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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan CHEMPUBLISH JOURNAL Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia Jambura Journal of Chemistry JFIOnline Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Riset Kefarmasian Indonesia Journal of Community Development Indonesian Journal of Biological Pharmacy Jurnal Kesehatan JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Jurnal Farmasi Indonesia Jurnal Ilmu Kesehatan dan Gizi Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Yasmiwar Susilawati
Departemen Biologi Farmasi Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : CHEMPUBLISH JOURNAL

 1 
Antidiabetic activity of combined extracts of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. on streptozotocin-induced diabetes Wistar rats Tjitraresmi, Ami; Febriyanti, Raden Maya; Anjabtsawa, Daffa; Susilawati, Yasmiwar; Muhaimin, Muhaimin
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46449

Abstract

The increasing prevalence of diabetes mellitus and the limitation in its conventional therapies underscores the need for alternative treatments. Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. have demonstrated individual antidiabetic activities attributed to their secondary metabolites, including flavonoid and phenolic compounds. This study employed an experimental in vivo design using rats induced with STZ. Thirty rats were divided into five groups (n=6): normal control, negative control, positive control (Glibenclamide), and two treatment groups receiving the combined aqueous extracts of H.sabdariffa and S.rebaudiana (RSAE) at 500 and 1000 mg/kgBW. Diabetes was induced using STZ (50 mg/kgBW administered i.p). Blood glucose levels were measured fasting and 2 hr postprandial at days 0, 3, and 14 after administration of RSAE. Data were analyzed using One-Way ANOVA. RSAE exhibited dose‐dependent hypoglycaemic activity in STZ‐induced diabetic rats, significantly reducing (p < .005) fasting blood glucose by up to 50.7 % and two‐hour post‐prandial glucose by 44.97% at 1000 mg/kgBW.
Co-Authors Achmad Rante Suparman, Achmad Rante Ade Zuhrotun Adrian Suparman Ahmad Muhtadi Ahmad Muhtadi AJENG DIANTINI Ajeng Diantini, Ajeng Ami Tjitraresmi Ami Tjitraresmi Ami Tjitraresmi, Ami Angga Geganaputra Anis Yohana Chaerunisa Anis Yohana Chaerunisaa Anita Apriliana, Anita Anjabtsawa, Daffa Annisa Maulida Azzahra Apriani Sulu Parubak Aryanti, Ninda Boima Ramses Situmeang Ch., Anis Yohana DIANA ALIFAH DINI HANIFA DOLIH GOZALI Eli Halimah Eli Halimah, Eli Ellin Febrina Ferry Ferdiansyah Sofyan Fuji Fadhilla Sandy Gofarana Wilar HENIVIA NOVANTI Hesti Purwaningsih Hidayati, Tita Kosima Holis Abdul Holik, Holis Abdul Ida Musfiroh Ida Musfiroh, Ida Imam Adi Wicaksono Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Ivan Surya Pradipta Jutti Levita Kokom, Asep Kusumastuti, Pinastya Purwakaning Megantara, Sandra Melinda Januarti MOCHAMAD RIZKY FAUZY Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono Moektiwardoyo Moelyono, M W Moelyono, M W Muchtaridi Muchtaridi MUFIDAH MAWADDAH Muhaimin Muhaimin Muhammad Ryan Radix Rahardhian Murtihapsari . Mutakin Mutakin Neli, Neli Ningrum, Sri Rahayu Widya Nita Listiani Norisca Aliza Putriana NORISCA ALIZA PUTRIANA Nugrahani, Hanny Okta Nama Putra Oktarina, Dewi Ria OKTAVIANI, DEDE JIHAN PRILLY MUTIARA SANDY Putri Churnia Arifin Putri, Chintiana Nindya Raden Maya Febriyanti Radite Yogaswara Rahayu, Fima Perdani Ramonah, Dewi Renny Amelia Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Rostinawati, Titin Rr. Kirana Andranilla Shafirany, Mareetha Zahra Silmi Auliya Zakariya Silmi Auliya Zakariya Silvia Sari Prastiwi Simorangkir, T.P.H. Simorangkir, T.P.H. Sri Adi Sumiwi Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo, Sriwidodo Sulistyaningsih, Widya Ayu Susilawati, Elis Syumillah Saepudin Tati Herlina TIANA MILANDA Tina Rostinawati Tira Soleha Rahmatullah Titi W Nikodemus Utami, Nadya Firdianna Utami, Nadya Firdianna Yoppi Iskandar Zakia, Syifa Zelika Mega Ramadhania Zelika Mega Ramadhania