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All Journal Journal of Food and Pharmaceutical Science Jurnal Sain Veteriner Jurnal Pendidikan Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Sains dan Teknologi Farmasi JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Pharmacon Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYA LAKSANA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASIMED (JFM) Jurnal Komunikasi Pendidikan Optika : Jurnal Pendidikan Fisika Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Journal of Research in Instructional AL-KHAZINI: JURNAL PENDIDIKAN FISIKA Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Wahyu Widyaningsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Jatropha curcas L. Leaf Extract Effects on Blood Pressure and Lipid Levels in Hypertensive Rats with High-Fat Diet Moch. Saiful Bachri; Wiki Yuli Anita; Putri Dwi Lestari; Desi Eko Wulansari; Dwi Retno Nengtyas; Muhammad Ma'ruf; Sapto Yuliani; Wahyu Widyaningsih; Laela Hayu Nurani; Daru Estiningsih; Vivi Sofia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.61-70

Abstract

Background: One of the main risk factors for cardiovascular diseases such as coronary atherosclerotic heart disease (CAHD) is dyslipidaemia or high levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL). Hypertension is also a cause of cardiovascular disease. One potential plant to lower LDL levels and blood pressure is Jatropha curcas, which is known to contain saponins, polyphenols, and flavonoids. Objective: The purpose of this study was to determine the effect of the ethanol extract of Jatropha curcas leaves (EEJCL) on blood pressure, LDL levels, and HDL levels in hypertensive rats given a high-fat diet. Methods: This study is an experimental study with a pretest-posttest control group design on male Wistar strain rats. Rats were divided into seven groups, namely the normal group, control group (induced with NaCl and given a high-fat diet), Captopril group, Simvastatin group, and EEJCL groups given doses of 1.8, 2.7, and 4.05 g/kg BW. The data obtained were analysed using the One-Sample Kolmogorov-Smirnov Test, Homogeneity of Variance, One-Way ANOVA, and Tukey Test. Results: The results showed that the administration of EEJCL could significantly lower LDL levels and blood pressure and increase HDL levels (p < 0.05) at doses of 1.8, 2.7, and 4.05 g/kg BW, and the dose of 4.05 g/KgBW was the most optimal dose. Conclusion: EEJCL has a potential for development in the treatment of hypertension and dyslipidaemia.
Co-Authors Aditya Prabowo Aditya Prabowo Ainiyah, Nadia Putri Aldri Frinaldi Amelia Regina Arsyad Anasyua, Fairuz Khairunnisa arsyad, regina Astutik, Novita Santi Ayu Wulandari Azis Ikhsanudin Bachri, Mochammad Saiful Br. Sebayang, Sri Rosepda Cahya, Sella Nur Danang Prasetyaning Amukti Dara Pranidya Tilarso Daru Estiningsih Dedi Kuswandi Desi Eko Wulansari Desi Iswahyuni Desyandri Desyandri Dini Rahmawati Dwi Fitriani Dwi Retno Nengtyas Dwi Utami Erliyana, Mila Eti Nurwening Sholikhah Fadilah, Nur Aini fatima, fatma Fauzi, Muh Fajar Fauziyyah, Khusna Fitriyati, Laeli Galang Pergiawan Ramadhan Hanifah, Azka Khansa Hari Susanti Iin Narwanti Iin Narwanti Iis Wahyuningsih Indra Primardiana, Indra Irfan Yusuf Iriwi L.S Sinon, Iriwi L.S Iriwi L.S. Sinon, Iriwi L.S. Istyarini Istyarini, Istyarini Jumina Jumina Jumina Jumina Kaffah, Silmi Kintoko Kusuma, Rio Jati Laela Hayu Nurani Laela Hayu Nurani Lalu Muhammad Irham M. Paden, Thereziana marpaung, Tio Widia A. Moch Saiful Bachri Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mujasam Mujasam Nina Salamah Nisa Isneni Hanifa Nur Asih, Nur Nurliawaty, Lilis Pramono, Suwidjiyo Primardiana, Indra Puteriragil Atma Pertiwi, Puteriragil Atma Putri Dwi Lestari Radjab Sutrisno, Radjab Ramadhan, Muhammad Marwan Rerung, Nensy Rezza Wahyudi Rifka Salsabila Riska Riska Riza Sativa, Riza Rumansara, Tamariska Herlindo Ryan Syahputra Sapto Yuliani Sapto Yuliani Sativa, Riza Septianingsih, Ulfah Silmi Kaffah Siswanti Siswanti Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Sri Rosepda Sebayang, Sri Rosepda Suci Kurniati Sugiyanto - Sugiyanto, Sugiyanto Sumiasih Sumiasih Suwidjiyo Pramono Tio Widia Astuti Marpaung Tirza Pangkali, Tirza Ulfah Septianingsih Vivi Sofia Vivi Sofia Wiki Yuli Anita Wiki Yuli Anita Wulandari, Silviana Wulandari, Silviana Wulansari, Widyanari Febriyana Wumu, Dea Anggrainy Y.T. Allo, Alberto Yenusi, Kaleb Amaghi Yoga Yuniadi