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All Journal Journal of Food and Pharmaceutical Science Majalah Obat Tradisional PROSIDING SEMINAR KIMIA Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research SANITAS: Jurnal Teknologi dan Seni Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Journal of Pharmaceutical and Sciences. Jurnal Janata Journal of Food and Pharmaceutical Sciences Sciences of Phytochemistry Journal of Tropical Pharmacy and Chemistry Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Yesi Desmiaty, Yesi
UNIVERSITAS PANCASILA
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Transportation Other

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Standardisasi dan Uji Aktivitas Antioksidan Ekstrak Bahan Alam Propolis untuk Terapi Infeksi SARS-CoV2 Diah Kartika Pratami; Yesi Desmiaty; Evita Maria Simorangkir; Deby Faradhila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1062

Abstract

Natural ingredients with immunomodulatory, anti-inflammatory, and antioxidant activities can be used as supportive therapy for SARS-CoV2 infection. The aims were standardized the quality and safety of propolis and determined the antioxidant activity of propolis. There are two types of propolis powder samples: microencapsulated propolis powder containing wax (SMPW) and non-waxed (SMP). Standardization includes specific and non-specific parameters. Antioxidant activity test using FRAP and ABTS methods. The total flavonoids of SMPW and SMP were 0.31% and 1.59%. The total phenolic of SMPW and SMP were 83.9082 and 98.0821 mg GAE/g. The losses on drying of SMPW and SMP were 3.65% and 3.88%. The water content of SMPW and SMP were 5.12% and 5.11%. The total ash content of SMPW and SMP were 0.80% and 0.65%. Heavy metal propolis powder negative. ALT and AKK values < 10 CFU/g, microbiology contamination was negative. Antioxidant activity of SMPW with IC50 ABTS 2.4177 ppm and EC50 FRAP 26.41 g/mL. Meanwhile, the antioxidant activity of SMP with IC50 ABTS 2.213 ppm and EC50 FRAP 32.10 g/mL. It was concluded that the extract of propolis met the requirements of the standard for extracts of natural ingredients and had strong antioxidant activity. Propolis powder can be developed for supportive therapy for SARS-CoV2 infection.
Pengaruh Metode Ekstraksi Terhadap Kandungan Senyawa Polifenol dan Aktivitas Antioksidan pada Rubus fraxinifolius Yesi Desmiaty; Berna Elya; Fadlina Chany Saputri; Iis Irawatty Dewi; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.654 KB) | DOI: 10.35814/jifi.v17i2.755

Abstract

Rubus fraxinifolius can be founded in the mountainous regions of West Java. Previous studies have shown that this plant has potent antioxidant activity. The content of polyphenol compounds in this species contributes substantially to antioxidant activity, and the extraction method will affect the content of the compound. In this study an evaluation of the extraction method effect on leaves, young fruits and stems of R. fraxinifolius on the content of polyphenols and their antioxidant activity, have been done. Method: The leaves, fruits, and stems of R. fraxinifolius were extracted by maceration, reflux, and soxhlet using methanol as a solvent. Each extract was determined the total polyphenol content using Folin-Ciocalteu reagent and antioxidant activity test using DPPH reduction method. Result: The highest extract yield was R. fraxinifolius leaf reflux extract (30.20%). The highest total polyphenol content was given by the Soxhlet extract of leaf R. fraxinifolius (48.79 mg GAE / g extract). The highest antioxidant activity was leaf Soxhlet extract of R. fraxinifolius (98.29% at 100 ppm). Conclusion: From this study it was shown that the methanol extract of R. fraxinifolius leaves extracted by Soxhlet gave the highest polyphenol content and antioxidant activity.
Antioxidant and Anti-aging Activities from Zodia (Evodia suaveolens J.R. Forst & G. Forst) Fruit and Leaf Extract Greesty F. Swandiny; Yesi Desmiaty; Haura Usna Rahmah
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.169

Abstract

Aging is a natural process that occurs in every living organism, including humans. Skin wrinkle, caused by deterioration activity of the elastase enzyme, is one example of the aging process. The activity of the elastase enzyme could be inhibited by flavonoid and phenolic compounds. Zodia (Evodia suaveolens) from the family of Rutaceae is one of the indigenous Indonesian plants widely known as rich in flavonoid and phenolic compounds. The purpose of this study is to explore antioxidant and anti-aging activity from ethanolic extract of fruit and leaf Zodia. The extracts were prepared by refluxing fruit and leaf zodia in 96% ethanol. The obtained extracts were characterized for the phytochemical constituent and its antioxidant activity determined using the 2,2-diphenyl-1-picrylhydrazyl method as well as anti-elastase activity for anti-aging evaluation. Phytochemical analysis of both samples showed the presence of flavonoids, saponins, tannins, steroids and essential oils. The calculation of IC50 in antioxidant activity using the DPPH method showed that ethanolic extract of zodia leaf (264.15 ppm) was higher compared to fruit extract (121.59 ppm). The fruit extract was further tested for anti elastase activity with IC50 of 145.67 ppm. In conclusion, the presence of phytochemicals in zodia fruit may be responsible for the antioxidant and anti-aging activities. 
Karakteristik Beberapa Biji Kopi Arabika Komersil di Indonesia Yesi Desmiaty; Liliek Nurhidayati; Ni Made Dwi Sandhiutami; Reczky Muhammad Ramdhan Hasan; Kharinta Adella Meynderth; Dianita Ayu Noviastuti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1277

Abstract

Arabica coffee is one of the mainstay commodities in the Indonesian plantation sector. Geographical differences and the environment where coffee grow can affect the characteristic, phytochemical content and antioxidant activity of the beans. The aim of this study was to determine the phytochemical characteristics and antioxidant activity of 10 items of commercial Arabica coffee beans in Indonesia. The extraction of 10 coffee beans was carried out by kinetic maceration in 1 hour with 70% ethanol, then evaporated. Each extract was examined for morphology, phytochemical screening, assay of caffeine content using HPLC method, levels of flavan-3-ol, total flavonoid content (TFC), total polyphenolic content (TPC), antioxidant determination using DPPH and FRAP methods. All bean samples showed the presence of flavonoids, alkaloids, triterpenoids, coumarins, and tannins. The chemical content determination showed caff eine content of 1.5-2.9%; flavan-3-ol content 4.85-12.38cat/g extract; TFC 9.71–23.67QE/g extract; and TPC 21.8–76.26GAE/g extract. Tests of antioxidant capacity using the DPPH reveal an inhibiting effect with varying IC₅₀ values from 19.49-81.41g/mL and using the FRAP method gave IC₅₀ values from 18.01-61.2g/mL. This study indicates that coffee samples have the same phytochemical characteristics and also have an important antioxidant activity, which justifies its potential to be developed into antioxidant nutraceuticals.
Kombinasi Colocasia esculenta L. dan Zingiber officinale Potensial Menghambat Inflamasi dan Nyeri Ni Made Dwi Sandhiutami; Ali Timucin Atayoglu; Yati Sumiyati; Yesi Desmiaty; Rizky Adam Hidayat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1373

Abstract

The active metabolites of Colocasia esculenta L. and Zingiber officinale L. have been reported to reduce pain and exert anti-inflammatory effects. This study aimed to examine the anti-inflammatory and analgesic effects of a combination of C. esculenta and Z. officinale extract. Thirty rats and mice were each divided into 6 groups (n=5), namely the normal group, negative control, positive control (Nadiclofenac), and 3 test groups were given a extract combination (dose 1.3 mg/20 gBW, 2.6 mg/20 gBW, and 5.2 mg/20 gBW). Winter's method was used for anti-inflammatory tests by inducing carrageenan in rat paws, and Sigmund's method was used for analgesic tests by the intraperitoneal induction of acetic acid in mice. The percentage of inhibition of leg edema in rats was 11.33%, 18.90%, and 19.10% for the three doses of the combined extracts of C. esculenta and Z. officinale, and 22.72% for Na-diclofenac (p<0.05). The percentage inhibition in the analgesic test in the positive control group and the three test groups was 61.17%, 41.19%, 51.79%, and 52.35%, respectively (p<0.05). The combination of the C. esculenta and Z. officinale extracts exhibited anti-inflammatory and analgesic effects. Dose of 2.6 mg/20 gBW and 5.2 mg/20 gBW as effective as Na-diclofenac.
PERBAIKAN EKSTRAKSI PRODUK HERBAL Arif Tatak; Yati Sumiyati; Rovida Camalia Hartantrie; Yesi Desmiaty; Gumilar Adhi Nugroho
Jurnal JANATA Vol 2 No 2 (2022): Jurnal Janata
Publisher : Program Studi Teknik Sipil Fakultas Teknik Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/janata.v2i2.4364

Abstract

Produk herbal yang dimanfaatkan untuk menjaga stamina dan pengobatan saat ini sudah diolah sehingga bisa diperoleh dalam sediaan serbuk yang dikemas sebagai kapsul, tablet atau sirup. Serbuk tersebut adalah hasil ekstraksi dari bahan herbal. Salah satu tahapan dalam proses ekstraksi herbal adalah proses pemasakan bahan herbal. Proses pemasakan ini memegang peranan sangat penting karena menentukan kualitas ekstrak herbal yang dihasilkan. Penggunaan panas berlebih (over heat) akan mengakibatkan rusaknya kandungan nutrisi yang ada pada bahan herbal. Untuk meminimalisasi terjadinya panas berlebih pada proses pemasakan maka digunakan panas dari uap air yang dihasilkan oleh boiler. Hal ini diharapkan dapat memperbaiki kualitas produk ekstrak herbal yang sebelumnya dimasak menggunakan kompor gas.
Edukasi Peningkatan Aspek Mutu Obat Tradisional bagi Pengguna dan Pelaku Usaha Obat Tradisional Desmiaty, Yesi; Nugroho, Gumilar Adhi; Okta, Fauzia Noprima; Sandhiutami, Ni Made Dwi; Sumiyati, Yati; Priyanti, Ike Ari
Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 2 (2023): Agustus 2023
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Bina Sarana Informatika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31294/jabdimas.v6i2.14627

Abstract

Adanya pandemi covid-19 membuat masyarakat berusaha lebih untuk menjaga kesehatan salah satunya dengan menggunakan obat herbal, sehingga terjadi peningkatan penggunaan obat herbal di Indonesia. Hal ini tentu harus diimbangi dengan mutu yang terjamin dari obat herbal di pasaran. Kegiatan pengabdian kepada masyarakat ini dalam rangka mengedukasi masyarakat sebagai pengguna obat herbal maupun pelaku usaha herbal agar memperhatikan aspek mutu obat herbal. Saat ini masih terdapat obat herbal yang beredar di masyarakat dan tidak memenuhi persyaratan. Metode edukasi dilakukan secara daring dengan menyebarkan kuisioner untuk mengetahui pengetahuan masyarakat, dilanjutkan dengan edukasi dan diskusi interaktif. Dari hasil survey menunjukkan responden umumnya belum terlalu memahami aspek mutu obat herbal sehingga perlu untuk dilakukan edukasi agar dapat memilih obat herbal yang bermutu baik serta bagi pelaku usaha herbal dapat meningkatkan mutu produknya sesuai dengan persyaratan yang diberlakukan oleh regulator yaitu Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM RI).
Pembuatan Nanopartikel Berbasis Kitosan dari Infus Daun Sirsak (Annona Muricata LINN) sebagai Antioksidan Yesi Desmiaty; Deni Rahmat; Nilam Sari Maulidina
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 4 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i4.119

Abstract

Daun Sirsak (Annona muricata Linn), Annonaceae telah diketahui memiliki kemampuan meredam radikal bebas yang kuat dan bisa dikembangkan menjadi sediaan farmasi antioksidan. Pembentukan nanopartikel dari ekstrak akan meningkatkan stabilitas, kemampuan mukoadhesif dan penetrasi ekstrak sehingga dapat meningkatkan efektifitasnya. Pembuatan nanopartikel dilakukan dengan melarutkan kitosan dalam larutan asam asetat glasial 1%, dan dicampurkan dengan infus daun sirsak. Suspensi nanopartikel ekstrak daun sirsak dikeringkan dengan menggunakan alat pengering semprot. Hasil evaluasi nanopartikel ekstrak diperoleh ukuran partikel 131,23 ± 1,81%, indeks polidispersitas 0,3 – 0,4; padatan total 0,47 %, warna coklat muda, bau khas ekstrak, rasa pahit, sifat serbuk halus, higroskopis, kadar air 6.86 ± 0,88%. Pemeriksaan aktivitas antioksidan pada nanopartikel ekstrak daun sirsak dengan menggunakan metode peredaman radikal bebas DPPH menunjukkan aktivitas antioksidan kuat dengan nilai 1C50 sebesar 80,98 bpj. Kata kunci : daun sirsak, Annona muricata Linn., DPPH, antioksidan, nanopartikel, kitosan
Serum Gel Formulation of Mundu Fruit Extract (Garcinia dulcis (Roxb.) Kurz) as Antioxidant and Anti-elastase Ambarwati, Neneng Siti Silfi; Desmiaty, Yesi; Noviani, Yuslia; Valeria; Triyani, Yulia
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.103-110.2024

Abstract

UV radiation can generate ROS, thereby damaging neutrophils, leading to the uncontrolled release of elastase, and causing aging. This study intends to examine the antioxidants and anti-elastase activity of the skin of Garcinia dulcis (Roxb.) Kurz fruit in serum gel extract preparation. The methods used in this research are microwave-assisted extraction and antioxidants using the ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) method. Three formulas were made with 100 x IC50, 200 x IC50, and 300 x IC50. The test results for the three formulas showed the best antioxidant and anti-elastase activity values in formula 3, with IC50 values ​​of 66.26 ppm and 111.48 ppm. This indicates that the higher the extract concentration in the formulation provides better activity in the serum gel preparation. In the third formulation, evaluation observations were made on the preparation, and a pH value close to the skin’s pH was produced, namely in formula 3. Therefore, it can be concluded that the Mundu fruit peel extract has antioxidant and anti-elastase activity. The extract is applied to cosmetic preparations and still provides good antioxidant and anti-elastase activity results.
Antioxidant and anti-elastase activity of Tampui (Baccaurea macrocarpa) and Ketapong (Terminalia badamia) barks and leaves Ariani, Lusiana; Wulandari, Endah; Desmiaty, Yesi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1393

Abstract

Elastase is a protease that is involved in the breakdown of elastin in the dermis. Likewise, free radicals can cause elastin damage. Inhibition of elastase enzyme activity and scavenging of free radicals can prevent premature aging of the skin, especially wrinkles. The current study was to investigate the antioxidant and elastase inhibition properties of the leaves and bark of the Tampui (Baccaurea macrocarpa L.) and Ketapong (Terminalia badamia L.) plants, which may be employed as an anti-aging ingredient in cosmetics and nutraceuticals. B. macrocarpa and T. badamia's leaves and bark were extracted using reflux and 96% ethanol. Anti-elastase was examined using N-succ-(Ala)3-nitroanilide as a substrate, and the DPPH reagent was used to test the antioxidants' activity. Phytochemical screening indicated the presence of flavonoids, quinone, tannins, and steroids. Antioxidant activity of B. macrocarpa leaves (BML), B. macrocarpa bark (BMB), T. badamia leaves (TBL), and T. badamia bark (TBB) had IC50 values were 15.09±0.51; 22.89±1.51; 36.43±1.94; 39.23±1.76 ppm, respectively. The anti-elastase activity of BML, BMB, TBL, and TBB had IC50 values were 48.86±2.29; 52.03±9.54; 44.42±4.53; 40.16±1.32 ppm, respectively. The ethanol extract of B. macrocarpa and T. badamia's leaves and bark exhibits anti-elastase and antioxidant action, proposing that it may be used as an anti-aging agent.
Co-Authors AFIZZA ANBAR Ali Timucin Atayoglu Amanda, Reistha Fazlia Andam Dewi, Mira Apriandini, Lisya Apriliana, Amalia Zahra Ardi, Maria Yedida Ariani, Lusiana Arif Tatak Berna Elya Camalia Hartantrie, Rovida Chandra, Amelia Ciang, Windy Danty Nur Alvionitasari Deby Faradhila Deni Rahmat Diah Kartika Pratami Dianita Ayu Noviastuti Djamil, Ratna Effionora Anwar Endah Wulandari Engita, Elvira Esti Mumpuni, Esti Evita Maria Simorangkir Fadlina Chany Saputri Fahleni Fahleni Fahrauk Faramayuda, Fahrauk Fahri Muhammad FAIZATUN, FAIZATUN Fajar, In Rahmi Fatria Fauzia Noprima Okta Fikri Alatas Greesty F. Swandiny Greesty Finotory Swandiny Griselda, Agnes Gumilar Adhi Nugroho Hakim, Ratu Mayra Handayani, Rizqya Cahya Haura Usna Rahmah Haura Usna Rahmah Iis Irawatty Dewi Irtan, Levina Diva Kartiningsih Kartiningsih Kharinta Adella Meynderth kurnia agustini Lhu Muslimah, Lhu Liliek Nurhidayati Lilik Sulasti Lilik Sulastri Lim, Helsa Lindawati Lindawati LOLA DYAH PITHALOKA Mardiyanti, Siti Mari Okatini Armandari Marvel, Nadya Sekar Moch Futuchul Arifin Muhammad Hanafi Narrij Lotulung, Puspa Dewi Nattika Sari Darmastuti Neneng Siti Silfi Ambarwati Ni Made Dwi Sandhiutami Nilam Sari Maulidina Nina Artanti Noor, Siti Umrah Noviani, Yuslia Okta , Fauzia Noprima Okta, Fauzia Noprima Partomuan Simanjuntak Prayoga, Tria Priyanti, Ike Ari R, Julia R, Julia R., Ika R., Ika RAHMAT, DENI Reczky Muhammad Ramdhan Hasan Risma Marisi Tambunan Rizky Adam Hidayat Shafira, Elza Siti Mardiyanti Siti Sadiah Siti Sadiah Sri Irta Widjajanti Suherman, Sandra Loretta Sumiyati , Yati Syamsudin Syamsudin Triastity, Sarinah Triyani, Yulia Valeria Wahyudi, Dion Wiwi Winarti Yashinta Larasati YATI SUMIYATI Yati Sumiyati Yati Sumiyati, Yati Yolanti