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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional PROSIDING SEMINAR KIMIA Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia SANITAS: Jurnal Teknologi dan Seni Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Journal of Pharmaceutical and Sciences. Jurnal Janata Journal of Food and Pharmaceutical Sciences Sciences of Phytochemistry Journal of Tropical Pharmacy and Chemistry Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Yesi Desmiaty, Yesi
UNIVERSITAS PANCASILA
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Other

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The Bitter Taste Masking of Sour Lime (Citrus aurantiifolia) Peel Extract using Β-Cyclodextrin Complex Desmiaty, Yesi; Sandhiutami, Ni Made Dwi; Engita, Elvira; Irtan, Levina Diva; Noor, Siti Umrah
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21370

Abstract

Sour lime (Citrus aurantifolia) is widely used in Indonesia for beverages and herbal remedies, but the bitterness of its peel limits its application in nutraceuticals. This study aimed to mask the bitter taste of sour lime peel (SLP) extract using β-cyclodextrin (β-CD) to form inclusion complexes. SLP was extracted with 70% ethanol via ultrasonication, then combined with β-CD at different ratios: Ci1 (0.5:2), Ci2 (0.75:2), and Ci3 (1:2), and freeze-dried. The resulting complexes were evaluated for antioxidant activity (DPPH assay) and physicochemical characteristics (bitterness value, FT-IR, SEM, XRD, and DSC). XRD and SEM analyses confirmed all inclusion complexes' amorphous and irregular structures, indicating successful encapsulation. Ci1 and Ci2 showed no detectable bitterness, while Ci3 and the crude extract exhibited bitterness values of 5 and 9 units/g, respectively. FT-IR showed the absence of ester group peaks in Ci1, and DSC indicated a shift in the endothermic peak, supporting complex formation. Among the formulations, Ci2 demonstrated the best performance in masking bitterness while retaining antioxidant activity. These results suggest that β-CD inclusion complexes, particularly Ci2, effectively improve the palatability of SLP extract and are suitable for further development in functional beverages and nutraceutical products.
Optimasi metode ekstraksi air umbi talas Jepang (Colocasia esculenta (L) Schott)): analisis aktivitas antioksidan, kandungan flavonoid, dan kadar luteolin Desmiaty, Yesi; Sandhiutami, Ni Made Dwi; Okta , Fauzia Noprima; Marvel, Nadya Sekar; Sumiyati , Yati
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.574

Abstract

Japanese taro (Colocasia esculenta (L) Schott)) is one of the edible plants that contain phytochemicals such as flavonoids, phenolics, triterpenoids, tannins, and vitamin C which are beneficial to the health of the human body. The compound is also known to have antioxidant activity. Proper extraction can produce quality extracts. This study aims to optimize the extraction method on Japanese taro tubers. Taro tuber was extracted using water with three different temperatures (room temperature, 40℃, and 60℃). The ABTS (2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) method was used to determine the antioxidant activity of the aqueous extract, in addition to determining the total flavonoid content by colorimetric test, and also analyzing the luteolin content by Thin Layer Chromatography (TLC) Densitometry. The total flavonoid content of Taro extracts at room temperature (TERT), 40℃ (TE 40), and 60℃ (TE 60) were 13.97±3.52 mg QE/gr extract; 7.99±2.10 mg QE/gr extract; and 5.98±0.49 mg QE/gr extract, respectively. Luteolin content of TERT, TE40, and TE60 were 0.27%±0.08; 0.25%±0.06; and 0.31%±0.05, respectively. Antioxidant IC50 values of TERT, TE40, and TE60 were 120.32, 137.03, and 159.37 µg/mL, respectively. The study shows that the greater the temperature in the extraction process, the less flavonoid and antioxidant compounds content. While there is a slight difference in determining luteolin levels, optimum luteolin content is obtained at 60°C for 6 hours.
Antioxidant and Anti-aging Activities from Zodia (Evodia suaveolens J.R. Forst & G. Forst) Fruit and Leaf Extract Greesty F. Swandiny; Yesi Desmiaty; Haura Usna Rahmah
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.169

Abstract

Aging is a natural process that occurs in every living organism, including humans. Skin wrinkle, caused by deterioration activity of the elastase enzyme, is one example of the aging process. The activity of the elastase enzyme could be inhibited by flavonoid and phenolic compounds. Zodia (Evodia suaveolens) from the family of Rutaceae is one of the indigenous Indonesian plants widely known as rich in flavonoid and phenolic compounds. The purpose of this study is to explore antioxidant and anti-aging activity from ethanolic extract of fruit and leaf Zodia. The extracts were prepared by refluxing fruit and leaf zodia in 96% ethanol. The obtained extracts were characterized for the phytochemical constituent and its antioxidant activity determined using the 2,2-diphenyl-1-picrylhydrazyl method as well as anti-elastase activity for anti-aging evaluation. Phytochemical analysis of both samples showed the presence of flavonoids, saponins, tannins, steroids and essential oils. The calculation of IC50 in antioxidant activity using the DPPH method showed that ethanolic extract of zodia leaf (264.15 ppm) was higher compared to fruit extract (121.59 ppm). The fruit extract was further tested for anti elastase activity with IC50 of 145.67 ppm. In conclusion, the presence of phytochemicals in zodia fruit may be responsible for the antioxidant and anti-aging activities. 
The Bitter Taste Masking of Sour Lime (Citrus aurantiifolia) Peel Extract using Β-Cyclodextrin Complex Desmiaty, Yesi; Sandhiutami, Ni Made Dwi; Engita, Elvira; Irtan, Levina Diva; Noor, Siti Umrah
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21370

Abstract

Sour lime (Citrus aurantifolia) is widely used in Indonesia for beverages and herbal remedies, but the bitterness of its peel limits its application in nutraceuticals. This study aimed to mask the bitter taste of sour lime peel (SLP) extract using β-cyclodextrin (β-CD) to form inclusion complexes. SLP was extracted with 70% ethanol via ultrasonication, then combined with β-CD at different ratios: Ci1 (0.5:2), Ci2 (0.75:2), and Ci3 (1:2), and freeze-dried. The resulting complexes were evaluated for antioxidant activity (DPPH assay) and physicochemical characteristics (bitterness value, FT-IR, SEM, XRD, and DSC). XRD and SEM analyses confirmed all inclusion complexes' amorphous and irregular structures, indicating successful encapsulation. Ci1 and Ci2 showed no detectable bitterness, while Ci3 and the crude extract exhibited bitterness values of 5 and 9 units/g, respectively. FT-IR showed the absence of ester group peaks in Ci1, and DSC indicated a shift in the endothermic peak, supporting complex formation. Among the formulations, Ci2 demonstrated the best performance in masking bitterness while retaining antioxidant activity. These results suggest that β-CD inclusion complexes, particularly Ci2, effectively improve the palatability of SLP extract and are suitable for further development in functional beverages and nutraceutical products.
Formulation of a peel-off gel mask containing mundu fruit extract (Garcinia dulcis (roxb.) kurz) for antioxidant and anti-elastase activity Ambarwati, Neneng Siti Silfi; Desmiaty, Yesi; Chandra, Amelia; Noviani, Yuslia; Triyani, Yulia; Hakim, Ratu Mayra; Amanda, Reistha Fazlia; Wahyudi, Dion
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1607

Abstract

The skin serves as a protective barrier against ultraviolet (UV) radiation. However, exposure to UV radiation can lead to various skin problems, including changes in the dermis. To prevent UV-induced damage, antioxidants and anti-elastase agents are needed to protect the skin from oxidative stress. This study aims to evaluate the antioxidant and anti-elastase activities of Mundu fruit extract (Garcinia dulcis (Roxb.) Kurz) and to formulate a peel-off gel mask using the concentrated extract. Antioxidant activity was assessed using the FRAP and ABTS methods, while anti-elastase activity was determined by measuring the release of p-nitroaniline from a substrate degraded by the elastase enzyme. The results showed that the IC50 value for antioxidant activity using the ABTS method is 29.57 ppm 0.72, and the FRAP value was 185.02 10.23 AAE/g. The anti-elastase activity showed IC50 of 82.21 ppm. Three peel-off gel mask formulations were developed, with Formula 3 (containing extract at 200 x IC50). showing the best performance. These findings suggest that the thick Mundu fruit extract, which tested positive for phenolic compounds, exhibits promising antioxidant and anti-elastase activities and is suitable for use in topical formulations.
Edukasi Keamanan Pangan dan Tanaman Herbal Pada MI Avia Scientific Manninda, Reise; Andayani, Nurita; Desmiaty, Yesi; Heryani, Aulia; Fatmawati, Yuli; Margono, Adi Dwi; Yolanda; Puspita, Rita; Endeline, Hanna Arystha; Jemmima, Jeanice; Viyoli, Divo; Ramadhani, Sasti Fauziyah
Abdi Implementasi Pancasila:Jurnal Pengabdian kepada Masyarakat Vol 5 No 2 (2025): November
Publisher : Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/8em26c38

Abstract

The food safety of schoolchildren's snacks is the most important thing in improving the quality and nutrition of snacks consumed to enhance the quality of student's health. Despite ongoing efforts, many snacks still contain biological, chemical, and physical hazards, posing long-term health risks. This community service initiative focuses on using medicinal plants like tomatoes and oranges. These plants can be transformed into healthy, attractive snack alternatives such as foods and drinks rich in vitamins E, C and antioxidants. The project aims to educate students about snack food additives and the benefits of medicinal plants. Outreach activities include video presentations on snack safety and the detection of hazards. The results showed that their knowledge before the educational intervention was 72,16% and it increased to 75,69% after the intervention, resulting in a 3,53% improvement. The result of the food samples tested, which were brought by the students, also showed negative results, indicating no harmful substances were present. This counseling activity went well and increased students' awareness and understanding of the importance of choosing safe snacks. It is hoped that this activity will positively impact students' daily consumption and help them choose food more wisely.
Serum Gel Formulation of Mundu Fruit Extract (Garcinia dulcis (Roxb.) Kurz) as Antioxidant and Anti-elastase Neneng Siti Silfi Ambarwati; Yesi Desmiaty; Yuslia Noviani; Valeria; Yulia Triyani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.103-110.2024

Abstract

UV radiation can generate ROS, thereby damaging neutrophils, leading to the uncontrolled release of elastase, and causing aging. This study intends to examine the antioxidants and anti-elastase activity of the skin of Garcinia dulcis (Roxb.) Kurz fruit in serum gel extract preparation. The methods used in this research are microwave-assisted extraction and antioxidants using the ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) method. Three formulas were made with 100 x IC50, 200 x IC50, and 300 x IC50. The test results for the three formulas showed the best antioxidant and anti-elastase activity values in formula 3, with IC50 values ​​of 66.26 ppm and 111.48 ppm. This indicates that the higher the extract concentration in the formulation provides better activity in the serum gel preparation. In the third formulation, evaluation observations were made on the preparation, and a pH value close to the skin’s pH was produced, namely in formula 3. Therefore, it can be concluded that the Mundu fruit peel extract has antioxidant and anti-elastase activity. The extract is applied to cosmetic preparations and still provides good antioxidant and anti-elastase activity results.
Ethanol Extract of Nigella sativa Attenuates Eosinophilic Inflammation and Epithelial Remodeling in an Ovalbumin-Induced Rat Model Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Desmiaty, Yesi; Dwiantika, Ajeng Sunthi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.67195

Abstract

Allergic airway inflammation is commonly associated with eosinophilic infiltration and epithelial remodeling, which impair respiratory function and contribute to tissue damage. This study investigated the therapeutic potential of the ethanol extract of Nigella sativa in an ovalbumin-induced rat model of allergenic airway response. Ethanol extracts were tested in an ovalbumin-induced rat model using Sprague-Dawley rats (n=36), comparing normal, negative controls, 0.009 mg/g BW salbutamol (positive control), and three inhaled extract doses (12.25, 24.50, 49 g/kg BW). Comprehensive analysis included physiological parameters (oxygen saturation), inflammatory biomarkers (lung eosinophil count), and pulmonary histopathology (epithelial thickness). The highest dose (49 g/kg) matched salbutamol in improving oxygen saturation (86.75% vs. 88%, p=0.9917) and reducing epithelial thickness (81.50 µm vs. 81.75 µm, p=0.9999), while suppressing eosinophil infiltration (0.73 vs. 1.45 cells/field, p=0.3348). These results confirm Nigella sativa’s efficacy in attenuating airway inflammation via eosinophil-targeted mechanisms without structural epithelial alterations. The study validates traditional applications of Nigella sativa and proposes an evidence-based framework for integrating phytotherapy into respiratory medicine.
Co-Authors AFIZZA ANBAR Ali Timucin Atayoglu Amanda, Reistha Fazlia Andam Dewi, Mira Andayani, Nurita Apriandini, Lisya Apriliana, Amalia Zahra Ardi, Maria Yedida Ariani, Lusiana Arif Tatak Berna Elya Camalia Hartantrie, Rovida Chandra, Amelia Ciang, Windy Danty Nur Alvionitasari Deby Faradhila Deni Rahmat Diah Kartika Pratami Dianita Ayu Noviastuti Djamil, Ratna Dwiantika, Ajeng Sunthi Effionora Anwar Endah Wulandari Endeline, Hanna Arystha Engita, Elvira Esti Mumpuni, Esti Evita Maria Simorangkir Fadlina Chany Saputri Fahleni Fahleni Fahrauk Faramayuda, Fahrauk Fahri Muhammad Faizatun, Faizatun Fajar, In Rahmi Fatria Fauzia Noprima Okta Fikri Alatas Greesty F. Swandiny Greesty Finotory Swandiny Griselda, Agnes Gumilar Adhi Nugroho Hakim, Ratu Mayra Handayani, Rizqya Cahya Haura Usna Rahmah Haura Usna Rahmah Heryani, Aulia Iis Irawatty Dewi Irtan, Levina Diva Jemmima, Jeanice Kartiningsih Kartiningsih Kharinta Adella Meynderth kurnia agustini Lhu Muslimah, Lhu Liliek Nurhidayati Lilik Sulasti Lilik Sulastri Lim, Helsa Lindawati Lindawati LOLA DYAH PITHALOKA Mardiyanti, Siti Margono, Adi Dwi Mari Okatini Armandari Marvel, Nadya Sekar Moch Futuchul Arifin Muhammad Hanafi Narrij Lotulung, Puspa Dewi Nattika Sari Darmastuti Neneng Siti Silfi Ambarwati Neneng Siti Silfi Ambarwati Ni Made Dwi Sandhiutami Nilam Sari Maulidina Nina Artanti Noor, Siti Umrah Noviani, Yuslia Okta , Fauzia Noprima Okta, Fauzia Noprima Partomuan Simanjuntak Prayoga, Tria Priyanti, Ike Ari Puspita, Rita R, Julia R, Julia R., Ika R., Ika RAHMAT, DENI Ramadhani, Sasti Fauziyah Reczky Muhammad Ramdhan Hasan Reise Manninda Rika Sari Dewi Risma Marisi Tambunan Rizky Adam Hidayat Shafira, Elza Siti Mardiyanti Siti Sadiah Siti Sadiah Sri Irta Widjajanti Suherman, Sandra Loretta Sumiyati , Yati Syamsudin Syamsudin Triastity, Sarinah Triyani, Yulia Valeria Viyoli, Divo Wahyudi, Dion Wiwi Winarti Yashinta Larasati YATI SUMIYATI Yati Sumiyati Yati Sumiyati, Yati Yolanda Yolanti Yuli Fatmawati Yulia Triyani Yuslia Noviani