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Pogostemon cablin from North Konawe Targets MCF-7 Cells and Inflammatory Responses Through Protein Denaturation and Membrane Stabilization Adryan Fristiohady; Jafriati Jafriati; Irvan Anwar; Rathapon Asasutjarit; La Ode Muhammad Julian Purnama; Lidya Agriningsih Haruna; Agung Wibawa Mahatva Yodha; Hariana Hariana; Mentarry Bafadal
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.10168

Abstract

Pogostemon cablin (Patchouli), a medicinal plant traditionally used in Indonesia, is gaining scientific attention for its potential pharmacological activities. This study aimed to investigate the anti-inflammatory and anticancer effects of P. cablin ethanolic leaf extract specifically sourced from North Konawe, Southeast Sulawesi. To evaluate its anti-inflammatory activity, two in vitro models were used: the protein denaturation inhibition assay, simulating inflammatory protein response, and the human red blood cell (HRBC) membrane stabilization assay, which mimics lysosomal membrane stability in inflamed tissues. The extract showed significant, dose-dependent inhibition of protein denaturation, with an IC50 value of 62.98 µg/mL. In the HRBC assay, the extract demonstrated membrane stabilization activity with a maximum inhibition of 64.24% at the highest tested concentration (100 µg/mL). The cytotoxic potential was assessed using the MTT assay on MCF-7 hormone-responsive breast cancer cells. The extract exhibited potent anti-proliferative activity, with an IC50 value of 91.56 ± 1.31 µg/mL, indicating its effectiveness in inhibiting breast cancer cell growth. These findings highlight P. cablin from North Konawe as a promising natural source of anti-inflammatory and anticancer agents, with the potential to contribute to the development of plant-based therapeutics. However, this study is limited to in vitro analyses; further investigations are needed to isolate active compounds and confirm efficacy through in vivo and mechanistic studies.
Co-Authors Agung Wibawa Mahatva Yodha Alvin Mahendra Salim Alya Zuhriyah Amalia Nur Lathifah Anja Meryandini Anja Meryandini Arba, Muhammad Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Cici Pulcerima Devi Agustina Enjelin Nur Fathika Sjahrul Fery Indradewi Firda, Andi Fitri Handayani Fitri Syahriani Djalil Friesca Dwi Cahyani Fristiohady, Adryan Halik Hamdani Sapuan Hariana Hariana Hasmi, Waode Indri Sasmita Hasnawati Hasnawati Hasrin Ainun Hikbar Hikmah, Nurull - Hukmah, Nurul Idrus, Loly Subhiaty Irnawati Irnawati Jafriati Jihan Rahmawati Jumilta Kasmawati, Henny La Aba La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama Lidya Agriningsih Haruna Loly Subhiaty Idrus Malina, Rachma Mawarni Mawarni Mega Fatimah Rosana Mega Nurjanah Mentarry Bafadal Muhamad Ali Yusran Djaari Nadiya Mutmainnah Nafiah, Afifatun Nita Trinovitasari Nur Afrianingsih Pasaeno Nur Apriani Baharudin Nur Illiyyin Akib Nur Islami Irwan Nur Isnawati Nur Rayani Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah, Nuralifah Nurramadhani A. Sida Nursavhira Ramadhani Nurul Jannah, Sitti Raodah Nurull Hikmah Parawansah Parawansah Purwanto La Sandi Putu Sintya Permani Rachma Malina Rachma Malina Rachma Malina RAHMAT MULIADI, RAHMAT Rathapon Asasutjarit Ratih Dewi Puspitasari Rifa'atul Mahmudah Riski RITA Ruslin Ruslin Ruslin Ruslin SABARUDIN Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sitti Raodah Nurul Jannah Sitti Zubaydah, Wa Ode Sri Astuti Handayani Sunandar Ihsan Sunandar Ihsan, Sunandar Titi Candra Sunarti Trinovitasari, Nita Ulul Husna Wa Ode Fauzia Ahmah Wa Ode Sitti Zubaydah Wa Ode Sitti Zubaydah Wahyuni Wahyuni Yamin Yamin Yamin, Yamin