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All Journal Majalah Obat Tradisional PROSIDING SEMINAR KIMIA Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research SANITAS: Jurnal Teknologi dan Seni Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Journal of Pharmaceutical and Sciences. Jurnal Janata Sciences of Phytochemistry Journal of Tropical Pharmacy and Chemistry Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Yesi Desmiaty, Yesi
UNIVERSITAS PANCASILA
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Transportation Other

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Optimizing Ultrasonic Extraction of Enhalus acoroides to Enhance Physicochemical Traits and Antioxidant Activity Mardiyanti, Siti; Anwar, Effionora; Desmiaty, Yesi; Sadiah, Siti
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.419

Abstract

Enhalus acoroides is a seagrass species known for its antioxidant potential due to its flavonoid content, including quercetin. This study aimed to optimize the extraction time using the ultrasound-assisted extraction (UAE) method based on physicochemical parameters and antioxidant activity. The simplicia was extracted for 20, 30, and 40 minutes, each in triplicate, using 96% ethanol acidified with 1% HCl. The results demonstrated that extraction time significantly influenced the physicochemical properties, including yield (highest at 30 minutes: 40.2%), total phenolic content (1.153 mg GAE/g), total flavonoid content (0.318 mg QE/g), quercetin content (0.316 mg/g), and antioxidant activity (IC₅₀ = 58.44 ppm), whereas no significant effect was observed on total ash content. Qualitative phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. Based on these findings, a 30-minute extraction time is recommended as the optimal condition for obtaining E. acoroides extract with the highest antioxidant activity.
Pharmacognostic and Phytochemical Characterization of Colocasia esculenta var. antiquorum Corm (Araceae) and Preliminary Evaluation of Its Antimicrobial Activity Sumiyati, Yati; Yesi Desmiaty; Gumilar Adhi Nugroho; Fauzia Noprima Okta
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i1.9218

Abstract

Colocasia esculenta has been reported in reputable journals to exhibit various bioactivities, including antioxidant, anti-inflammatory, and antidiabetic properties. This study aimed to investigate the pharmacognostic characteristics and phytochemical profile of Colocasia esculenta var. antiquorum corm (Araceae). The corms were collected, authenticated, oven-dried, and subjected to preliminary pharmacognostic and phytochemical analyses. Pharmacognostic evaluations included organoleptic, microscopic, and physicochemical examinations. The dried corm powder was extracted with distilled water, followed by qualitative phytochemical screening. The extract was found to contain saponins, flavonoids, tannins, and triterpenoids. Antimicrobial activity was further evaluated against Staphylococcus aureus, Escherichia coli, and Candida albicans, which were selected as representative pathogenic microorganisms for Gram-positive bacteria, Gram-negative bacteria, and fungi, respectively. These microorganisms were chosen based on previous reports demonstrating that the ethanolic leaf extract of taro exhibited antifungal activity against Candida albicans and antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, and Escherichia coli. However, no inhibitory effect was observed in this study. All analyses were performed in accordance with the guidelines of the Indonesian Herbal Pharmacopeia. The findings provide reference data for the pharmacognostic identification of Colocasia esculenta corm and highlight its phytochemical constituents. Further investigations on other biological activities are required to validate its therapeutic potential. 
Antioxidant and Antidiabetic Compounds from Ebony Leaf Extract (Diospyros celebica Bakh.) and Their Correlation with Total Phenolic and Flavonoid Compounds in Various Solvent Extraction Apriandini, Lisya; Hanafi, Muhammad; Djamil, Ratna; Desmiaty, Yesi; Narrij Lotulung, Puspa Dewi; Artanti, Nina
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5454

Abstract

Ebony (Diospyros celebica. Bakh) is a native plant of Indonesia that is used as a traditional medicine for diabetes mellitus. Previous studies state that ethanol extract from ebony leaves significantly reduced blood glucose levels of diabetic rats induced by alloxan. This ability is thought to be caused by secondary metabolites which is phenolic and flavonoid compound. However, research related to structure compounds in extract and composition of solvent variations in the extraction process to get the most optimal activity and also their correlation with total phenolic and flavonoid compounds has not been carried out. This study aimed to evaluate the composition of the optimum solvent in the extraction process and also to know the structure compounds contained in the extract. In the present study, we extracted the ebony leaves with three solvents of different polarity (ethanol-water), i.e. ethanol 50% (EtOH), EtOH 70%, and EtOH 96%. Quantitative estimation of total phenolic and flavonoid contents. These extracts were future evaluated for their activity and the content of compounds in the extract was identified using LCMS/MS. The results showed that phenolic compounds that have been identified in ebony leaf extract are methyl gallate and (-)-Epiafzelechin 3-gallate and we found there were significant differences in all test parameters between the three extracts which is EtOH 96% extract gave the best.
Enhanced Efficacy of Kaffir Lime (Citrus hystrix) Essential Oil Spray Gel Against Aedes aegypti Mosquitoes Nugroho, Gumilar Adhi; Desmiaty, Yesi; Fahleni, Fahleni; Lhu Muslimah, Lhu; Andam Dewi, Mira
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5469

Abstract

The primary mode of dengue disease transmission is by the Aedes aegypti mosquito. The essential oil derived from Kaffir lime (Citrus hystrix) leaves comprises 66.85% beta-citronellal, 6.59% beta-citronellol, 3.90% linalol, and 1.76% citronellol. These constituents exhibit repelling properties. The objective of this study was to develop a spray gel formulation using kaffir lime leaf essential oil to create an efficient repellent. The process involves tearing fresh kaffir lime leaves and subsequently distilling them with distilled water. The distillation procedure yields an essential oil that is subsequently incorporated into a spray gel formulation, with varying concentrations of 1%, 5%, and 10%. Based on the findings of the efficacy test from 3 spray gel formulas through mosquito repelling activity conducted over 6 hours, it can be concluded that all tested formulas exhibited variation in effectiveness in repelling mosquito bites. The efficacy of the protection index against Aedes aegypti mosquito bites is contingent upon the concentration of kaffir lime essential oil in the formulation. There is a positive correlation between concentration and the duration of protection.
Literature Study: Potential of Garcinia latissima Miq. for Skin Care - a Mini Review Neneng Siti Silfi Ambarwati; Yesi Desmiaty; Mari Okatini Armandari; Sri Irta Widjajanti; Triastity, Sarinah; Yolanti
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6663

Abstract

The species Garcinia Latissima Miq. is native to Southeast Asia's tropical rain forests, primarily in Papua and Maluku. This plant is well-known for its thick-skinned fruit, used as a spice in traditional recipes. Garcinia Latissima Miq is also used in traditional medicine. Its use as a traditional medicine is because Garcinia Latissima Miq. has long been recognized as a source of phenolic compounds, and earlier research has shown that the chemicals extracted have biological activity as antioxidants, antibacterials, and antimicrobials. This study aimed to gather adequate information on the Garcinia Latissima Miq. plant's potential for usage as a cosmetic or skincare ingredient. A literature review was done in this study to obtain data from prior investigations. According to the findings of this investigation, the Garcinia Latissima Miq. plant possesses anti-elastase, which helps maintain skin elasticity, and contains flavonoids that inhibit tyrosinase in melanogenesis. Garcinia Latissima Miq. plant has the potential to maintain skin elasticity and brightness.
Co-Authors AFIZZA ANBAR Ali Timucin Atayoglu Amanda, Reistha Fazlia Andam Dewi, Mira Apriandini, Lisya Ardi, Maria Yedida Ariani, Lusiana Arif Tatak Berna Elya Camalia Hartantrie, Rovida Chandra, Amelia Ciang, Windy Danty Nur Alvionitasari Deby Faradhila Deni Rahmat Diah Kartika Pratami Dianita Ayu Noviastuti Djamil, Ratna Effionora Anwar Endah Wulandari Esti Mumpuni, Esti Evita Maria Simorangkir Fadlina Chany Saputri Fahleni Fahleni Fahrauk Faramayuda, Fahrauk Fahri Muhammad FAIZATUN, FAIZATUN Fajar, In Rahmi Fatria Fauzia Noprima Okta Fauzia Noprima Okta Fikri Alatas Greesty Finotory Swandiny Gumilar Adhi Nugroho Hakim, Ratu Mayra Handayani, Rizqya Cahya Haura Usna Rahmah Iis Irawatty Dewi Kartiningsih Kartiningsih Kharinta Adella Meynderth kurnia agustini Lhu Muslimah, Lhu Liliek Nurhidayati Lilik Sulasti Lilik Sulastri Lim, Helsa Lindawati Lindawati LOLA DYAH PITHALOKA Mardiyanti, Siti Mari Okatini Armandari Muhammad Hanafi Nadya Sekar Marvel Narrij Lotulung, Puspa Dewi Nattika Sari Darmastuti Neneng Siti Silfi Ambarwati Ni Made Dwi Sandhiutami Nilam Sari Maulidina Nina Artanti Noviani, Yuslia Okta, Fauzia Noprima Partomuan Simanjuntak Prayoga, Tria Priyanti, Ike Ari R, Julia R, Julia R., Ika R., Ika RAHMAT, DENI Reczky Muhammad Ramdhan Hasan Risma Marisi Tambunan Rizky Adam Hidayat Siti Mardiyanti Siti Sadiah Siti Sadiah Sri Irta Widjajanti Suherman, Sandra Loretta Syamsudin Syamsudin Triastity, Sarinah Triyani, Yulia Valeria Wahyudi, Dion Wiwi Winarti Yashinta Larasati Yati Sumiyati YATI SUMIYATI Yati Sumiyati Yati Sumiyati, Yati Yolanti