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All Journal Dentika Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obat Tradisional Indonesian Journal of Cancer Padjadjaran Journal of Dentistry JCRS (Journal of Community Research and Service) International Journal of Multidisciplinary: Applied Business and Education Research Biofaal Journal Denta: Jurnal Kedokteran Gigi IRA Jurnal Pengabdian Kepada Masyarakat Jurnal Bisnis Kehutanan dan Lingkungan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Kalwedo Sains (KASA) Waste Handling and Environmental Monitoring JURNAL REKAYASA KIMIA & LINGKUNGAN
Supriatno
Departemen Ilmu Penyakit Mulut Fakultas Kedokteran Gigi Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Kaempferol and Quercetin Isolated from The Leaves of Atingia Excelsa to Arrest Cell Cycle in G0/G1 Phase Human Tongue Cancer SP-C1 Cell Lines Risyandi Anwar; Arlette Setiawan; Supriatno; Unang Supratman
Denta Journal Kedokteran Gigi Vol 14 No 1 (2020): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i1.4

Abstract

The leaves of Altingia excelsa were found to strongly inhibit SP-C1 human tongue cancer cell lines. This study was focused on identifying the antiproliferative compound found in A. excelsa leaves and assessing its mechanism of action. The active compound was isolated using column chromatography and identified by the spectroscopic method and was also tested for its anti-proliferative properties and the cell cycle analysis in SP-C1 cells by flowcytometry analysis. This work resulted in the isolation of a flavonoid, which was identified to be kaempferol and quercetin. The compounds inhibited SP-C1 cell proliferation in a time- and dose-dependent manner with IC50 values of 0.72 µg/mL and 0. 70 µg/mL for the 24 hours treatments, respectively. Furthermore, the flowcytometry analysis suggested that the compounds exerted its anticancer activities by inhibiting cell cycle. These results suggested that compounds found in A. excelsa providies a basis for its potential use in cancer disease management.
Heavy metal contamination of Hg and Pb in water, sediment and Violet Batissa (Batissa violacea Lamark, 1818) meat in Teunom River, Aceh Jaya Regency, Indonesia Fauziah, Fauziah; Abdullah, Abdullah; Supriatno, Supriatno; Firdus, Firdus; Nasir, Muhammad; Mellisa, Siska; Batubara, Agung Setia
Depik Vol 10, No 3 (2021): December 2021
Publisher : Faculty of Marine and Fisheries, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13170/depik.10.3.23432

Abstract

Violet Batissa (Batissa violacea) is an important economic organism on the west-south coast of Aceh, because it is relatively high consumed by the community. However, gold mining activities carried out around the watershed are estimated to pollute the river and cause B. violacea to also be affected. The purpose of this study was to determine the level of mercury (Hg) and Lead (Pb) contamination in clam meat in Teunom, Aceh Jaya Regency. The research was conducted from June to September 2021. Sampling of clam was done by purposive sampling method. Hg and Pb were analyzed in clam meat using the Atomic Absorption Spectrophotometer (AAS) method. The results of the analysis showed that the Hg content in clam meat was between 0.12-0.63 mg/kg (mean 0.350.26 mg/kg), water 0.0026-0.0103 mg/kg (mean 0.00520.004 mg/kg), and sediment 1.3224-3.8767 mg/kg (mean 2.23241.427 mg/kg). Furthermore, the results of the analysis showed that the Pb content in clam meat, water and sediment had the same value at 3 stations with values 0.00020 mg/kg, 0.00030 mg/kg, and 0.00020 mg/kg, respectively. The conclusion of this study is that the Hg content in water and sediment has exceeded the threshold, while the clam meat is still in good quality standards. The Pb content in clam meat, water and sediment were also in good quality standards. Based on our study, B. violacea is still safe for consumption, while the water has been polluted and is recommended not to be utilized for human consumption.Keywords:Heavy metalRiverWaterSedimentBatissa violacea
Co-Authors Abdullah - Abdullah Abdullah Achmad Syawqie Agus Setiawaty Aldhori, Yopan Rahmad Ali Sarong Almeida, Maria Ana Medawati, Ana Arifian, Hanggara Arifuddin, M Arlette Setiawan Atiek Driana Rahmawati, Atiek Baso Didik Hikmawan Batubara, Agung Setia Bone, Mahfuzun Darianto, Darianto Dibyo Pramono Didik Setyo Heriyanto Djufri - Dyah Irnawati Edi Suanto, Edi Eka Safitri Eriska Riyanti Erwin Samsul Farah, Harra Ismi Fauziah Fauziah Fimma Naritasari Firdus Firdus Gina Arfianti Putri, Gina Arfianti Hafnati Rahmatan Haniza Harun Achmad, Harun Hendri Susanto Herman Herman Himmaturojuli Rosyid Ridlo, Himmaturojuli Ibrahim, Arsyik Ilham Maulana Indwiani Astuti Inne Suherna Sasmita Isadora Gracia, Isadora Islamudin Ahmad Ismul Huda Iswandi Iswandi Junaidin, Junaidin Keri Pangesti Yudi Harhari, Keri Pangesti Yudi Laode Rijai Lelifajri Lelifajri Lizma Febrina Martono, Dwi Nowo Maulinda, Maulinda Maureen Martina, Maureen Mieke Hemiawati Satari Muhammad Nasir N. Nazaruddin Rahmadi Rahmadi Rija’i, Hifdzur Rashif RIKI RIKI, RIKI Rinaldi Idroes Risyandi Anwar Rolan Rusli Roosje Rosita Oewen, Roosje Rosita Rusman, Arman Safrida Safrida Sapurti, Mimie Siska Mellisa Sri Budiarti Poerwanto Suhud, Khairi Tino Hermanto Totok Utoro Ulva, Susi Mulia Unang Supratman Wardiah Wardiah Yuliani, Wirda Zakiyana, Yulida