, Eliza Kristina M Nanan Nur'aeny Nanan Nur’aeny Nanan Nur’aeny Nanan Nur’aeny Nur'aeny, Nanan Nuri Fitriasari Nurmilah Maelani, Nurmilah Oki Suwarsa Radzuan, Maryam Rahmat Gunadi Rahmi Harmiyati Ratna Indriyanti, Ratna Revi Nelonda Revi Nelonda Ria N.Firman Ria Noerianingsih Firman, Ria Noerianingsih Riani Setiadhi Riezki Amalia Risti Saptarini Risti Saptarini Primarti Rita Wardhani Rudi Wisaksana S. Suniti Samsuridjal Djauzi Sarifah, Norlaila Siti Aliyah Pradono Sri Tjahajawati Sunardhi Widyaputra Sunardhi Widyaputra Sunardhi Widyaputra Syarifah Fatimah, Syarifah Tenny Setiani Tenny Setiani Dewi Tony S. Djajakusumah Tony S. Djajakusumah Vatchala Rani Ramamoorthy Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wicaksono, Imme Kris Wijaya, Indra