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All Journal Jurnal Kedokteran Brawijaya Althea Medical Journal AGRIVITA, Journal of Agricultural Science Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Jurnal Terapan Abdimas UNEJ e-Proceeding Berkala Kedokteran Jurnal Kimia Riset BIOMA Padjadjaran Journal of Dentistry Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kedokteran dan Kesehatan Jurnal Biologi Tropis The Indonesian Journal of Infectious Diseases Interdental Jurnal Kedokteran Gigi (IJKG) Medika Kartika : Jurnal Kedokteran dan Kesehatan Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Multidisciplinary Applied Natural Science Berkala Penelitian Hayati Hang Tuah Medical Journal JAPI: Jurnal Akses Pengabdian Indonesia Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran JI-KES (Jurnal Ilmu Kesehatan)
Masfufatun Masfufatun
Departemen Biokimia, Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Antibiofilm Activity Test of Apis Dorsata Honey Against Candida albicans Biofilm Dwi Cahyani, Herawati; Masfufatun, Masfufatun; Diah Setijowati, Eva; masfufatun
Prosiding Seminar Nasional Kusuma Vol 3 (2025): Prosiding Seminar Nasional Kusuma
Publisher : LPPM UWKS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Madu Apis dorsata memiliki aktivitas untuk menghambat pembentukan biofilm Candida albicans . Madu mengandung fenolik, steroid, tannin dan flavonoid. Dimana flavonoid merupakan salah satu kelas dari keluarga fenolik (setengah dari jumlah total senyawa fenolik) berfungsi untuk menghambat pembentukan biofilm Candida albicans . Tujuan: penelitian ini bertujuan untuk mengetahui aktivitas antibiofilm madu Apis dorsata terhadap biofilm Candida albicans . Metode: Sampel yang digunakan berupa madu Apis dorsata yang diperoleh dari Gunung Mutis Nusa Tenggara Timur. Sampel madu dilarutkan dalam media RPMI 1640 dengan konsentrasi larutan konsentrasi 50%, 25%, 12,5%, 6,25%, dan 3,125%. Uji aktivitas antibiofilm madu terhadap biofilm Candida albicans  dilakukan dengan metode Mikrotiter plate menggunakan ELISA reader.  Hasil: Hasil penelitian menunjukkan bahwa semua konsentrasi madu memiliki aktivitas menghambat pembentukan biofilm Candida albicans  dengan penghambatan terbesar konsentrasi madu 50% sebesar 69,78%. Penelitian ini menunjukkan bahwa madu Apis dorsata dari Gunung Mutis NTT secara kuat menghambat pembentukan biofilm Candida albicans . Efektivitas ini bersifat dosis-dependen, di mana konsentrasi madu 50% memberikan tingkat penghambatan tertinggi sebesar 69,78%. Kesimpulan: Dengan demikian, madu ini patut dipertimbangkan sebagai sumber agen antibiofilm alami yang potensial, berkat kandungan senyawa fenolik dan flavonoidnya.
Prevalence Pattern of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli in the Intestinal Flora of Milkfish Dinara Safina Salsabillah; Kuntaman Kuntaman; Masfufatun Masfufatun; Putu Oky Ari Tania
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11259

Abstract

Escherichia coli is one of the gram-negative bacteria that produces the Extended Spectrum Beta-Lactamase (ESBL) enzyme and has a role in resistance to the beta-lactam group. The presence of E. coli bacteria that produce ESBL in food, especially in fish such as milkfish (Chanos chanos) poses a potential source of the spread of antimicrobial resistance (AMR) in humans. This study aims to determine the prevalence of ESBL-producing E. coli in the intestinal flora of milkfish sold in traditional markets in Surabaya City. This study used a descriptive observational method with a cross-sectional approach. There were 50 samples of milkfish intestines taken from several stalls in traditional markets randomly. Identification of E. coli bacteria by planting in MacConkey media with 4 µL/ml cefotaxime followed by the Double Disk Synergy Test (DDST). Of the 50 milkfish intestine samples used, 34 (68%) samples showed positive results for ESBL-producing E. coli. The high prevalence may indicate that the potential for the spread of antimicrobial resistance through the food chain, food hygiene management and controlling the use of antibiotics in fish farming need serious attention.
Development of Curcuma xanthorrhiza Nanoemulsion as an Antibiofilm Agent against Multidrug-Resistant Candida albicans: Formulation Approach and In Vitro Evaluation Dzulfira Arifah; Nurul Izzah; Dyah Virga Pujiani; Abidah Ardilia; Masfufatun Masfufatun
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11274

Abstract

Candida albicans infection is a serious health concern, particularly in immunocompromised individuals, due to its ability to form biofilms that are resistant to conventional antifungal therapies. Curcuma xanthorrhiza Roxb. (temulawak) possesses antifungal properties; however, its effectiveness is limited by poor solubility and bioavailability. Nanoemulsion formulation offers a promising strategy to enhance the penetration of active compounds. This study aimed to develop and evaluate the effectiveness of temulawak nanoemulsion as an antibiofilm agent against multidrug-resistant (MDR) C. albicans. Using a post-test control group only design, the antibiofilm assay was conducted via the microtiter plate method and analyzed based on Optical Density (OD) measurements. The results showed that temulawak nanoemulsion significantly reduced biofilm formation, with an 89% reduction in OD at the 100% concentration. These findings support the potential use of temulawak nanoemulsion as an alternative therapeutic strategy for Candida albicans infections, particularly those involving drug-resistant biofilms.
Prevalence of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli in the Intestinal Flora of Pet Cats Marshanda Venda Dora Putri Aziz; Kuntaman Kuntaman; Masfufatun Masfufatun
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.11906

Abstract

Antimicrobial resistance (AMR) has become a serious global health issue, affecting both humans and pets. Cats, which frequently interact closely with humans, can serve as reservoirs of resistant Escherichia coli. This study aimed to assess the prevalence of ESBL-producing Escherichia coli in the intestinal flora of pet cats in Balongbendo, Sidoarjo, applying a One Health approach to explore the transmission interface between animals, humans, and the environment.A descriptive observational study with a cross-sectional design was conducted. A total of 50 fecal samples were collected by simple random sampling from pet cats in RW 01, Desa Jabaran, Sidoarjo (January–February 2025). Samples were incubated on MacConkey agar enriched with 4 µg/mL cefotaxime for screening ESBL, and confirmation was conducted utilizing the Double Disk Synergy Test (DDST). Prevalence was determined as the ratio of positive isolates to the overall total . The results showed that 20 of 50 samples (40%) were positive for ESBL-producing Escherichia coli. The highest prevalence was found in Area 1 (60%), which was characterized by poor sanitation and high population density. This indicates widespread ESBL-producing Escherichia coli in domestic animals and underscores the risk of cross-transmission to humans. Therefore, educating animal owners, monitoring antibiotics, and ensuring environmental sanitation are crucial for preventing cross-transmission to humans.
Co-Authors Abidah Ardilia AFAF BAKTIR Agusniar Furkani Listyawati akhmad sudibya, akhmad ALMAIDAH SAFITRI Amalia Nadiasari Ananta Sandi Putra Ananta, Zahrah Aswa Andini Risma Ayunda Dewi Andriani, Chenny Aritania, Putu Oky Asyamsa Hidayat, Rheina Faticha Atik Sri Wulandari Ayly Soekanto Ayu Cahyani Noviana Budhi Setiawan Budhi Setiawan Budhi Setyawan Chenny Andriani Wiyono Colin, Muhammad Dadik Raharjo Diah Setijowati, Eva Dinara Safina Salsabillah Dwi Cahyani, Herawati Dyah Virga Pujiani Dzulfira Arifah Elika Joeniarti Emilia Devi D.R, Emilia Devi Farizah El Husna Fauzan, Laili Shafarina Fehima Syachsiyat Alya Firdausi Nuzula Handy Arief HARMAN AGUSAPUTRA Harsono Harsono Haryanto, Loo Herliani, Olivia I Kadek Wawan Agus Wijaya I MADE DWIKY KARINA JAYA Inawati Inawati Inawati Inawati Inawati Inawati, Inawati Indahasari, Noer Kumala JAMES HADIPUTRA SUNARPO Jonathan Kartika Ishartadiati Kuntaman Kuntaman Kuntaman Kuntaman Kuntaman Kuntaman Laili Shafarina Fauzan Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Marshanda Venda Dora Putri Aziz Masfufatun Meilya Putri Syahida Mohammad Ali Izzudin Mokhtar, Siti Aisyah Muhammad Rozzan Prananda Nadila, Sucia Narotama, Harya Ni Luh Narita Vijayanti Ni Made Putri Pradnyandari NI PUTU MANIK SURYANINGSIH Noer Kumala Noer Kumala NOER KUMALA Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika NUGROHO EKO WIRAWAN BUDIANTO Nur Kumala Indahsari, Nur Kumala Nur Kumala, Nur Nurma Fitri Nurul Izzah Parawidnyaningsih, Putu Ayu Aryanda Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda Putu Oky Ari Tania Rachmawati Dwi Apriliyani Ratnasari, Diana Tri Rianti, Emilia Devi Dwi Rini Purbowati Rini Purbowati Riska Ammalia Putri Risnanda, Kadek Rio Sakri, Brian Manggala Setijowati, Eva Diah Siswahyudianto Sri Lestari Utami Sugiharto Suhartati Suhartati Suhartati Syahrefi Syahrefi TEOFILUS DANI PRASETYOADI Tikapa Muwawiyai Pigome Tri Juliati Tri Rahayuningsih Tri Ratnasari, Diana Utami, Sri Lestari Vini Anggraini Wahyuni Dyah Parmasari, Wahyuni Dyah Wiyono, Chenny A Yaniari, Roethmia