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The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts) Almaz, Ayyasi Izaz; Purnawati, Ratna Dama; Istiadi, Hermawan; susilaningsih, Neni
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1120.434 KB) | DOI: 10.30659/sainsmed.v11i1.7614

Abstract

Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase.Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton®, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney.Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05.Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton®
Feeding rats with used cooking oil elevates malondialdehyde, TNF-α, and creatinine compared to tempe fried with used oil Murwani, Retno; Susilaningsih, Neni; Ariyanto, Diaza O.; Ambariyanto, Ambariyanto
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.853

Abstract

In vivo studies on the hazards of deep-fried foods were commonly done by feeding used- or heated-cooking oil to rats. The aim of this study was to determine the effect of feeding tempe deep-fried in palm, olive, and coconut oils and the used frying oil on the blood biochemical profile of laboratory rats. An in vivo randomized control group study with pre-test and post-test was conducted. This study included healthy male Sprague-Dawley rats aged 2–3 months and weighing 100−200 grams. After acclimatization, the rats were randomly assigned to seven groups, which were: (1) regular diet (control diet); (2) diet of tempe deep-fried in 5× used palm oil (Tempe-in-used-Po); (3) diet of tempe deep-fried in 5× used coconut oil (Tempe-in-used-Co); (4) diet of tempe deep-fried in 5× used olive oil (Tempe-in-used-Oo); (5) diet of 5× used palm oil (Used-Po); (6) diet of 5× used coconut oil (Used-Co); and (7) diet of 5× used olive oil (Used-Oo). Each rat received 15 grams of a treatment diet daily and blood samples were collected after four weeks for a complete blood count and serum biochemistry analysis. The results showed that the final body weight and the weight gain of Tempe-in-used-Po, Tempe-in-used-Co, Tempe-in-used-Oo group, and Used-Po groups increased significantly compared to the control, Used-Co, and Used-Oo groups. However, there was a significant increase in serum tumor necrosis factor-alpha (TNF-α) in the Used-Co and Used-Oo groups (p<0.05), suggesting the used oil's detrimental effect. The Used-Co and Used-Oo were the only two groups whose creatinine increased significantly (p<0.05). Subsequently, only the Used-Oo group had a significantly increased malondialdehyde (MDA) level compared to all groups (p<0.05). These results prove that the effect of feeding fried food differs from used oils. Feeding used oil did not reflect the consumption of fried foods as part of the whole diet and generally resulted in more harmful effects. This is the first study to report an in vivo rat feeding study of deep-fried tempe and the used oil as part of the diet.
EFEKTIVITAS OZONATED VIRGIN COCONUT OIL TERHADAP PENYEMBUHAN LUKA FULL THICKNESS SKIN GRAFT AUTOLOG TIKUS SPRAGUE DAWLEY Ditinjau dari Ekspresi TGF-? dan Jumlah Neutrofil Kusuma, Nauval Marta; Hardian, Hardian; Najatullah, Najatullah; Yuniati, Renni; Susilaningsih, Neni
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (710.499 KB) | DOI: 10.36408/mhjcm.v8i3.489

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Abstract Introduction : Skin grafts are now one of treatment option in wound healing process that is always developing. TGF-bexpression and the number of neutrophils have an important role in healing skin graft wounds. Ozone (O3) has disinfecting properties that are effective in wound healing. Objective : Proving the effectiveness of Ozonated VCO for Full Thickness Skin Graft wound healing using parameter of TGF-b expression and neutrophil number. Method : This study is an experimental study with a post-test only design group of 40 Sprague Dawley rats performed autologous skin graft at the same time. Samples were divided randomly into 8 groups (K1 = without Ozonated VCO), (A1 = Ozonated VCO 50 mg / ml), (B1 = Ozonated VCO 100 mg / ml), (C1 = Ozonated VCO 200 mg / ml), ( K2 = without Ozonated VCO) (A2 = Ozonated VCO 50 mg / ml), (B2 = Ozonated VCO 100 mg / ml), (C2 = Ozonated VCO 200 mg / ml). Assessment of TGF-b expression and neutrophil number of tissue was performed by staining hematoxylin & eosin and immunohistochemistry on days 6 and 12 after skin graft. Results : There were significant differences (p <0.05) TGF-b expression and neutrophils number of tissue between the control group and the administration of Ozonated VCO doses of 50 mg / ml, 100 mg / ml and 200 mg / ml on days 6 and 12 post skin graft. Conclusion : The administration of Ozonated VCO effectively improve Full Thickness Skin Graft wound healing seen from macroscopic wounds, increase TGF-b expression and decrease the number of neutrophils.
Antioxidant and Anti-inflammatory effect of Graptophyllum pictum (L.) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids Azhar, Abu; Riwanto, Ignatius; Nugroho, Eriawan Agung; Susilaningsih, Neni; Prajoko, Yan Wisnu; Budiono, Parish; Prasetyo, Sigit Adi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.539 KB) | DOI: 10.36408/mhjcm.v7i2.515

Abstract

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory and plebotonic medicines, high fiber diet and changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory and plebotonic medicine) since its anti-inflammatory effect may be related to antioxidant property. ObjectiveTo elaborate the anti-inflammatory and anti-oxidant effect of GP on experimental hemorrhoid in male Wistar rats. MethodsA Randomized Controlled Trial Post-test only design in hemorrhoid-like rats using croton oil induced into the anus for 30 seconds each day for 3 consecutive days. 14 Wistar rats were randomly allocated into 2 groups. Group 1 got normal saline solution, while group 2 treated with GPE 100mg/Kg bw for 5 consecutive days. On the 9th experimental day, the blood was drawn for Elisa examination of COX-2 and SOD levels. As COX-2 and SOD normally distributed, pool t-test and product moment correlation was used for statistical analysis. Results All of Wistar rats were still alive. COX-2 levels (ng/ml) in the GPE group was 266.28±158.47, was significantly lower compared to control (595.21±68.92) (p=0.000). Serum SOD levels (ng/ml) in the GPE was 77.00±11.0, and was significantly higher than the control 28.00±4.00 (p=0.02). Correlation between COX-2 and SOD serum level was significantly strong negative correlation (p=0,000 and r=-0.842) Conclusions GPE at a dose of 100 mg/kg bw has antioxidant and anti-inflammatory effects on artificial hemorrhoids through decreased COX-2 levels, and elevated SOD levels. There is a strong negative correlation between SOD and COX-2 serum level. KeywordsGraptophyllum pictum, hemorrhoids, Croton oil, COX-2, SOD.
The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus: The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus Cahyono, Chemy Wiryawan; Mughni, Abdul; Susilaningsih, Neni; Nugrahadi, Dimas Erlangga; Mahendra, Vito
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.764

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INTRODUCTION: WHO predicts an increase in the number of people with diabetes in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. Another marker for measuring insulin resistance is the homeostasis model assessment-insulin resistance (HOMA-IR). Bariatric surgery is the most effective therapy for patients both in terms of weight loss and improvement in obesity-related diseases such as Type-2 Diabetes Mellitus (DM). OBJECTIVE: This study aims to prove the improvement of HOMA Beta values and Diameter of the islets of Langerhans in type 2 diabetes mellitus rats that underwent Sleeve Gastrectomy and Pancreatic Omentoplasty. METHODS: This study is an experimental post-test control group design study with 18 male Sprague-Dawley rats. Samples are divided into 1 control group and 2 treatment groups (Sleeve gastrectomy and Omentoplasty). Rats’ pancreas and glucose level were measured by using HOMA IR method and Hematoxylin eosin-paraffin block method. Data of islets Langerhans were measured using ANOVA, while HOMA Beta values were measured by Mann Whitney and Kruskall Wallis test. RESULTS: HOMA Beta values in treatment Group P1 (Sleeve gastrectomy) and Group P2 (Sleeve gastrectomy + omentoplasty) are statistically different compared to control group. Islets cells of Langerhans diameter in treatment groups 1 and 2 was not statistically different compared to control group. HOMA Beta Value and Langerhans diameter was correlated moderately. CONCLUSION: Sleeve Gastrectomy and Pancreatic Omentoplasty in type 2 diabetes mellitus rats improved the HOMA Beta values and the diameter of the islets of Langerhans. KEYWORDS: Sleeve Gastrectomy; Omentoplasty; Diabetes mellitus; HOMA Beta; Langerhan's Islet
The Effectiveness Of E-Backnshou Exercise To The Improvement Of Neck, Shoulder And Back Pain In Computer Vision Syndrome Patient Julianti, Hari Peni; Nugroho, Trilaksana; Kesoema, Tanti Ajoe; Susilaningsih, Neni; Rahmi, Fifin Luthfia; Pritadesya, Maharani Prizka
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1017

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BACKGROUND : Extra-ocular complaints of Computer Vision Syndrome (CVS) are neck, shoulder, back pain.  The 20-20-20 rule and E-BACKNSHOU exercise are expected to improve accommodative mechanisms, ocular surface of the eye and extra ocular symptoms of CVS. AIMS :  Proving the effectiveness of E-BACKNSHOU exercise for the improvement of neck, shoulder and back pain in CVS patient. METHOD : The research design was Pre-Post Test with Control Design. Subjects were 30 medical students of Faculty of Medicine, Diponegoro University, Semarang, Indonesia who experienced CVS and neck, shoulder and back pain. The treatment group got the 20-20-20 rule and E-BACKNSHOU exercise and the control group got the 20-20-20 rule for 1 month. Pain was measured by Visual Analogue Scale (VAS). Statistical test was conducted using paired t-test, unpaired t-test and chi square. Value of significance p<0.05. RESULT :  There were significant differences in VAS score of neck, shoulder, upper back pain (p=0.00), and low back pain (p=0.022) before and after the intervention in the treatment group and VAS score of neck (p=0,002), shoulder (p=0.020), upper back (p=0.011), and low back pain (p=0.019) in the control group. Delta VAS score of the treatment group was greater than the control group and there was a significant difference in delta VAS score of shoulder pain (p=0,030), but there were no significant differences in delta VAS score of neck (p=0,934), upper back (p=0,356), and low back pain (p=0,150). CONCLUSION : The effectiveness of 20-20-20 rule and E-BACKNSHOU exercise is better than the 20-20-20 rule alone on treating neck, shoulder and back pain in CVS patient.
Pengaruh Ekstrak Kayu Secang terhadap Kadar Superoxide Dismutase dan Malondialdehid Tikus yang Terpapar Gas Formaldehid Nurullita, Ulfa; Susilaningsih, Neni; Suwondo, Ari
Medica Arteriana (Med-Art) Vol 5, No 1 (2023): Juni 2023
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.5.1.2023.1-11

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Latar Belakang: Formaldehid merupakan radikal bebas yang bila masuk pada mahluk hidup akan diikat oleh antioksidan. Paparan radikal yang melebihi kapasitas antioksidan akan mendorong terjadinya peroksidasi lipid yang berakhir dengan kerusakan sel, ini dapat diatasi dengan antioksidan eksogen, salah satunya dari kayu secang (Caesalpinia sappan L.). Antioksidan alami lebih aman terhadap sel dibanding yang sintetik. Tujuan penelian adalah untuk mengetahui efektifitas kayu secang dalam meningkatkan antioksidan endogen dan menekan peroksidasi lipid.Metode: Penelitian true experimental secara in vivo ini dengan desain Randomized Post Test Only Control Group. Subyek penelitian adalah tikus Sprague dawley jantan, umur 2-3 bulan, berat 200-300 gram, sebanyak 20 ekor. Tikus dibagi menjadi empat kelompok, kelompok 1 sebagai kontrol tidak mendapat perlakuan apapun, kelompok 2 mendapat paparan formaldehid, kelompok 3 mendapat paparan formaldehid dan ekstrak kayu secang (EKS) secara bersamaan, dan kelompok 4 mendapat EKS 14 hari sebelum dipapari formaldehid, terus berlanjut selama paparan paparan formaldehid. Gas formaldehid diberikan secara inhalasi dari formaldehid cair 10%, 8 jam/hari selama 2 minggu. Ekstrak kayu secang 0,2 ml/kg berat badan/hari diberikan secara oral dengan variasi waktu. Variabel yang diukur adalah kadar antioksidan endogen (Superoxide dismutase/SOD) dengan metode Elisa dan tingkat peroksidasi lipid (kadar Malondialdehid/MDA) dengan metode TBARS. Data dianalisis dengan one way anova dan Kruskal wallis dengan kemaknaan 95%.Hasil: Rata-rata kadar SOD terendah pada kelompok 2 (3,5 u/ml), rata-rata tertinggi pada kelompok 1 (9.5 u/ml), rata-rata kadar MDA terendah pada kelompok 1 (1,9 u/ml), tertinggi pada kelompok 2 (7,23 u/ml). Uji perbedaan kadar SOD dengan nilai p=0,000, perbedaan kadar MDA p=0,023, uji hubungan kadar SOD dan MDA p=0,000.Kesimpulan:Pada tikus yang terpapar gas formaldehid, pemberian ekstrak kayu secang sebanyak 0,2 ml/ kg/berat badan/ hari  mampu meningkatkan kadar SOD, namun belum mampu menekan kadar MDA, dan peningkatan SOD berhubungan dengan penurunan kadar MDA.
Predictors for 30-day mortality in hepatocellular carcinoma patients undergoing liver resection Prabowo, Erik; Susilaningsih, Neni; Suharti, Catharina; Purnomo, Hery D.; Riwanto, Ignatius; Fuadi, Ahmad F.; Ar, Ardiyana; Bulandari, Beatrice LA.; Tjandra, Kevin C.; Respati, Danendra RK.; Rampengan, Derren DCH.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1001

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Hepatocellular carcinoma (HCC) ranks among the most prevalent and fatal liver cancers globally. Liver surgery, particularly resection, offers the potential for cure but poses challenges, especially in Indonesia, where patients often present in advanced stages. This study aimed to determine the intraoperative and perioperative factors associated with 30-day mortality of HCC patients undergoing liver resection at a tertiary referral hospital. The study included HCC patients undergoing liver resection at Karadi General Hospital, Semarang, Indonesia, between January 2018 and September 2023. Demographic data, intraoperative, perioperative, and postoperative factors were collected, with the primary outcome being 30-day mortality. Factors influencing 30-day survival were assessed using a log-rank test and the survival analysis employed Kaplan-Meier curves. Among 58 HCC patients who had liver resection, 62.1% were males, with a mean age was 57.27±9.56 years old. Preoperative comorbidities, notably hepatitis B, affected 34.4% of patients. Child-Pugh Score categorized 91.4% as class A. The study found a 30-day mortality rate of 10.3% with no subsequent increase in incidence. The failure-to-rescue rate (FTR) of this study was found to be 46%. Factors associated with 30-day mortality were Child-Pugh classification (p<0.001), intraoperative bleeding (p=0.001), creatinine levels (p=0.005), Clavien-Dindo classification (p<0.001), and posthepatectomy liver failure (PHLF) (p<0.001). This study suggests that pre-operative (Child-Pugh classification), intraoperative (blood loss volume) and postoperative factors (Creatinine level, Clavien-Dindo classification, and PHLF) could predict the mortality rate of HCC patients undergoing liver resection.
Clove Flower Extract (Syzygium aromaticum) enhance Wound Healing Time, Bacterial Count, and IL 10 Levels in Methicillin Resistant Staphylococcus aureus infected Rats Muttaqien, Rizal Arief,; Lestari, Endang Sri; Prajoko, Yan Wisnu; Susilaningsih, Neni
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/potensi.%Y.24213

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To determine the effect of clove flower extract on the healing time of incision wounds, bacterial count and IL-10 levels in rats infected with MRSA.Method. Experimental study with a post-test-only control group design in rats that were given incisions on their backs. Random allocation was carried out to divide the Sprague Dawley rats into 6 groups (@5 rats). Healing time was assessed based on the length of days, the bacterial count was examined from the blood and then counted by culture using nutrient agar. IL-10 levels were examined from the venous blood of rats and then measured using an ELISA kit assessed by a certified microbiologist. Data were analyzed and processed using the One Way Anova - Post Hoc hypothesis test.Results. The bacterial count in the clove flower extract group was lower than the group without antibiotics and there was no difference compared to the group given antibiotics. IL-10 levels in the group given clove flower extract were lower when compared to the group given antibiotics. The wound healing time in the clove flower extract group was faster when compared to the group with or without antibiotics.Conclusion. Clove flower extract enhancewound healing in MRSA-infected rats.
Perception and use of herbal medicine by Indonesian Medical Doctors Simatupang, Abraham; Widyawati, Tri; Susilaningsih, Neni; Tobing, Romauli; Kurniaty, Linggom; Silaban, Hertina; Djojosaputro, Mulyadi; Mahabuana, Bintang
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.15768

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Indonesia has a long experience in traditional medicine such as jamu. The government has been encouraging all sectors, especially pharmaceutical industries together with research institutions and academia to increase herbal medicine research so that herbal medicine is increasingly used in health services, including by medical doctors. Various efforts have been made but empirically it seems that this goal has not been achieved. For this reason, it is necessary to conduct a survey to determine the understanding and use of herbal medicine among doctors. I was a cross-sectional study using an electronic questionnaire distributed to doctors who are members of the Indonesian Medical Association (IMA) per province. Three-hundred sixty-two respondents from 29 out of 38 (76%) provinces of Indonesia responded, and 263 out 362 respondents (72%) are general practitioners. In prescribing herbal medicines only 18.5% prescribed, 35% did not and 46.6% sometimes prescribed, respectively. Of the eleven phytopharmaceuticals/standardised herbal medicines only one medicine No. 5 was widely recognized by respondents (46.6%). This study showed that doctors' understanding of herbal medicine still needs to be improved through various means including webinars/seminars, journals that show good clinical trials so that they are more confident when prescribing herbal medicine to their patients. There is a need for more comprehensive information regarding the indications, efficacy and side effects of herbal medicine, through books or formularies that can be accessed by doctors. In addition, respondents agreed that herbal medicine should be taught in medical schools both in the pre-clinical and clinical phases.
Co-Authors , Yan Wisnu Prajoko Abdul Hakam Abdul Mughni Abraham Simatupang Aditya Purnama Agnes Stella Valentina Akhmad Ismail Almaz, Ayyasi Izaz Ambariyanto , Ar, Ardiyana Ari Suwondo Ariyanto, Diaza O. Asri, Hairul Astika Widy Utomo, Astika Widy Awal Prasetyo Azhar, Abu Bambang Joni Karjono Bambang Witjahjo Bambang Witjahjo Bernadus Parish Budiono Budiono, Bernardus Parish Bulandari, Beatrice LA. Cahyono, Chemy Wiryawan Catharina Suharti Damma Purnawati, Ratna Desy Armalina Dimarti, Safira Chairani Dwi Marliyawati Elvira Yunita Endang Sri Lestari Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Eva Annisa Fahmi Syarif Fanti Saktini Ferry Sandra Fidela Hanan Zivana Fifin Luthfia Rahmi Fuadi, Ahmad F. Hardhono Susanto Hardian Hardian Hari Peni Julianti Helmia Farida Hermawan Istiadi Iffiyana, Alifatul Ignatius Riwanto, Ignatius Indah Saraswati Joni Karjono, Bambang Kanti Yunika Kurniaty, Linggom Kusuma, Nauval Marta Mahabuana, Bintang Mahendra, Vito Maria Eka Patri Y Maria Mexitalia Mario Sadar Bernitho Hutagalung Maryam Restiwijaya Meiny Suzery Muhammad Nur Mulyadi Djojosaputro, Mulyadi Muniroh, Muflihatul Muttaqien, Rizal Arief, Najatullah Najatullah Najatullah, Najatullah Nani Maharani Nugrahadi, Dimas Erlangga Nugroho, Trilaksana Parish Budiono Prabowo, Erik Prihharsanti, Christina H.N. Pritadesya, Maharani Prizka Purnawati, Ratna Dama Purnomo, Hery D. Putri, Ajeng Kurniasari Rahajeng, Herera Rampengan, Derren DCH. Ratna Damma Purnamawati Ratna Damma Purnawati Renni Yuniati Respati, Danendra RK. Retno Murwani Ryco Giftyan Ardika Selamat Budijitno Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Silaban, Hertina Sri Susilowati Suhartono, Suhartono Supandi Andy SyarofilAnam, Moh. Tanti Ajoe Kesoema, Tanti Ajoe Tjandra, Kevin C. Tobing, Romauli Tri Widyawati, Tri Trilaksana Nugroho Udadi Sadhana, Udadi Ulfa Nurullita Utami, Widoasti Putri Wahyu Haris Prabowo Widiastiti, Nyoman Suci Yan Wisnu Prajoko Yuriz Bakhtiar Zhafran Hafizhki