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All Journal Pharmasipha Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health Jurnal Ilmiah Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA The International Science of Health Journal CERATA Usadha Journal of Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan International Journal of Health and Medicine Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Danang Raharjo
Pogram Studi Farmasi, Fakultas Kesehatan, Universitas Duta Bangsa, Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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ANALISIS IN SILICO SENYAWA POLIFENOL DAUN ALPUKAT (Persea americana Mill.) SEBAGAI POTENSI INHIBITOR SGLT-2 MENGGUNAKAN MOLECULAR DOCKING DAN PREDIKSI ADMET Rahardian Ariana Putri; Tiara Ajeng Listyani; Danang Raharjo
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1255

Abstract

Diabetes melitus tipe 2 menjadi ancaman kesehatan global yang signifikan dengan prevalensi mencapai 562 juta jiwa pada tahun 2025 dan diperkirakan meningkat menjadi 853 juta kasus pada tahun 2050. Terapi yang tersedia saat ini masih memiliki berbagai keterbatasan dan efek samping seperti infeksi saluran kemih dan resiko ketoasidosis euglikemik. Daun alpukat (Persea americana Mill.) diketahui mengandung berbagai senyawa polifenol yang berpotensi sebagai antidiabetes melalui mekanisme penghambatan Sodium glucose cotransporters 2 (SGLT-2). Penelitian ini bertujuan untuk menganalisis aktivitas penghambatan senyawa polifenol daun alpukat terhadap protein SGLT 2 dengan pemanfaatan CAAD melalui molecular docking dan prediksi sifat ADMET. Penelitian menggunakan desain eksperimental berbasis komputer terhadap 30 senyawa polifenol daun alpukat dengan empagliflozin sebagai kontrol positif dan parasetamol sebagai kontrol negatif. Analisis dilakukan menggunakan perangkat lunak ChemDraw, VegaZZ, DSV, PyRx, PyMOL, SwissADME, dan Toxtree. Hasil penelitian menunjukkan bahwa Syringic acid merupakan senyawa terbaik dengan RMSD 1,274 dan ΔG −6,4, ikatan residu asam amino spesifik dengan empaglifozin, memenuhi kriteria Lipinski’s Rule of Five, dan dalam kategori toksisitas rendah (class I) berdasarkan cramer rules. Sehingga dapat disimpulkan bahwa senyawa polifenol daun alpukat (Persea americana Mill.) menunjukkan potensi sebagai inhibitor SGLT-2 dengan syringic acid sebagai kandidat terbaik (ΔG −6,4 kkal/mol; RMSD 1,274 Å).
FORMULASI SEDIAAN GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) SEBAGAI TERAPI LUKA SAYAT PADA KELINCI NEW ZEALAND WHITE Raharjo, Danang; Ika Dwi Ningrum; Listyani, Tiara Ajeng
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.443

Abstract

Breadfruit leaf (Artocarpus altilis) is a type of plant that has a single to oval leaf from the Moraceae family. There are secondary metabolites in breadfruit leaves (Artocarpus altilis), namely flavonoids, tannins, and saponins which are efficacious as a treatment for the wound healing process. This study aims to determine whether breadfruit leaf extract (Artocarpus altilis) can be formulated into a gel preparation and to determine the maximum concentration of breadfruit leaf extract (Artocarpus altilis) in wound healing. This study was an experimental study to determine the maximum concentration in healing cuts with varying concentrations of 6.25%, 12.5%, and 25% tested on 5 male rabbits with 3 treatment groups. Wound healing data were analyzed using One Way ANOVA (Analysis of Varian) and the physical evaluation of the gel preparation was analyzed descriptively. The results showed that breadfruit leaf extract (Artocarpus altilis) could be formulated into gel preparations and fulfilled the physical evaluation test for gel preparations. Statistical test results had a significant effect on wound healing in rabbits p=0.001 (p<0.05) and the maximum concentration in wound healing was a concentration of 25% with a healing time of 11 days.        
Formulasi Sediaan Serum Fraksi Aktif Ekstrak Etanol Daun Nangka (Artocarpus Heterophyllus L.) Sebagai Antioksidan Shafi Surya Donar E K; Danang Raharjo; Kusumaningtyas Siwi Artini; Bangkit Riska Permata
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3848

Abstract

Free radicals can damage the skin and accelerate aging, so natural antioxidants are needed. Jackfruit leaves (Artocarpus heterophyllus L.) contain flavonoids that have the potential as antioxidants. This study aims to extract the active fraction from jackfruit leaves and formulate it in the form of serum. Extraction was carried out through maceration with 96% ethanol, followed by fractionation using n-hexane and ethyl acetate. Antioxidant activity was tested using the ABTS method, and the serum formulation was tested for physical stability and was accepted through irritation and hedonic tests. The results showed that the ethyl acetate fraction had the highest antioxidant activity (IC50 = 32.041 ppm). Serum with 5% active fraction showed strong activity (IC50 = 60.301 ppm), was physically stable, and was well accepted by users. Serum from the ethyl acetate fraction of jackfruit leaves has the potential as a natural skin care product with good antioxidant activity.
Pengaruh Variasi Tween 80 dan Propilen Glikol terhadap Karakteristik Nanoemulsi Lotion Daun Ubi Jalar Ungu (Ipomoea batatas L.) Riska Amelia; Danang Raharjo; Bangkit Riska Permata
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i2.10357

Abstract

Exposure to ultraviolet radiation and environmental pollution triggers an increase in free radicals in the skin, leading to oxidative stress and premature aging. Purple sweet potato leaves (Ipomoea batatas L.) contain high antioxidant compounds such as anthocyanins and flavonoids; however, conventional topical applications face stability and penetration challenges. Nanoemulsions serve as a solution to enhance the penetration and stability of active compounds. This study aimed to analyze the effect of Tween 80 and propylene glycol variations on the characteristics of nanoemulsion lotion from purple sweet potato leaves. This laboratory experimental research employed a completely randomized design (CRD) using five formulas with varying concentrations of Tween 80 (30-35%) and propylene glycol (5-15%). The extract was obtained through maceration using 96% ethanol and formulated into a nanoemulsion lotion using a high-speed homogenization method. Evaluations included organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, particle size, and polydispersity index (PDI) tests. The results showed that all formulas produced semisolid, homogeneous preparations with pH of 5.21-6.31, viscosity of 2,063-3,075 cPs, spreadability of 6.17–7.88 cm, and adhesion of 4.63–5.96 seconds. Formula F4 (Tween 80:propylene glycol 55:15) exhibited the best characteristics with the smallest particle size of 128.54 nm and PDI of 0.187. Variations in Tween 80 and propylene glycol significantly influenced the characteristics of the nanoemulsion lotion. Formula F4 is recommended as the optimal formulation for developing nanoemulsion lotions based on purple sweet potato leaves.
Co-Authors Addawiyyah, Muniroh Adiyantoro, Bagas Aini, Riszki Nur Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anita Dwi Septiarini Anita Dwi Septiarini S Anna Fitriawati Apriliawan, Hidayah apriliyanti, laela intan Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Bangkit Riska Permata Desy Ayu Irma Permatasari Diana Nurrah Ashari Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Budi Santoso Dwi Nurul Khotimah Dwi S, Anita Eny Wijayanti Fadilla, Fitri Hansa Fatimah Azzahro Febriyani, Rima Fevi Indri Oktaviani Fitriwati, Anna Gusmao, Nandito Manuel Ximenes Haryoto Haryoto Haryoto, H Hidayat, Allif Nur Ika Dwi Ningrum Ilham Zikri Kharisma Jayak Pratama Kharisma Riskiana kristian saputra, samuel Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Lisyani, Tiara Ajeng Luthfia Dhiyaul Amalia Lydia Fitriana Musniati, Musniati Nafiah, Azidatun Niken Luthfiyanti Nuniek Nizmah Fajriyah Nurcahyani, Dona Agustin NURUL HIDAYAH Oktafia Nur Fatimah Pambudi, Dwi Bagus Permata, Bangkit Riska Permatasari, Desy Ayu Irma Pratama, Kharisma Jayak Rafidah Hanifah Rahardian Ariana Putri Raharjo, Oktavia Wijaya Rahmat Hidayat Retno Kurnia Dewi Riska Amelia Rohmana, Vivin Marwiyati Rusmiati Rusmiati Salsabila Khoerunniyssa Sania, Sania Septian Maulid Wicahyo Setyaningrum, Fidya Shafi Surya Donar E K Siska Wardani, Tatiana Siti Fatimah Siti Fatimah Siwi Artini, Kusumaningtyas Sya'bania, Muti' Tiara Ajeng L Tiara Ajeng L. Vinkasari, Elriza Wardani , Tatiana Siska Wardani, Tatiana Siska Wulandari, Nia Isa Yuliya Rahma