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Studi Bioekivalensi Obat Paracetamol Generik Dan Non Generik Secara In Vitro Siti Mutaharah; Saftia Aryzki; Rina Saputri; Yusuf Anggoro Mukti
Sains Medisina Vol 1 No 6 (2023): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Drugs are one component of health that is irreplaceable in order to improve public health status. There are 2 types of drugs circulating in the market, namely generic and non-generic. Paracetamol is classified as a class 1 biopharamcetic drug which is formulated as a product with high solubility in water and has high intestinal permeability, almost 100% absorption can be expected at least as much as 85% of the soluble product in in vitro testing. In vitro testing was carried out for 180 minutes with a span of 15 minutes using generic paracetamol and patented paracetamol to determine whether there is a difference in the quality of the drugs and to make comparisons with the aim of knowing their bioequivalence.
HUBUNGAN PERILAKU DAN PENGETAHUAN MASYARAKAT DALAM PENGGUNAAN ANTIBIOTIK DI DESA TELUK TAMBA KECAMATAN TABUKAN KALIMANTAN SELATAN Rini Ardila Ipnas; Saftia Aryzki; Erlina Syamsu
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 3 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i3.5648

Abstract

Di Indonesia, pengetahuan masyarakat dalam penggunaan antibiotik sering tidak tepat. Hal tersebut dapat menyebabkan angka resistensi antibiotik meningkat. Hasil RISKESDAS 2013 menunjukkan Kalimantan Selatan memiliki angka proporsi rumah tangga menyimpan antibiotika tanpa resep sebanyak 90,6 %, hal ini menunjukkan masyarakat tidak menggunakan antibiotik secara tepat. Penggunaan antibiotik dipengaruhi oleh beberapa faktor yaitu, perilaku dan pengetahuan sehingga tujuan penelituan ini untuk melihat hubungan perilaku dan pengetahuan masyarakat dalam penggunaan antibiotik di Desa Teluk Tamba Kecamatan Tabukan Kalimantan Selatan. Metode penelitian yang digunakan adalah observasional analitik non eksperimental (kuantitatif analitik) dengan metode cross-sectional. Sampelnya adalah masyarakat Desa Teluk Tamba dengan umur diatas 17 tahun dan berjumlah 91 orang. Pengambilan sampel dengan teknik purposive sampling. Instrumen yang digunakan berupa kuesioner perilaku dan pengetahuan. Data dianalisis menggunakan uji spearman rank dengan program spss versi 26.  Hasil penelitian menunjukan masyarakat di Desa Teluk Tamba memiliki tingkat perilaku penggunaan antibiotik dalam kategori kurang (82,41%). Tingkat pengetahuan penggunaan antibiotik dalam kategori kurang (75,82%). Hasil spearman rank menunjukan adanya hubungan signifikan yang searah antara perilaku dan pengetahuan sebesar (0,000) dan nilai koefisien korelasi (0,588) dengan arah korelasi positif, kekuatan korelasi dari kedua variabel tersebut berada dalam tingkat hubungan sedang. Kesimpulan terdapat hubungan perilaku dan pengetahuan dalam penggunaan antibiotik
Meningkatkan Pengetahuan Remaja Dalam Penggunaan Antibiotik Di Pondok Pesantren Darul Istiqamah Kalimantan Selatan Saftia Aryzki; Melviani Melviani
Jurnal Pengabdian Masyarakat Panacea Vol 1, No 1 (2023): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v1i1.8830

Abstract

Antibiotik merupakan obat untuk pengobatan infeksi yang disebabkan oleh berbagai bakteri. Antibiotik saat ini banyak beredar di masyarakat sebagai salah satu obat umum. Periode awal remaja adalah masa transisi menuju tahap dewasa. Kegiatan ini bertujuan untuk meningkatkan pengetahuan remaja dalam penggunaan antibiotik. Kegiatan dilakukan pada hari Sabtu, 23 Juli 2022 di Pondok Pesantren Darul  Istiqamah secara daring. Jumlah peserta dalam kegiatan ini sebanyak 31 orang yaitu terdiri dari perwakilan kelas X, kelas XI dan kelas XII SMA. Metode pelaksanaan kegiatan pengabdian masyarakat ini adalah dengan menggunakan metode ceramah. Metode ini dilakukan dengan memberikan edukasi secara langsung menggunakan media power point. Hasil penyuluhan siswa SMA Pondok Pesantren Darul Istiqomah dengan nilai pretes baik sebanyak 10 siswa (32,25%) dan buruk sebanyak 21 siswa (67,74%). Setelah pemberian penyuluhan dilakukan penilaian kembali dengan nilai postest baik sebanyak 23 siswa (74,19%) dan buruk sebanyak 8 siswa (25,8%). Kesimpulan dari penyuluhan ini dapat meningkatkan pengetahuan siswa dalam hal ini remaja dalam penggunaan antibiotik. Kata Kunci: Antibiotik, Remaja, Penyuluhan, Resistensi Antibiotics are drugs to prevent and treat infections caused by bacteria. As one of the common types of drugs, antibiotics are widely circulated in the community. The early adolescent stage is a transitional period from the stage of adulthood. The activity was carried out on Saturday, 23 July 2022 at the Darul Istiqamah Islamic Boarding School in a brave manner. The number of participants in this activity was 31 people consisting of representatives from class X, class XI and class XII SMA. The implementation method in this community service activity is a lecture. This method is done by providing education directly with power point media. The results of the counseling showed that there were differences in knowledge of the use of antibiotics in students of SMA Pondok Pesantren Darul Istiqomah with good pretest scores of 10 students (32.25%) and bad as many as 21 students (67.74%). After the counseling was given, a re-judgment was carried out with good posttest scores for 23 students (74.19%) and bad for 8 students (25.8%). The conclusion of this counseling can increase students' knowledge in this case teenagers in the use of antibiotics. 
Improving Environmental Sanitation Knowledge through Clean and Healthy Living Behavior (CHLB) Education Saftia Aryzki; Noverda Ayuchecaria; Ana Khumaira Sari
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 6, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v6i2.10816

Abstract

Environmental cleanliness is always associated with health because maintaining a clean environment can prevent the emergence of various types of diseases. This service activity aims to increase awareness, experiences, and knowledge and foster a sense of community towards a clean and healthy environment to avoid various diseases. This community service method uses service learning (SL), which refers to experiential learning, namely providing direct knowledge to the community regarding the importance of maintaining a clean environment. The activity begins with a pretest, providing CHLB knowledge material on environmental cleanliness, questions and answers, and a post-test. Community service is also accompanied by health checks and the provision of vitamin C supplements and Fe tablets (blood supplements). The results of community service showed that the average pretest and post-test scores for community knowledge in PHBS were 70 and 92.5, the results showed that there was an increase in community knowledge to improve environmental sanitation after being given education regarding CHLB.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 96% DAUN RAMANIA (Bouea macrophylla Griffith.) DARI DAERAH KALIMANTAN SELATAN DENGAN METODE DPPH Saftia Aryzki; Setia Budi; Yanti
Jurnal Insan Farmasi Indonesia 2023: JIFI: Webinar & call for paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i3.1692

Abstract

Ramania (Bouea macrophylla Griffith.) is a herbal plant that has antioxidant properties and inhibits free radicals. This research aims to determine the antioxidant potential of ramania leaf ethanol extract by looking at the IC50 value. Ramania leaves were extracted using the maceration method using 70% ethanol solvent. Antioxidant potential is determined using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method by comparing vitamin C which has been proven to have very potent free radical potential. The ramania leaves made had a concentration of 10% and then diluted to a concentration of (20,40,60,80,100) µg/mL. 2 mL of each infusion was taken and reacted with 2 mL of 50 µg/mL DPPH solution in an aluminum-lined test tube for a period of time (30 minutes). The results showed that the IC50 value of the ethanol extract of ramania leaves was 0.8126 ± 78.56387 µg/mL. The IC50 value obtained was compared with the inhibition value of the vitamin C solution made with varying concentrations (2,4,6,8,10) µg/ mL, based on this value, ramania leaf extract from the Sleman area is categorized as very potent so it can be developed as a source of antioxidants from natural ingredients.
Hubungan Tingkat Kepatuhan Penggunaan Obat Antihipertensi Dengan Kontrol Tekanan Darah Pada Pasien Hipertensi Di Puskesmas Terminal Banjarmasin Humaira, Muhammad Nurridho Alfian; Mustaqimah, Mustaqimah; Aryzki, Saftia
Jurnal Farmasi SYIFA Vol 1 No 2 (2023): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v1i2.181

Abstract

Hipertensi merupakan salah satu penyakit yang meningkat seiring perkembangan zaman dan paling banyak diderita oleh masyarakat Indonesia, dimana penderita mengalami peningkatan tekanan darah ≥140/90 mmHg. Keberhasilan dan kesembuhan pasien dalam terapi hipertensi dipengaruhi oleh beberapa faktor, salah satunya yaitu kepatuhan pasien dalam minum obat. Tujuan penelitian mengetahui hubungan tingkat kepatuhan penggunaan obat antihipertensi dengan kontrol tekanan darah pada pasien hipertensi di Puskesmas Terminal Banjarmasin. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan Cross Sectional, pengumpulan data dilakukan secara prospektif menggunakan kuesioner kepatuhan Hill-Bone yang telah diuji validitas dan reliabilitas. Penelitian ini mendapatkan hasil uji statistik dengan nilai p = 0,000 < α 0,05 menggunakan uji spearman rho correlation yang artinya Ho ditolak dan Ha diterima. Simpulan dari penelitian ada hubungan mengenai tingkat kepatuhan penggunaan obat antihipertensi dengan kontrol tekanan darah pada pasien hipertensi di Puskesmas Terminal Banjarmasin.
Compliance of Pharmacy Service Standards at The Phcussia of Banjarmasin City Nufus, Hayatun; Aryzki, Saftia; Malahayati, Siti; Kurniawati, Darini
Berkala Kedokteran Vol 20, No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i2.20596

Abstract

Pharmaceutical work carried out in the acquisition, production, distribution and maintenance of drugs must be carried out by health workers who have the appropriate knowledge and authority for that. Based on the description above, researchers are very interested in knowing whether or not there is a conformity of pharmaceutical service activities in all Banjarmasin city health centers based on Permenkes RI No. 26 of 2020 related to Pharmaceutical Service Standards. The purpose of this study was to determine the suitability of Pharmaceutical Services at public health center in Banjarmasin City against Permenkes No. 26 of 2020 concerning Pharmaceutical Service Standards at public health center. The research design method used is observation, namely making direct observations accompanied to obtain information on the Management of Pharmaceutical Supplies and Consumable Medical Materials, as well as Clinical Pharmacy Services. There are 26 health centers in Banjarmasin City. All health centers have met the suitability of pharmaceutical preparation management and Medical Consumables (BMHP) in accordance with the Minister of Health Regulation No. 26 of 2020. However, 10 public health center in Banjarmasin City have not met the requirements of clinical pharmacy services, such as Counseling, Monitoring Drug Side Effects, Monitoring Drug Therapy, and Evaluating Drug Use. This is influenced by limited human resources at these health centers. 26 health centers in Banjarmasin City are appropriate in managing pharmaceutical preparations and Consumable Medical Materials (BMHP) and 16 health centers are appropriate in implementing clinical pharmacy services.
Cost Minimization Analysis of Oral Antidiabetic Drugs in Type II Diabetes Mellitus Patiens at Sultan Suriansyah Hospital January-December 2022 Period Ain, Farah Noor; Aryzki, Saftia; Abdi, Muhammad Mahendra
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18764

Abstract

Diabetes According to WHO (2016) is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. The high cost of treating DM patients is reaching USD 1,500 to 9,000 in developing countries. The difference in costs for oral antidiabetics and the high cost analysis method. This study aims to determine the minimum cost between metformin 500 mg and acarbose 100 mg drugs in Sultan Suriansyah Banjarmasin in adult patients. This research was conducted using a cross-sectional design based on medical records and detail of patient costs in January-December 2022. The number of sample in this study were 39 patients. The statistic analysis used in study is the Mann-Whitney test and the Independent T-Test. The result of the analysis of cost minimization based on the average total cost of therapy are Rp 419,560 for metformin 500ng and Rp 680,922 for acarbose 100 mg with a probability value > 0.05 for the cost of co morbidities which means that there is no significant difference between the two drugs. Probability value < 0.05 for antidiabetic oral drug costs, lab costs and total therapy costs which means the there is a significant difference between the two drugs. Conclusion in this study is aral antidiabetic therapy for minimal diabetes mellitus is metformin compared to acarbose.
Effectiveness of Ramania Leaves (Bouea macrophylla Griffith) from South Kalimantan as a Mosquito Larvae Biolarvicidal Aryzki, Saftia; Febrianti, Dwi Rizki
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17386

Abstract

Indonesia itself as a tropical country has many plants that can be used as biolarvicides, one of which is the ramania plant (Bouea macrophylla Griffith). Ramania fruit epidermis contains secondary metabolites such as flavonoids, saponins, phenolic tannins, alcohol, steroids and terpenoids where these compounds have a larvicidal effect. The purpose of this study was to determine the activity of the ethanol extract of the epidermis of the ramania fruit as a biolarvicidal Mosquito larvae from the LC50 value. This research is a laboratory experimental research. The treatment concentrations used in this study were 25 ppm, 50 ppm, and 100 ppm. Temephos 1% was used as a positive control. Concentrations were then tested on 20 larvae instar III. The results of SPSS analysis with a significance of <0.05 showed that there was an effect of treatment on the number of larvae deaths, where the results of Tuckey analysis showed that concentrations of 50 ppm and 100 ppm and Temephos 1% showed differences. which means the number of deaths of test larvae. The results showed that the ethanol extract of ramania rind of ramania fruit (Bouea macrophylla Griffith) was effective as a biolarvicidal mosquito larvae. The results of probit analysis showed that the LC50 of ethanol extract of ramania rind against larvae was 20,844 ppm which is a low toxic group in aquatic environments.
Uji Aktivitas Antiseptik Ekstrak Etanol Tanaman Bundung (Scirpus grossus L.) Terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Amalia, Ghina Rezki; Saftia Aryzki; Darini Kurniawati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.531

Abstract

Bundung Plant (Scirpus grossus L.) is one of the wild plants that is very easy to get, but not many people know its properties. This plant is empirically used by the community as a wound treatment and antimicrobial. This plant is proven to contain several compounds such as tannins, flavonoids, phenolics, saponins, steroids and terpenoids. This study aims to determine the antiseptic activity of ethanol extract of Bundung Plant with various concentrations and the most effective concentration in healing white rat incision wounds (Rattus norvegicus). the method used begins with the extraction process, making extract concentrations, preparing test animals, dividing test animal groups, treating test animals, observing the healing phase and testing antiseptic activity. The results of the group test on the measurement of the average length and healing time of the incision wound, the wound that closed the fastest was the 4% extract group which was seen clinically could be distinguished by its healing speed, from the results of the analysis there was no significant difference in the healing time span and measurement of the average length of the incision wound. The conclusion of this study is that the ethanol extract of the Bundung Plant (Scirpus grossus L.) has antiseptic activity on the healing of incision wounds of white rats (Rattus norvegicus) which is observed through the healing time span and there is no significant difference in changes in wound healing time and the length of the incision wound in the five groups and the most optimal concentration of ethanol extract of the Bundung Plant (Scirpus grossus L.) with the concentration of the extract observed clinically is 4%.