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All Journal Jurnal Kedokteran Diponegoro PENELITIAN DAN KARYA ILMIAH Universa Medicina Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Masyarakat Trimedika
Husnun Amalia
Departement Of Opthalmology, Faculty Of Medicine, Universitas Trisakti, Jakarta, Indonesia
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Efficacy of liposomal amphotericin B eye drops at two concentrations in experimental aspergillus keratomycosis in rabbits Husnun Amalia; Rahmawati Ridwan; Ari Estuningtyas; Ratna Sitompul; Robiatul Adawiyah; Hans-Joachim Freisleben
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.240

Abstract

Background: Keratomycosis, a fungal corneal infection prevalent in tropical regions, frequently leads to visual impairment and blindness. Liposomal amphotericin B (L-AmB) offers improved efficacy and reduced toxicity compared to conventional amphotericin B deoxycholate and represents a promising option for topical ophthalmic use. Objective: To evaluate and compare the therapeutic efficacy of L-AmB eye drops at 0.15% and 0.5% concentrations in experimental Aspergillus keratomycosis in New Zealand White rabbits. Methods: Four rabbits received midstromal corneal inoculation with a mixed suspension of Aspergillus flavus, A. fumigatus, A. niger, and A. terreus (2 x 10⁴ CFU/0.05 mL). L-AmB eye drops were applied hourly from day 8 post-inoculation until corneal cultures became negative. Antifungal susceptibility was assessed by disc diffusion. Clinical response was monitored by slit lamp examination using a modified scoring system. Results: Negative corneal cultures were achieved in all treated eyes within 10 to 18 days (mean 15 days, L-AmB 0.15%) and 11 to 15 days (mean 14 days, L-AmB 0.5%). No toxic effects were observed. Complete corneal transparency without cicatrix was achieved in one eye treated with L-AmB 0.15%. Conclusion: Both concentrations were effective and safe. Liposomal AmB 0.15% appears as efficacious as 0.5% for experimental Aspergillus keratomycosis. Clinical studies in humans are warranted.
Hubungan Pterigium dengan Kejadian Dry Eye pada Masyarakat di Kabupaten Tojo Una-Una, Sulawesi Anggraeni Adiwardhani; Husnun Amalia; Noviani Prasetyaningsih; Riani Witjaksana; Rizky Eka Adeliani
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.121-128

Abstract

Background Indonesia is a tropical country exposed to ultraviolet (UV) rays year-round, particularly in Central Sulawesi Province, which lies on the equator. Tojo Una Una Regency is located in this province, and the majority of its residents work as fishermen, who are frequently exposed to UV radiation, a risk factor for pterygium and dry eye. This profession has the highest incidence of pterygium, reaching 15.8%. This study will analyze the relationship between pterygium and dry eye. Methods The study design was cross-sectional with consecutive non-random sampling. A questionnaire was used to assess characteristics. Pterygium was diagnosed through an anterior segment examination by a general practitioner, followed by a double-blind ophthalmologist to assess the degree, location, and whether the pterygium was single or double-headed. The degree and diagnosis of dry eye were confirmed using the OSDI questionnaire. Results The study involved 400 respondents, and the prevalence of pterygium reached 85.25%, with cases predominantly bilateral (66.5%), single-headed (70.25%), female (72.75%), 26-45 age group (49.25%), and those working outdoors (77%). DES cases were found in 54.25%, with the majority being severe DES. A chi-square test showed a relationship between dry eye and pterygium (p<0.001). Conclusions There was a significant relationship between DES severity and pterygium incidence (p<0.001).
Hantavirus : Ancaman Zoonosis sebagai penyebab penyakit Infeksi Emerging Husnun Amalia; Gladys Kusumowidagdo; Wawan Kurniawan
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.117-120

Abstract

Hantavirus is a zoonotic virus belonging to the genus Orthohantavirus which causes emerging infectious diseases with high levels of morbidity and mortality. This virus is transmitted primarily through exposure to aerosols containing urine, feces, or saliva of infected rodents. Climate change, urbanization, changes in land use, and increasing interactions between humans and reservoirs contribute to the increasing risk of hantavirus transmission in various regions, including Indonesia. Hantaviruses are divided into Old World hantaviruses which cause Hemorrhagic Fever with Renal Syndrome (HFRS) and New World hantaviruses which cause Hantavirus Cardiopulmonary Syndrome (HCPS). Clinical manifestations vary from acute fever to renal or respiratory failure with a fatality rate that can reach 30–50% in HCPS. Diagnosis is made through a combination of history, clinical manifestations, serological examination, and molecular detection using RT-PCR. Until now, there is no specific antiviral or vaccine available that is widely used, so management still focuses on supportive therapy. In Indonesia, hantavirus infections are thought to still be underdiagnosed and underreported, even though serological and molecular evidence shows the circulation of the virus in humans and rodents. Hantavirus is an emerging zoonotic disease that has the potential to become a threat to public health. Increasing clinical awareness, strengthening surveillance, early detection, rodent control, and implementing the One Health approach are important strategies to reduce the risk of disease transmission and impact, especially in developing countries like Indonesia.
Co-Authors Adhiwardan, Anggraeni Adianto, Raymond Adlani, Hadianti Ahmed, Dina Alsayed, Raghda Alvina Alvina Andrianjah Andrianjah, Andrianjah Anggiat, Desi Anggraeni Adiwardhani Anggraeni Adiwardhani Anisa Henintya Rizki Putri Antin Tri Laksmi Ari Estuningtyas Ariyani, Aziza Bella, Isa Christian Christian David Tjahyadi dianawati, dianawati Diani Nazma Diani Nazma Djebli, Noureddine Effendi, Ida Emad Yousif Erlani Kartadinata Erlani Kartadinata, Erlani Eveline Margo, Eveline Faradila, Meutia Atika Ferdhian, Farrel Ferina, Mutiara Gladys Kusumowidagdo Grace Nerry Legoh Gusti G. Suardana, Gusti G. Hadi Sumarsono Hairunisa, Nany Hameed, Seenar Handriwei Handriwei Hans-Joachim Freisleben Hosea Jaya Edy Husain, Amani Isa Bella Johan Hutauruk Joice Viladelvia Kalumpiu, Joice Viladelvia Kadhom, Mohammed Karina Karina Karlina Mahardieni Kartini Kartini Kudaer, Nuha B Kurniasari LEKOK, WIDYAWATI Lira Panduwaty Lira Panduwaty Maharani, Ronaningtyas Mahdi, Sarah Marja, Triyoko Septio Mashab, Yasmine Mashabi, Yasmine Mohammed Kadhom Mohsen Hashim Risan Monica Dwi Hartanti Monica Dwi Hartanti, Monica Dwi Mun’im, Abdul Mustopa, Ita Tazkiatul Izzati Nadia Fernanda Natadidjaja, Ronald Irwanto Noviani Prasetyaningsih Noviani Prasetyaningsih Noviani Prasetyaningsih Nuha Kudaer Oladimeji, Ashaolu Victoria Onny Hernik Saputro Parwanto, Edy Patricia Budihartanti Liman Pertiwi, Iin Indra Prasetyaningsih, Noviani Pratiwi, Megawati Yulia Wina Rachmiyani, Irmiya Raheem, Rasha Rahmawati Ridwan Rantung, Alvin Lekonardo Rasha Raheem Ratna Sitompul Ratna Sitompul Redwan, Amamer M Riani Witjaksana Risan, Mohsen Hashim Rizky Eka Adeliani Robiatul Adawiyah Sabrina, Isra Salman, Israa Samira, Jihan Sri Mulyani Thamer, Hamsa Trilaksmi, Antin Tubagus Ferdi Fadilah, Tubagus Ferdi Wawan Kurniawan Widya Artini Witjaksana, Riani YENNY YENNY Yohana Yousif, Emad Yuliana Yuliana Yuliarsa, Cyntha Nasyanda Yusop, Rahimi M Zaina, Nashita Amira Zainulabdeen, Khalid Zalfa, Afifah