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Saputro, Amung Logam
Laboratorium Klinik, Departemen Klinik Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga Kampus-C Unair Jln. Mulyorejo, Surabaya, Jawa Timur, Indonesia, 60115
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Journal : Veterinary Biomedical and Clinical Journal

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The Potentials of Robusta Coffee Seed Extract as Antioxidant on Kidney Histopathology in Mice Exposed to Monosodium Glutamate: Potensi Pemberian Ekstrak Biji Kopi Robusta sebagai Antioksidan Terhadap Gambaran Histopatologi Ginjal Mencit yang Dipapar Monosodium Glutamat Wisudawati, Feby Dwi; Hidajati, Nove; Fikri, Faisal; Santoso, Kuncoro Puguh; Saputro, Amung Logam; Purnama, Muhammad Thohawi Elziyad
Veterinary Biomedical and Clinical Journal Vol. 5 No. 1 (2023)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2023.005.01.3

Abstract

The purpose of this study was to determine the potential of administration robusta coffee extract as an antioxidant on the renal histopathology in mice exposed to monosodium glutamate (MSG) orally. This study used 20 adult male rats with Balb C strain divided into 5 experimental groups, namely K + (MSG 0.12 mg / head and Vitamin C 6 mg/mice), K- (MSG 0.12 mg/mice and Sodium carboxymethyl cellulose (CMC Na) 0,1 ml/mice), P1 (MSG 0.12 mg/mice and Robusta coffee extract 0.1 mg/mice), P2 (MSG 0.12 mg/mice and Robusta coffee extract 0.2 mg/mice), and P3 (MSG 0.12 mg/mice and 0.4 mg Robusta coffee extract mg/mice). The experimental group was treated every day at intervals between MSG and Vitamin C, CMC Na, and Robusta coffee extract for 60 min, the treatment was carried out for 42 days. Kidney histopathology scores were analyzed using the Saphiro-Wilk and Levene test to evaluate homogeneity, followed by the Kruskal Wallis test. The results of the Saphiro Wilk and Levene statistical analysis obtained p<0.05, thus the data continued with the Kruskal Wallis test scores of kidney cell damage obtained 0.043 which showed that the data were significant. The mean score of kidney cell damage in the treatment groups was K+ 1.60; K- 1.63; P1 1.70; P2 1.63; and P3 1.73. The conclusion is that Robusta coffee bean extract did not show a decrease in kidney cell damage that was different between treatment groups. Further research is needed to find out about the effect of different dosages of Robusta Coffee Extract to different organs
Co-Authors Abdul Samik Agustono, Bodhi Amaliya, Anny Anastasya, Anastasya Ani Wijayanti Ashari, Lukman Ashilla Afandik, Nadya Atikah Madarina Hisyam, Mirza Boedi Setiawan Cahya, Rizka Wulan Dini, Sayyida Kamila Dinul, Ahmad Rajul ERMA SAFITRI Erma Safitri Estoepangestie, Agnes Theresia Soelih Faisal Fikri Faizah, Ayu Nur Farhan, Muhammad Riesta Haditanojo, Wiyanto Hamid, Iwan Sharial Hani Plumeriastuti Hermin Ratnani Hidajati, Nove Hidayatuh Sholihah, Alfi IMAM MUSTOFA Imam Mustofa iqbal dwi warsito Ira Sari Yudaniayanti Ivanalee, Angela Swasti Iwan Sahrial Hamid Iwan Sahrial Hamid Khafsah, Khafsah Lailiyah, Fahlevi Lake, Werenfridus Kono Lestari, Dewi Sri Luqman, Epy Muhammad Mafruchati, Maslichah Masyitoh, Herlina Milladiya Khuriyah Zahra, Reyza Mirni Lamid Muhammad Gufron Muhammad Thohawi Elziyad Purnama Muhandis, Putri Jauza Aulia Mumtazi, Fauzan Murjianingsih, Fitriani Nurina Naqsmagita, Salsabilla Nusdianto Triakoso Pahlevy, Jolly Rifqi Pasha, Zehansyah Algifari Poedji Hastutiek Praja, Ratih Novita Prastika, Dinda Dwi Prastiya, Ragil Angga Primarizky, Hardany Pudji Srianto Puspitasari, Vina Putri, Lusi Rosita Sartono Rachmanita, Rona Taufiqul Rahmadhani, Nurmitasari Rofiqi, Mohammad Miftahur Romadhona, Ma'rifatunnisa' Safitri, Ainun Merta Santoso, Kuncoro Puguh Sarudji, Suryanie Satria, Rafif Galih Sekarsari, Dara Ayu Pramesti Setyawan, Firman Solikhah, Tridiganita Intan Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Sulaeman, Nur Sa'adah Sulistyowati, Deny Sunarso, Agus Tatik Hernawati Tito, Muhammad Tjuk Imam Restiadi Tri Wahyu Suprayogi Trilas Sardjito Trisnawati, Sharfina Habibah Tyasningsih, Wiwiek Ulinuha, Meidina Zulva Umama, Ayu Riza Wahjuni, Retno Sri Warsito, Sunaryo Hadi Wibawati, Prima Ayu Widayani, Prasita Widya Paramita Lokapirnasari Wisudawati, Feby Dwi Yudhana, Aditya Yulianto, Rangga Yunita, Maya Nurwartanti Yustinasari, Lita Rakhma