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All Journal HAYATI Journal of Biosciences SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Microbiology Indonesia Health Science Journal of Indonesia AL KAUNIYAH Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Jurnal Biologi Universitas Andalas BIOMA Jurnal Farmasi Sains dan Komunitas Jurnal Pendidikan Informatika dan Sains Majalah Kesehatan FKUB Jurnal Fitofarmaka Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Jurnal Kesehatan Manarang Pharmacology and Clinical Pharmacy Research GERVASI: Jurnal Pengabdian kepada Masyarakat Majalah Kedokteran Andalas Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Muhammadiyah Medical Journal Jakiyah : Jurnal Ilmiah Umum dan Kesehatan Aisyiyah Kapuas Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Inovasi dan Terapan Pengabdian Masyarakat Cermin Dunia Kedokteran
Mahyarudin, Mahyarudin
Departemen Mikrobiologi, Fakultas Kedokteran Universitas Tanjungpura, Kalimantan Barat, Indonesia
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VIDEO EDUKASI CUCI TANGAN SEHAT SEBAGAI PROGRAM PENGENDALIAN DAN PENCEGAHAN COVID-19 Mahyarudin; Andriani; Rini Andriani; Willy Handoko
Jurnal Inovasi dan Terapan Pengabdian Masyarakat Vol. 1 No. 1 (2021)
Publisher : Politeknik 'Aisyiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35721/jitpemas.v1i1.11

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of virus from the coronavirus that can cause mild, severe respiratory disorders, and even death. The disease is called Coronavirus Disease (20) 19 or COVID-19. The virus is transmitted via droplets spread by coughing or sneezing on an infected person. A clean and healthy lifestyle, and trying to protect ourselves by doing healthy hand washing is one of the ways to prevent the spread of this more massive virus. The community is at the forefront of preventing the spread of COVID-19. The role of public knowledge is very important to prevent the spread of COVID 19 to the family level. This activity aims to provide education to the public on the importance of healthy hand washing to prevent the spread of COVID-19. The target of this activity is the people in Pontianak City. The output of this activity is that the community understands the importance of clean and healthy behavior for disease prevention so that they are more disciplined in carrying out healthy hand washing.
UJI AKTIVITAS ANTIBAKTERI AIR PERASAN JERUK SAMBAL (Citrus Microcarpa Bunge) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus Aureus Vanesa, Vanesa; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Mardhia, Mardhia; Mahyarudin, Mahyarudin
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P16

Abstract

Latar Belakang: Pneumonia dapat diakibatkan oleh infeksi dari salah satu strain bakteri S. aureus, yaitu Methicillin Resistance Staphylococcus aureus (MRSA). Staphylococcus aureus memiliki potensi untuk mengembangkan resistensi terhadap hampir semua kelas antibiotik. Diperlukan pengembangan alternatif agen terapi lain dalam menangani peningkatan kasus resistensi bakteri. Jeruk sambal (Citrus microcarpa Bunge) adalah tanaman yang terdapat di Kalimantan Barat, Indonesia. Air perasan dari buah ini mengandung metabolit sekunder yang memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui kemampuan air perasan jeruk sambal sebagai antibakteri terhadap pertumbuhan bakteri Staphylococcus aureus. Metode: Air perasan jeruk sambal dibuat dengan mensterilkan buah, kemudian dipotong menjadi dua, diambil sari buahnya dengan diperas dan disaring menggunakan kertas saring. Metode difusi cakram (Kirby-Bauer) digunakan sebagai metode pengujian aktivitas antibakteri. Kelompok perlakuan dibagi menjadi 4 konsentrasi: 25%, 50%, 75%, dan 100%, kontrol positif (Siprofloksasin 5 ?g/disk) dan kontrol negatif (akuades steril). Hasil: Analisis fitokimia menunjukan terdapat kandungan alkaloid, flavonoid, saponin, tanin, dan fenolik pada air perasan jeruk sambal. Dimana saponin (+++) sebagai kandungan terbanyak. Aktivitas antibakteri didapati pada semua kosentrasi dengan terbentuknya zona hambat disekitar kertas cakram. Kesimpulan: Air perasan jeruk sambal mampu mengambat pertumbuhan bakteri Staphylocaccus aureus secara in vitro, sehingga dapat disimpulkan memiliki aktivitas antibakteri.
Edukasi Vaksinasi COVID-19 Pada Orang Tua Pelajar Sekolah Dasar Sebagai Bentuk Percepatan Penanganan COVID-19 Pada Anak Mahyarudin, Mahyarudin
Kapuas Vol. 4 No. 1 (2024): Kapuas : Jurnal Publikasi Pengabdian Pada Masyarakat
Publisher : Politeknik Negeri Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31573/jk.v4i1.606

Abstract

Vaksin merupakan langkah terpenting untuk mencegah penularan penyakit dan virus. Vaksin dapat mengurangi potensi seseorang untuk terinfeksi. Ini karena vaksin bekerja dengan sistem kekebalan untuk membentuk perlindungan alami. Saat mendapatkan vaksin, sistem kekebalan merespons dengan beberapa cara yaitu mengenali patogen yang menyerang, seperti bakteri atau virus, menghasilkan antibodi. Jika sistem kekebalan mengenali penyakit yang ditularkan melalui vaksin, sistem kekebalan secara otomatis akan membentuk kekebalan untuk melawan virus. Semakin meningkatnya penyebaran berita hoax juga menjadi dasar masih banyak orang tua siswa belum memvaksinasi anak anak mereka. Beberapa berita hoax meliputi WHO belum mengizinkan vaksinasi pada anak, vaksinasi pada anak belum ada uji coba terlebih dahulu, vaksin juga mengandung senyawa berbahaya dan dapat merusak organ anak. Kegiatan ini bertujuan untuk memberikan edukasi kepada masyarakat akan pentingnya vaksin dan keamanan vaksin bagi anak untuk mencegah pennularan COVID-19. Mitra kegiatan ini yaitu Kelurahan Saigon, Kecamatan Pontianak Timur, Kota Pontianak. Metode kegiatannya menggunakan metode ceramah dan diskusi. Hasil kegiatan edukasi menunjukkan bahwa terjadi peningkatan sebesar 35% yaitu dari 47,25% menjadi 82,25%. Pentingnya kegiatan edukasi mengenai kesehatan agar meningkatkan pengetahuan Masyarakat dan mengurangi penyebaran berita hoax mengenai kesehatan.
Antifungal activity test of single clove garlic and single clove black garlic (Allium sativum L.) against Trichophyton rubrum Minami, Gabriella Stephanie; Zakiah, Mistika; Mahyarudin, Mahyarudin
Jurnal Pendidikan Informatika dan Sains Vol. 13 No. 1 (2024): Jurnal Pendidikan Informatika dan Sains
Publisher : IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/saintek.v13i1.7757

Abstract

Dermatophytosis is a fungal infection of the skin surface which mostly caused by Trichophyton rubrum in Indonesia. Single clove garlic (Allium sativum) exhibits superior antimicrobial properties compared to conventional garlic. When incubated at a specific temperature and humidity (70°C, 90%), single clove garlic transforms into black garlic, further enhancing its antimicrobial efficacy. This research aims to evaluate the antifungal properties of extracts from both single clove garlic and single clove black garlic against Trichophyton rubrum. The antifungal activity was tested by disc diffusion at concentrations of 25%, 50%, 75% and 100%. No inhibition zones were observed in the group treated with single clove garlic extract at concentrations of 25%, 50%, 75%, and 100%, nor with single clove black garlic extract at a concentration of 25%. However, single clove black garlic extract at concentrations of 50%, 75%, and 100% demonstrated inhibition zones ranging from 16.4 to 21.8 mm, indicating strong to very strong antifungal activity. Single clove garlic exhibited no antifungal activity against Trichophyton rubrum. In contrast, single clove black garlic demonstrated antifungal activity against Trichophyton rubrum at concentrations of 50%, 75%, and 100%, with an effective dose starting at 50%. These findings indicate that black garlic extract may serve as a potential alternative treatment for dermatophyte fungal infections, particularly those caused by Trichophyton rubrum.
Chlorogenic Acid Protects Cell Death in the Cerebellum through Anti-Apoptotic Protein Bcl2 in Transient Global Ischemia Cases Hermawati, Ery; Handini, Mitra; Ilmiawan, Muhammad In'am; Mahyarudin, Mahyarudin
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.411

Abstract

Background: Cerebellum is one of the vital components of the brain that will be affected by ischemia-reperfusion (IR) injury. IR injury will increase free radicals, which in turn can trigger apoptosis and cell death. Therefore, this study was conducted to examine the effect of chlorogenic acid administration on apoptosis and the number of cells in the cerebellum of rats with global ischemic transients.Materials and methods: Wistar rats were divided into five groups: sham-operated (C1), IR (C2), IR + 15 mg/kgBW chlorogenic acid (T1), IR + 30 mg/kgBW chlorogenic acid (T2), and IR + 60 mg/kgBW chlorogenic acid (T3). C2, T1, T2, and T3 groups received bilateral common carotid occlusion (BCCO) surgery to induce IR injury. Thirty minutes after BCCO surgery, T1, T2, and T3 rats were administered chlorogenic acid in various doses intraperitoneally. RNA extraction and real-time polymerase chain reaction (PCR) measurements were then performed on NeuN, Bcl2, Bax, caspase 3, as well as on GAPDH as housekeeping genes.Results: There were significant differences in NeuN expressions between groups, with the highest expression shown in C1 followed by T3. Bcl2 expressions were also significantly different between groups, and rats in C1 and T3 showed to be significantly higher compared to C2, while T1 was significantly lower than C1. However, Bax and caspase 3 expressions showed no significant differences.Conclusion: Chlorogenic acid in 60 mg/kgBW dose increases NeuN expression and Bcl2 mRNA expression after transient global ischemia. These increases might correlate with the heightened level of protection against apoptosis in the cerebellum, hence showing its potential in protecting neuron cells.Keywords: transient global ischemia, chlorogenic acid, cerebellum, apoptosis
Skrining Penyakit Tidak Menular (PTM): #GERMAS untuk Hidup Sehat Tafwidhah, Yuyun; Maulana, Muhammad Ali; Purwanti, Nera Umilia; Rahmawati, Nadia; Najini, Robby; Mahyarudin, Mahyarudin; Liana, Delima Fajar; Pramana, Yoga; Mita, Mita
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.14963

Abstract

Pemeriksaan kesehatan secara berkala merupakan salah satu pilar Gerakan Masyarakat Hidup Sehat (GERMAS) yang berguna untuk mendeteksi keberadaan faktor risiko Penyakit Tidak Menular (PTM). Tujuan dari pengabdian masyarakat ini yaitu melakukan skrining PTM meliputi pengukuran tekanan darah, pemeriksaan gula darah, kolesterol, dan asam urat. Metode pelaksanaan skrining PTM yaitu pendaftaran dan wawancara faktor risiko PTM, pengukuran antropometri, pemeriksaan penunjang serta konseling dan edukasi. Skrining ini dilakukan pada 2 (dua) tempat dengan sasaran usia lebih dari 15 tahun. 155 peserta berhasil dijaring dengan hasil karakteristik sebagian besar adalah perempuan dan berada pada usia remaja akhir serta dewasa akhir. Analisis selanjutnya menunjukkan sebagian besar berada dalam kategori normal dan optimal untuk pemeriksaan tekanan darah dan sebagian besar berada dalam kategori normal untuk pemeriksaan gula darah. Temuan lain gambaran pemeriksaan kolesterol yang menghasilkan lebih dari separuh peserta dalam kategori buruk serta hampir separuhnya memiliki kadar asam urat tidak normal. Skrining PTM berguna mengetahui faktor risiko PTM lebih awal agar dapat diambil tindakan berikutnya sebagai langkah pencegahan. Upaya yang dapat diambil antara lain melakukan pola hidup sehat dan berkonsultasi lebih lanjut kepada tenaga kesehatan.
Uji Aktivitas Antibakteri Air Perasan Jeruk Siam Sambas terhadap Escherichia coli Bimo Hendrayana; Mistika Zakiah; Syarifah Nurul Yanti Rizki Syahab Assegaf; Delima Fajar Liana; Mahyarudin Mahyarudin
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 1 (2025): Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i1.1021

Abstract

Escherichia coli is a bacterium that typically resides as a normal flora in the gastrointestinal tract of humans and animals. However, certain strains of E. coli can cause infections in humans. Therefore, antibiotics are needed to inhibit the growth of these infection-causing bacteria. The increasing cases of antibiotic resistance in E. coli necessitate alternative therapies, including the use of natural substances. In West Kalimantan, one potential source is the Pontianak Orange (Citrus nobilis var. microcarpa). This plant contains secondary metabolites that can be used for medicinal purposes, such as the juice extract. The compounds within these secondary metabolites possess antimicrobial properties that could be used as antibacterials. To determine the antibacterial potential of Pontianak Orange juice (Citrus nobilis var. microcarpa) against Escherichia coli. This study utilized an experimental design featuring a post-test only group design. Phytochemical analysis indicated that Pontianak Orange juice (Citrus nobilis var. microcarpa) contains phenolics (+), alkaloids (+), and terpenoids (++). Antibacterial activity testing at all concentrations (25%, 50%, 75%, and 100%) showed no inhibition zones. The juice of Pontianak Orange (Citrus nobilis var. microcarpa) did not show antibacterial effects against the growth of Escherichia coli bacteria.
Nitrofurantoin Susceptibility Profile on Bacterial Isolates from Urinary Tract Infection in Patients with Diabetes Mellitus Kurniawan, Prayoga; Mardhia, Mardhia; Mahyarudin, Mahyarudin
Muhammadiyah Medical Journal Vol 4, No 2 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.2.79-85

Abstract

Background: Patients with diabetes mellitus have a higher risk of urinary tract infection (UTI) incidence than those without. One of the first-line therapy for UTI is nitrofurantoin. The emergence of drug-resistant UTIs is increasing both in community and healthcare setups. Purposes: Determine the nitrofurantoin susceptibility profile to bacteria causing UTI in diabetic patients. Method: A cross-sectional study was conducted at the Microscopic Laboratory, Faculty of Medicine, Universitas Tanjungpura, Pontianak, from February to November 2019. The antibiotic susceptibility testing was performed by the Kirby-Bauer disk diffusion method on 22 bacterial isolates. The samples were collected on a sterile urine pot, cultured on agar, and identified by biochemistry test, and bacterial isolates were stored at 2-8oC. The bacterial isolates were sub-cultured 24h before the susceptibility test. The susceptibility testing used a 300 µg nitrofurantoin disk. The diameter of zone inhibition was measured and classified based on Clinical and Laboratory Standard Institute guidelines. Result: The results showed that Escherichia coli was 41.67% susceptible (5/12), Shigella sp. was 100% intermediate (1/1), and Enterobacter aerogenes (3/3), Pseudomonas aeruginosa (1/1), Klebsiella sp (1/1) were 100% resistant. Conclusion: The majority of the causative bacteria for UTI in diabetic patients are resistant to nitrofurantoin, suggesting the use of nitrofurantoin should be reconsidered as an empirical antibiotic in Pontianak. Further study using a larger population should be conducted to describe a more extensive antibiotic susceptibility profile of diabetic patients with UTI in Pontianak.
Knowledge and Behavior Regarding Antibiotic Stewardship in Health Workers at Sultan Syarif Mohammad Alkadrie Hospital, Indonesia Restika, Risma A.; Mardhia, Mardhia; Mahyarudin, Mahyarudin; Liana, Delima F.; IH, Hariyanto
Pharmacology and Clinical Pharmacy Research Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i3.56573

Abstract

Antimicrobial resistance is a global public health concern. The World Health Organization reports that antimicrobial resistance constitutes a serious threat to public health worldwide. One of the risk factors in the development of antimicrobial resistance cases is the irrational use of antibiotics. Knowledge and behavior of health worker about antibiotic stewardship play a role in preventing antibiotic resistance cases. This study aimed to demonstrate knowledge and behavior regarding antibiotic stewardship in health workers at Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. This was a cross-sectional descriptive study using consecutive sampling with total of 39 respondents. Data were collected through questionnaires with total of 45 questions. Knowledge and behavior of respondents were categorized as good, moderate, and low. The data was analyzed using the spearman rank correlation coefficient. The results showed that most health workers had good knowledge 97.44% (38/39) and good behavior 87.18% (34/39) related to antibiotic stewardship with a spearman p-value >0.05. Antibiotic stewardship is important for health workers to prevent an increase in antibiotic resistance cases and their impact on public health worldwide. As we know, increasing antibiotic resistance is a globally major problem as health system depends on effective antibiotics to treat bacterial infections.
Evaluation of Antibiotic Use in the Internal Medicine Ward and ICU at Universitas Tanjungpura Hospital Pontianak with ATC/DDD Rifdah, Dzuria Adhana; Ih, Hariyanto; Liana, Delima Fajar; Mardhia, Mardhia; Mahyarudin, Mahyarudin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.92330

Abstract

Background: Evaluating the wise use of antibiotics is needed to control antibiotic resistance in hospitals.Objectives: This study aimed to analyze patient characteristics, antibiotic profiles, and quantitative use of antibiotics in inpatients prescribed by internal medicine specialists in the internal medicine ward and Intensive Care Unit (ICU) at Universitas Tanjungpura Hospital Pontianak from August to October 2022.Methods: This study method is descriptive observational, and data collection was done retrospectively using a purposive sampling technique. There were 143 samples that met the inclusion criteria, and then using the Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) method, the samples were analyzed quantitatively.Results: Most patient characteristics were female patients (60.14%), patients aged 56-65 (26.57%), and the most common diagnosis was typhoid fever (32.74%). Of the 13 types of antibiotics used, cephalosporin was the most commonly prescribed antibiotic group to patients (58.48%), with the most types of antibiotics in ceftriaxone (42,69%) and intravenous administration of antibiotics was the standard route given to patients. The results of the quantitative analysis of all antibiotic prescriptions obtained a total value of 88.55 DDD/100 patient-days. Antibiotics with the most considerable DDD/100 patient-days value were ceftriaxone (44.71), followed by meropenem (10.46) and levofloxacin (9.28). Furthermore, the value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method.Conclusion: The value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method as qualitative evaluation to obtain information regarding the rationality of prescribing antibiotics.
Co-Authors Abror Irsan Agustina, Risa Alex Alex Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Analekta Tiara Perdana Andriani Andriani Andriani Andriani Andriani Anggie, Joycely Anggita Serli Verdian Anja Asmarany Anzas Niam Saputra Arif Wicaksono Asseggaf, Syarifah Nurul Yanti Rizki Syahab Bimo Hendrayana Delima Fajar Liana Diana Natalia Diana Natalia Diana Natalia Diana Natalia Diana Natalia Effiana Effiana Eka Ardiani Putri Elliska Murni Harfinda Elvin Felix Pratama Ery Hermawati Fajar Liana, Delima Fitaloka, Fahira Amanda Handini, Mitra Hariyanto IH Helmi Sastriawan Herwandi Herwandi Hutahaean, Olifer Jannes Ilmiawan, Muhammad In'am Ilmiawan, Muhammad In’am Iman Rusmana Irvandy, Muhammad Syifa Kahtan, Muhammad Ibnu Kurniawan, Prayoga Ledi RN Sulistyawati Liana, Delima F. Liauw, Josephine Johan Mardhia , Mardhia Mardhia Mardhia Mardhia, Mardhia Marizca Okta Syafani Maulana, Muhammad Ali Meika Meidina Yuanita Minami, Gabriella Stephanie Mistika Zakiah Mita Mita, Mita Mitra Handini Muhammad Asril Najini, Robby Nera Umilia Purwanti, Nera Umilia Nizarrahmadi Nizarrahmadi Nur Al Huda Patrio Victorianus Baraga Prasetyo, Raditia Tri Pratama, Elvin Felix Putri, Lidya Hafidzah Qurrota Ayun Rahmat Dani, Kafa Rahmawati, Nadia Restika, Risma A. Reza Wahyudi Rialita, Ambar Rifdah, Dzuria Adhana Riki Vernando Rini Andriani Rista Delyani Safira Sukma Dewinda Saputra, Andhika Fadhil Saskya Maulidya Astari Sembodho Edi Kurniawan Shafira Kurnia Warianti Shintya Dewi Sigit Normagiat Sukma Ayu Anandhita Syarifah Nurul Yanti Rizki Syahab Assegaf Syarifah NYRS Asseggaf Tafwidhah, Yuyun Tanti Melinda Tomi Lim Uswatun Hasanah Vanesa, Vanesa Veren Evelyn Chandra Vernando, Riki Vica Vionita Rosalim Virhan Novianry Vivi Yanthi Warianti, Shafira Kurnia Willy Handoko Willy Sanjaya Yanthi, Vivi Yoga Pramana YULIN LESTARI Zaitin Nur Zulfikar Dwi Kiswahyu Nindo ‘Ariqah ‘Azizah, Intan