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All Journal Jurnal Ilmiah Farmasi Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Konselor Disease Prevention and Public Health Journal Jurnal Kesehatan Masyarakat MEDISAINS Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Kedokteran Anatomica (Anatomica Medical Journal) IKRA-ITH ABDIMAS Majalah Kedokteran Andalas ACTIVE: Journal of Physical Education, Sport, Health and Recreation JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Health and Medical Journal Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan World Nutrition Journal INTEGRITAS : Jurnal Pengabdian Jurnal Bakti Masyarakat Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat Berita Kedokteran Masyarakat Medika Respati : Jurnal Ilmiah Kesehatan Jurnal Farmasi Indonesia SEGARA : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Ilmu Kesehatan Masyarakat (The Public Health Science Journal) Jurnal Pengabdian Maleo JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Preventif : Jurnal Kesehatan Masyarakat
Mila Citrawati
: Universitas Pembangunan Nasional Veteran Jakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : MEDISAINS

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Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Co-Authors Abda Abda Adisaputra, Chantika Zahra Agneta Irmarahayu Agus Aulung Agus Aulung, Agus Amanah, Salma Rizqi Ananda, Regita Siska Andri Pramesyanti Annisa Afifah Anughrayasa, Mikhaella Pritananda Aprilia, Citra Ayu Arman Yurisaldi Saleh Aulia Chairani, Aulia Baehaqi Basuki Supartono Bobby Singh Cahyaninglatri, Wendi Corlia Citra Ayu Aprilia Citra Ayu Aprilia Citra Ayu Aprilia Devora, Angelina Dhigna Luthfiyani Citra Pradana Diana Agustini Diana Agustini Purwaningastuti Dwi Rafita Lestari Erna Harfiani Etra Ariadno Fachruddin Perdana Fadhilah Apriliandri Firda Amalia Fitriya, Ismah Nurul Sittah Gandung Prakoso Gandung Prakoso, Gandung Hadiwiardjo, Yanti Harjiono Hany Yusmaini Harli Amir Mahmudji Heristyorini, Ayodya Hikmah Muktamiroh Hikmah Muktamiroh Imarta Retri Putri Kholib, Abdul Kristina Simanjuntak Kusumawardani, Kunthi Ayu Maria Selvester Thadeus Mayang Ameilia Putri Melly Kristanti Nadifa Kartika Dewi Niniek Hardini Niniek Hardini Noor Az Zhahra Nooramadhani, Tasya Novri Rahmadika Nugrahayu Widyawardani Nunuk Nugrohowati Nur Fasya, Ratu Azka Nur, Hendi Fulvian Fauzan Parameswari, Aryadhira Qori Aini Afiati Rahma Rufaida Susetyo Raihan, Muhamad Pandji Retno Yulianti Retno Yuliyanti Riezky Valentina Astari Rukman Abdullah Ruth Tio Napitupulu Safira, Lisa Setyaningsih, Yuni Shaifuddin, Zakky Shifa Azzahra Simanjuntak, Kristina Soroy Lardo Sri Wahyuningsih Sri Wahyuningsih Sri Wahyuningsih Syamsiar, Syamsiar Syeftiani, Nabilatussalma Theodora Putri Simanjaya Tiwuk Susantiningsih Tresnawati, Nden Ajeng Widyawardani, Nugrahayu Yanti Harjono Hadiwiardjo Yuli Suciati Yuliyanti, Retno