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All Journal Jurnal Kedokteran Brawijaya Althea Medical Journal AGRIVITA, Journal of Agricultural Science Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Jurnal Terapan Abdimas UNEJ e-Proceeding Berkala Kedokteran Jurnal Kimia Riset BIOMA Padjadjaran Journal of Dentistry Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kedokteran dan Kesehatan Jurnal Biologi Tropis The Indonesian Journal of Infectious Diseases Interdental Jurnal Kedokteran Gigi (IJKG) Medika Kartika : Jurnal Kedokteran dan Kesehatan Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Multidisciplinary Applied Natural Science Berkala Penelitian Hayati Hang Tuah Medical Journal JAPI: Jurnal Akses Pengabdian Indonesia Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran JI-KES (Jurnal Ilmu Kesehatan)
Masfufatun Masfufatun
Departemen Biokimia, Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Comparative analysis of IL-6 levels in post-tooth extraction inflammation among menopausal and non-menopausal: in vivo experimental Parmasari, Wahyuni Dyah; Asyamsa Hidayat, Rheina Faticha; Rianti, Emilia Devi Dwi; Masfufatun, Masfufatun; Mokhtar, Siti Aisyah
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.62766

Abstract

Introduction: IL-6 acts as a biomarker of the inflammatory process. In elderly, especially women, the demand for tooth extraction treatment is quite high. A failure in the wound healing process during the menopausal period can prolong the inflammation process, thereby increasing the probability of infection, including alveolar osteitis. The menopausal process affects estrogen levels in the blood, which leads to reduced collagen formation as a key component of tissue regeneration. IL-6 levels can also increase during inflammation, especially in the chronic phase following tooth extraction. The study aims to analyze the differences in inflammatory IL-6 levels between menopausal and non-menopausal rats. Methods: This study applied an in vivo experimental design. A total of 30 Rattus novergicus were divided into two groups: a control group and a treatment group. The control group consisted of rats in which no oophorectomy was performed (non-menopausal), while the treatment group underwent ovariectomy to induce menopause. One after the procedure, tooth extraction were performed, and observations were conducted on days 3, 7, and 14 post-extractions. IL-6 levels were measured using ELISA from blood serum samples. The data were analyzed using One-Way ANOVA.  Results: The average IL-6 levels (in ng/L) in the control (non-menopausal) group on days 3, 7, and 14 were 0.087, 0.318, and 0.247, respectively. The average IL-6 levels in the treatment (menopausal) group were 0.191, 0.452, and 0.318, respectively. The One-Way ANOVA test showed no significant difference between the groups (p=0.799 > 0.05).  Conclusion: The trend of higher IL-6 levels in the menopausal group suggests a potential impact of hormonal changes on post-extraction inflammation. Although no significant difference was found, the elevated IL-6 levels in menopausal rats indicate a potential effect of estrogen deficiency on the inflammatory response following tooth extraction.
Antibiofilm Activity Test of Apis Dorsata Honey Against Candida albicans Biofilm Dwi Cahyani, Herawati; Masfufatun, Masfufatun; Diah Setijowati, Eva; masfufatun
Prosiding Seminar Nasional Kusuma Vol 3 (2025): Prosiding Seminar Nasional Kusuma
Publisher : LPPM UWKS

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Abstract

Latar belakang: Madu Apis dorsata memiliki aktivitas untuk menghambat pembentukan biofilm Candida albicans . Madu mengandung fenolik, steroid, tannin dan flavonoid. Dimana flavonoid merupakan salah satu kelas dari keluarga fenolik (setengah dari jumlah total senyawa fenolik) berfungsi untuk menghambat pembentukan biofilm Candida albicans . Tujuan: penelitian ini bertujuan untuk mengetahui aktivitas antibiofilm madu Apis dorsata terhadap biofilm Candida albicans . Metode: Sampel yang digunakan berupa madu Apis dorsata yang diperoleh dari Gunung Mutis Nusa Tenggara Timur. Sampel madu dilarutkan dalam media RPMI 1640 dengan konsentrasi larutan konsentrasi 50%, 25%, 12,5%, 6,25%, dan 3,125%. Uji aktivitas antibiofilm madu terhadap biofilm Candida albicans  dilakukan dengan metode Mikrotiter plate menggunakan ELISA reader.  Hasil: Hasil penelitian menunjukkan bahwa semua konsentrasi madu memiliki aktivitas menghambat pembentukan biofilm Candida albicans  dengan penghambatan terbesar konsentrasi madu 50% sebesar 69,78%. Penelitian ini menunjukkan bahwa madu Apis dorsata dari Gunung Mutis NTT secara kuat menghambat pembentukan biofilm Candida albicans . Efektivitas ini bersifat dosis-dependen, di mana konsentrasi madu 50% memberikan tingkat penghambatan tertinggi sebesar 69,78%. Kesimpulan: Dengan demikian, madu ini patut dipertimbangkan sebagai sumber agen antibiofilm alami yang potensial, berkat kandungan senyawa fenolik dan flavonoidnya.
Development of Curcuma xanthorrhiza Nanoemulsion as an Antibiofilm Agent against Multidrug-Resistant Candida albicans: Formulation Approach and In Vitro Evaluation Arifah, Dzulfira; Izzah, Nurul; Pujiani, Dyah Virga; Ardilia, Abidah; Masfufatun, Masfufatun
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11274

Abstract

Candida albicans infection is a serious health concern, particularly in immunocompromised individuals, due to its ability to form biofilms that are resistant to conventional antifungal therapies. Curcuma xanthorrhiza Roxb. (temulawak) possesses antifungal properties; however, its effectiveness is limited by poor solubility and bioavailability. Nanoemulsion formulation offers a promising strategy to enhance the penetration of active compounds. This study aimed to develop and evaluate the effectiveness of temulawak nanoemulsion as an antibiofilm agent against multidrug-resistant (MDR) C. albicans. Using a post-test control group only design, the antibiofilm assay was conducted via the microtiter plate method and analyzed based on Optical Density (OD) measurements. The results showed that temulawak nanoemulsion significantly reduced biofilm formation, with an 89% reduction in OD at the 100% concentration. These findings support the potential use of temulawak nanoemulsion as an alternative therapeutic strategy for Candida albicans infections, particularly those involving drug-resistant biofilms.
Prevalence Pattern of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli in the Intestinal Flora of Milkfish Salsabillah, Dinara Safina; Kuntaman, Kuntaman; Masfufatun, Masfufatun; Tania, Putu Oky Ari
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11259

Abstract

Escherichia coli is one of the gram-negative bacteria that produces the Extended Spectrum Beta-Lactamase (ESBL) enzyme and has a role in resistance to the beta-lactam group. The presence of E. coli bacteria that produce ESBL in food, especially in fish such as milkfish (Chanos chanos) poses a potential source of the spread of antimicrobial resistance (AMR) in humans. This study aims to determine the prevalence of ESBL-producing E. coli in the intestinal flora of milkfish sold in traditional markets in Surabaya City. This study used a descriptive observational method with a cross-sectional approach. There were 50 samples of milkfish intestines taken from several stalls in traditional markets randomly. Identification of E. coli bacteria by planting in MacConkey media with 4 µL/ml cefotaxime followed by the Double Disk Synergy Test (DDST). Of the 50 milkfish intestine samples used, 34 (68%) samples showed positive results for ESBL-producing E. coli. The high prevalence may indicate that the potential for the spread of antimicrobial resistance through the food chain, food hygiene management and controlling the use of antibiotics in fish farming need serious attention.
Co-Authors Adi Candra, Adi AFAF BAKTIR akhmad sudibya, akhmad ALMAIDAH SAFITRI Amalia Nadiasari Amrulloh, Azmi Khalid Ananta Sandi Putra Ananta, Zahrah Aswa Andini Risma Ayunda Dewi Andriani, Chenny Ardilia, Abidah Arifah, Dzulfira Aritania, Putu Oky Asyamsa Hidayat, Rheina Faticha Atik Sri Wulandari Ayly Soekanto Ayu Cahyani Noviana Budhi Setiawan Budhi Setiawan Budhi Setyawan Chenny Andriani Wiyono Colin, Muhammad Dadik Raharjo Diah Setijowati, Eva Dwi Cahyani, Herawati Elika Joeniarti Emilia Devi D.R, Emilia Devi Fardiansyah, Al Farizah El Husna Fauzan, Laili Shafarina Fehima Syachsiyat Alya Firdausi Nuzula Habibi, Miftahul Handy Arief HARMAN AGUSAPUTRA Harsono Harsono Haryanto, Loo Herliani, Olivia I Kadek Wawan Agus Wijaya I MADE DWIKY KARINA JAYA Inawati Inawati Inawati Inawati Inawati Inawati, Inawati Indahasari, Noer Kumala Islam, Afif Fajrul Isnaeni, Mutia IZZAH, NURUL Jalal, Ismul JAMES HADIPUTRA SUNARPO Jonathan Kartika Ishartadiati Kuntaman Kuntaman Laili Shafarina Fauzan Laily, Aulia Nur Listyawati, Agusniar Furkani Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Masfufatun Meilya Putri Syahida Mentari, Andi Oktaviana Mohammad Ali Izzudin Mokhtar, Siti Aisyah Muhammad Rozzan Prananda Nadila, Sucia Narotama, Harya Ni Luh Narita Vijayanti Ni Made Putri Pradnyandari NI PUTU MANIK SURYANINGSIH NOER KUMALA Noer Kumala Noer Kumala Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika NUGROHO EKO WIRAWAN BUDIANTO Nur Kumala Indahsari, Nur Kumala Nur Kumala, Nur Nurma Fitri Parawidnyaningsih, Putu Ayu Aryanda Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda Pujiani, Dyah Virga Putu Oky Ari Tania Qurraty’ain, Seryna Hasna Rachmawati Dwi Apriliyani Ratnasari, Diana Tri Rianti, Emilia Devi Dwi Rini Purbowati Rini Purbowati Riska Ammalia Putri Risnanda, Kadek Rio Sakri, Brian Manggala Salsabillah, Dinara Safina Setijowati, Eva Diah Soebandhi, Santirianingrum Sri Lestari Utami Sugiharto Suhartati Suhartati Suhartati Syahrefi Syahrefi TEOFILUS DANI PRASETYOADI Tikapa Muwawiyai Pigome Tri Juliati Tri Rahayuningsih Tri Ratnasari, Diana Utami, Sri Lestari Vini Anggraini Wahyuni Dyah Parmasari, Wahyuni Dyah Wibisono, Freegied Satriya Wibisono, Freshinta Jellia Wiyono, Chenny A Yaniari, Roethmia