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Ocktaviana Saputri, Legis
Departemen Farmakologi Fakultas Kedokteran Universitas Mataram
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Risk Factors for Cognitive Impairment in Adult Population of Coastal Area: A Cross-Sectional Study in Maringkik Island, Indonesia Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati, Nurhidayati; Zubaidi, Fitriannisa Faradina; Suryani, Dini; Saputri, Legis Ocktaviana; Indrayana, Yanna; Andhera, Athalita; Hilam, Muhammad; Haq, Abiyyu Didar
Kesmas Vol. 19, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cognitive impairment is a medical condition commonly found in elderly populations, which can be due to vascular risk factors in patients. There remains limited data on risk factors for cognitive impairment among coastal region populations. This study aimed to investigate risk factors for cognitive impairment in the adult population of Maringkik Island, West Nusa Tenggara Province, Indonesia. Data collected were age, sex, education level, hypertension, antihypertensive treatment, diabetes mellitus, cigarette smoking, and body mass index status. A total of 114 participants were recruited using a consecutive sampling method. The participants’ cognitive function assessment used the Mini-Cog instrument. The cognitive impairment frequency in the island’s adult population was approximately 48.2%. The final model of multiple regression analysis showed that hypertension (OR: 2.3; 95%CI: 1.0 – 5.0; p-value: 0.045) was a characteristic associated with the cognitive impairment frequency. Thus, the high frequency of cognitive impairment and hypertension frequency as primary risk factors for cognitive impairment in the island’s adult population implies the need to develop strategies for detecting and managing hypertension and hypertension-related cognitive impairment in the population by local health authorities.
Potensi Senyawa Bioaktif Xyloketal B dan Asperlin dalam Menghambat Proses Aterosklerosis pada Penyakit Jantung Koroner Rizkia, Ananda; Chusaeri, Andhito Rafid; Saputri, Legis Ocktaviana
Lombok Medical Journal Vol. 3 No. 1 (2024): Lombok Medical Journal Volume 3 Nomor 1
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i1.3188

Abstract

Penyakit jantung koroner merupakan salah satu penyakit kardiovaskular yang memiliki angka kecacatan dan kematian yang tinggi di dunia. Penyebab paling umum yang mendasari penyakit ini adalah tersumbatnya arteri koroner yang menyuplai darah ke jantung akibat adanya penumpukan plak atau yang sering dikenal sebagai aterosklerosis. Saat ini, pilihan terapi konvensional yang tersedia memiliki banyak efek samping yang parah, seperti salah satunya statin yang memiliki efek samping terhadap liver. Banyaknya efek samping yang ditimbulkan memberikan celah untuk ditemukannya obat baru salah satunya yang berasal dari bahan alam laut. Bahan alam laut memiliki fungsi sebagai reservoir dalam metabolit bioaktif baru dengan berbagai aktivitas farmakologis di dalamnya seperti xyloketal B dan asperlin. Ulasan ini merangkum pemahaman kami mengenai manfaat xyloketal B dan asperlin dalam proses aterosklerosis pada penyakit jantung koroner.
UPAYA INTERVENSI FISIK MELALUI SOSIALISASI SENAM OTAK (BRAIN GYM) SEBAGAI UPAYA MENGHAMBAT PROGRESIFITAS DAN MENURUNKAN ANGKA KEJADIAN DEMENSIA Rivarti, Arina Windri; Saputri, Legis Ocktaviana; Harahap, Herpan Syafii; Nurhidayati, Nurhidayati; Suryani, Dini; Stephen, Mishael Enoch; Prawiro, Aurellia Wongso; Wulandari, Inayah; muttaqin, Syihabul; Ristia, Ovia Intan; Azizaturrahmah, Gina Aulia; Balqis, Ananda amirah
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1724

Abstract

The high incidence of dementia not only poses health problems but also leads to significant social impacts and economic losses. While no potential therapy has been found to cure this disease, early diagnosis and prevention are important alternatives to prevent dementia. Brain gym is one of the physical activities known to enhance and maintain cognitive function. Various studies on brain gym have shown positive effects on the cognitive function of the elderly. This activity aims to provide socialization of Brain Gym to the community in Maringkik Island and is expected to have an impact on reducing the progression of cognitive impairment and dementia. This community service activity is divided into three stages, consisting of health education, health and cognitive function assessment, and socialization of brain gym movements to the community. This activity was enthusiastically attended by 50 participants from late adulthood to elderly. The activity went well until the end. Health education regarding brain gym techniques and benefits successfully introduced 9 types of brain gym movements and their benefits, which were well received and understood by the community. After the education session, the community successfully performed the brain gym movements introduced by the service team together. The socialization of brain gym to the community in Maringkik was carried out well with high enthusiasm from the community.
UPAYA MENURUNKAN PREVALENSI DEMENSIA MEALUI EDUKASI KESEHATAN TERKAIT FAKTOR RESIKO DEMENSIA DAN DETEKSI DINI GANGGUAN KOGNITIF PADA POPULASI LANSIA DI MASYARAKAT PESISIR LOMBOK Saputri, Legis Ocktaviana; Rivarti, Arina Windri; Harahap, Herpan Syafii; Nurhidayati, Nurhidayati; Suryani, Dini; Stephen, Mishael Enoch; Prawiro, Aurellia Wongso; Wulandari, Inayah; muttaqin, Syihabul; Ristia, Ovia Intan; Azizaturrahmah, Gina Aulia; Balqis, Ananda Amirah
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1743

Abstract

Dementia is a progressive disease that affects memory and other cognitive functions. Coastal communities have a higher incidence of certain diseases compared to other areas. Degenerative diseases such as coronary heart disease, stroke, hypertension, diabetes mellitus, and dementia have an incidence rate of two to eight percent higher in coastal areas. This community engagement aims to provide health education related to the signs and symptoms as well as prevention efforts for degenerative diseases and cognitive function disorders. Health screenings are also conducted in an effort to detect cases of degenerative diseases and cognitive function disorders early. The community service activities are carried out in three coastal areas of Lombok Island. Participants enthusiastically attend health education and health screening. The results of cognitive function disorder screening show that 50.7% of the 225 participants experience cognitive function disorders. The community service activities are conducted according to plan.
PEMANFAATAN DAUN MANGROVE MENJADI MINUMAN NUTRASEUTIKAL: SOLUSI ANTIOKSIDAN ALAMI UNTUK PENCEGAHAN PENYAKIT DEGENERATIF PADA MASYARAKAT PESISIR DESA SEKOTONG TENGAH Permatasari, Lina; Isnaini, Nisa; Aditya Astarika, Yolanda; Fatihatussir, Layla; Sulthanah Ahmad, Dzakiyyah; Fitriani, Risma; Junaida, Alfini; Cintya Ganes Budastra, Wayan; Anandia Intan Maulidya, Selvira; Ocktaviana Saputri, Legis; Haryanto, Wahyu
Jurnal Pepadu Vol 6 No 4 (2025): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v6i4.9109

Abstract

  Penyakit degenaratif merupakan penyakit kronis yang dapat berdampak pada kualitas hidup masyarakat. Desa Sekotong Tengah merupakan wilayah pesisir dengan masyarakat yang rentan terhadap penyakit degeneratif akibat pola hidup tidak sehat, seperti tingginya konsumsi garam. Selain itu, desa Sekotong Tengah memiliki potensi sumber daya alam berupa mangrove (Rhizophora mucronata) yang kaya senyawa bioaktif, seperti flavonoid dan tanin. Senyawa tersebut berfungsi sebagai antioksidan alami yang dapat membantu mencegah penyakit degeneratif dan kardiovaskular. Pengabdian ini bertujuan memberikan edukasi penyakit degeneratif, pemeriksaan kesehatan dasar, dan pelatihan pembuatan teh daun mangrove sebagai minuman nutrasetikal kaya antioksidan bagi masyarakat pesisir. Metode yang digunakan meliputi edukasi kesehatan terkait penyakit degeneratif serta pelatihan pembuatan minuman teh daun mangrove. Masyarakat juga dilakukan pemeriksaan tekanan darah, kadar gula darah, dan kadar asam urat menggunakan GCU meter (Glucose, Cholesterol, Uric acid) yang kemudian dianalisis untuk mengetahui profil kesehatan masyarakat Desa Sekotong Tengah secara umum. Kegiatan ini diikuti oleh 25 peserta, dengan 64% di antaranya merupakan lansia perempuan. Mayoritas peserta bekerja sebagai petani, pedagang, dan ibu rumah tangga. Teh daun mangrove sangat disukai oleh warga. Hasil pemeriksaan menunjukkan bahwa 32% peserta mengalami hipertensi, sementara 8% memiliki tekanan darah tinggi normal. Selain itu, 12% teridentifikasi mengidap diabetes berdasarkan kadar gula darah, dan sekitar 12% lainnya memiliki kadar asam urat yang tinggi. Secara keseluruhan, pengabdian ini meningkatkan kesadaran masyarakat tentang penyakit degeneratif melalui edukasi dan pemeriksaan kesehatan, serta memberdayakan masyarakat dalam pemanfaatan daun mangrove R. mucronata sebagai teh antioksidan sebagai upaya pencegahan dan penanganan dini penyakit degeneratif.
Ekstrak Air Biji Pepaya (Carica Papaya) dapat Menurunkan Kadar Kolesterol Total dan Kadar Serumglutamat Piruvat Transaminase (Sgpt) pada Tikus Putih Jantan Galur Wistar yang Hiperkolesterolemia Legis Ocktaviana Saputri; Bagus Komang Satriyasa; Wayan Putu Sutirta Yasa
WMJ (Warmadewa Medical Journal) Vol 2 No 1 (2017): Mei 2017
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.2.1.73.1-10

Abstract

Hiperkolesterolemia merupakan kelainan metabolisme lemak yang dianggap sebagai faktor yang berkontribusi dalam peningkatan risiko PJK. Biji pepaya diduga memiliki aktivitas hipolipidemik karena mengandung senyawa fitokimia yang berpengaruh pada metabolisme lemak. Penelitian ini menggunakan model eksperimental randomized pretest-posttestcontrol-group design terhadap 30 ekor tikus yang hiperkolesterolemia setelah diinduksi pakan tinggi kolesterol selama 48 hari. Tikus tersebut dibagi ke dalam 3 kelompok yaitu kelompok kontrol negatif (P0), kontrol positif (P1), dan kelompok perlakuan (P2).Aktivitas antihiperkolesterolemik dinilai melalui pengukuran kadar kolesterol total dan SGPT pretest dan posttest. Berdasarkan hasil penelitian, ekstrak air biji pepaya dosis 300 mg/kg/hari mampu menurunkan kadar kolesterol total sebesar 13,39% dan kadar SGPT sebesar 31,4% (p<0,05). Uji One Way Anova menunjukkan bahwa kadar kolesterol total dan SGPT posttest antar kelompok berbeda bermakna (p<0,05). Uji LSD menunjukkan bahwa pemberian ekstrak air biji pepaya dapat secara signifikan menurunkan kadar kolesterol total pada tikus yang hiperkolesterolemia jika dibandingkan dengan kelompok placebo. Kadar tersebut tidak berbeda signifikan dengan kelompok yang diberi simvastatin (beda rerata 0,6 mg/dL; p>0,05). Penurunan kadar SGPT diketahui berbeda bermakna jika dibandingkan kelompok placebo. Hasil tersebut dapat membuktikan bahwa pemberian ekstrak air biji pepaya dapat menurunkan kadar kolesterol total dan SGPT pada tikus putih jantan galur wistar yang hiperkolesterolemia.Kata Kunci: hipekolesterolemia, ekstrak biji papaya, kolesterol total, SGPT. [Aqueous Extract of Papaya (Carica Papaya) Seeds Decreased Total Cholesterol and Alanine Aminotransferase (Alt) Levels in Hypercholesterolemic Male Wistar Rats]Hypercolesterolemic is fat metabolism disorder which contributes to increase the risk of CHD. Papaya seeds issuspected having anti-hipercholesterolemic activity, because contains several phytochemical compounds. This study uses a model of experimental randomized pretest-posttestcontrol-group design in 30 rats that had induced hypercholesterolemia with high cholesterol diet for 48 days. Rats were divided into 3 groups: negative control (P0), positive control (P1), and the treatment group (P2). Antihypercholesterolemic activities were assessed through total cholesterol and ALT pretest and posttest levels. Results of this study has shown that aqueous extract of papaya seeds dose 300 mg/kg/day can reduce total cholesterol by 13.39% and ALT by 31.4% (p<0.05). One Way ANOVA test showed that the levels of total cholesterol and SGPT posttest are significantly different between groups (p<0.05). Further test with LSD showed that the aqueous extract of papaya seeds can significantly reduce total cholesterol when compared to P0. These results do not differ significantly from group that given simvastatin (mean difference 0.6 mg/dL; p>0.05). Decreased levels of ALT are also known significantly different when compared to P0.These result proved that aqueous extract of Carica papaya seeds can decreased total cholesterol and ALT levels in hypercholesterolemic male wistar rats.Keywords: hypercholesterolemic, papaya seeds extract, total cholesterol, ALT
Pengaruh Ukuran Partikel Simplisia Daun Rhizophora mucronata terhadap Profil FTIR yang Dikombinasi dengan Kemometrik Lina Permatasari; Neneng Rachmalia Izzatul Mukhlishah; Legis Ocktaviana Saputri; Selvira Anandia Intan Maulidya; Alfini Junaida; Risma Fitriani; Dzakiyyah Sulthanah Ahmad; Nisa Isnaini
Sinteza Vol. 6 No. 2 (2026): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i2.34383

Abstract

Rhizophora mucronata leaves contain various secondary metabolites that contribute to several pharmacological activities. The extraction efficiency and metabolite composition can be influenced by several factors, including the particle size of plant materials. This study aimed to evaluate the effect of particle size of R. mucronata leaves on their secondary metabolite composition using Fourier Transform Infrared (FTIR) spectroscopy combined with chemometric analysis. Dried leaves were ground and sieved into different particle sizes (4000 μm, 2000 μm, 500 μm, 177 μm, and 105 μm) using mesh sizes 5, 10, 35, 80, and 140. Each sample was extracted by ultrasound-assisted extraction (UAE) using 96% ethanol. The chemical profiles of the extracts were analyzed using FTIR spectroscopy. The dominant wavenumbers were further evaluated using Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). The results showed that smaller particle sizes produced higher extraction yields. FTIR spectra revealed the presence of functional groups including O–H, C=O, C–O, and aromatic groups. Biplot on PCA indicated that O–H and C=O functional groups strongly influenced samples with particle sizes of 500 µm and 105 µm. The score plot classified the five samples into three groups: 105 µm and 500 µm (Group I), 2000 µm and 4000 µm (Group II), and 177 µm (Group III). Meanwhile HCA revealed high similarity (79.49%) between the 105 µm and 500 µm samples, while the sample 4000 µm and 105 µm  showed low similarity (24.50%). These findings indicate that particle size significantly influences the composition of extracted secondary metabolites.
Co-Authors AA Sudharmawan, AA Adam Trojan Alisyahbana Adinda Ilsa Maulida Aditya Astarika, Yolanda Aini, Siti Rahmatul Alfia Mawaddah Alfini Junaida Ali Ramzi Alma Dyah Perwita Alvi Kusuma Wardani Anak Agung Ayu Niti Wedayani Anak Agung Sagung Mas Meisyarawati Putra Ananda Rizkia Anandia Intan Maulidya, Selvira Anang Hermansyah Andhera, Athalita Andhito Rafid Chusaeri Anna Pradiningsih Astri Ferdiana Attaya, Kalisa Azhar Rafiq Azizaturrahmah, Gina Aulia Bagus Komang Satriyasa Baiq Leny Nopitasari Balqis, Ananda Amirah Bambang Priyanto Chusaeri, Andhito Rafid Cintya Ganes Budastra, Wayan Diayanti Tenti Lestari Dini Suryani Dini Suryani, Dini Dzakiyyah Sulthanah Ahmad Eka Arie Yuliani Fahrin Andiwijaya Fatihatussir, Layla Fidelia, Puspa Zalika Fitriani, Risma Fitriannisa Faradina Zubaedi Fitriannisa Faradina Zubaidi Fitriannisa Faradina Zubaidi Haq, Abiyyu Didar Haryanto, Wahyu Hasbi, Nurmi - Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Hilam, Muhammad I Kadek Dwi Semadi I Wayan Putu Sutirta Yasa Ida Made Hrisikesa Wejeg Ilsa Hunaifi Ilsa Hunaifi, Ilsa Indrayana, Yanna Indrayana, Yanna Isnaini, Nisa Junaida, Alfini Lalu Auliya Akraboe Littaqwa Lestari, Diayanti Tenti Lina Permatasari M Said Ramdlan Mahacita Andanalusia Mahacita Andanalusia Metta Octora Muhammad Ghalvan Sahidu Muhammad Hilman Rizaldi Muttaqin, Syihabul Neneng Rachmalia Izzatul Mukhlishah Ni Nyoman Ayu, Susilawati Ni Putu Della Diarna Nisa Isnaini Nisa Isneni Hanifa Novia Andansari Putri Novisma, Mutia Nugraha, Kadek Nandita Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurul Qiyaam, Nurul Permatasari, Lina Prawiro, Aurellia Wongso Putra, Made Raditya Arhya Putri, Ajeng Ayu Restia Restia Risma Fitriani Ristia, Ovia Intan Rivarti, Arina Windri Rizkia, Ananda Rosyunita Sahidu, Muhammad Ghalvan Salsabila, Rika Kamila Selvira Anandia Intan Maulidya Sri Budhi Rianawati, Sri Budhi Stephen, Mishael Enoch Sulthanah Ahmad, Dzakiyyah Susilawati Ni Nyoman Ayu Teguh Budi Wicaksono Vitri, Desy Aryanti Pardilla Wulandari, Inayah Yanna Indrayana Yanna Indrayana Yusra Pintaningrum Zubaidi, Fitriannisa Faradina