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Histopathological Analysis of Liver Damage in Rasbora lateristriata Fish Induced by Extract Butterfly Pea Flower (Clitoria ternatea) Pertiwi, Anggita Endar; Illiyin, Sirayya; Sadewo, Imran; Rahayu, Sekar; Rumansara, Papuani Samparisna; Podhi, Felisitas Moli; Sularsah, Sais; Adelfiani, Adelfiani; Retnoaji, Bambang; Sofyantoro, Fajar; Nuriliani, Ardaning; Wijayanti, Nastiti; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Empra, Desi Eka Putri; Ariesti, Wiwin; Septriani, Nur Indah
RUMPHIUS Vol 8 No 1 (2026): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

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Abstract

Butterfly pea flower (Clitoria ternatea) is an Indonesian native plant known for its medicinal properties due to its rich content of anthocyanins, flavonoids, and ternatins. Although widely recognized for its health benefits, the long-term effects of its bioactive compounds require careful evaluation. This study aimed to investigate the potential hepatotoxic effects of butterfly pea flower extract on the liver of Rasbora lateristriata fish. Fish were exposed to 0 (control), 50, 75, and 100 ppm of butterfly pea extract for four days, with four fish allocated per group. Histological markers, including necrosis, vacuolization, pyknosis, and hemorrhage, were assessed in liver tissues. Data were analyzed using the Kruskal-Wallis test and Mann-Whitney U test at a 95% confidence level. Results indicated that butterfly pea flower extract caused significant hepatic damage, with increased severity at higher concentrations. The most pronounced damage was observed at 75 ppm, suggesting an optimal dose for inducing oxidative stress. This study highlights the potential hepatotoxicity of butterfly pea flower extract in aquatic species and underscores the need for further research to evaluate its safety for therapeutic use.
Comparative Analysis of Hematological Profiles in Diabetic Mice Treated with D-Allulose and Neoagaro-Oligosaccharides Salsabila Faradisa Nuris; Wiwin Ariesti; Tri Rini Nuringtyas; Budi Saksono; Rahadian Yudo Hartantyo; Fajar Sofyantoro; Nastiti Wijayanti
Quagga: Jurnal Pendidikan dan Biologi Vol 18 No 2 (2026): QUAGGA : Jurnal Pendidikan dan Biologi
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25134/quagga.v18i2.504

Abstract

Diabetes mellitus is characterized by chronic hyperglycemia that induces oxidative stress and inflammation, contributing to hematological dysfunction and increased systemic risk. This study comparatively evaluated the effects of D-allulose and neoagarooligosaccharides (NAOS) on hematological parameters in BALB/c mice with type 2 diabetes induced by streptozotocin. Experimental groups consisted of control, negative control, positive control (metformin), and treatment groups receiving D-allulose (0.05, 0.1, 0.2 g/kg BW) or NAOS (100, 200, 400 mg/kg BW) orally for 28 days. Hematological assessments included red blood cell (RBC) count, erythrocyte indices (hemoglobin, hematocrit, mean corpuscular hemoglobin), leukocyte count, and lymphocyte levels. Negative controls displayed decreased RBC parameters and lymphocytes, with elevated leukocytes, indicating hematological impairment associated with hyperglycemia. D-allulose improved RBC count, hemoglobin, and MCH, while reducing leukocyte count and elevating lymphocytes, especially at lower doses. NAOS primarily enhanced erythrocyte quality by improving hemoglobin, hematocrit, and MCH, while also modulating leukocyte and lymphocyte profiles. Overall, D-allulose was more effective in restoring erythrocyte quantity, whereas NAOS contributed more prominently to erythrocyte index improvement. Both agents show potential in reducing hematological disorders associated with inflammation in diabetes cases.
Co-Authors Abiyyi, Muhammad Hawi Qabus Adania, Baik Aisyah Adelfiani, Adelfiani Aeniah, Siti Allimi, Hayu Swari Almunawar, Muhammad Fikri Ammaru Bisandyaloka Andri Frediansyah Andri Frediansyah, Andri Aphrodita, Adiva Aprilia Sufi Subiastuti Apriliyani, Tia Ardaning Nuriliani Arief Maulana Sabilillah Ariel Hananya Ariesti, Wiwin Ashfiya Hanif Hasnadewi Athira Nur Rahma Azmatun Fildzah Azzahira, Faiha Azka Bambang Retnoaji Budi Saksono Chusnul Azhar Cinta Alivia Atha Dafa, Maula Haqul Dewi, Umi Rosita Dimas, Abimanyu Dwi Eny Djoko Setyono Dwi Sendi Priyono Empra, Desi Eka Putri Erinda Putri Dewiyanti Fadhlurrohman, Galih Dzaky Ganies Riza Aristya Gizela Aulia Agustin Halim, Shuha Ma’muriyah Hendrix I. Kusuma Hendry Tri Sakti Saragih Hidayat, Rheina Faticha Asyamsa Himarosa, Rela Adi Illiyin, Sirayya Ishana, Aurelia Araya Isra Wahid Joko Nugroho Wahyu Karyadi Karlina, Ina Khairul Anam Khoiruddin Anshori Krisdiyanto Krisdiyanto Krisdiyanto, Krisdiyanto Kusuma, Hendrix I. Lathief Al Umami Lisna Hidayati, Lisna Maharesi, Chesa Ekani Marius Rademaker Mataram, Made Bagus Auriva Mayani, Olvita Muhammad Ardillah Rusydan Muhammad Baihaqi Muhammad Budi Nur Rahman Muhammad Hafid Dinata Muhammada, Khusnus Syifa Muliawati, Adina Mulyati Mulyati Nareta Defiani Nastiti Wijayanti Nasution, Nurlita Putri Bela Nata Dwi Annisa Nizma Nur Rachman Maulana Nurhidayah, Septika Nuringtyas, Tri R. Oktaviana, Shintia Pertiwi, Anggita Endar Podhi, Felisitas Moli Pradnya Paramita Primadian Adhi Wardana Primahesa, Alfian Prissandi, Anthera Al Firdaus Purwestri, Yekti A. Pusparini, Nur Ainun Oktavia Rademaker, Marius Rahadian Yudo Hartantyo Rahayu, Sekar Rahmi, Sri N. Ramadhani, Gilang Afif Setya Rarastoeti Pratiwi Rela Adi Himarosa Rela Adi Himarosa Rizky Nuryani Rohmah, Zuliyati Rumansara, Papuani Samparisna Sadewo, Imran Saeed, Faisal Safitri, Della Thasya Liona Salsabila Faradisa Nuris Sandro Vento Saragih, Hendry T. S. S. G. Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Senny Helmiati Sentono, Diva N. Septriani, Nur Indah Septriani, Nur Indah Simanungkalit, Eben Ezer Slamet Raharjo Slamet Widiyanto Sritanjung, Opi Sudarisman Sudarisman Sukirno Sukirno Sularsah, Sais Supraitno, Murtiadi Erlan Syafei, Dio Rachmaputra Syam, Adi Mazdi Tri Rini Nuringtyas Ulfa, Siti Zakia Utami, Mia Vento, Sandro Wahyu Aristyaning Putri Wahyu Aristyaning Putri Wahyu Nursehan Wahyudi, Setyanto T. Wiwin Ariesti Woro Anindito Sri Tunjung Wulandari, Mutiara Tri Yekti Asih Purwestri Yudha, Donan S. Zusrina, Laili Mufli