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All Journal Jurnal Kedokteran Diponegoro PENELITIAN DAN KARYA ILMIAH Universa Medicina Jurnal Kreativitas PKM Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Jurnal Pengabdian Masyarakat Trimedika
Husnun Amalia
Departement Of Opthalmology, Faculty Of Medicine, Universitas Trisakti, Jakarta, Indonesia
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Studi Banding tentang pengembangan vaksin untuk COVID-19 Alsayed, Raghda; Zainulabdeen, Khalid; Salman, Israa; Hairunisa, Nany; Amalia, Husnun; Yusop, Rahimi M; Redwan, Amamer M; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.127-132

Abstract

The human respiratory system can be infected with coronaviruses (CoVs), one of the families of viruses that can lead to symptoms ranging from mild to fatal. Seven genera of CVS have been identified as having human infection to date. The virus can spread as fine, liquid particles from the mouth or nose of an infected person when coughing, sneezing, speaking, or breathing. The diameter of droplet particles ranges from large to small. In this review, we summarize vaccine development for COVID-19. We anticipate this study will be a valuable resource for any researcher interested in creating a COVID-19 vaccine.
Pterigium berhubungan dengan Sindroma Mata Kering pada Pengemudi Ojek Online Kartadinata, Erlani; Amalia, Husnun; Adiwardhani, Anggraeni; Witjaksana, Riani; Prasetyaningsih, Noviani; Margo, Eveline; Yohana, Yohana
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.71-81

Abstract

Background Dry eye syndrome (DES) is an eye disease caused by many factors involving the ocular surface, with characteristic damage to tear layer homeostasis accompanied by ocular symptoms due to tear layer instability, hyperosmolarity, damage and inflammation of the ocular surface, and neurosensory abnormalities. Delivery motorbike drivers are often on the streets where the role of environmental factors will be able to pose a risk of experiencing DES. This study aims to assess risk factors associated with the incidence of dry eye syndrome in delivery motorbike drivers.  The benefit of this research is to improve public health, especially in preventive behavior against factors associated with dry eye syndrome. Methods This study used observational analytical methods with a cross-sectional research design.  The selection of samples by consequential non-random sampling amounted to 124 with the criteria of inclusion of delivery motorbike drivers, exclusion of not using artificial tears eye drops, and not use of contact lenses.  Data were collected by filling out a DES risk factor questionnaire and a Tear Break Up Time (TBUT) examination to assess DES. The research data were analyzed using the Chi-Square test. Results This study's results show that subjects with dry eye syndrome are dominated by adults aged 19–44 and male sex. Subjects who experienced DES 76.6%, adult age 78.2%, male 80.6%, no pterygium 66.1%, working period 2-5 years 62.9%, length of work ≥8 hours 94.4%, always using a closed helmet 83.9%, not using protective glasses 39.5%, coffee consumption 71.8%, active smokers 66.1%, using gadgets >6 hours 91.9%.  There is no significant relationship between subjects' characteristics and DES (p>0.05). The incidence of DES in pterygium showed significant results (p= 0.001). Conclusions There is a significant relationship between the incidence of pterygium and DES.
Emerging Threats in the Age of Pandemics: A Focus on COVID-19 and the Novel Sub-Variant EG 5 ("Eris"): Review Article Alsayed, Raghda; Thamer, Hamsa; Hameed, Seenar; Kadhom, Mohammed; Hairunisa, Nany; Amalia, Husnun; Mashabi, Yasmine; Ahmed, Dina; Mahdi, Sarah; Husain, Amani; Salman, Israa; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.262-267

Abstract

This paper draws attention to a recently identified sub-variant of SARS-CoV-2 known as EG 5, colloquially named "Eris," designated by the World Health Organization (WHO) as a variant of interest. The organization has urged nations to monitor and respond to the spread of this sub-variant since its identification on February 17, 2023. The discovery of the EG 5 variant, a sublineage of the Omicron variant, has introduced new challenges. Designated a "variant of interest" by the WHO, EG 5 carries distinctive genetic mutations, including an additional F456L amino acid mutation in the spike protein. Global prevalence has doubled, raising concerns about increased transmissibility. Although specific symptoms of EG 5 are not yet fully characterized, the variant has spread to 51 countries, with over 7,000 reported cases by August 15, 2023. The manuscript also explores the unique situation in Iraq, where, as of August 17, 2023, no EG 5 cases have been officially recorded. However, challenges such as self-treatment at. As the world grapples with the ongoing challenges of the COVID-19 pandemic, understanding the dynamics of emerging variants is crucial for effective public health responses and the development of targeted interventions.
JN.1 COVID-19: Variant of interest Amalia, Husnun; Mashabi, Yasmine
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.261-263

Abstract

Corona Virus Disease-19 (COVID-19) is an acute respiratory syndrome caused by the Coronavirus 2 (SARS-CoV-2) virus. WHO groups the SARS-CoV-2 virus into two categories, namely a variant of interest (VOI) and a variant of concern (VOC). The VOI category is given if there is a new mutation with predictable phenotypic implications and must be fulfilled by one mutation that causes local transmission or causes multiple clusters or is detected in several countries. In September 2023, a new variant of COVID-19 was detected in the United States, namely JN.1 as VOI. This variant is a variation of the BA.2.86 variant with the only difference being the mutation of 1 spike protein, namely the addition of the L455S protein in the JN.1 variant. This variant has the potential to evade the immune system. Globally, there has been a rapid increase in the number of sufferers, especially in 3 WHO regions, namely America (AMR), West Pacific (WPR) and Europe (EUR). However, the effectiveness of the monovalent vaccine against this variant can still protect sufferers. Several studies show that the risk of hospitalization is low in the case of elderly and young patients.
Palpebral Kista Dermoid Witjaksana, Riani; Amalia, Husnun; Hairunisa, Nany; Kartadinata, Erlani; Adhiwardan, Anggraeni; Prasetyaningsih, Noviani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.245-250

Abstract

Dermoid and epidermoid cysts are prevalent benign orbital tumors in childhood, representing 3-9% of pediatric ocular tumors. Occasionally, dermoid cysts can attain significant size, leading to cosmetic deformities. A precise surgical approach to dermoid cysts can lead to considerable cosmetic improvement for the patient. A 19-year-old female presented with swelling in the outer corner of her left eye, accompanied by minor discomfort in the affected area. Upon ophthalmologic examination 1.5x1 cm masses were detected in the upper left eyelid near the lateral canthus Clinical diagnosis of Dermoid cyst left eye upper eyelid made. Subsequently, a surgical excision under general anesthesia was scheduled. During the procedure, the cyst was successfully excised while preserving the cyst wall integrity. The conclusion is imperative for ophthalmologists to recognize the necessity of precisely performing surgical excision of these cysts to achieve favorable functional and aesthetic outcomes.
Masalah infeksi Palpebra pada Lanjut Usia Amalia, Husnun; Pratiwi, Megawati Yulia Wina; Mustopa, Ita Tazkiatul Izzati
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.133-137

Abstract

Blepharitis is an eyelid infection that increases in incidence with age. This infection can cause anterior and posterior blepharitis and is caused by bacteria, viruses, fungi, and parasites. The most common bacteria that cause blepharitis is Staphylococcus. Blepharitis that is not caused by infection is allergic blepharitis. The pathophysiology of anterior blepharitis is the occurrence of bacterial colonization that triggers an excessive inflammatory response, while in posterior blepharitis it is mainly due to a decrease in the quality of the meibomian glands which causes dry eye and causes friction on the conjunctiva and cornea, causing inflammation. Symptoms of blepharitis are discomfort on the eyelid's surface such as itching, burning, stinging, watery eyes, and others. Risk factors for this infection include seborrheic dermatitis, acne rosacea, contact allergies, diabetes mellitus, chemical irritation, poor hygiene, low socioeconomic status, cosmetics, and the elderly. Diagnosis can be made based on anamnesis and ophthalmological examination which a general practitioner or eye specialist can perform. Based on the diagnosis, further management is given to avoid complications. The management that can be given is maintaining eyelid hygiene, warm compresses, not rubbing the eyes, and giving topical antibiotics (in anterior blepharitis) which can be added with systemic antibiotics (posterior blepharitis). Complications that can occur are eyelash abnormalities, lacrimal punctum malposition, eyelid malposition, recurrent hordeolum, keratitis, dry eye, keratopathy, corneal ulcers, and corneal opacities that can cause impaired visual function.
Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Parwanto, Edy; Tjahyadi, David; Amalia, Husnun; Hairunisa, Nany; Edy, Hosea Jaya; Oladimeji, Ashaolu Victoria; Djebli, Noureddine
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

Abstract

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.
Multiple Decubitus Ulcers in Dm type II Patients with Autologous Plasma-Rich Platelet therapy : A Case Report Diani Nazma; Husnun Amalia; Lira Panduwaty; Antin Tri Laksmi; Christian Christian; Karlina Mahardieni; Karina Karina
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 6 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i6.41101

Abstract

Background:Multiple decubitus ulcers are a condition of injury that appears on several parts of the body’s skin due to pressure for a long time without any change in position. This condition usually occurs in someone with limited movement, for example, due to experiencing certain disease conditions that require the person to rest in bed for a long time, especially patients in the Intensive Care Unit (ICU) or after ICU care with chronic diseases and limited movement. Case Presentation: This case report assesses the success of multiple cases of decubitus ulcers in patients with type II diabetes mellitus with Autologous Plasma Rich Platelet therapy. Case report: Autologous PRP therapy is given by intralesional injection; debridement is done every three days and assessed every one week. Patients are also subjected to blood sugar control, blood pressure control, blood correction, and albumin to speed up the wound healing process in multiple decubitus ulcers. Conclusion:the conclusion of this case report with additional management in the form of intralesional injection of autologous PRP performed on multiple decubitus ulcer patients with Diabetes Mellitus, which is rich in growth hormone, will greatly help the wound healing process.
EDUKASI KESEHATAN MATA UNTUK MENCEGAH KEBUTAAN AKIBAT KELAINAN REFRAKSI PADA PENDUDUK PONDOK AREN-TANGERANG Adiwardhani, Anggraeni; Hairunisa, Nany; Mashab, Yasmine; Zaina, Nashita Amira; Amalia, Husnun
Jurnal Pengabdian Masyarakat Trimedika Vol. 3 No. 1 (2026)
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/abdimastrimedika.v3i1.25869

Abstract

Latar Belakang Indonesia adalah negara kepulauan terbesar di dunia dan masalah kesehatan mata masih menjadi sesuatu yang belum dapat diselesaikan arena sirtuasi geografis dan demografis. Terdapat 0,4% angka kebutaan pada penduduknya, dan 80% adalah kebutaan yang dapat dicegah atau diobati dan refraksi adalah menjadi penyebab utama (42%). Kelainan refraksi sampai saat ini masih menjadi tantangan kesehatan masyarakat karena menjadi penyebab gangguan penglihatan yang paling besar dan mengenai seluruh kelompok usia dan percepatan terjadinya gangguan penglihatan pada berusia produktif akan merugikan perekonomian negara karena terganggunya sumber daya manusia. Fakultas Kedokteran Universitas Trisakti dan masyarakat dapat membantu berpartisipasi pada program ini dengan melaksanakan pengabdian skrining Kesehatan mata dan memberikan tatalaksananya agar mencegah kebutaan akibat kelainan refraksi khususnya. Metode Kegiatan pengabdian diikuti oleh 136 peserta, dilakukan penyuluhan, anamnesis, pemeriksaan Kesehatan mata termasuk pemeriksaan refraksi. Kacamata diberikan bagi peserta yang memerlukan. Hasil Peserta berusia anatara 3 tahun sampai 71 tahun, dengan 83,1% adalah laki-laki dan 16,9% adalah perempuan dan Sebagian besar peserta tidak memiliki pekerjaan (41,9%). Sekitar 42,6% memiliki Riwayat pengguna kacamata namun yang membutuhkan kacamata adalah 57,4% peserta. Setelah dilakukan edukasi terdapat peningkatan pengertian pentingnya mengkoreksi penglihatan dengan kacamata dari 50% menjadi 85%. Kesimpulan Pada 136 penduduk kurang mampu di Pondok Aren, 57,4% memerlukan kacamata untuk memperbaiki penglihatannya.
Efficacy of liposomal amphotericin B eye drops at two concentrations in experimental aspergillus keratomycosis in rabbits Amalia, Husnun; Ridwan, Rahmawati; Estuningtyas, Ari; Sitompul, Ratna; Adawiyah, Robiatul; Freisleben, Hans-Joachim
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.240

Abstract

Background: Keratomycosis, a fungal corneal infection prevalent in tropical regions, frequently leads to visual impairment and blindness. Liposomal amphotericin B (L-AmB) offers improved efficacy and reduced toxicity compared to conventional amphotericin B deoxycholate and represents a promising option for topical ophthalmic use. Objective: To evaluate and compare the therapeutic efficacy of L-AmB eye drops at 0.15% and 0.5% concentrations in experimental Aspergillus keratomycosis in New Zealand White rabbits. Methods: Four rabbits received midstromal corneal inoculation with a mixed suspension of Aspergillus flavus, A. fumigatus, A. niger, and A. terreus (2 x 10⁴ CFU/0.05 mL). L-AmB eye drops were applied hourly from day 8 post-inoculation until corneal cultures became negative. Antifungal susceptibility was assessed by disc diffusion. Clinical response was monitored by slit lamp examination using a modified scoring system. Results: Negative corneal cultures were achieved in all treated eyes within 10 to 18 days (mean 15 days, L-AmB 0.15%) and 11 to 15 days (mean 14 days, L-AmB 0.5%). No toxic effects were observed. Complete corneal transparency without cicatrix was achieved in one eye treated with L-AmB 0.15%. Conclusion: Both concentrations were effective and safe. Liposomal AmB 0.15% appears as efficacious as 0.5% for experimental Aspergillus keratomycosis. Clinical studies in humans are warranted.
Co-Authors Adhiwardan, Anggraeni Adianto, Raymond Adlani, Hadianti Ahmed, Dina Alsayed, Raghda Alvina Alvina Andrianjah Andrianjah, Andrianjah Anggiat, Desi Anggraeni Adiwardhani Antin Tri Laksmi Ari Estuningtyas, Ari Ariyani, Aziza Bella, Isa Christian Christian David Tjahyadi dianawati, dianawati Diani Nazma Diani Nazma Djebli, Noureddine Effendi, Ida Emad Yousif Erlani Kartadinata Erlani Kartadinata, Erlani Eveline Margo, Eveline Faradila, Meutia Atika Ferdhian, Farrel Ferina, Mutiara Grace Nerry Legoh Gusti G. Suardana, Gusti G. Hadi Sumarsono Hairunisa, Nany Hameed, Seenar Handriwei Handriwei HANS-JOACHIM FREISLEBEN Hosea Jaya Edy Husain, Amani Irawan, Achmad Isa Bella Johan Hutauruk Joice Viladelvia Kalumpiu, Joice Viladelvia Kadhom, Mohammed Karina Karina Karlina Mahardieni Kartini Kartini Kudaer, Nuha B Kurniasari LEKOK, WIDYAWATI Lira Panduwaty Lira Panduwaty Maharani, Ronaningtyas Mahdi, Sarah Marja, Triyoko Septio Mashab, Yasmine Mashabi, Yasmine Mohammed Kadhom Mohsen Hashim Risan Monica Dwi Hartanti Monica Dwi Hartanti, Monica Dwi Mun’im, Abdul Mustopa, Ita Tazkiatul Izzati Nadia Fernanda Natadidjaja, Ronald Irwanto Noviani Prasetyaningsih Noviani Prasetyaningsih Nuha Kudaer Oladimeji, Ashaolu Victoria Onny Hernik Saputro Parwanto, Edy Patricia Budihartanti Liman Pertiwi, Iin Indra Prasetyaningsih, Noviani Pratiwi, Luh Ade Dinda Pradnya Pratiwi, Megawati Yulia Wina Rachmiyani, Irmiya Raheem, Rasha Rahman, Athaya Nayla Pasca Rahmawati Ridwan Rantung, Alvin Lekonardo Rasha Raheem Ratna Sitompul Redwan, Amamer M Risan, Mohsen Hashim Robiatul Adawiyah Sabrina, Isra Salman, Israa Samira, Jihan Sri Mulyani Thamer, Hamsa Trilaksmi, Antin Tubagus Ferdi Fadilah, Tubagus Ferdi Widya Artini Witjaksana, Riani YENNY YENNY Yohana Yousif, Emad Yuliana Yuliana Yuliarsa, Cyntha Nasyanda Yusop, Rahimi M Zaina, Nashita Amira Zainulabdeen, Khalid Zalfa, Afifah