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All Journal Pharmasipha Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia Indonesian Journal of Global Health research Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health Jurnal Ilmiah Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA The International Science of Health Journal CERATA Usadha Journal of Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan International Journal of Health and Medicine Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Danang Raharjo
Pogram Studi Farmasi, Fakultas Kesehatan, Universitas Duta Bangsa, Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pemanfaatan Serbuk Tempe Non-Lemak sebagai Pangan Fungsional melalui Pemberdayaan Kader PKK Desa Baturan Danang Raharjo; Vivin Marwiyati Rohmana; Kharisma Jayak Pratama
Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan Vol. 3 No. 1 (2026): Januari : Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/aksinyata.v3i1.2865

Abstract

Regarding the Utilization of Non-Fat Tempeh Powder as a Functional Food Based on Local Potential. The activity was conducted in Baturan Village, Colomadu District, Karanganyar Regency, involving 55 members of the PKK (Family Welfare Empowerment) cadre. The community service method employed a Community-Based Research (CBR) approach combined with Asset-Based Community Development (ABCD). The activities included participatory counseling, group discussions, and evaluation through pre-tests and post-tests. The results demonstrated an increase in knowledge, a shift in attitudes, and a growing awareness among the PKK cadre regarding the importance of functional food based on non-fat tempeh. Furthermore, the cadre emerged as peer educators with the potential to drive program sustainability at the community level. This community service proves that community-based counseling is effective in fostering initial social transformation towards healthier and more self-reliant food consumption patterns.
Analisis Kadar Hidrokuinon pada Day cream yang Beredar di Kecamatan X Kabupaten Sukoharjo Kharisma Riskiana; Danang Raharjo
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8501

Abstract

The use of cosmetics, especially day creams, is increasing along with the high public interest in facial skin care. However, day cream products are still found to potentially contain hydroquinone, a skin whitening agent whose use is restricted because it can cause harmful side effects on skin health. This study aims to identify the presence and determine the levels of hydroquinone in day cream products circulating in District X, Sukoharjo Regency, and to assess their compliance with the regulations of the Food and Drug Monitoring Agency (BPOM). This study was a descriptive analytical study using a purposive sampling technique. A total of 15 day cream products were analyzed, consisting of 8 BPOM-registered products and 7 products not registered with BPOM. Qualitative analysis was conducted using color reaction tests with FeCl₃, Benedict’s, and o-phenanthroline reagents. Furthermore, quantitative analysis was performed using the High Performance Liquid Chromatography (HPLC) method to accurately and specifically confirm the presence and determine the levels of hydroquinone. The results showed that the color reaction test has limitations in specifically identifying hydroquinone. HPLC confirmation revealed the presence of hydroquinone in several day cream samples, with concentrations ranging from 0.024% to 0.150%. These findings indicate the need for stricter monitoring of day cream distribution to ensure the safety of cosmetic products for the wider public.
Deteksi dan Kuantifikasi Hidrokuinon pada Sampel Night Cream di Kecamatan X Sukoharjo Retno Kurnia Dewi; Danang Raharjo; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8503

Abstract

Hydroquinone is a skin lightening agent that effectively inhibits melanogenesis, but its use in cosmetics is restricted due to the potential for serious side effects. Although banned in over-the-counter cosmetics, hydroquinone is still found in unregistered night cream products. This study aims to detect the presence, determine the levels of hydroquinone, and evaluate its safety risks in night cream products sold in District X, Sukoharjo Regency. The study was conducted experimentally in a laboratory using a purposive sampling technique on 15 night cream samples consisting of 8 BPOM-registered products and 7 non-BPOM products. Qualitative analysis was carried out using FeCl₃, Benedict's, and o-phenanthroline color reaction tests, while quantitative analysis used the HPLC method with a C18 column and a UV-Vis detector at a wavelength of 280 nm. The results showed that all BPOM-registered samples did not contain hydroquinone, while several non-BPOM samples were detected to contain hydroquinone at levels ranging from 0.0688%–0.2043%. These findings indicate a higher safety risk in non-BPOM products. The implications of this research emphasize the importance of strengthening regulatory oversight and increasing public literacy in choosing safe and legal cosmetic products.
In-Vitro Antioxidant, Antihyperlipidemic, and Antihypertensive Activities of Ethanol Extract of Pedada Stem Bark (Sonneratia caseolaris L.) Haryoto, Haryoto; Raharjo, Danang
Urecol Journal. Part C: Health Sciences Vol. 5 No. 2 (2025): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pedada (Sonneratia caseolaris) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This study aims to examine the potential of kedabu leaf extract as an antioxidant, antihypertensive and antihyperlipidemia agent tested in vitro. Antioxidant testing was carried out using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6sulfonate) method, antihypertensive testing was carried out by inhibiting Angiotensin converting enzyme and antihyperlipidemia was carried out by inhibiting the lipase enzyme. The results of the study showed that the total flavonoid content was 24.827 ± 0.327 mgQE / g mgQE / g with an antioxidant capacity with an IC50 value of 54.166 ± 0.558 ppm. From the Angiotensin converting enzyme inhibition test and lipase enzyme inhibition, the IC50 values ??were 33.843±0.157 ppm and 63.709±0.819 ppm, respectively. Based on these results, the pedada bark extract showed antihypertensive and antihyperlipidemic activity by inhibiting the activity of Angiotensin converting enzyme and lipase enzyme.
FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN BODY SCRUB DARI EKSTRAK DAUN SRIKAYA (Annona squamosa L.) DENGAN METODE ABTS Susilowati, Ucik; Listyani, Tiara Ajeng; Raharjo, Danang
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2038

Abstract

ANALISIS IN SILICO SENYAWA POLIFENOL DAUN ALPUKAT (Persea americana Mill.) SEBAGAI POTENSI INHIBITOR SGLT-2 MENGGUNAKAN MOLECULAR DOCKING DAN PREDIKSI ADMET Rahardian Ariana Putri; Tiara Ajeng Listyani; Danang Raharjo
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1255

Abstract

Diabetes melitus tipe 2 menjadi ancaman kesehatan global yang signifikan dengan prevalensi mencapai 562 juta jiwa pada tahun 2025 dan diperkirakan meningkat menjadi 853 juta kasus pada tahun 2050. Terapi yang tersedia saat ini masih memiliki berbagai keterbatasan dan efek samping seperti infeksi saluran kemih dan resiko ketoasidosis euglikemik. Daun alpukat (Persea americana Mill.) diketahui mengandung berbagai senyawa polifenol yang berpotensi sebagai antidiabetes melalui mekanisme penghambatan Sodium glucose cotransporters 2 (SGLT-2). Penelitian ini bertujuan untuk menganalisis aktivitas penghambatan senyawa polifenol daun alpukat terhadap protein SGLT 2 dengan pemanfaatan CAAD melalui molecular docking dan prediksi sifat ADMET. Penelitian menggunakan desain eksperimental berbasis komputer terhadap 30 senyawa polifenol daun alpukat dengan empagliflozin sebagai kontrol positif dan parasetamol sebagai kontrol negatif. Analisis dilakukan menggunakan perangkat lunak ChemDraw, VegaZZ, DSV, PyRx, PyMOL, SwissADME, dan Toxtree. Hasil penelitian menunjukkan bahwa Syringic acid merupakan senyawa terbaik dengan RMSD 1,274 dan ΔG −6,4, ikatan residu asam amino spesifik dengan empaglifozin, memenuhi kriteria Lipinski’s Rule of Five, dan dalam kategori toksisitas rendah (class I) berdasarkan cramer rules. Sehingga dapat disimpulkan bahwa senyawa polifenol daun alpukat (Persea americana Mill.) menunjukkan potensi sebagai inhibitor SGLT-2 dengan syringic acid sebagai kandidat terbaik (ΔG −6,4 kkal/mol; RMSD 1,274 Å).
FORMULASI SEDIAAN GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) SEBAGAI TERAPI LUKA SAYAT PADA KELINCI NEW ZEALAND WHITE Raharjo, Danang; Ika Dwi Ningrum; Listyani, Tiara Ajeng
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.443

Abstract

Breadfruit leaf (Artocarpus altilis) is a type of plant that has a single to oval leaf from the Moraceae family. There are secondary metabolites in breadfruit leaves (Artocarpus altilis), namely flavonoids, tannins, and saponins which are efficacious as a treatment for the wound healing process. This study aims to determine whether breadfruit leaf extract (Artocarpus altilis) can be formulated into a gel preparation and to determine the maximum concentration of breadfruit leaf extract (Artocarpus altilis) in wound healing. This study was an experimental study to determine the maximum concentration in healing cuts with varying concentrations of 6.25%, 12.5%, and 25% tested on 5 male rabbits with 3 treatment groups. Wound healing data were analyzed using One Way ANOVA (Analysis of Varian) and the physical evaluation of the gel preparation was analyzed descriptively. The results showed that breadfruit leaf extract (Artocarpus altilis) could be formulated into gel preparations and fulfilled the physical evaluation test for gel preparations. Statistical test results had a significant effect on wound healing in rabbits p=0.001 (p<0.05) and the maximum concentration in wound healing was a concentration of 25% with a healing time of 11 days.        
Co-Authors Addawiyyah, Muniroh Adiyantoro, Bagas Aini, Riszki Nur Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anita Dwi Septiarini Anita Dwi Septiarini S Anna Fitriawati Apriliawan, Hidayah apriliyanti, laela intan Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Chyang, Pang Jyh Desy Ayu Irma Permatasari Diana Nurrah Ashari Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Budi Santoso Dwi Nurul Khotimah Dwi S, Anita Eny Wijayanti Fadilla, Fitri Hansa Fatimah Azzahro Febriyani, Rima Fevi Indri Oktaviani Fitriwati, Anna Gusmao, Nandito Manuel Ximenes Haryoto Haryoto Haryoto, H Hidayat, Allif Nur Ika Dwi Ningrum Ilham Zikri Kharisma Jayak Pratama Kharisma Riskiana kristian saputra, samuel Kusumaningtyas Siwi Artini Lisa Amalia Listyani, Tiara Ajeng Lisyani, Tiara Ajeng Luthfia Dhiyaul Amalia Luthfiyanti, Niken Lydia Fitriana Muhamad Farid Nurohman Krisnadi Musniati, Musniati Nafiah, Azidatun Niken Luthfiyanti Nuniek Nizmah Fajriyah Nurcahyani, Dona Agustin NURUL HIDAYAH Oktafia Nur Fatimah Pambudi, Dwi Bagus Permata, Bangkit Riska Permatasari, Desy Ayu Irma Pratama, Kharisma Jayak Rafidah Hanifah Rahardian Ariana Putri Raharjo, Oktavia Wijaya Rahmat Hidayat Ramadhani, Diza Aulia Retno Kurnia Dewi Rohmana, Vivin Marwiyati Rusmiati Rusmiati Salsabila Khoerunniyssa Sania, Sania Septian Maulid Wicahyo Setyaningrum, Fidya Siska Wardani, Tatiana Siti Fatimah Siti Fatimah Siwi Artini, Kusumaningtyas Susilowati, Ucik Sya'bania, Muti' Tiara Ajeng L Tiara Ajeng L. Vinkasari, Elriza Wardani , Tatiana Siska Wardani, Tatiana Siska Wulandari, Nia Isa Yuliya Rahma