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All Journal Jurnal Kedokteran Brawijaya Althea Medical Journal AGRIVITA, Journal of Agricultural Science Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Jurnal Terapan Abdimas UNEJ e-Proceeding Berkala Kedokteran Jurnal Kimia Riset BIOMA Padjadjaran Journal of Dentistry Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kedokteran dan Kesehatan The Indonesian Journal of Infectious Diseases Interdental Jurnal Kedokteran Gigi (IJKG) Medika Kartika : Jurnal Kedokteran dan Kesehatan Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Multidisciplinary Applied Natural Science Berkala Penelitian Hayati Hang Tuah Medical Journal JAPI: Jurnal Akses Pengabdian Indonesia Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran JI-KES (Jurnal Ilmu Kesehatan)
Masfufatun Masfufatun
Departemen Biokimia, Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Comparative analysis of IL-6 levels in post-tooth extraction inflammation among menopausal and non-menopausal: in vivo experimental Parmasari, Wahyuni Dyah; Asyamsa Hidayat, Rheina Faticha; Rianti, Emilia Devi Dwi; Masfufatun, Masfufatun; Mokhtar, Siti Aisyah
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.62766

Abstract

Introduction: IL-6 acts as a biomarker of the inflammatory process. In elderly, especially women, the demand for tooth extraction treatment is quite high. A failure in the wound healing process during the menopausal period can prolong the inflammation process, thereby increasing the probability of infection, including alveolar osteitis. The menopausal process affects estrogen levels in the blood, which leads to reduced collagen formation as a key component of tissue regeneration. IL-6 levels can also increase during inflammation, especially in the chronic phase following tooth extraction. The study aims to analyze the differences in inflammatory IL-6 levels between menopausal and non-menopausal rats. Methods: This study applied an in vivo experimental design. A total of 30 Rattus novergicus were divided into two groups: a control group and a treatment group. The control group consisted of rats in which no oophorectomy was performed (non-menopausal), while the treatment group underwent ovariectomy to induce menopause. One after the procedure, tooth extraction were performed, and observations were conducted on days 3, 7, and 14 post-extractions. IL-6 levels were measured using ELISA from blood serum samples. The data were analyzed using One-Way ANOVA.  Results: The average IL-6 levels (in ng/L) in the control (non-menopausal) group on days 3, 7, and 14 were 0.087, 0.318, and 0.247, respectively. The average IL-6 levels in the treatment (menopausal) group were 0.191, 0.452, and 0.318, respectively. The One-Way ANOVA test showed no significant difference between the groups (p=0.799 > 0.05).  Conclusion: The trend of higher IL-6 levels in the menopausal group suggests a potential impact of hormonal changes on post-extraction inflammation. Although no significant difference was found, the elevated IL-6 levels in menopausal rats indicate a potential effect of estrogen deficiency on the inflammatory response following tooth extraction.
Co-Authors Adi Candra, Adi AFAF BAKTIR akhmad sudibya, akhmad ALMAIDAH SAFITRI Amalia Nadiasari Amrulloh, Azmi Khalid Ananta Sandi Putra Ananta, Zahrah Aswa Andini Risma Ayunda Dewi Andriani, Chenny Aritania, Putu Oky Asyamsa Hidayat, Rheina Faticha Atik Sri Wulandari Ayly Soekanto Ayu Cahyani Noviana Budhi Setiawan Budhi Setiawan Budhi Setyawan Chenny Andriani Wiyono Colin, Muhammad Dadik Raharjo Elika Joeniarti Emilia Devi D.R, Emilia Devi Fardiansyah, Al Farizah El Husna Fauzan, Laili Shafarina Fehima Syachsiyat Alya Firdausi Nuzula Habibi, Miftahul Handy Arief HARMAN AGUSAPUTRA Harsono Harsono Haryanto, Loo Herliani, Olivia I Kadek Wawan Agus Wijaya I MADE DWIKY KARINA JAYA Inawati Inawati Inawati Inawati Inawati Inawati, Inawati Indahasari, Noer Kumala Islam, Afif Fajrul Isnaeni, Mutia Jalal, Ismul JAMES HADIPUTRA SUNARPO Jonathan Kartika Ishartadiati Kuntaman Kuntaman Laili Shafarina Fauzan Laily, Aulia Nur Listyawati, Agusniar Furkani Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Meilya Putri Syahida Mentari, Andi Oktaviana Mohammad Ali Izzudin Mokhtar, Siti Aisyah Muhammad Rozzan Prananda Nadila, Sucia Narotama, Harya Ni Luh Narita Vijayanti Ni Made Putri Pradnyandari NI PUTU MANIK SURYANINGSIH NOER KUMALA Noer Kumala Noer Kumala Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika NUGROHO EKO WIRAWAN BUDIANTO Nur Kumala Indahsari, Nur Kumala Nur Kumala, Nur Nurma Fitri Parawidnyaningsih, Putu Ayu Aryanda Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda Putu Oky Ari Tania Qurraty’ain, Seryna Hasna Rachmawati Dwi Apriliyani Ratnasari, Diana Tri Rianti, Emilia Devi Dwi Rini Purbowati Rini Purbowati Riska Ammalia Putri Risnanda, Kadek Rio Sakri, Brian Manggala Setijowati, Eva Diah Soebandhi, Santirianingrum Sri Lestari Utami Sugiharto Suhartati Suhartati Suhartati Syahrefi Syahrefi TEOFILUS DANI PRASETYOADI Tikapa Muwawiyai Pigome Tri Juliati Tri Rahayuningsih Tri Ratnasari, Diana Utami, Sri Lestari Vini Anggraini Wahyuni Dyah Parmasari, Wahyuni Dyah Wibisono, Freegied Satriya Wibisono, Freshinta Jellia Wiyono, Chenny A Yaniari, Roethmia Yoga Yuniadi