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All Journal Jurnal Veteriner Jurnal Vokasi Indonesia Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology IGKOJEI: Jurnal Pengabdian Masyarakat Jurnal ABM Mengabdi journal of Basic Medical Veterinary Journal of Multidisciplinary Applied Natural Science Jurnal Vokasi Indonesia
Gandul Atik Yuliani
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Journal : Journal of Multidisciplinary Applied Natural Science

 1 
The Potential of Moringa Leaf Nanoparticles (Moringa oleifera) on the Expression of TNFα, IL10, and HSP 27 in Oral Cavity Cancer Theresia Indah Budhy; Deddy Adam; Zulikran Moh Rizki Azis; Vania Syahputri; M Gandul Atik Yuliani; Muhammad Febriano Sugiarso Suwarto; Fery Setiawan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.198

Abstract

Oral cancer is currently the sixth leading malignancy in the world, with over 330,000 cases resulting in death. Several cytokines and proteins protect the survival of cancer cells, such as TNF-α, HSP27, and IL-10. Moringa oleifera is an herbal medicine with anti-cancer properties. Nanoparticles of M. oleifera have the property to be easily absorbed by water-soluble cells, so only small doses are needed to be used as anti-cancer ingredients. This research aims to prove the ability of M. oleifera nanoparticle extract against oral cancer through the expression of tumour necrosis factor α (TNF-α), heat shock protein (HSP27), and interleukin 10 (IL-10). Rat as non-human experimental subjects were divided into four groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Cancer induction was carried out by injecting with benzo[a]pyrene, and then M. oleifera nanoparticle extract was administered in three forms of treatment doses of 125 μg/mL (P1), 250 μg/mL (P2), and 500 μg/mL (P3). Immunohistochemical examination was analysed through TNF-α, HSP27, and IL-10’s expression. The expression of TNF-α and HSP27 between control and treatment groups was significantly different. P2 had the lowest expression of TNF-α and HSP27. The expression of IL-10 between control and treatment groups was also significantly different. P1 had the lowest expression of IL-10. M. oleifera nanoparticle extract can reduce oral cancer progression by decreasing the expression of TNF-α, HSP27, and IL-10.
Co-Authors Agung Budianto Achmad, Agung Budianto Agus Widodo Agus Widodo Ahmad Thoriqul Firdaus Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Almira Aurellia Amalia Ristanti Andini Avita Ayu Anggri Septiana Annise Proboningrat Anwar Ma'ruf Anwar Ma'ruf Asrar, Siti Iqmallisa Nurrill Bambang Sumaryono Bimo Aksono Herupradoto Chrismanto, Dony Chusniati, Sri Dadik Rahardjo Daiva Ilyaning Asrin Dalila Fadhila Hidayat Deddy Adam Devi Listiani Dewi Setiyoningsih Dimas Kunto Satrio Diyantoro Diyantoro, Diyantoro Djoko Legowo Dwi Lestari Ega Putri Novitasari Erina Devi Yuniara Sari Ernawati, Rahaju Fansurina Erdayanti Fery Setiawan Ginta Riady Hariyono Hariyono Hidajati, Nove Hidayatik, Nanik Ismudiono Ismudiono Iwan Sahrial Hamid Jasmina Vidi Quamilla Kurnia Nisa Kinasih Laeli Amelia Melani Lia Lusanti Lucia Tri Suwanti, Lucia Tri M. Aji Saputro M. Wildan Sulthon Al Fikri Ma'ruf, Anwar Mafruchati, Maslichah Mochammad Yusuf M. Muhammad Febriano Sugiarso Suwarto Muhammad Sururi M’ Izi Kumala Lazuardi Sultoni NASHIHATUS SHOLIHAH Nidia Syafira Nove Hidajati Nunuk Dyah Retno Lastuti Nur Mariam Kusuma Nurrahmad, Nanda Rino Nusdianto Triakoso Oriza Cahya Rahmadiati Poedji Hastutiek Poetranto, Emmanuel Djoko Pricilia Yuniar Sianggi Pudji Srianto Ratna Ayu Ningrum Ratna Damayanti Retno Sri Wahjuni Rimayanti Rimayanti Roby Atul Nazila Adawiyah Rochmi, Siti Eliana Sherbina Bai Soeharsono Soeharsono Sofyan, Miyayu Soneta Sri Hidanah Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja ST. Nabilah Mardhiyah Sunarso, Agus Tasya Apritalia Putri Taufik Tri Laksono Theresia Indah Budhy Tita Damayanti Lestari Tri Wahyu Suprayogi Vania Syahputri Vida Brilian Wahjuni, Retno Sri Wahyu Perdana Wahyuni, Retno Sri Wardhana, Dhandy Koesoemo Warsito, Sunaryo Hadi Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Wildan Hakam Maulidy Wiranata, Try Ardhi Wiwin Retnowati Wurlina, W Yuliawan, Rahmat Yusril Nur Mahendra Zulikran Moh Rizki Azis