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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal SOLMA Media Farmasi MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Journals of Ners Community FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Cendekia Eksakta KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan SINTA Journal (Science, Technology, and Agricultural) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Klinik dan Sains Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Sapto Yuliani
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Optimization of thin layers of coated turmeric extract (Curcuma longa L) tablets using a dipping method Adi Permadi; Sapto Yuliani; Iis Wahyuningsih; Ibdal Satar
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.249 KB) | DOI: 10.12928/mf.v19i1.20130

Abstract

Turmeric extracts have many benefits, such as an anti-oxidant, anti-inflammatory, and neuro-protector for dementia. The turmeric extracts can be prepared in the form of a thin layer of coated tablets through a dipping method using the dip coating and Simplex lattice design (SLD) methods. The quality of the thin layers of coated tablets is much related to the formulation in the coating process. This research aims to formulate and optimize the coating composition of HPMC, PEG-400, and dip time. Consequently, the TSLT meets the standard requirements. The core tablets were made by using the wet granulation method with the formulation of turmeric extract, erosol, lactose, gelatin, and aquades. Before the core tablets had been produced, the eligibility of granules was initially evaluated based on the standard requirements. Subsequently, the core tablets that meet the standard requirements were printed and replicated. The coating processes on core tablets were performed by dipping into the coating solution in the various duration of dipping times: 5, 30, and 60 seconds. The coating solution consists of HPMC, PEG-400, glycerine, sunset yellow, and distillate water. Then, produced TSLTs were evaluated based on the hardness, friability, and disintegration time. The best optimization process for the mixture of HPMC and PEG-400 indicates a more positive value of R (R = 0.2024).
EFEK EKSTRAK ETANOL BIJI BUAH KEBIUL (Caesalpinia bonduc L. Roxb) TERHADAP BATU GINJAL TIKUS SPRAGUE DAWLEY YANG DIINDUKSI ETILEN GLIKOL 0,75% DAN AMONIUM KLORIDA 2% Tiara Rizki Handayani; Sapto Yuliani
Media Farmasi: Jurnal Ilmu Farmasi Vol 13, No 2: September 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.198 KB) | DOI: 10.12928/mf.v13i2.7774

Abstract

Penyakit ginjal dapat disebabkan karena ada pembentukan batu yang terbentuk dari komplek kalsium sehingga dapat mengganggu fungsi ginjal. Biji buah kebiul (Caesalpinia bonduc (L.) Roxb) mengandung flavonoid yang dapat mencegah pembentukan endapanbatu di ginjal. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstrak etanolbiji buah kebiul pada batu ginjal tikus Sprague Dawley (SD) yang diinduksi etilen glikol 0,75% dan amonium klorida 2%. Sebanyak 30 ekor tikus, dewasa, jantan, dibagi menjadi 6 kelompok yang mendapat perlakuan sebagai berikut: kontrol normal diberi akuades; kontrol sakit, diberi akuades; kontrol positif, diberi obat X dengan dosis 2,7 mL/kg BB, dan kelompok ekstrak diberi ekstrak biji kebiul dengan variasi dosis yaitu 250, 500, dan 1000 mg/kg BB. Induksi batu ginjal dilakukan dengan pemberian etilen glikol 0,75% dan amonium klorida 2% 2 jam setelah pemberian esktrak etanol biji buah kebiul dan obat X  selama 10 hari pada semua kelompok, kecuali kelompok normal. Efek terhadap batu ginjal ditentukan berdasarkan jumlah kalsium urin, kadar kreatinin dan ureum serum. Data jumlah kalsium yang diperoleh dianalisis secara statistik dengan uji Kruskall Wallis dilanjutkan dengan uji Mann Whitney, sedangkan data kreatinin dan ureum serum yang diperoleh dianalisis dengan one way ANOVA dilanjutkan dengan uji LSD. Signifikansi hasil dinyatakan dengan p<0,05. Jumlah kalsium urin, kadar kreatinin dan ureum serum kelompok ekstrak tidak berbeda bermakna (p>0,05) dibandingkan dengan kelompok kontrol sakit. Berdasarkan hasil penelitian dapat disimpulkan bahwa pemberian ekstrak etanol biji buah kebiul dosis 250, 500 dan 1000 mg/kg BB tidak memberikan efek pada batu ginjal tikus SD yang diinduksi etilen glikol dan amonium klorida.
Anti-inflammatory Activity of Camellia sinensis, l. Extract Cream Combined with Vitamin C as Antioxidant on Croton Oil-induced Inflamation in Male Mice Strain BALB/C Nining Sugihartini; Ratih Saridewi; Ulfa Ramdhani M; Fitri Rahmawanti; Sapto Yuliani; Vivi Sophia
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.87 KB) | DOI: 10.22146/tradmedj.27915

Abstract

Green tea extract cream contains epigallocatechin gallate (EGCG) as the active ingredient for anti-inflammatory. Epigallocatechin gallate is easyly oxidized and able to reduce its effectivity as an anti-inflammatory. Therefore, an addition of antioxidants in order to increase its stability is required. The purpose of this study was to determine the effect of adding the antioxidant Vitamin C on the effectivity of green tea extract as an anti-inflammatory. This study uses 6 groups of male mice strain BALB/C which were given treatment as follows: normal control, negative control, base cream, green tea extract (0.2%), Vitamin C cream (1%) and green tea extract cream with addition of Vitamin C. The anti-inflammatory activity was evaluated based on the expression of COX-2, inflammatory cells and the thickness of the epidermis in the skin tissue of mice after given crotton oil (0.1%) on the back for the induction of inflammation. After treatment cream for 3 days, mice were sacrificed for histopathological tissue preparations made with hematoxylin eosin staining and immunohistochemistry COX-2. Data were analyzed statistically with one way Anova followed by t-test to determine differences between groups at a significance level of 0.05. The test results indicate that cream of green tea extract is higher in decreasing inflammatory parameters in comparison with cream of Vitamin C, except in the thickness of epidermal parameter. Green tea extract cream with the addition of Vitamin C is higher in reducing inflammatory parameters than cream of green tea extract or cream of Vitamin C. The decline percentage of cells that express COX-2, inflammatory cells and the thickness of the epidermis in the each of groups were cream of green tea extract:57.95%;53.75%;34.83%, cream of Vitamin C:48.76%;34.96%;34.27%, cream of green tea extract and Vitamin C:61,89%;65,54%;46.30%, respectively. Based on the results of this study, it can be concluded that anti-inflammatory activity of green tea extract cream increased due to the addition of 1% vitamin C as an antioxidant.
Lymphocyte Proliferation Activity MTT -Test of Ethanolic Extract of Pasak Bumi Root (Eurycoma longifolia Jack) On Induced 7,12-Dimethylbenz[A] Antracene (DMBA) Female Sprague Dawley Rat Lily Noor Falah; Sapto Yuliani
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss1pp187-192

Abstract

Pasak bumi root (Eurycoma longifolia Jack) contains quasinoid. Quasinoid potentially has antitumor/anticancer, anti-parasitic, and immunostimulatory activity. The aim of this research was to study the lymphocyte proliferation activity MTT-test of ethanol extract of Eurycoma longifolia Jack root on induced by 7,12-dimethylbenz[a] antracene (DMBA) female Sprague Dawley rat. The test was done at 6 groups of 10 SD rat each. Each groups was administered orally with DMBA (Group I) dose of 20 mg/kg bw, corn oil (Group II), baseline (Group III), and  ethanol extract of pasak bumi root dose 12.6; 25.2; and 50.4 mg/kg bw (Group IV,V,and VI). Ethanol extract is given for 5 weeks. At the second week five rats were sacrificed to isolate the lymphocytes of spleen then rats are injected orally with DMBA 2 times a week for 5 weeks. At the eight until twenty fourth week all groups were just administered by aquades. Measurement of spleen relative weight and isolation of the lymphocyte spleen were done at second week and the last of experiment. Lymphocyte proliferation activity were measured by MTT-reduction method. Data were analyzed statistically by analyzes of variance (anova) continued by LSD test and Kruskall Wallis continued by Mann Whitney test. The result showed that limphocyte proliferation activity MTT of ethanol extract of E. longifolia root doses of 12.6; 25.2; and 50.4 mg/kg bw for 14 days prior to DMBA-induced are  339.35 ± 8.43;61.20 ± 6.27;310.28 ±  6.81   and  dose 50,4 mg/kg bw after  DMBA-induced is 122.108 ±  11.426 .Keyword: E. longifolia root, spleen,  lymphocyte cell, 7,12-Dimetilbenz (a) antracene (DMBA)
EFEKTIVITAS EKSTRAK PEGAGAN (Centella asiatica) DALAM PENCEGAHAN EKSPRESI GEN CASPASE 8 PADA SEL PYRAMIDAL TIKUS MODEL DEMENSIA Sapto Yuliani; Suci Kurniati; Desi Iswahyuni; Vivi Sofia; Wahyu Widyaningsih; Moch. Saiful Bachri
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 11, No 2 (2021): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v11i2.3193

Abstract

Penelitian sebelumnya membuktikan bahwa pemberian ekstrak pegagan (Centela asiatica) dapat mencegah peningkatan ekspresi protein caspase 3 dan menurunkan ekspresi Bcl-2 yang berkaitan dengan apoptosis di daerah CA1 dan CA2-CA3 sel pyramidal hippocampus  pada tikus model demensia.  Selain ekspresi protein tersebut, mekanisme apoptosis juga melibatkan protein lain yaitu caspase 8, yaitu protease sistein yang berperan sebagai inisiator apoptosis di jalur ekstrinsik. Tujuan penelitian ini adalah untuk mengetahui efek ekstrak pegagan dalam mencegah ekspresi gen caspase 8 di sel pyramidal hippocampus pada tikus model demensia yang diinduksi dengan trimetiltin (TMT). Sebanyak 30 ekor tikus Sprague Dawley, 3 bulan, jantan, berat 200-300 g dibagi menjadi 6 kelompok.  sebagai berikut: Kelompok Normal dan TMT diberi CMC-Na,  kelompok ekstrak diberi ekstrak dosis 100 (EP-100), 200 (EP-200)  dan 400 mg/kg BB (EP-400), sedangkan kelompok Sitikolin diberi sitikolin dosis 200 mg/kg B. Pemberian perlakuan selama 35 hari.  Injeksi TMT dilakukan pada hari ke-8 perlakuan dengan dosis 8 mg/kg BB secara intraperitoneal, kecuali pada kelompok normal. Pada hari ke 36 tikus dikorbankan, otak diambil, kemudian bagian hippocampus dipisahkan untuk pembuatan preparat imunohistokimia untuk pengamatan ekspresi gen caspase 8 di sel pyramidal daerah CA1 dan CA2CA3. Jumlah sel yang mengekspresikan gen caspase 8 pada sel pyramidal di daerah CA1 dan CA2CA3 dianalisis dengan uji anava satu jalur dilanjutkan dengan uji LSD dengan tingkat signikansi 0.05. Hasil penelitian menunjukkan bahwa pemberian TMT meningkatkan secara signifikan jumlah sel yang mengekspresikan caspase 8 di daerah CA1 namun tidak pada daerah CA2CA3. Pemberian ekstrak pegagan dosis 400 mg/kg BB menurunkan secara signifikan ekspresi caspase 8 namun tidak terjadi pada dosis 100 dan 200 mg/kg BB. Dengan demikian ekstrak pegagan berpotensi dikembangkan untuk  mencegah demensia.
SIFAT FISIK KRIM TIPE M/A EKSTRAK ETANOL DAUN KELOR [Moringa oleifera L] DENGAN VARIASI KONSENTRASI MENGGUNAKAN EMULGATOR ASAM STEARAT DAN TRIETANOLAMIN Rikadyanti Rikadyanti; Nining Sugihartini; Sapto Yuliani
Media Farmasi XXX Vol 16, No 1 (2020): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.381 KB) | DOI: 10.32382/mf.v16i1.1423

Abstract

Flavonoid compounds in moringa leaves have high antioxidants and can be used to prevent the effects of free radicals. Therefore, Moringa leaf extract needs to be formulated in the form of M / A cream. The purpose of this study determines the effect of cream concentration on physical properties, such as pH, spreadability, adhesion, and viscosity, as well as the stability of the cream. Moringa leaf extract was macerated using 50% ethanol solvent and further formulated in the form of M / A cream preparations with various concentrations, including Formula I (0%), Formula II (1%), Formula III (3%), and Formula IV 5%. The creams were evaluated for physical properties, including pH, spreadability, adhesion, and viscosity, as well as stability. The test results showed that an increase in the concentration of the ethanol extract of Moringa leaves in cream type M / A led to a decrease in pH, viscosity, adhesion, and increased spreadability. An increase in the concentration of ethanol extract of Moringa leaves influence the physical properties of M / A type creams, such as a decrease in pH, viscosity, adhesion, increased spread, though it is unstable at a concentration of 5%.Keywords: M / A cream, Moringa leaf Ethanol Extract, physical propertiesSenyawa flavonoid yang terkandung dalam daun kelor (Moringa oleifera L) memiliki  antioksidan yang tinggi sehingga dapat digunakan sebagai zat yang dapat mencegah efek radikal bebas. Oleh karena itu ekstrak daun kelor perlu diformulasikan dalam bentuk sediaaan krim M/A. Penelitian ini untuk mengetahui  pengaruh konsentrasi krim terhadap sifat fisik (pH, daya sebar, daya lekat, viskositas) dan stabilitas krim  tipe M/A ekstrak etanol daun kelor. Ekstrak daun kelor dimaserasi dengan menggunakan pelarut etanol 50%. Ekstrak kemudian di formulasikan dalam bentuk sediaan krim M/A dengan variasi konsentrasi yaitu Formula I (0%), Formula II (1%), Formula III (3%), dan Formula IV 5%. Krim dievaluasi sifat fisik (pH, daya sebar, daya lekat, viskositas) dan stabilitas. Hasil uji menunjukan bahwa adanya peningkatan konsentrasi ekstrak etanol daun kelor dalam krim tipe M/A menyebabkan penurunan pH, viskositas, daya lekat, dan peningkatan daya sebar. Dengan adanya peningkatan konsentrasi ekstrak etanol daun kelor memiliki pengaruh terhadap sifat fisik krim tipe M/A yaitu terjadi penurunan pada Ph, viskositas, daya lekat, peningkatan daya sebar dan tidak stabil pada konsentrasi 5%.Kata kunci : krim M/A, Ekstrak Etanol daun kelor, sifat fisik
Burn wound healing activity of ethanol extract gel of Green Algae (Ulva lactuca L) in mice Wahyu Widyaningsih; Sapto Yuliani; Vivi Sofia; Reka Rukmiati; Khozanatul Ulwy
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.425 KB) | DOI: 10.12928/pharmaciana.v12i2.22833

Abstract

Recently, burn injuries have become a major cause of morbidity and mortality in low-middle-income countries. Burn injuries are tissue loss caused by contact with heat sources such as hot water, fire, chemicals, electricity, and radiation. According to the WHO Global Burden Disease, in 2017 an estimated 180.000 people died from burn injuries. Ethanol extract of green algae (EEGA) contains compounds that potentially heal burn injuries. The research was conducted to obtain a gel formulation from EEGA and test its burn wound healing properties in mice (Mus musculus). Forty-five mice were divided into five groups: I (negative control), II (treated with gel base), III (positive control, Bioplacenton gel), IV (5% EEGA gel), and V (10% EEGA gel). Wound diameters and description scores were observed every fourth, seventh, and fourteenth day, and the derived data were analyzed in the SPSS program with the one-way analysis of variance (ANOVA) and least significance difference (LSD) test. The results indicate that EEGA can be formulated into gels with physical properties compliant with the requirements of the dosage form. Further, it was found that Groups IV and V showed significant reductions in wound description scores and diameters (p<0.05). In conclusion, gels containing 5% and 10% EEGA possess burn wound healing properties.
The effect of Tumeric Rhizome (Curcuma Longa L) on radial arm maze and passive avoidance test in Trimethyltin-induced rat models Sapto Yuliani; Leni Setiani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art2

Abstract

Backround : Oxidative stress can cause death of hippocampal cells associated to the deficit of learning and memory function. Turmeric rhizome contains curcuminoid which has antioxidant activity that can prevent oxidative stress, thus it was expected to prevent the deficit of learning and memory function on trimethyltin (TMT)-induced rat models. Objectve : This study aimed to determine the effect of turmeric rhizome extract on cognitive learning and memory fuction which was tested using radial arm maze and passive avoidance tests on Wistar rats injected with TMT. Methods : A total of 30 Wistar rats, male, 8-12 weeks of age were divided into 6 groups. The first (normal) group was given CMC-Na, the second (TMT) group was given CMC-Na, the third-the fifth groups were given turmeric rhizome extract (TRE) orally in the dosage of 120mg/kgBW (TRE120), 240 mg/kgBW (TRE240) and 480 mg/kgBW (TRE480), respectivelly. The sixth (P500) group was given piracetam in the dosage of 500 mg/kgBW. Treatments were given for 8 days orally. At day-9th, excluding the first group, all rats were injected with 12 mg/kgBW TMT solution intraperitoneally. One day after TMT injection, the cognitive learning and memory function was measured using radial maze and passive avoidance tests. The datas of cognitve function tests were analyzed statistically by ANOVA test followed by LSD test at significance level 0.05. Results : The results of radial maze and passive avoidance tests showed that the TRE240 group was not statistically significant different with TMT group(p>0.05). However there were significant difference between TRE120 and TMT groups, as well as between TRE480 and TMT groups (p<0.05). The administration of 480 mg/kgBW of TRE showed that its cognitive function was not significantly different with the administration of Piracetam (p>0.05). Conclusion : It can be concluded that the administration of 480 mg/kgBW of TRE can improve cognitive learning and memory function of Wistar rats injected by TMT.
Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review Daffara Kinanthi Lustikaiswi; Sapto Yuliani; Rahmah Annura; Elmi Rahmadani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art11

Abstract

As the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tryptophan acts as a precursor to serotonin and kynurenine. The serotonin metabolite, 5-hydroxyindoleacetate or 5-hydroxyindoleacetic acid (5-HIAA), can degrade amyloid-ß (Aß) oligomers, a peptide group of 36–43 amino acids derived from amyloid precursor protein found in people with Alzheimer's disease. The degradation of brain cells through the increase of neprilysin (NEP) and melatonin inhibits glycogen synthase kinase-3ß (GSK3ß) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?ß) by reducing the decrease in peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). Meanwhile, in the kynurenine pathway, kynurenic acid (KYNA) also induces the NEP gene, thus preventing Aß.
Formulasi Solid Snedds (Self-Nano Emulsifying Drug Delivery System) Furosemid Dengan Pengering Aerosil Dan Aktivitas Diuretiknya Putri Dina Pelita; Iis Wahyuningsih; Sapto Yuliani
Journals of Ners Community Vol 13 No 1 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.1745

Abstract

Furosemid adalah obat golongan diuretika yang umum digunakan dalam terapi edema yang terkait dengan penyakit heart failure dan pada pengobatan hipertensi. Furosemid termasuk dalam Biopharmaceutical Class System (BCS) IV yang diketahui memiliki kelarutan dan permeabilitas yang rendah. Untuk mengatasi masalah tersebut dibuat sediaan Self-Nano Emusifying Drug Delivery System (SNEDDS). SNEDDS memiliki keterbatasan dalam hal stabilitas sehingga dilakukan penelitian lanjutan dengan membuat sediaan SNEDDS dalam bentuk padatan atau Solid SNEDDS (S-SNEDDS). Tujuan penelitian ini adalah memformulasi SNEDDS furosemid menjadi S-SNEDDS furosemid dan menentukan pengaruh S-SNEDDS furosemid terhadap aktivitas diuretikapada tikus dibandingkan dengan SNEDDS furosemid maupun furosemid saja tanpa modifikasi. Metode pembuatan S-SNEDDSfurosemid pengering aerosil dilakukan dengan metode absorbtion to solid carrier kemudian dilanjutkan pengujian karakterisasi kejernihan, waktu emulsifikasi, sifat alir, bulk density dan tapped density. Selanjutnya dilanjutkan uji aktivitas diuretika pada 25 ekor tikus jantan galur Wistar yang dibagi menjadi 5 kelompok yaitu kelompok normal, kontrol negatif diberi pembawa S-SNEDDS, perlakuan 1 diberi suspensi furosemid, perlakuan 2 diberi SNEDDS furosemid, perlakuan 3 diberi S-SNEDDSfurosemid dengan dosis 5,04 mg/KgBB. Seluruh kelompok diberikan perlakuan secara peroral lalu diperiksa volume urin yang dikeluarkan tikus pada jam ke 1, 2, 3, 4, 5 dan 6 setelah pemberian. Volume urin yang diperoleh di masing-masing kelompok dihitung rata-rata dan standar deviasinya kemudian dianalisis statistik dengan LSD dengan IBM SPSS (Statistical Product and Service Solution) 25 for Windows. S-SNEDDS furosemid dengan pengering aerosil memiliki karakteristik persen transmitan 96,94 ± 0,13 %, waktu emulsifikasi 7,40 ± 1,14 detik, sudut diam 31,71 ± 2,24, carr’s index 8,74 ± 0,49 dan hausner ratio 0,99 ± 0,10 dan dinyatakan memenuhi persyaratan. Hasil pengujian secara in vivo S-SNEDDS furosemid dengan pengering aerosil dapat meningkatkan volume urin kumulatif yang berbeda bermakna dengan kelompok kontrol negative pada dengan signifikansi lebih dari 0,05. Berdasarkan hasil penelitian dapat disimpulkan bahwa S-SNEDDS furosemid dengan pengering aerosil memiliki karakter dan aktivitas diuretika lebih baik dibandingkan dengan SNEDDS furosemid dan furosemid tanpa modifikasi.
Co-Authors Adhi Gunawan Adi Permadi Adi Permadi, Adi Ainiyah, Nadia Putri Aisha Raihana Anggraeni, Linda Suci Arif Budi Setianto Arsyannur Pratiwi Aspamufita, Nuroh Ayu Shabrina Ayu Wulandari Azali, Aulia Syafadilla Bachri, Mochammad Saiful Botutihe, Lisa Agustina Daffara Kinanthi Lustikaiswi Daipadli Daipadli Danang Prasetyaning Amukti Dandy Annas Muttaqien Daru Estiningsih Davit Nugraha Desi Ambarwati Desi Iswahyuni Dian Prasasti Didik Yuni Prasetya Dwi Utami Elmi Rahmadani Enti Rikomah, Setya Fitri Rahmawanti Galuh Rista Putri Gina Lestari Gina Lestari, Gina Gunawan, Adhi Handayani, Tiara Rizki Handayani, Tiara Rizki Hari Susanti Hartati, Meity Hasana, Siti Nur Ibdal Satar Iis Wahyuningsih Intan Dwi Rahmita Khozanatul Ulwy Khrisna Agung Cendekiawan Kintoko Kintoko Kintoko Kintoko, Kintoko Laela Hayu Nurani Lasanudin, Rindi Ibrahim Leni Setiani Lily Noor Falah Lily Noor Falah Ma'ruf, Muhammad Magfirah Septiani Yusuf Maghfirah, Rahmayani Maysara, Risha Moch Saiful Bachri Moch Saiful Bachri Moch. Saiful Bachri Muhammad Alfian, Muhammad Muhammad Ma'ruf Muhammad Marwan Ramadhan Muhammad Nuh Muhammad Yusron Maulana El-Yunusi Nadia Putri Ainiyah Nadia Selvia Najini, Robby Ningrum, Lailatul Fitria Nining Sugihartini Nur Mahdi Nurkhasanah Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Nuroh Aspamufita Pelita, Putri Dina Poerwahyuningrum, Neny Putri Dina Pelita Rabiatul Adawiyah Rahayu, Titi Pudji Rahmah Annura Rahmah Niar Ulfah Rahmawati, Dhea Ramadhan, Muhammad Marwan Ratih Saridewi Reka Rukmiati Rifka Salsabila Rikadyanti Rikadyanti Risha Maysara Risha Maysara Robby Najini Safira, Rizka Safwan Safwan Saraswati, Yasti Rizkandar Sari, Eka Anisa Satar, Ibdal Sofina Rahmadita Sri Mulyaningsih Suci Kurniati Supriyanto, Sugeng Suwidjiyo Pramono Tiara Rizki Handayani Ulfa Ramdhani M Uswatun Chasanah Vivi Sofia Vivi Sophia Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wardhani, Firdha Aprillia