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Sekolah Tinggi Ilmu Kesehatan Indah Medan
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Exploration of the Wound Healing Activity of Ethanol Extract-Based Ointment from Curry Leaves on the Wound Healing Process Andilala, Andilala; Sihombing, Juliana Sion
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25000

Abstract

Indonesian society widely utilizes traditional medicinal plants, including curry leaves (Murraya koenigii L.), which contain alkaloids, tannins, flavonoids, saponins, steroids, and triterpenoids known to possess antioxidant and anti-inflammatory properties. This study aims to formulate curry leaf ethanol extract ointments as wound healing agents and to determine the most effective concentration in accelerating incision wound recovery. Five treatments were prepared: ointment base (negative control), Betadine 10% (positive control), and curry leaf ethanol extract ointments at concentrations of 5%, 10%, and 15%. The ointments were assessed for physical properties and tested on male white rats. The results showed that all formulations met the organoleptic, stability, homogeneity, pH, adhesion, and spreadability requirements. Quantitative wound-healing analysis demonstrated that the 15% extract ointment produced the highest healing percentage, achieving 56.4% on day 5, 70.9% on day 8, and 100% by day 14, outperforming Betadine 10% (80% by day 14). One-way ANOVA revealed significant differences among treatment groups (p < 0.05), with the 15% formulation showing the most effective therapeutic response. These findings indicate that curry leaf ethanol extract ointment, particularly at a 15% concentration, has strong potential as a topical Wound Healing agent.
Co-Authors Adiansa, Nopa Akbar Haknas Nugraha Ambali Azwar Siregar Anggraini, Kharisma Apridiansyah, Yovi Aryeshi Putri Aulia, Syafitri Bagas F, Muhammad Cut Fatimah Cut Fatimah David Maria Vironika, Nuri Devi Purnama Sari Dewi Safitri Dewi Safitri Dian Zulkarnain Lubis Dinda Ilyasa Fatihah Dwiki Novriadi Elly Hertita Fadhillah Lubis, Muhammad Arif Fadillah, Rizka Fadlikal Ilham Aditma, Afredo Fatimah, Cut Fitria, Devi Nur Fitria, Monica Desi Fitriani Nasution Fitriani Nasution Fitriani Nasution, Fitriani Fitriani, Enny Gibran, M Khalil Gibran, M. Khalil Gunawan Gunawan Gunawan, M Handayani, Sri Happy, Happy Hasanah, Mardhiati Hasniar Hasniar, Hasniar hidayah, agung kharisma Husni Rifqo, Muhammad Juansen, Monsya Juhardi , Ujang Juhardi, Ujang Juliana Sion Sihombing Juliantika Khomariah, Putri Ayu Kirman Kirman Kirman Kirman, Kirman Lili Nurmaliza Lili Nurmaliza Lubis, Muhammad Arif Fadhillah Lubis, Nur Azizah M. Gunawan M. Gunawan Mahfuzy, AR. Walad marhalim, marhalim Marwiyah, Rizky Masni Masni Mayanda, Suci Mayang Sari Melati Yulia Kusumastuti Mhd Ikhsan Rifki Mohamad Aji Prasetia Mona Melinda Monica Desi Fitria Muhammad Arif Fadhillah Lubis Muhammad Bagas Fahriansyah Muhammad Gunawan Muhammad Gunawan Muhammad Gunawan Muhammad Nizam Nawawi Muntahanah, Muntahanah Nur Azizah Lubis Nurhapiani Nurhapiani Nurhapiani, Nurhapiani Nursiah Oki, M. Pahrizal, Pahrizal Putra, Toto Dwi Putri Ayu Indah Setyarini Ransesta, Lingga Rismawati Rizky Marwiyah Ruseni Safriana Safriana Safriana Safriana Safriana Safrina Safrina, Safrina Salim Salim Salsabila Maydina Samran, Samran Sarkawi, Sarkawi Selfi Setyarini, Putri Ayu Indah Shopiana, Sella SIHOMBING, JULIANA SION Siregar, Ambali Azwar Siti Aisyah Tanjung Sumardi Suprianto Suprianto Surya Ade Saputera Tanjung, Siti Aisyah Ujang Juhardi Wijaya, Ardi Winda Wardani Wijaya