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All Journal WMJ (Warmadewa Medical Journal) Biology, Medicine, & Natural Product Chemistry MNJ (Malang Neurology Journal) Jurnal Biologi Tropis SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pengabdian Magister Pendidikan IPA Jurnal Pengabdian Masyarakat Sains Indonesia (Indonesian Journal Of Science Community Services) Jurnal Abdi Insani Jurnal Pepadu Acta Neurologica Indonesia Lombok Medical Journal Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Ocktaviana Saputri, Legis
Departemen Farmakologi Fakultas Kedokteran Universitas Mataram
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DISEMINASI INFORMASI DAN DETEKSI DINI GANGGUAN KOGNITIF TERKAIT HIPERTENSI PADA PENDUDUK DI DESA PULAU MARINGKIK, KABUPATEN LOMBOK TIMUR Herpan Syafii Harahap; Yanna Indrayana; Yusra Pintaningrum; Bambang Priyanto; Arina Windri Rivarti; Dini Suryani; Nurhidayati Nurhidayati; Legis Ocktaviana Saputri; Fitriannisa Faradina Zubaidi; Muhammad Hilman Rizaldi; Anang Hermansyah; Restia Restia
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.1010

Abstract

Hypertension-related cognitive impairment has a wide spectrum, ranging from mild cognitive impairment to severe cognitive impairment in hypertensive individuals. Hypertension is currently also known as a risk factor for Alzheimer's dementia and vascular dementia. In its severe form, cognitively impaired individuals will have a high dependence on family members to carry out their daily activities. This community service event aims to increase the understanding of the residents of Maringkik Island Village regarding ​​the importance of prevention and early detection of hypertension-related cognitive impairment. This event was carried out in Pulau Maringkik Village, East Lombok Regency, which is a representative of a coastal area whose population generally has a high level of consumption of sodium salt. This community service activity is carried out in 3 forms of activities, including health education, screening of hypertension, and early detection of cognitive impairment in hypertensive participants. This health education event was attended by 53 participants. Of these, 29 participants (54.7%) were hypertensive. In early detection of cognitive dysfunction, of the 29 hypertensive participants, 19 of them (65.5%) were categorized as having impaired cognitive function. Thus, in this community service events, health education activity, screening of hypertension, and early detection of hypertension-related cognitive impairment are successfully done. The frequency of residents of Maringkik Island Village with hypertension and hypertension-related cognitive impairment is quite high. Promotive efforts to change high-sodium salt consumption habits need to be carried out on an ongoing basis with an educational strategy that is adjusted to the education level of the participants.
The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient Alma Dyah Perwita; Adam Trojan Alisyahbana; Adinda Ilsa Maulida; Alfia Mawaddah; Ali Ramzi; Legis Ocktaviana Saputri
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6162

Abstract

Abstract: Hypertension is a condition of chronic high blood pressure in the systemic arteries which is a major risk factor for cardiovascular disease, kidney disorders, and death. There are two types of hypertension, the primary hypertension is thought to be caused by hereditary factors, age, gender, race, and an unhealthy lifestyle. Secondary hypertension is caused by an obvious cause. The prevalence of hypertension in Indonesia is quite high with the highest incidence rate in South Kalimantan (44,1%) and the lowest in Papua (22,2%). The pathophysiology of hypertension involves the enzyme Angiotensin Converting Enzyme (ACE) which plays a role in regulating blood pressure. The process of converting Angiotensinogen to Angiotensin I, then Angiotensin II by ACE can cause vasoconstriction and fluid retention, which contribute to hypertension. The changes in circulation and blood vessel structure have played a role in the risk of hypertension complications, including stroke. The marine organisms such as fish, shellfish, cephalopods, seaweed, and algae contain peptides with antihypertensive, anticoagulant, antithrombotic, and hypercholesterolemic activities. For example, hydrolyzate of the jellyfish, Rhopilema esculentum can inhibit ACE with a high level of effectiveness. The current hypertension treatment often uses synthetic drugs such as ACE inhibitors and Angiotensin Receptor Blockers (ARBs), but these have undesirable side effects. Therefore, bioactive peptides from marine organisms can be an efficient and safe natural alternative. The research on protein hydrolysates from various sources has found ACE inhibitory activity and several peptides such as Trp-Pro-Met-Gly-Phe (WPMGF) and APP, KPLL, and VYPFPGPIPNSLPQNIPP were identified to have strong ACE inhibitory activity. These findings indicate the potential use of bioactive peptides from marine organisms as a natural alternative for the treatment and prevention of hypertension.
In Vitro Mucolytic Activity of Cardamom Fruit (Amomum compactum) Decoction on Duck Egg Albumens Vitri, Desy Aryanti Pardilla; Aini, Siti Rahmatul; Saputri, Legis Ocktaviana
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.541-547

Abstract

Cardamom (Amomum compactum) is empirically used as a cough medicine by using its seeds and fruits. Cardamom seeds have been shown to have mucolytic activity at a concentration of 0.8%, while cardamom fruit has not been studied. This study aimed to determine the mucolytic activity of cardamom fruit decoction at variation concentrations. Mucolytic activity tests were carried out in vitro on duck egg albumens at 3%, 6%, and 12% variation concentrations of cardamom fruit decoction. N-acetylcysteine 0.1% was positive control, while phosphate buffer and Tween 80 were negative controls. The mucolytic activity was determined based on the viscosity value measured by flow time using an Ostwald viscometer and density measurement using a pycnometer. Data from each group were analyzed using SPSS with parametric One-Way ANOVA and Post Hoc tests. The results showed that cardamom fruit decoction at concentrations of 3%, 6%, and 12% had values that were not significantly different from N-acetylcysteine (p>0.05) and there was no significant difference (p>0.05) between each concentration group. Accordingly, the research concludes that cardamom fruit decoction at concentrations of 3%, 6%, and 12% has mucolytic activity comparable to N-acetylcysteine.
Prospecting Marine Natural Products as the Disease-Modifying Treatment of Alzheimer’s Diseases Saputri, Legis Ocktaviana; Harahap, Herpan Syafii; Rivarti, Arina Windri; Zubaidi, Fitriannisa Faradina
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.433-441

Abstract

Alzheimer's disease (AD) is a severe and high costs health problem all over the world. To date, there is no therapy capable of curing AD, making drug discovery a challenging and intriguing field to explore. Targeting marine natural products (MNPs) as a source of drug leads is a suitable choice considering the content of bioactive compounds and promising pharmacological benefits. This article aims to look at MNPs with prospects in several prime targets in AD pathology to cure AD. Marine vertebrates (fishes), marine invertebrates (sponges, tunicates, ascidian, clams, scallops, sand dollars, crabs, cockle, sea cucumber, shrimp, bryozoa, marine worm), algae/seaweed, and marine microorganisms (marine fungi, bacterium, dinoflagellata, microalgae) can be potentially used as disease-modifying treatments (DMTs) for AD. By targeting multiple aspects of AD pathology, these MNPs offer a multifaceted approach to treating and potentially modifying the disease course. This result is an intriguing gap for researchers in the discovery and development of new drugs that can improve AD pathology.
Cognitive Decline Among the Middle-aged Living in the Coastal Area in Lombok Island Suryani, Dini; Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati; Zubaidi, Fitriannisa Faradina; Saputri, Legis Ocktaviana
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.50

Abstract

INTRODUCTION: Dementia is a leading cause of disability, dependency and poor quality of life. Its prevalence has increased consistently in recent years. Coastal communities who have limited access to health services have a higher risk of developing degenerative diseases including dementia. METHOD: A total of 154 middle-age peoples from four coastal area were recruited in this study. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle and medical history, then completed neuropsychological tests. Cognitive function was assesed by Mini-cog instruments. RESULT: The number of participants with cognitive decline was 87 people (56%) out of a total of 154 participants. 66% of all participants with cognitive decline were female. History of hypertension (67%), DM (16%), 40% with a BMI ≥22.5, 23% with a history of smoking, and 45% of participants with a low activity level. Multiple linear regression shows that Age and history of Hypertension is associated with cognitive decline (Sig.0.005 and 0.037). DM, BMI, smoking history and activity level is not associated significantly. CONCLUSION: More than half of middle age people on the coast of Lombok Island have cognitive decline. Age and history of hypertension are influencing factors.
Potensi Senyawa Bioaktif Xyloketal B dan Asperlin dalam Menghambat Proses Aterosklerosis pada Penyakit Jantung Koroner Ananda Rizkia; Andhito Rafid Chusaeri; Legis Ocktaviana Saputri
Lombok Medical Journal Vol. 3 No. 1 (2024): Lombok Medical Journal Volume 3 Nomor 1
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i1.3188

Abstract

Penyakit jantung koroner merupakan salah satu penyakit kardiovaskular yang memiliki angka kecacatan dan kematian yang tinggi di dunia. Penyebab paling umum yang mendasari penyakit ini adalah tersumbatnya arteri koroner yang menyuplai darah ke jantung akibat adanya penumpukan plak atau yang sering dikenal sebagai aterosklerosis. Saat ini, pilihan terapi konvensional yang tersedia memiliki banyak efek samping yang parah, seperti salah satunya statin yang memiliki efek samping terhadap liver. Banyaknya efek samping yang ditimbulkan memberikan celah untuk ditemukannya obat baru salah satunya yang berasal dari bahan alam laut. Bahan alam laut memiliki fungsi sebagai reservoir dalam metabolit bioaktif baru dengan berbagai aktivitas farmakologis di dalamnya seperti xyloketal B dan asperlin. Ulasan ini merangkum pemahaman kami mengenai manfaat xyloketal B dan asperlin dalam proses aterosklerosis pada penyakit jantung koroner.
THE THE POTENTIAL ROLE OF NRF2 AS A TARGET SITE FOR THERAPEUTIC INTERVENTIONS IN ALZHEIMER'S DISEASE Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Ocktaviana; Suryani, Dini; Rianawati, Sri Budhi
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.10

Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration leading to cognitive decline and memory impairment, affecting various cognitive functions. AD pathology involves the accumulation of neurotoxic substances such as amyloid beta (Aβ) and tau proteins, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation, resulting in synaptic loss and neuronal apoptosis. The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as a pivotal regulator of cellular defense mechanisms, including antioxidant response, autophagy, and inflammation. NRF2 not only inhibits Aβ synthesis and enhances tau protein clearance via autophagy but also reduces neuroinflammation by modulating microglial activation and cytokine production. Additionally, NRF2 activation preserves mitochondrial function by attenuating reactive oxygen species (ROS) production and sustaining mitochondrial biogenesis. Recent studies highlight the therapeutic potential of NRF2 activators, such as sulforaphane and echinacoside, in preclinical AD models, demonstrating reductions in Aβ and tau pathologies and improved cognitive outcomes. These findings underscore the multifaceted role of NRF2 in mitigating AD progression and its promise as a target for developing novel therapeutic interventions. By integrating NRF2-based strategies, future treatments may offer more effective approaches to combat the complex pathophysiology of AD.
Literature Review: Extraction Methods and Antioxidant Activity of Rhizophora mucronata Leaves Attaya, Kalisa; Saputri, Legis Ocktaviana; Permatasari, Lina
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8949

Abstract

Free radicals are highly reactive molecules and can trigger various degenerative diseases, so prevention efforts are needed through effective antioxidants. This study aims to review and analyze the extraction method of R. mucronata leaves in increasing antioxidant activity against DPPH free radicals. This study was conducted through a literature review of experimental research articles obtained from Google Scholar and PubMed databases using specific keywords, covering national and international publications for the period 2015-2025. The obtained articles were analyzed based on the extraction technique, solvent type, and IC₅₀ value reported in the article. The analysis showed that cold extraction methods, especially multi-step maceration with methanol solvent, can produce R. mucronata leaf extracts with very strong antioxidant activity with an IC₅₀ value of 0.04 ppm. The conclusion of this study confirms that extraction technique and solvent selection can affect the antioxidant activity of R. mucronata leaves. These findings support the need for optimization of extraction methods to maximize antioxidant effectiveness in the development of natural antioxidants.
Edukasi tentang Penyakit Myastenia Gravis pada Pengunjung Poliklinik Neurologi Rumah Sakit Universitas Mataram Harahap, Herpan Syafii; Hunaifi, Ilsa; Sahidu, Muhammad Ghalvan; Indrayana, Yanna; Ni Nyoman Ayu, Susilawati; Lestari, Diayanti Tenti; Zubaidi, Fitriannisa Faradina; Nurhidayati, Nurhidayati; Saputri, Legis Ocktaviana
Jurnal Pengabdian Masyarakat Sains Indonesia (Indonesian Journal Of Science Community Services) Vol. 4 No. (1) (2022)
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Myasthenia gravis is one of the most common autoimmune diseases at the neuromuscular junction. Although this disease is rare, the incidence of this disease is believed to have increased in the last seven decades. This community service activity aims to provide education to the public regarding myasthenia gravis. This community service activity was carried out in the form of counseling at the Neurology Polyclinic of UNRAM Hospital on Friday, January 20 2023. All participants were asked to take part in all counseling activities which consisted of pre-test activities, delivery of material on the topic of myasthenia gravis, and post-test. The enthusiasm of the participants in this activity was presented in the form of photo documentation. Statistical analysis using paired t-test was carried out to analyze the difference between the pre-test and post-test mean values ​​and the results were considered significant if a p value <0.05 was obtained. As many as 23 participants who attended the Neurology Polyclinic at UNRAM Hospital enthusiastically participated in the whole series of activities. The average participant post-test score was significantly higher than the pre-test means score (p = 0.025). This activity was able to increase the participants' knowledge about myasthenia gravis.
Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
Co-Authors AA Sudharmawan, AA Adam Trojan Alisyahbana Adinda Ilsa Maulida Aditya Astarika, Yolanda Aini, Siti Rahmatul Alfia Mawaddah Ali Ramzi Alma Dyah Perwita Alvi Kusuma Wardani Anak Agung Ayu Niti Wedayani Anak Agung Sagung Mas Meisyarawati Putra Ananda Rizkia Anandia Intan Maulidya, Selvira Anang Hermansyah Andhera, Athalita Andhito Rafid Chusaeri Anna Pradiningsih Astri Ferdiana Attaya, Kalisa Azhar Rafiq Azizaturrahmah, Gina Aulia Bagus Komang Satriyasa Baiq Leny Nopitasari Balqis, Ananda Amirah Bambang Priyanto Chusaeri, Andhito Rafid Cintya Ganes Budastra, Wayan Diayanti Tenti Lestari Dini Suryani Dini Suryani, Dini Eka Arie Yuliani Fahrin Andiwijaya Fatihatussir, Layla Fidelia, Puspa Zalika Fitriani, Risma Fitriannisa Faradina Zubaedi Fitriannisa Faradina Zubaidi Fitriannisa Faradina Zubaidi Haq, Abiyyu Didar Haryanto, Wahyu Hasbi, Nurmi - Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Hilam, Muhammad I Kadek Dwi Semadi I Wayan Putu Sutirta Yasa Ida Made Hrisikesa Wejeg Ilsa Hunaifi Ilsa Hunaifi, Ilsa Indrayana, Yanna Indrayana, Yanna Isnaini, Nisa Junaida, Alfini Lalu Auliya Akraboe Littaqwa Lestari, Diayanti Tenti M Said Ramdlan Mahacita Andanalusia Mahacita Andanalusia Metta Octora Muhammad Ghalvan Sahidu Muhammad Hilman Rizaldi Muttaqin, Syihabul Ni Nyoman Ayu, Susilawati Ni Putu Della Diarna Nisa Isneni Hanifa Novia Andansari Putri Novisma, Mutia Nugraha, Kadek Nandita Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurul Qiyaam, Nurul Permatasari, Lina Prawiro, Aurellia Wongso Putra, Made Raditya Arhya Putri, Ajeng Ayu Restia Restia Ristia, Ovia Intan Rivarti, Arina Windri Rizkia, Ananda Rosyunita Sahidu, Muhammad Ghalvan Salsabila, Rika Kamila Sri Budhi Rianawati, Sri Budhi Stephen, Mishael Enoch Sulthanah Ahmad, Dzakiyyah Susilawati Ni Nyoman Ayu Teguh Budi Wicaksono Vitri, Desy Aryanti Pardilla Wulandari, Inayah Yanna Indrayana Yanna Indrayana Yusra Pintaningrum Zubaidi, Fitriannisa Faradina