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Ethanol extract of Cyclea barbata Miers induces follicle development through 17ß-estradiol level and LHR expression Noviyanti Noviyanti; Yuyun Yueniwati; Bambang Rahardjo; Galuh W. Permatasari
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.195-203

Abstract

HIGHLIGHTS Docking analysis revealed that there are four novel compounds in barbata, including Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octytldecyl phthalate have stronger affinity -9.7; -9.6; -9,2; and -7.7 kcal/mol, respectively. The extract of barbata leaves increased follicle development (75%) by elevating estrogen levels and LHR expression at all doses.   ABSTRACT Objective: Infertility, often linked to anovulation from impaired follicular maturation, affects millions globally. Cyclea barbata Miers, a plant with estrogen-like properties, may enhance follicle development through hormonal modulation. This study evaluated the ethanol extract of C. barbata leaves for its ability to promote in vitro follicle development by increasing 17ß-estradiol levels and luteinizing hormone receptor (LHR) expression. Materials and Methods: Molecular docking analysis identified four novel compounds in C. barbata, Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octyl decyl phthalate, with binding affinities of -9.7, -9.6, -9.2, and -7.7 kcal/mol to estrogen receptor alpha (ESRa). Secondary follicles (2-3 mm) from goat ovaries were cultured in vitro using TCM-199 medium supplemented with 10% FBS, PMSG, hCG, and C. barbata extract at 25, 50, or 100 ppm for six days. Follicle maturation was assessed via microscopy for size, cumulus-oocyte complex formation, and polar body extrusion. 17ß-estradiol levels and LHR expression were analyzed using one-way ANOVA and LSD tests. Results: The 100 ppm dose achieved 75% follicle maturation, significantly higher than 25% at lower doses and controls. It increased 17ß-estradiol levels (36.83 ± 2.33 pg/mL, p < 0.000) and LHR expression (261.874 ± 54.606, p < 0.000), with dose-dependent effects confirmed by statistical analysis. Conclusion: C. barbata extract at 100 ppm enhances follicular maturation by elevating 17ß-estradiol and LHR expression, likely due to its estrogenic compounds. Further in vivo and clinical studies are needed to confirm its therapeutic potential for ovulatory disorders.
Bibliometric Analysis: Research Trends In Vitamin D And Magnesium as A Diabetes Mellitus Therapy Model (2013-2024) Balqis Faizah Azzahra; Yuyun Yueniwati; Happy Kurnia Permatasari
Plexus Medical Journal Vol. 3 No. 5 (2024): Oktober
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/bfgta242

Abstract

Pendahuluan: Diabetes Melitus (DM) merupakan masalah kesehatan global yang serius. Penelitian ini bertujuan untuk mengetahu bagaimana kombinasi Vitamin D dan magnesium dapat memberikan manfaat sinergis yang digunakan sebagai terapi diabetes melitus. Metode: Penelitian ini menggunakan database Scopus untuk mengumpulkan dan menganalisis artikel yang relevan. Sebanyak 410 artikel dimasukkan untuk analisis bibliometrik. Data dianalisis menggunakan software Vos Viewer versi 1.6.19, Microsoft Excel, dan Biblioshinny versi R 4.3.0 Hasil: Sebanyak 410 artikel dimasukkan untuk dianalisis. Temuan tersebut mengungkapkan tren peningkatan penelitian tentang vitamin D dan magnesium dalam beberapa tahun terakhir. Negara yang dominan dalam publikasi adalah Amerika Serikat. Artikel ilmiah mendominasi jenis publikasi dengan persentase sebesar 70,7%. Penulis paling produktif adalah Bener A dan Martinez Gonzalez M.A, masing-masing dengan 4 dokumen. Jurnal "Nutrisi" adalah sumber utama yang membahas topik ini secara ekstensif. Bidang studi yang paling dominan adalah bidang kedokteran dengan persentase 51,7%. Isu hangat dan potensial di masa depan divisualisasikan melalui VOSviewer dengan warna kuning, termasuk kontrol glikemik, mikronutrien, pola makan, asam lemak Omega-3, dan vitamin. Kesimpulan: Analisis bibliometrik ini memberikan wawasan status penelitian terkini mengenai peran vitamin D dan magnesium pada Diabetes Mellitus. Temuan ini penting untuk memandu arah penelitian dan kolaborasi di masa depan, serta menawarkan perspektif dan strategi baru untuk pencegahan dan pengobatan Diabetes Mellitus.
Co-Authors Abd. Rasyid Syamsuri Achmad Bayhaqi Nasir Aslam Adam Fauzi Ade Lina Nur Fadlilah Adiantara, Ken Rangga Galang Agung Setyawan Agus Naba Agustin , Aisyiyah Alviana Agustina, Tanti Ahmad DW, Ahmad Alam, Satria Sabda Aldita Husna Violita Aldita Husna Violita Alfred Julius Petrarizky Alfrina Hany Alimsjah, Yohanes Audric Andrijani Sumarahinsih Anggia, Amelia Anugrah, Tessa Septian Aprilianingtyas , Arvidareyna Panca Arief Iskandar Atsil Lathifa, Jauza Ayu Hardianti Pratiwi Azmi, Mukhammad Azzahra, Balqis Faizah Azzakiy , Ahmad Abdul Hadiy Balqis Faizah Azzahra Bambang Rahardjo Basya Adnani Basyar Adnani Begum Fauziyah Berlian Cyntia Devi, Berlian Cyntia Brian Wasita Chomsin Sulistya Widodo Damayanti, Ria DAVID SANTOSO Dewi Kartikawatiningsih Diana Lyrawati Diana Yuswanti Putri Dina Dewi SLI Dini Rachma Erawati Diptya, Ibnu Djatmiko, Ahmad Eko Arisetijono Erlangga, Eggi Ernanda , Shelby Amrus Ernanda, Shelby Amrus Esther Palupi Fahanani, Agwin Fahmi Fahmi Fahanani, Agwin Farah Nurdiana Fatimah Kunti Hentihu Faturrohmaniah, Ari Friscillia , Febrina Galuh W. Permatasari Gumelar , Enggar Habiba Aurora Hafiedz Maulana Handoko, Edi Handono Kalim Hanifa Fathinatul Amirahayu Happy Kurnia Permatasari Happy Kurnia Permatasari Haq, Nabiila Ala Qoonita Najma Hasibuan , Muhammad Effendy Nugraha Heri Kristianto Husnul Khotimah Husnul Khotimah Ibrahim , Ananto Suar Bhakti Inganatul Islamiyah Irawan, Amelia Tjandra Irawan, Paulus Lucky Tirma Iriana Maharani, Iriana Irnanda , Miranthi Ayu Johan Andoyo Effendi Noor Johan Andoyo Effendi Noor Karimah Karimah Karimah Ken Rangga Galang Adiantara Kurnia Widyaningrum Kurnia, Jodii Arlan Kusumaningrum, Sulistyani Lathifa, Jauza Atsil M. Yunus Maharina, Luths Maliga , Helnida Anggun Margaretha Berek Masruroh Rahayu Mohamad Hidayat Mokhamad Fahmi Rizki Syaban Muhammad , Galang Mahasin Muhammad Zacky Hafiyyan Maulana Mukhamad Fathoni Mukhammad Fathoni Muthaminah, Muthaminah N. Diana Yulisa Nabilla Hardiyanti, Ginanda Nanang Wiyono Nanik Setijowati Nasywa Talitha Zahran Ni Kadek Indah Sunar A Nirmala Halid Noviyanti Noviyanti Ns. Rinik Eko Kapti Nugroho, Rafiq Sulistyo Nur Permatasari Prabata, Adam Prabowo , Bisma Dewanto Ari Pradana, Wisniardhy Suarnata Pradhana, Satwika Pranowo, Muhammad Royyan Pratama , Senoadji Purnama , Sari Dianita Purnama, Avief Destian Putri , Firda Aunidiah Rachmi Fauziah Rahayu Rahmaditta , Allyssa Rahmawan, Fajri Andi Raihana, Naura Salwa Ratih Dewi Yudhani Riandono , Dody Rinik Eko Kapti, Rinik Eko Rislan Faiz Muhammad Rislan Faiz Muhammad Riza Novierta Pesik Romadhoni, Muhammad Rifqy Ropitasari Ropitasari Rulli Rosandi Safira Dita Arviana Sakdullah, Istianah Sarni J. Ishak Savira, Tsalsa Dzikria Savitri, Kania Aviandi Servasius Ratu Banin Setianto , Catur Ari Shahdevi Nandar Kurniawan, Shahdevi Nandar Sholikah, Tri Agusti Sigma Nur Rismawati Sinaga, Alexandra Maria Rossadwina Sriharkita Siraj, Resnanda Naufal Siswanto, Febby Gunawan Siti Maimunah Sri Utami Suyatmi Suyatmi Taqiyyah, Masyalia Hasna Tazuyyun, Shanaz Hanani Tifani, Amara Syifa Titin Andri Wihastuti Tony Suharsono Tony Suharsono, Tony Tri Mukti Lestari Wahyudi, Mgs Ahmad Wardhani, Lusi Oka Widya Addiarto Wulansari, Yunita Wahyu Yarso, Kristanto Yuli Yudisthira, Dewangga Yulian Wiji Utami Yunita Wahyu Wulansari, Yustina Ni Putu yusniawati Zaenal Arifin Zahra, Farah Shabri Alifia Zahrah, Fathimah Afifah